Article(id=1324077669687632218, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202509134, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1757260800000, receivedDateStr=2025-09-08, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793614316627, onlineDateStr=2026-11-02, pubDate=1774368000000, pubDateStr=2026-03-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793614316627, onlineIssueDateStr=2026-11-02, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793614316627, creator=13701087609, updateTime=1793614316627, updator=13701087609, issue=Issue{id=1324077560820282023, tenantId=1146029695717560320, journalId=1227665162245664772, year='2026', volume='53', issue='6', pageStart='961', pageEnd='1152', issueExtLink='null', onlineDate='null', pubDate='1774368000000', pubDateStr='2026-03-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793614290671, creator='13701087609', updateTime=1793614391469, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1324077983656444429, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1324077983660638734, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1017, endPage=1023, ext={EN=ArticleExt(id=1324077669880570203, articleId=1324077669687632218, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Characterization of spatial contamination and cumulative risk assessment of multiple mycotoxins in corn and its products, Jinan City, columnId=1228016572783063333, journalTitle=Modern Preventive Medicine, columnName=Nutrition and Food Hygiene, runingTitle=null, highlight=null, articleAbstract=
Objective

To analyze the contamination characteristics of multiple mycotoxins in cornand corn products across districts and counties in Jinan City during 2022—2023, and to assess the cumulative exposure risk among different age groups.

Methods

We collected 173 samples of maize and products from 12 districts and counties in Jinan City from 2022 to 2023, and simultaneously detected 12 mycotoxins by isotope dilution liquid chromatography tandem mass spectrometry, and evaluated the cumulative exposure risk of the population of different age groups based on the data of dietary consumption of residents in Shandong Province by using compositional analysis combined with the equivalence factor (EF) and the exposure boundary value (MOE).

Results

Fumonisins (FBs) were the most contaminated (detection rate, 91.3%, mean, 1 506.1 μg/kg), followed by deoxynivalenol and metabolites (tDON, detection rate, 89.6%, mean, 91.7μg/kg) and zearalenone (ZEN, detection rate,72.8%, mean,41.1μg/kg). 91.9% of samples contained two or more toxins concurrently, with FB+tDON+ZEN being the predominant co-contamination pattern. Contamination characteristics varied across districts: Laiwu District exhibited relatively higher FB detection levels(2 653.7 μg/kg), while Huaiyin District showed relatively higher tDON levels (259.6 μg/kg). No distinct high-risk areas for ZEN contamination were identified citywide. The MOE values for all population groups fell below the safety threshold (100),indicating potential health risks. At the same time, it is necessary to consider the uncertainty of evaluation caused by sample size and consumption data. The younger age group exhibited relatively higher risks. No statistically significant differences in exposure risk were observed between genders. FBs contributed the most (93.6%) to cumulative exposure risk and were identified as the primary risk factor. Corn milling products served as the main exposure source (Contribution rate 67%), with consumption levels positively correlated to mycotoxin exposure.

Conclusion

Mycotoxin contamination in Jinan exhibits a spatial distribution pattern characterized by higher levels in peripheral areas and lower levels in central areas. The population faces potential health risks from cumulative exposure to mycotoxins through the consumption of corn and corn products. Younger age groups, due to their higher intake per unit of body weight, should be prioritized as key targets for prevention and control.

, authors=Xiao-li CAO, Xiang-ji WANG, Min ZHENG, Hong WU, Wen-xia TIAN, Yan KUANG, Xiao-qian YANG, authorsList=Xiao-li CAO, Xiang-ji WANG, Min ZHENG, Hong WU, Wen-xia TIAN, Yan KUANG, Xiao-qian YANG, authorCompany=null, correspAuthors=Xiao-qian YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1324077671046586726, articleId=1324077669687632218, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=济南市玉米及制品中多种真菌毒素的污染特征分析与累积风险评估, columnId=1228016573034721597, journalTitle=现代预防医学, columnName=营养与食品卫生, runingTitle=null, highlight=null, articleAbstract=
目的

分析济南市2022—2023年各区县玉米及制品中多种真菌毒素的污染特征,并评估不同年龄组人群的累积暴露风险。

方法

采集2022—2023年济南市12个区县173份玉米及制品样本,采用同位素稀释液相色谱串联质谱法同时检测12种真菌毒素,基于山东省居民膳食消费数据,采用成分分析法结合等效因子(EF)和暴露边界值(MOE),评估不同年龄组人群的累积暴露风险。

结果

伏马菌素(FBs)的检出情况相对突出(检出率91.3%,均值1 506.1 μg/kg),其次为脱氧雪腐镰刀菌烯醇及代谢物(tDON,检出率89.6%,均值 91.7 μg/kg)和玉米赤霉烯酮(ZEN,检出率 72.8%, 均值 41.1 μg/kg)。91.9%样品存在两类及以上毒素共存,其中以FBs+tDON+ZEN为主要共污染模式。不同区县污染特征存在差异,莱芜区FBs检出水平相对较高(2 653.7 μg/kg),槐荫区 tDON 检出水平相对较高(259.6 μg/kg),而ZEN污染在全市范围内未呈现明显的区域差异性。各人群的MOE值均低于参考阈值(100),提示需关注其累积暴露水平,低年龄组人群的相关膳食暴露指标相对偏高,同时需要考虑由于样品量及消费数据带来的评估不确定性,性别间暴露水平差异不显著。FBs对人群累积暴露的贡献率最高(93.6%),是主要风险因子。玉米碾磨制品为主要暴露来源(贡献率为67%),其消费量与真菌毒素暴露量正相关。

