Article(id=1324078097582129435, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324078037817504735, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202507179, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752249600000, receivedDateStr=2025-07-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793614418644, onlineDateStr=2026-11-02, pubDate=1770652800000, pubDateStr=2026-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793614418644, onlineIssueDateStr=2026-11-02, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793614418644, creator=13701087609, updateTime=1793614418644, updator=13701087609, issue=Issue{id=1324078037817504735, tenantId=1146029695717560320, journalId=1227665162245664772, year='2026', volume='53', issue='3', pageStart='385', pageEnd='576', issueExtLink='null', onlineDate='null', pubDate='1770652800000', pubDateStr='2026-02-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793614404396, creator='13701087609', updateTime=1793614474144, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1324078330420527919, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324078037817504735, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1324078330420527920, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324078037817504735, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=460, endPage=465, ext={EN=ArticleExt(id=1324078097812816156, articleId=1324078097582129435, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Association between weight status and atherogenic index of plasma in adolescents from Liangshan Prefecture: a cohort study, columnId=1228016568949474136, journalTitle=Modern Preventive Medicine, columnName=Child and Adolescent Health, Maternal and Child Health, runingTitle=null, highlight=null, articleAbstract=
Objective This study aims to investigate the association between weight status and the atherogenic index of plasma(AIP) among adolescents in Liangshan Prefecture, with the goal of providing evidence for the prevention of atherosclerosis in this population.
Methods In October 2021, a sample of middle school students from three schools in Liangshan Prefecture was selected. Follow-up survey was conducted in March 2023. General demographic characteristics were collected via structured questionnaires. Anthropometric measurements, including height, weight, and waist circumference(WC), were obtained. Fasting blood samples were collected to measure serum triglycerides(TG) and high-density lipoprotein cholesterol (HDL-C). The associations between baseline body mass index(BMI) and WC with follow-up atherogenic index of plasma (AIP) were assessed using a linear regression model incorporating restricted cubic splines (RCS). A mediation analysis model was employed to evaluate the potential mediating role of baseline AIP in the relationship between baseline BMI (or WC) and follow-up AIP.Furthermore, the association between baseline weight and WC categories and changes in AIP from baseline to follow-up was examined using logistic regression.
Results The median baseline age of the 1 023 participants was 14.0 years, with 43.7% being male. The RCS curve indicated that baseline BMI was linearly associated with follow-up AIP (Pgeneral<0.001, Pnonlinearity=0.108). In contrast, baseline WC exhibited a nonlinear association with follow-up AIP (Pgeneral<0.001, Pnonlinearity=0.002). Mediation analysis revealed that baseline AIP fully mediated the association between baseline BMI (or WC) and follow-up AIP (BMI: Pdirect=0.06,Pindirect<0.001; WC: Pdirect=0.13, Pindirect<0.001). Compared with adolescents with normal BMI, those who were overweight or obese at baseline had significantly higher odds of persistent elevated AIP levels (OR=3.570, P<0.001). Similar findings were observed when WC was used as the indicator of weight status (OR=3.388, P<0.001).
Conclusion Both elevated BMI and increased WC in adolescents are associated with an increased short-term risk of high AIP. Preventive strategies targeting middle school students should be implemented to mitigate the early onset of atherosclerosis.
