To explore the clinical efficacy of optimal pulse technology (OPT) combined with 0.1% fluorometholone eye drops in the treatment of dry eye related to Sjögren's syndrome.

One hundred patients with Sjögren's syndrome-related dry eye treated in our hospital from March 2021 to March 2025 were selected as the study subjects and randomly divided into a control group and an experimental group, with 50 patients in each group. The control group received 0.3% sodium hyaluronate eye drops, 0.1% fluorometholone eye drops combined with standardized meibomian gland massage and warm compress. The experimental group received the same treatment as the control group, with the addition of OPT treatment. The tear film break-up time (BUT), tear meniscus height (TMH), results of the Schirmer I test (SIt), ocular surface disease index (OSDI) score, corneal fluorescein staining (FL) score, emotional status [self-rating anxiety scale (SAS) score and self-rating depression scale (SDS) score], and treatment efficacy were compared between the two groups.

After treatment, the experimental group exhibited significantly higher values in BUT, TMH, and SIt compared to the control group, with statistically significant differences (P<0.05). The OSDI and FL scores of the experimental group were significantly lower than those of the control group after treatment, showing statistically significant differences (P<0.05). Furthermore, the SAS and SDS scores of the experimental group were significantly lower than those of the control group after treatment, with statistically significant differences (P<0.05). The clinical efficacy of the experimental group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).

The combination of optimal pulse technology and fluorometholone eye drops in the treatment of dry eye related to Sjögren's syndrome can effectively improve the clinical symptoms of patients, reduce their negative emotions, and has a good therapeutic effect, which has clinical promotion value.