结论

济南市人群通过摄入玉米及制品存在真菌毒素累积暴露的相关情况,低年龄组人群为重点关注群体,建议开展针对性的膳食健康指导与风险管控。

, authors=曹小丽, 王相际, 郑敏, 吴虹, 田文霞, 匡彦, 杨晓倩, authorsList=曹小丽, 王相际, 郑敏, 吴虹, 田文霞, 匡彦, 杨晓倩, authorCompany=null, correspAuthors=杨晓倩, authorNote=

曹小丽(1979—),女,硕士,主任技师,研究方向:食品安全

, correspAuthorsNote=
杨晓倩,E-mail:
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Toxins, 2024, 16(9): 402-422., articleTitle=Exposure of cattle breeding herds to naturally Co-Contaminated zearalenone and deoxynivalenol: the relevance of a urinary mycotoxin monitoring system for herd health and food safety, refAbstract=null)], funds=[Fund(id=1324077674909540766, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, awardId=20240307007, language=CN, fundingSource=济南市卫生健康委员会科技计划项目(20240307007), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1324077671344382311, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, xref=null, ext=[AuthorCompanyExt(id=1324077671356965224, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, companyId=1324077671344382311, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department for Physical and Chemical Inspection,Jinan Center for Disease Control and Prevention, Jinan, Shandong 250021, China), AuthorCompanyExt(id=1324077671377936745, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, companyId=1324077671344382311, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=济南市疾病预防控制中心理化检验所,山东 济南 250021)])], figs=[ArticleFig(id=1324077674100040086, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, language=EN, label=Fig.1, caption=Average corn and corn product consumption among different age groups in Shandong Province, figureFileSmall=XUwYTPChOquznLW3s/fAWQ==, figureFileBig=y5DcaltYi/kFsN/Znl3ulg==, tableContent=null), ArticleFig(id=1324077674175537559, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, language=CN, label=图1, caption=山东省不同年龄段玉米及制品食用人群的平均消费量, figureFileSmall=XUwYTPChOquznLW3s/fAWQ==, figureFileBig=y5DcaltYi/kFsN/Znl3ulg==, tableContent=null), ArticleFig(id=1324077674368475544, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, language=EN, label=Fig.2, caption=Contribution of different corn subtypes and products to cumulative exposure in consumers, figureFileSmall=ca5BNOGEVVr/abCI/tlQ6A==, figureFileBig=bP9IKRoNyjKhxN2osRIw7w==, tableContent=null), ArticleFig(id=1324077674435584409, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, language=CN, label=图2, caption=不同亚类玉米及制品对食用人群累积暴露量的贡献, figureFileSmall=ca5BNOGEVVr/abCI/tlQ6A==, figureFileBig=bP9IKRoNyjKhxN2osRIw7w==, tableContent=null), ArticleFig(id=1324077674515276186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, language=EN, label=Table 1, caption=

Contamination levels of multiple mycotoxins in corn and corn products

, figureFileSmall=null, figureFileBig=null, tableContent=
样品类型参数tDONaFBsb
玉米及制品(n=173)检出率[%, (n)]89.6(155)91.3 (158)
均值[μg/kg, MB(LB~UB)]d145.0(139.6~150.4)1 506.1(1 493.5~1 518.7)
中位值[μg/kg, MB(LB~UB)]91.7(86.0~97.7)420.0(413.8~425.5)
P95[μg/kg, MB(LB~UB)]446.7(442.3~452.6)7 923.8
最大值 (μg/kg)916.017 661.0
玉米/玉米粒(n=47)检出率[%, (n)]74.5 (35)83.0 (39)
均值 [μg/kg, MB(LB~UB)]194.5(189.0~200.0)2 176.0(2 158.9~2193.0)
中位值 [μg/kg, MB(LB~UB)]206.5(203.2~209.7)290.5(265.5~315.5)
P95[μg/kg, MB(LB~UB)]496.7(493.0~501.4)10 281.3
最大值 (μg/kg)820.817 661.0
玉米碾磨制品(n=80)检出率[%, (n)]96.2 (77)97.5 (78)
均值 [μg/kg, MB(LB~UB)]145.1(140.0~150.5)1 478.8(1 468.7~1 488.8)
中位值[μg/kg, MB(LB~UB)]90.9(85.1~95.8)509.3(504.5~521.8)
P95[μg/kg, MB(LB~UB)]555.1(551.8~558.3)8 002.9
最大值 (μg/kg)916.015 112.0
玉米面制品(n=46)检出率[%, (n)]93.5 (43)89.1(41)
均值 [μg/kg, MB(LB~UB)]d94.0(88.2~99.8)869.3(856.8~881.8)
中位值 [μg/kg, MB(LB~UB)]64.8(57.8~71.8)338.0(325.5~358.8)
P95([μg/kg, MB(LB~UB)]304.2(300.9~307.4)3781.0
最大值 (μg/kg)428.55 163.0
样品类型参数ZENAFscOTA
玉米及制品(n=173)检出率[%, (n)]72.8 (126)24.3 (42)4.6(8.0)
均值[μg/kg, MB(LB~UB)]441.1(40.5~41.8)1.4(0.69~2.06)0.4(0.2~0.6)
中位值 [μg/kg, MB(LB~UB)]14.60.7(0~1.4)0.3(0~0.5)
P95[μg/kg, MB(LB~UB)]4.3(3.7~5.0)0.5(0.0~1.0)0.3(0.2~0.5)
最大值 (μg/kg)720.020.310.2
玉米/玉米粒(n=47)检出率[%, (n)]57.4 (27)6.4 (3)4.3 (2)
均值 [μg/kg, MB(LB~UB)]31.0(30.0~32.1)1.3(0.6~2.0)0.3(0.1~0.5)
中位值 [μg/kg, MB(LB~UB)]8.60.7(0.0~1.4)0.2(0.0~0.5)
P95[μg/kg, MB(LB~UB)]223.65.80.8(0.7~0.9)
最大值 (μg/kg)407.019.12.0
玉米碾磨制品(n=80)检出率[%, (n)]77.5 (62)31.5(25)2.5(2)
均值 [μg/kg, MB(LB~UB)]42.4(41.9~43.0)1.2(0.6~1.9)0.4(0.2~0.6)
中位值[μg/kg, MB(LB~UB)]14.20.7(0.0~1.4)0.2(0.0~0.5)
P95[μg/kg, MB(LB~UB)]232.24.0(3.4~4.6)0.2(0.0~0.5)
最大值 (μg/kg)720.09.010.2
玉米面制品(n=46)检出率[%, (n)]80.4 (37)30.4 (14)8.7 (4)
均值 [μg/kg, MB(LB~UB)]d49.1(48.6~49.6)1.6(1.0~2.3)0.5(0.3~0.7)
中位值 [μg/kg, MB(LB~UB)]26.50.7(0.0~1.4)0.2(0.0~0.5)
P95([μg/kg, MB(LB~UB)]174.95.3(4.7~6.0)1.7
最大值 (μg/kg)196.06.28.2
), ArticleFig(id=1324077674603356571, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, language=CN, label=表1, caption=

