To explore the effects of ultrasound-guided transversus abdominis plane block combined with general anesthesia on patients undergoing laparoscopic cholecystectomy (LC).

From January 2022 to January 2025, 124 patients who underwent LC treatment in our hospital were randomly divided into two groups, with 62 cases in each group. The control group received simple general anesthesia, while the observation group received ultrasound-guided transversus abdominis plane block combined with general anesthesia. The hemodynamic indicators, analgesic effect, postoperative recovery indicators, and adverse reactions were compared between the two groups.

Immediately after tracheal intubation (T1), the establishment of pneumoperitoneum (T2), and at the end of the operation (T3), the mean arterial pressure (MAP) and heart rate (HR) of the observation group were higher than those of the control group (P<0.05); at 1 h, 6 h, 12 h, and 24 h after surgery, the visual analogue scale (VAS) scores of the observation group were lower than those of the control group (P<0.05); the postoperative spontaneous breathing recovery time, extubation time, and awakening time of the observation group were shorter than those of the control groupt (P<0.05); the incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05).

Ultrasound-guided transversus abdominis plane block combined with general anesthesia for LC patients can stabilize hemodynamics, improve analgesic effect, and have a fast postoperative recovery and higher safety.