, authors=Chun-yi LI
1, Tao GUAN
2, Bao-feng CHEN
3, Hui FAN
4, authorsList=Chun-yi LI, Tao GUAN, Bao-feng CHEN, Hui FAN, authorCompany=null, correspAuthors=Bao-feng CHEN, Hui FAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1324078100153237794, articleId=1324078097582129435, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=凉山州青少年体重状态与动脉粥样硬化指数关系的队列研究, columnId=1228016570031604578, journalTitle=现代预防医学, columnName=儿少卫生与妇幼保健, runingTitle=null, highlight=null, articleAbstract=
目的 本研究旨在探明凉山州青少年体重状态与动脉粥样硬化指数（atherogenic index of plasma，AIP）的关系，为预防青少年动脉粥样硬化的发生提供依据。
方法 2021年10月选取凉山州3所中学的学生进行调查，2023年3月开展随访。通过问卷收集了一般人口学特征，测量学生的身高、体重和腰围，并采集空腹状态下的血液用于测定血清中的甘油三酯、高密度脂蛋白胆固醇（high-density lipoprotein cholesterol, HDL-C）等指标。使用线性模型结合限制性立方样条(restricted cubic spline, RCS)评估基线体质量指数（body mass index, BMI）、腰围与随访AIP的关系。使用中介效应模型探索基线AIP在基线BMI（基线腰围）与随访AIP关系中的中介效应。使用logistic回归模型分析了基线时体重和腰围状态与基线到随访AIP的关系。
结果 1 023名中学生基线中位数年龄为14.0岁，男性占43.7%。RCS曲线显示，基线BMI与随访AIP呈线性关联（P总趋势<0.001，P非线性=0.108）；基线腰围与随访AIP呈非线性关联（P总趋势<0.001，P非线性= 0.002）。经中介效应模型分析，基线AIP在基线BMI（基线腰围）与随访AIP的关系中起完全中介作用（BMI:P直接=0.06，P间接<0.001；腰围:P直接= 0.13，P间接<0.001)。相对于基线BMI正常的青少年，基线超重肥胖的青少年更容易出现持续高AIP（OR=3.570, P<0.001）;当使用腰围定义体重状态时，得到类似的结果（OR=3.388, P<0.001）。
结论 在短期内，青少年高BMI或高腰围均会增加高AIP的发生风险。应针对中学生采取相关措施，以防止动脉粥样硬化的启动。
, authors=李春义
1, 关陶
2, 陈保锋
3, 范晖
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李春义( 2001-)，男，硕士在读，研究方向：生命全程心血管流行病学
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陈保锋与范晖为共同通信作者
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=bkjHVxy8GxktQoN446MMaQ==, magXml=d2yWrNHxMBqHg5Fu6guBxQ==, pdfUrl=null, pdf=v8tgs3W49TM1nb+slZyh+A==, pdfFileSize=750178, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=2Nm96RnShaXW+juCYX5Puw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=7EWzJnI+BHQK/hTdTnmISQ==, mapNumber=null, fund=null)}, authors=[Author(id=1324078100807549230, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324078100895629616, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, authorId=1324078100807549230, language=EN, stringName=Chun-yi LI, firstName=Chun-yi, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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Dose-response relationship between baseline BMI and follow-up AIP, figureFileSmall=LNDkvM9hX7VyCag3Mx1TaA==, figureFileBig=2Nm96RnShaXW+juCYX5Puw==, tableContent=null), ArticleFig(id=1324078102447522120, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, language=CN, label=图1, caption=
基线BMI与随访AIP的剂量-反应关系, figureFileSmall=LNDkvM9hX7VyCag3Mx1TaA==, figureFileBig=2Nm96RnShaXW+juCYX5Puw==, tableContent=null), ArticleFig(id=1324078102703374665, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, language=EN, label=Figure 2, caption=