玉米及其制品中多种真菌毒素的污染情况

, figureFileSmall=null, figureFileBig=null, tableContent=
样品类型参数tDONaFBsb
玉米及制品(n=173)检出率[%, (n)]89.6(155)91.3 (158)
均值[μg/kg, MB(LB~UB)]d145.0(139.6~150.4)1 506.1(1 493.5~1 518.7)
中位值[μg/kg, MB(LB~UB)]91.7(86.0~97.7)420.0(413.8~425.5)
P95[μg/kg, MB(LB~UB)]446.7(442.3~452.6)7 923.8
最大值 (μg/kg)916.017 661.0
玉米/玉米粒(n=47)检出率[%, (n)]74.5 (35)83.0 (39)
均值 [μg/kg, MB(LB~UB)]194.5(189.0~200.0)2 176.0(2 158.9~2193.0)
中位值 [μg/kg, MB(LB~UB)]206.5(203.2~209.7)290.5(265.5~315.5)
P95[μg/kg, MB(LB~UB)]496.7(493.0~501.4)10 281.3
最大值 (μg/kg)820.817 661.0
玉米碾磨制品(n=80)检出率[%, (n)]96.2 (77)97.5 (78)
均值 [μg/kg, MB(LB~UB)]145.1(140.0~150.5)1 478.8(1 468.7~1 488.8)
中位值[μg/kg, MB(LB~UB)]90.9(85.1~95.8)509.3(504.5~521.8)
P95[μg/kg, MB(LB~UB)]555.1(551.8~558.3)8 002.9
最大值 (μg/kg)916.015 112.0
玉米面制品(n=46)检出率[%, (n)]93.5 (43)89.1(41)
均值 [μg/kg, MB(LB~UB)]d94.0(88.2~99.8)869.3(856.8~881.8)
中位值 [μg/kg, MB(LB~UB)]64.8(57.8~71.8)338.0(325.5~358.8)
P95([μg/kg, MB(LB~UB)]304.2(300.9~307.4)3781.0
最大值 (μg/kg)428.55 163.0
样品类型参数ZENAFscOTA
玉米及制品(n=173)检出率[%, (n)]72.8 (126)24.3 (42)4.6(8.0)
均值[μg/kg, MB(LB~UB)]441.1(40.5~41.8)1.4(0.69~2.06)0.4(0.2~0.6)
中位值 [μg/kg, MB(LB~UB)]14.60.7(0~1.4)0.3(0~0.5)
P95[μg/kg, MB(LB~UB)]4.3(3.7~5.0)0.5(0.0~1.0)0.3(0.2~0.5)
最大值 (μg/kg)720.020.310.2
玉米/玉米粒(n=47)检出率[%, (n)]57.4 (27)6.4 (3)4.3 (2)
均值 [μg/kg, MB(LB~UB)]31.0(30.0~32.1)1.3(0.6~2.0)0.3(0.1~0.5)
中位值 [μg/kg, MB(LB~UB)]8.60.7(0.0~1.4)0.2(0.0~0.5)
P95[μg/kg, MB(LB~UB)]223.65.80.8(0.7~0.9)
最大值 (μg/kg)407.019.12.0
玉米碾磨制品(n=80)检出率[%, (n)]77.5 (62)31.5(25)2.5(2)
均值 [μg/kg, MB(LB~UB)]42.4(41.9~43.0)1.2(0.6~1.9)0.4(0.2~0.6)
中位值[μg/kg, MB(LB~UB)]14.20.7(0.0~1.4)0.2(0.0~0.5)
P95[μg/kg, MB(LB~UB)]232.24.0(3.4~4.6)0.2(0.0~0.5)
最大值 (μg/kg)720.09.010.2
玉米面制品(n=46)检出率[%, (n)]80.4 (37)30.4 (14)8.7 (4)
均值 [μg/kg, MB(LB~UB)]d49.1(48.6~49.6)1.6(1.0~2.3)0.5(0.3~0.7)
中位值 [μg/kg, MB(LB~UB)]26.50.7(0.0~1.4)0.2(0.0~0.5)
P95([μg/kg, MB(LB~UB)]174.95.3(4.7~6.0)1.7
最大值 (μg/kg)196.06.28.2
), ArticleFig(id=1324077674695631260, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, language=EN, label=Table 2, caption=

