To explore the application effect of microneedle radiofrequency acne treatment device in the treatment of acne, in order to guide the formulation of clinical treatment measures and improve the treatment effect on acne patients.

According to the random number table method, 513 acne patients admitted to the hospital from November 2021 to October 2022 were divided into an observation group (257 cases, treated with microneedle radiofrequency acne treatment device combined with minocycline hydrochloride) and a control group (256 cases, treated with minocycline hydrochloride), both treated for 12 weeks. Evaluate the clinical efficacy of two groups, compare the acne situation and quality of life before and after treatment, and statistically analyze the adverse reactions of the two groups.

The results showed that compared with the control group (67.97%), the observation group had a higher total effective rate (85.60%), with statistical differences (P<0.05). After treatment, both groups showed a decrease in the general acne grading system (GAGS) score, with the observation group having a lower score (P<0.05). The acne specific quality of life (Acne QoL) scores increased in both groups after treatment, with the observation group having a higher score (P<0.05). There was no statistically significant difference in adverse reactions between the two groups (P>0.05).

The microneedle radiofrequency acne treatment device has significant therapeutic effects on acne, can improve patients' quality of life, alleviate clinical symptoms, and has a certain degree of safety.