Dose-response relationship between baseline WC and follow-up AIP, figureFileSmall=ZxCNTA+d5qWe4bylHUhaNQ==, figureFileBig=yiOY511DMR374VfDmltU+A==, tableContent=null), ArticleFig(id=1324078102795649354, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, language=CN, label=图2, caption=
基线腰围与随访AIP的剂量-反应关系, figureFileSmall=ZxCNTA+d5qWe4bylHUhaNQ==, figureFileBig=yiOY511DMR374VfDmltU+A==, tableContent=null), ArticleFig(id=1324078102883729739, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, language=EN, label=Table 1, caption=
The basic characteristics of the research subjects at baseline (n=1 023)
, figureFileSmall=null, figureFileBig=null, tableContent=
| 项目 | 人数(%) |
|---|
| 性别 | |
| 男性 | 447 (43.7) |
| 女性 | 576 (56.3) |
| 运动不足 | 358 (35.0) |
| 民族 | |
| 汉族 | 370 (36.2) |
| 彝族 | 627 (61.3) |
| 其他民族 | 26 (2.5) |
| 学校 | |
| 学校A | 327 (32.0) |
| 学校B | 322 (31.5) |
| 学校C | 374 (36.5) |
| 摄入含糖饮料 | 641 (62.7) |
| 最近一个月每天平均睡眠时间 (h) | 8.33 (7.86, 8.81) |
| 收缩压(mm Hg) | 108 (100.33, 115.33) |
| 舒张压 (mm Hg) | 63.33 (57.33, 69.33) |
| 腰围 (cm) | 65.70 (62.20, 70.50) |
| 年龄 (岁) | 14.00 (13.00, 16.00) |
| 空腹甘油三酯 (mmol/L) | 0.86 (0.66, 1.12) |
| 空腹HDL-C (mmol/L) | 1.28 (1.11, 1.48) |
| 超重肥胖 | 200 (19.6) |
| 血压偏高 | 219 (21.4) |
| BMI (kg/m2) | 20.05 (18.37, 21.94) |
| AIP | -0.18 (-0.32, -0.03) |
), ArticleFig(id=1324078104599200076, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, language=CN, label=表1, caption=
研究对象基线基本特征 (n=1 023)
, figureFileSmall=null, figureFileBig=null, tableContent=
| 项目 | 人数(%) |
|---|
| 性别 | |
| 男性 | 447 (43.7) |
| 女性 | 576 (56.3) |
| 运动不足 | 358 (35.0) |
| 民族 | |
| 汉族 | 370 (36.2) |
| 彝族 | 627 (61.3) |
| 其他民族 | 26 (2.5) |
| 学校 | |
| 学校A | 327 (32.0) |
| 学校B | 322 (31.5) |
| 学校C | 374 (36.5) |
| 摄入含糖饮料 | 641 (62.7) |
| 最近一个月每天平均睡眠时间 (h) | 8.33 (7.86, 8.81) |
| 收缩压(mm Hg) | 108 (100.33, 115.33) |
| 舒张压 (mm Hg) | 63.33 (57.33, 69.33) |
| 腰围 (cm) | 65.70 (62.20, 70.50) |
| 年龄 (岁) | 14.00 (13.00, 16.00) |
| 空腹甘油三酯 (mmol/L) | 0.86 (0.66, 1.12) |
| 空腹HDL-C (mmol/L) | 1.28 (1.11, 1.48) |
| 超重肥胖 | 200 (19.6) |
| 血压偏高 | 219 (21.4) |
| BMI (kg/m2) | 20.05 (18.37, 21.94) |
| AIP | -0.18 (-0.32, -0.03) |
), ArticleFig(id=1324078104754389325, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, language=EN, label=Table 2, caption=
The mediating role of baseline AIP in the association between baseline BMI (baseline WC) and follow-up AIP
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 效应估计值a | 95%CI | P值 |
|---|
| 基线BMI（暴露因素）-基线AIP（中介变量）-随访AIP（结局变量） | | | |
| 模型1：基线BMI-基线AIP | 0.015 | 0.012~0.019 | <0.001 |
| 模型2：基线BMI-随访AIP | 0.003 | 0.000~0.007 | 0.049 |