Mean exposure levels to major mycotoxins in corn and corn products among different age groups

, figureFileSmall=null, figureFileBig=null, tableContent=
食用人群真菌毒素玉米/玉米粒 MB(LB~UB)
单一毒素暴露量μg/(kg·bw·d)累积暴露量μg/(kg·bw·d)累积暴露限量值MOE
食用人群tDON0.055 2(0.0536~0.056 7)0.667 6(0.661 4~0.673 9)149.8(151.2~148.4)
FBs0.617 4(0.612 6~0.622 3)
ZEN0.008 8(0.008 5~0.009 1)
食用人群(男)tDON0.040 5(0.039 4~0.041 7)0.490 5(0.486 0~0.495 2)203.9(205.8~202.0)
FBs0.453 6(0.450 1~0.457 2)
ZEN0.006 5(0.006 3~0.006 7)
食用人群(女)tDON0.067 2(0.065 3~0.069 1)0.812 9(0.805 2~0.820 5)123.0(124.2~121.9)
FBs0.751 7(0.745 8~0.757 6)
ZEN0.010 7(0.010 4~0.011 1)
儿童(3~6岁)tDON0.344 3(0.334 6~0.354 1)4.166 0(4.126 8~4.204 9)24.0(24.2~23.8)
FBs3.852 6(3.822 3~3.882 6)
ZEN0.054 9(0.053 1~0.056 8)
少年(7~12岁)tDON0.190 2(0.184 8~0.195 6)2.301 1(2.279 5~2.322 6)43.5(43.9~43.1)
FBs2.128 0(2.111 3~2.144 6)
ZEN0.030 3(0.029 3~0.031 4)
青少年(13~17岁)tDON0.173 1(0.168 2~0.178 0)2.094 0(2.074 4~2.113 6)47.8(8.2~47.3)
FBs1.936 5(1.921 3~1.951 6)
ZEN0.027 6(0.026 7~0.028 6)
成年人(18~59岁)tDON0.041 2(0.040 1~0.042 4)0.498 9(0.494 3~0.503 6)200.4(202.3~198.6)
FBs0.461 4(0.457 8~0.465 0)
ZEN0.006 6(0.006 4~0.006 8)
老年人(>=60岁)tDON0.040 7(0.039 5~0.041 8)0.492 1(0.487 5~0.496 7)203.2(205.1~201.3)
FBs0.455 1(0.451 5~0.458 7)
ZEN0.006 5(0.006 3~0.006 7)
食用人群真菌毒素玉米碾磨制品 MB(LB~UB)
单一毒素暴露量μg/(kg·bw·d)累积暴露量μg/(kg·bw·d)累积暴露限量值MOE
食用人群tDON0.122 4(0.118 1~0.126 9)1.358 8(1.346 3~1.371 4)73.6(74.3~72.9)
FBs1.247 4(1.238 9~1.255 8)
ZEN0.035 8(0.035 3~0.036 3)
食用人群(男)tDON0.122 4(0.118 1~0.126 9)1.358 8(1.346 4~1.371 3)73.6(74.3~72.9)
FBs1.247 4(1.238 9~1.255 8)
ZEN0.035 8(0.035 3~0.036 3)
食用人群(女)tDON0.113 7 (0.109 7~0.117 9)1.262 2(1.250 7~1.273 8)79.2(80.0~78.5)
FBs1.158 7(1.150 8~1.166 5)
ZEN0.033 2(0.032 8~0.033 7)
儿童(3~6岁)tDON0.133 9(0.129 2~0.138 9)1.486 7(1.473 0~1.500 4)67.3(67.9~66.6)
FBs1.364 8(1.355 4~1.374 0)
ZEN0.039 1(0.038 7~0.039 7)
少年(7~12岁)tDON0.192 0(0.185 3~0.199 2)2.132 0(2.112 6~2.151 8)46.9(47.3~46.5)
FBs1.957 2(1.943 9~1.970 5)
ZEN0.056 1(0.055 5~0.056 9)
青少年(13~17岁)tDON0.050 9(0.049 1~0.052 8)0.565 1(0.559 9~0.570 4)176.9(178.6~175.3)
FBs0.518 8(0.515 2~0.522 3)
ZEN0.014 9(0.014 7~0.015 1)
成年人(18~59岁)tDON0.127 6(0.123 1~0.132 3)1.416 6(1.403 7~1.429 6)70.6(71.2~69.9)
FBs1.300 4(1.291 6~1.309 2)
ZEN0.037 3(0.036 8~0.037 8)
老年人(>=60岁)tDON0.110 3(0.106 5~0.114 5)1.225 0(1.213 8~1.236 4)81.6(82.4~80.9)
FBs1.124 6(1.116 9~1.132 2)
ZEN0.032 2(0.031 9~0.032 7)
食用人群真菌毒素玉米面制品 MB(LB~UB)
单一毒素暴露量μg/(kg·bw·d)累积暴露量μg/(kg·bw·d)累积暴露限量值MOE
食用人群tDON0.021 9(0.020 5~0.023 2)0.222 3(0.218 2~0.226 4)449.8(458.4~441.7)
FBs0.202 4(0.199 5~0.205 3)
ZEN0.011 4(0.011 3~0.011 6)
食用人群(男)tDON0.026 8(0.025 2~0.028 5)0.272 3(0.267 2~0.277 4)367.2(374.2~360.4)
FBs0.247 9(0.244 3~0.251 5)
ZEN0.014 0(0.013 9~0.014 1)
食用人群(女)tDON0.017 9(0.016 8~0.019 0)0.181 5(0.178 1~0.184 8)551.0(561.5~541.1)
FBs0.165 2(0.162 8~0.167 5)
ZEN0.009 3(0.009 2~0.009 4)
儿童(3~6岁)tDON---
FBs-
ZEN-
少年(7~12岁)tDON0.049 8(0.046 7~0.052 8)0.505 5(0.496 1~0.514 9)197.8(201.6~194.2)
FBs0.460 2(0.453 6~0.466 8)
ZEN0.026 0(0.025 7~0.026 3)
青少年(13~17岁)tDON0.021 4(0.020 1~0.022 8)0.217 8(0.213 8~0.222 0)459.2(467.7~450.5)
FBs0.198 3(0.195 5~0.201 2)
ZEN0.011 2(0.011 1~0.011 3)
成年人(18~59岁)tDON0.019 0(0.017 8~0.020 2)0.193 1(0.189 4~0.196 7)517.9(528.0~508.4)
FBs0.175 8(0.173 2~0.178 3)
ZEN0.009 9(0.009 8~0.010 0)
老年人(>=60岁)tDON0.028 1(0.026 4~0.029 9)0.285 9(0.280 5~0.291 2)349.8(356.5~343.4)
FBs0.260 3(0.256 5~0.264 0)
ZEN0.014 7(0.014 5~0.014 8)
), ArticleFig(id=1324077674779517341, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077669687632218, language=CN, label=表2, caption=

不同年龄组人群对玉米及制品主要真菌毒素的暴露水平均值

, figureFileSmall=null, figureFileBig=null, tableContent=
食用人群真菌毒素玉米/玉米粒 MB(LB~UB)
单一毒素暴露量μg/(kg·bw·d)累积暴露量μg/(kg·bw·d)累积暴露限量值MOE
食用人群tDON0.055 2(0.0536~0.056 7)0.667 6(0.661 4~0.673 9)149.8(151.2~148.4)
FBs0.617 4(0.612 6~0.622 3)
ZEN0.008 8(0.008 5~0.009 1)
食用人群(男)tDON0.040 5(0.039 4~0.041 7)0.490 5(0.486 0~0.495 2)203.9(205.8~202.0)
FBs0.453 6(0.450 1~0.457 2)
ZEN0.006 5(0.006 3~0.006 7)
食用人群(女)tDON0.067 2(0.065 3~0.069 1)0.812 9(0.805 2~0.820 5)123.0(124.2~121.9)
FBs0.751 7(0.745 8~0.757 6)
ZEN0.010 7(0.010 4~0.011 1)
儿童(3~6岁)tDON0.344 3(0.334 6~0.354 1)4.166 0(4.126 8~4.204 9)24.0(24.2~23.8)
FBs3.852 6(3.822 3~3.882 6)
ZEN0.054 9(0.053 1~0.056 8)
少年(7~12岁)tDON0.190 2(0.184 8~0.195 6)2.301 1(2.279 5~2.322 6)43.5(43.9~43.1)
FBs2.128 0(2.111 3~2.144 6)
ZEN0.030 3(0.029 3~0.031 4)
青少年(13~17岁)tDON0.173 1(0.168 2~0.178 0)2.094 0(2.074 4~2.113 6)47.8(8.2~47.3)
FBs1.936 5(1.921 3~1.951 6)
ZEN0.027 6(0.026 7~0.028 6)
成年人(18~59岁)tDON0.041 2(0.040 1~0.042 4)0.498 9(0.494 3~0.503 6)200.4(202.3~198.6)
FBs0.461 4(0.457 8~0.465 0)
ZEN0.006 6(0.006 4~0.006 8)
老年人(>=60岁)tDON0.040 7(0.039 5~0.041 8)0.492 1(0.487 5~0.496 7)203.2(205.1~201.3)
FBs0.455 1(0.451 5~0.458 7)
ZEN0.006 5(0.006 3~0.006 7)
食用人群真菌毒素玉米碾磨制品 MB(LB~UB)
单一毒素暴露量μg/(kg·bw·d)累积暴露量μg/(kg·bw·d)累积暴露限量值MOE
食用人群tDON0.122 4(0.118 1~0.126 9)1.358 8(1.346 3~1.371 4)73.6(74.3~72.9)
FBs1.247 4(1.238 9~1.255 8)
ZEN0.035 8(0.035 3~0.036 3)
食用人群(男)tDON0.122 4(0.118 1~0.126 9)1.358 8(1.346 4~1.371 3)73.6(74.3~72.9)
FBs1.247 4(1.238 9~1.255 8)
ZEN0.035 8(0.035 3~0.036 3)
食用人群(女)tDON0.113 7 (0.109 7~0.117 9)1.262 2(1.250 7~1.273 8)79.2(80.0~78.5)
FBs1.158 7(1.150 8~1.166 5)
ZEN0.033 2(0.032 8~0.033 7)
儿童(3~6岁)tDON0.133 9(0.129 2~0.138 9)1.486 7(1.473 0~1.500 4)67.3(67.9~66.6)
FBs1.364 8(1.355 4~1.374 0)
ZEN0.039 1(0.038 7~0.039 7)
少年(7~12岁)tDON0.192 0(0.185 3~0.199 2)2.132 0(2.112 6~2.151 8)46.9(47.3~46.5)
FBs1.957 2(1.943 9~1.970 5)
ZEN0.056 1(0.055 5~0.056 9)
青少年(13~17岁)tDON0.050 9(0.049 1~0.052 8)0.565 1(0.559 9~0.570 4)176.9(178.6~175.3)
FBs0.518 8(0.515 2~0.522 3)
ZEN0.014 9(0.014 7~0.015 1)
成年人(18~59岁)tDON0.127 6(0.123 1~0.132 3)1.416 6(1.403 7~1.429 6)70.6(71.2~69.9)
FBs1.300 4(1.291 6~1.309 2)
ZEN0.037 3(0.036 8~0.037 8)