| 模型2：基线AIP-随访AIP | 0.479 | 0.427~0.530 | <0.001 |
| 总效应 | 0.011 | 0.006~0.016 | <0.001 |
| 直接效应 | 0.003 | -0.000~0.010 | 0.060 |
| 间接效应 | 0.007 | 0.005~0.010 | <0.001 |
| 中介百分比（%） | | 63.6 | |
| 基线腰围（暴露因素）-基线AIP（中介变量）-随访AIP（结局变量） | | | |
| 模型1：基线腰围-基线AIP | 0.007 | 0.006~0.009 | <0.001 |
| 模型2：基线腰围-随访AIP | 0.001 | -0.000~0.003 | 0.132 |
| 模型2：基线AIP-随访AIP | 0.481 | 0.430~0.532 | <0.001 |
| 总效应 | 0.005 | 0.003~0.007 | <0.001 |
| 直接效应 | 0.001 | -0.000~0.003 | 0.130 |
| 间接效应 | 0.004 | 0.003~0.005 | <0.001 |
| 中介百分比（%） | | 80.0 | |
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在基线BMI（基线腰围）与随访AIP关系中基线AIP的中介效应
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 效应估计值a | 95%CI | P值 |
|---|
| 基线BMI（暴露因素）-基线AIP（中介变量）-随访AIP（结局变量） | | | |
| 模型1：基线BMI-基线AIP | 0.015 | 0.012~0.019 | <0.001 |
| 模型2：基线BMI-随访AIP | 0.003 | 0.000~0.007 | 0.049 |
| 模型2：基线AIP-随访AIP | 0.479 | 0.427~0.530 | <0.001 |
| 总效应 | 0.011 | 0.006~0.016 | <0.001 |
| 直接效应 | 0.003 | -0.000~0.010 | 0.060 |
| 间接效应 | 0.007 | 0.005~0.010 | <0.001 |
| 中介百分比（%） | | 63.6 | |
| 基线腰围（暴露因素）-基线AIP（中介变量）-随访AIP（结局变量） | | | |
| 模型1：基线腰围-基线AIP | 0.007 | 0.006~0.009 | <0.001 |
| 模型2：基线腰围-随访AIP | 0.001 | -0.000~0.003 | 0.132 |
| 模型2：基线AIP-随访AIP | 0.481 | 0.430~0.532 | <0.001 |
| 总效应 | 0.005 | 0.003~0.007 | <0.001 |
| 直接效应 | 0.001 | -0.000~0.003 | 0.130 |
| 间接效应 | 0.004 | 0.003~0.005 | <0.001 |
| 中介百分比（%） | | 80.0 | |
), ArticleFig(id=1324078105006047567, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, language=EN, label=Table 3, caption=
The relationship between baseline body weight and WC status and AIP from baseline to follow-up ［OR（95% CI）］
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 基线+随访均正常AIP vs. 基线+
随访均高AIP | 基线+随访均正常AIP vs.
基线高AIP+随访正常AIP | 基线+随访均正常AIP vs.
基线正常AIP+随访高AIP |
|---|
| BMI | | | |
| 基线正常体重 | Ref | Ref | Ref |
基线超重肥胖
腰围 | 3.570 (2.286~5.576)*** | 2.481 (1.572~3.915)*** | 1.691(1.030~2.776)* |
| 基线正常腰围 | Ref | Ref | Ref |
| 基线高腰围 | 3.388 (2.198~5.222)*** | 2.357 (1.522~3.651)*** | 1.214 (0.744~1.982) |
), ArticleFig(id=1324078105148653904, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324078097582129435, language=CN, label=表3, caption=
基线体重和腰围状态与基线到随访AIP的关系研究［OR（95% CI）］
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 基线+随访均正常AIP vs. 基线+
随访均高AIP | 基线+随访均正常AIP vs.
基线高AIP+随访正常AIP | 基线+随访均正常AIP vs.
基线正常AIP+随访高AIP |
|---|
| BMI | | | |
| 基线正常体重 | Ref | Ref | Ref |
基线超重肥胖
腰围 | 3.570 (2.286~5.576)*** | 2.481 (1.572~3.915)*** | 1.691(1.030~2.776)* |
| 基线正常腰围 | Ref | Ref | Ref |
| 基线高腰围 | 3.388 (2.198~5.222)*** | 2.357 (1.522~3.651)*** | 1.214 (0.744~1.982) |
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