老年人(>=60岁)tDON0.110 3(0.106 5~0.114 5)1.225 0(1.213 8~1.236 4)81.6(82.4~80.9)
FBs1.124 6(1.116 9~1.132 2)
ZEN0.032 2(0.031 9~0.032 7)
食用人群真菌毒素玉米面制品 MB(LB~UB)
单一毒素暴露量μg/(kg·bw·d)累积暴露量μg/(kg·bw·d)累积暴露限量值MOE
食用人群tDON0.021 9(0.020 5~0.023 2)0.222 3(0.218 2~0.226 4)449.8(458.4~441.7)
FBs0.202 4(0.199 5~0.205 3)
ZEN0.011 4(0.011 3~0.011 6)
食用人群(男)tDON0.026 8(0.025 2~0.028 5)0.272 3(0.267 2~0.277 4)367.2(374.2~360.4)
FBs0.247 9(0.244 3~0.251 5)
ZEN0.014 0(0.013 9~0.014 1)
食用人群(女)tDON0.017 9(0.016 8~0.019 0)0.181 5(0.178 1~0.184 8)551.0(561.5~541.1)
FBs0.165 2(0.162 8~0.167 5)
ZEN0.009 3(0.009 2~0.009 4)
儿童(3~6岁)tDON---
FBs-
ZEN-
少年(7~12岁)tDON0.049 8(0.046 7~0.052 8)0.505 5(0.496 1~0.514 9)197.8(201.6~194.2)
FBs0.460 2(0.453 6~0.466 8)
ZEN0.026 0(0.025 7~0.026 3)
青少年(13~17岁)tDON0.021 4(0.020 1~0.022 8)0.217 8(0.213 8~0.222 0)459.2(467.7~450.5)
FBs0.198 3(0.195 5~0.201 2)
ZEN0.011 2(0.011 1~0.011 3)
成年人(18~59岁)tDON0.019 0(0.017 8~0.020 2)0.193 1(0.189 4~0.196 7)517.9(528.0~508.4)
FBs0.175 8(0.173 2~0.178 3)
ZEN0.009 9(0.009 8~0.010 0)
老年人(>=60岁)tDON0.028 1(0.026 4~0.029 9)0.285 9(0.280 5~0.291 2)349.8(356.5~343.4)
FBs0.260 3(0.256 5~0.264 0)
ZEN0.014 7(0.014 5~0.014 8)
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济南市玉米及制品中多种真菌毒素的污染特征分析与累积风险评估
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曹小丽 , 王相际 , 郑敏 , 吴虹 , 田文霞 , 匡彦 , 杨晓倩
现代预防医学 | 营养与食品卫生 2026,53(6): 1017-1023
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现代预防医学 |营养与食品卫生 2026 , 53 (6) : 1017 -1023
济南市玉米及制品中多种真菌毒素的污染特征分析与累积风险评估
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曹小丽(1979—),女,硕士,主任技师,研究方向:食品安全

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曹小丽, 王相际, 郑敏, 吴虹, 田文霞, 匡彦, 杨晓倩
作者信息
  • 济南市疾病预防控制中心理化检验所,山东 济南 250021
通讯作者:
杨晓倩,E-mail:
作者简介:

曹小丽(1979—),女,硕士,主任技师,研究方向:食品安全

Characterization of spatial contamination and cumulative risk assessment of multiple mycotoxins in corn and its products, Jinan City
Xiao-li CAO, Xiang-ji WANG, Min ZHENG, Hong WU, Wen-xia TIAN, Yan KUANG, Xiao-qian YANG
Affiliations
  • Department for Physical and Chemical Inspection,Jinan Center for Disease Control and Prevention, Jinan, Shandong 250021, China
出版时间: 2026-03-25 doi: 10.20043/j.cnki.MPM.202509134
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目的

分析济南市2022—2023年各区县玉米及制品中多种真菌毒素的污染特征,并评估不同年龄组人群的累积暴露风险。

方法

采集2022—2023年济南市12个区县173份玉米及制品样本,采用同位素稀释液相色谱串联质谱法同时检测12种真菌毒素,基于山东省居民膳食消费数据,采用成分分析法结合等效因子(EF)和暴露边界值(MOE),评估不同年龄组人群的累积暴露风险。

结果

伏马菌素(FBs)的检出情况相对突出(检出率91.3%,均值1 506.1 μg/kg),其次为脱氧雪腐镰刀菌烯醇及代谢物(tDON,检出率89.6%,均值 91.7 μg/kg)和玉米赤霉烯酮(ZEN,检出率 72.8%, 均值 41.1 μg/kg)。91.9%样品存在两类及以上毒素共存,其中以FBs+tDON+ZEN为主要共污染模式。不同区县污染特征存在差异,莱芜区FBs检出水平相对较高(2 653.7 μg/kg),槐荫区 tDON 检出水平相对较高(259.6 μg/kg),而ZEN污染在全市范围内未呈现明显的区域差异性。各人群的MOE值均低于参考阈值(100),提示需关注其累积暴露水平,低年龄组人群的相关膳食暴露指标相对偏高,同时需要考虑由于样品量及消费数据带来的评估不确定性,性别间暴露水平差异不显著。FBs对人群累积暴露的贡献率最高(93.6%),是主要风险因子。玉米碾磨制品为主要暴露来源(贡献率为67%),其消费量与真菌毒素暴露量正相关。

结论

济南市人群通过摄入玉米及制品存在真菌毒素累积暴露的相关情况,低年龄组人群为重点关注群体,建议开展针对性的膳食健康指导与风险管控。

多种真菌毒素  /  玉米及制品  /  共污染  /  累积风险评估
Objective

To analyze the contamination characteristics of multiple mycotoxins in cornand corn products across districts and counties in Jinan City during 2022—2023, and to assess the cumulative exposure risk among different age groups.

Methods

We collected 173 samples of maize and products from 12 districts and counties in Jinan City from 2022 to 2023, and simultaneously detected 12 mycotoxins by isotope dilution liquid chromatography tandem mass spectrometry, and evaluated the cumulative exposure risk of the population of different age groups based on the data of dietary consumption of residents in Shandong Province by using compositional analysis combined with the equivalence factor (EF) and the exposure boundary value (MOE).

Results

Fumonisins (FBs) were the most contaminated (detection rate, 91.3%, mean, 1 506.1 μg/kg), followed by deoxynivalenol and metabolites (tDON, detection rate, 89.6%, mean, 91.7μg/kg) and zearalenone (ZEN, detection rate,72.8%, mean,41.1μg/kg). 91.9% of samples contained two or more toxins concurrently, with FB+tDON+ZEN being the predominant co-contamination pattern. Contamination characteristics varied across districts: Laiwu District exhibited relatively higher FB detection levels(2 653.7 μg/kg), while Huaiyin District showed relatively higher tDON levels (259.6 μg/kg). No distinct high-risk areas for ZEN contamination were identified citywide. The MOE values for all population groups fell below the safety threshold (100),indicating potential health risks. At the same time, it is necessary to consider the uncertainty of evaluation caused by sample size and consumption data. The younger age group exhibited relatively higher risks. No statistically significant differences in exposure risk were observed between genders. FBs contributed the most (93.6%) to cumulative exposure risk and were identified as the primary risk factor. Corn milling products served as the main exposure source (Contribution rate 67%), with consumption levels positively correlated to mycotoxin exposure.

Conclusion

Mycotoxin contamination in Jinan exhibits a spatial distribution pattern characterized by higher levels in peripheral areas and lower levels in central areas. The population faces potential health risks from cumulative exposure to mycotoxins through the consumption of corn and corn products. Younger age groups, due to their higher intake per unit of body weight, should be prioritized as key targets for prevention and control.

Mycotoxin polymorphism  /  Corn and products  /  Co-contamination  /  Cumulative risk assessment
曹小丽, 王相际, 郑敏, 吴虹, 田文霞, 匡彦, 杨晓倩. 济南市玉米及制品中多种真菌毒素的污染特征分析与累积风险评估. 现代预防医学, 2026 , 53 (6) : 1017 -1023 . DOI: 10.20043/j.cnki.MPM.202509134
Xiao-li CAO, Xiang-ji WANG, Min ZHENG, Hong WU, Wen-xia TIAN, Yan KUANG, Xiao-qian YANG. Characterization of spatial contamination and cumulative risk assessment of multiple mycotoxins in corn and its products, Jinan City[J]. Modern Preventive Medicine, 2026 , 53 (6) : 1017 -1023 . DOI: 10.20043/j.cnki.MPM.202509134
玉米是中国最重要的粮食作物之一,约占世界总产量的 20%。在中国的一些地区,玉米是继小麦和水稻之后的主要主食来源[1-2]。已发表的研究表明,玉米和玉米产品在生长和储存期间极易受到真菌污染[3-6]。杨欣等[7]报告称,全国市场上60%的玉米及制品检出两种或两种以上真菌毒素。长期接触这些真菌毒素会对人类和动物产生肝毒性、肾毒性、免疫毒性、致畸性、致癌性和诱变性[8-9]。此外,接触多种真菌毒素混合物可能会对人体产生拮抗、叠加或协同累积效应[10]。即使接触单种真菌毒素的风险低于阈值效应,累积接触混合物也可能达到有效剂量,从而对健康产生不利影响[11-13]。尽管多项研究已证实玉米及其制品中普遍存在多种霉菌毒素共污染现象及其潜在的累积膳食风险[14-15],但现有研究多聚焦于结构相似毒素的累积评估。此外,关于中国不同区域玉米产品的多毒素污染特征与累积风险,目前仍缺乏系统性认知。杨欣等[7]的研究便揭示了其污染水平存在显著的地区差异性。在此背景下,为明确济南市真菌毒素的共存污染模式并系统评估其累积暴露风险,开展本研究显得尤为必要。
济南市地处山东省中西部,南枕泰山,北濒黄河,属温带季风气候,夏季高温高湿,冬季干燥少雨。作为山东省省会与区域性中心城市,济南亦是黄河流域重要的粮食消费枢纽,当地主食以玉米制品为主,涵盖玉米面、玉米糁及即食玉米谷物等品类。本研究基于济南市食品安全风险监测数据,对济南市12个区县玉米及制品中真菌毒素的污染特征进行分析,构建了基于膳食暴露量的累积风险评估模型,揭示了不同年龄段人群的累积暴露风险及梯度,为制定靶向防控策略提供了科学依据。
2022—2023年,按照随机采样的原则,从济南市12个区县(莱芜区、钢城区、槐荫区、长清区、市中区、历下区、天桥区、商河县、历城区、济阳区、章丘区、平阴县)的当地市场(超市、商店和市场摊位)及玉米种植区共采集了173份玉米及其制品,共包含三个亚类:玉米/玉米粒(47份)、玉米碾磨制品(玉米面、玉米碴、玉米片等,80份)和玉米面制品(46份)。样本量要求大于1 kg,用高速粉碎机进行粉碎和筛分,粒径小于1 mm,混匀后将样品分成100 g/份,冷冻保存。
分析的真菌毒素包括5类12种,即黄曲霉毒素(AFB1、AFB2、AFG1、AFG2)、伏马毒素(FB1、FB2、FB3)、赭曲霉毒素A (OTA)、玉米赤霉烯酮(ZEN)和脱氧雪腐镰刀菌素及其代谢物(DON、15-AC-DON、3-AC-DON)。参考《国家食品污染物和有害因素监测工作手册》中的同位素稀释高效液相色谱-质谱法(UPLC-MS/MS)对玉米及其制品中的多种真菌毒素进行分析,实验过程进行空白试验、加标回收、平行双样等严格的质量控制措施,确保检测结果的准确性。样品检测结果依据GB 2761—2017《食品安全国家标准-食品中真菌毒素限量》中规定的玉米及制品中真菌毒素的各项限值进行评价。
玉米及制品的膳食消费数据来自2012年中国食品消费调查中山东省的消费数据[16],包括山东省3 246名4至96岁的参与者。其中,404名参与者是玉米和玉米制品消费者。将消费者分为5个年龄组,即3~6岁、7~12岁、13~17岁、18~59岁和≥60岁,食物摄入量以平均值描述。
本研究基于组分的分析方法,采用暴露边界值(MOE)结合等效因子(EF)进行剂量相加,对真菌毒素混合物(tDON、FBS和ZEN)进行累积风险评估[17]。首先将玉米及制品中每类真菌毒素的污染水平乘以消费量,再除以体重,得到单类真菌毒素的暴露量(EXPi),然后将单类真菌毒素的暴露量乘以EF,相加,得到真菌毒素混合物的总暴露量。每类真菌毒素的EFi是将检定的指标化合物的分离点(PODi)除以单类真菌毒素的POD(PODi)得到。其中POD值取自欧洲食品安全局(EFSA)的评估报告:tDON采用5%效应基准剂量下限(BMDL5=110 μg/(kg·bw·d)),基于摄食量减少和体重增长抑制的临界效应;FBs以非致癌肝毒性为基准,选取10%效应(BMDL10=100 μg/(kg·bw·d))小鼠大细胞肝细胞增生为组织病理学标志;ZEN依据雄性大鼠肝细胞胞浆空泡化发生率,确定无观测不良效应水平(NOAEL=1 000 μg/(kg·bw·d))。通过比较POD值,确定FBs毒性最强,设定其等效因子(EF)为1.0,则tDON和ZEN的相对EF分别为0.91和0.1。本研究中tDON、FBS和ZEN被认为既不具有遗传毒性,也不具有致癌性,MOE选择100作为参考/临界值,当MOE值大于100时可认为暴露风险较低,反之则需对其风险水平予以一定关注[17]。
根据公式1、2和3分别计算暴露量、等效因子和暴露边界值:
(1)
(2)
(3)
其中EXPi为单个真菌毒素的暴露量(μg/(kg·bw·d)),EFi为真菌素素的等效因子,Ci为玉米和玉米产品样品真菌毒素的平均污染水平(μg/kg),Fi为玉米及制品的个人消费量(g/d),bw是指个体体重(kg),Sum(EXPi)×(EFi)为多种真菌毒素的累积暴露量(μg/(kg·bw·d))。
本研究中,真菌毒素浓度低于检测限(LOD)时,分别以低值(LB=0)、中值(MB=0.5LOD)和高值(UB=LOD)替代,确保数据完整性[18-19]。对5类毒素计算平均值、中位数、第95百分位数(P95)及最大值,并报告检出率。使用SPSS 26.0的Kruskal-Wallis检验,采用非参数Kruskal-Wallish检验分析了不同玉米制品亚类间真菌毒素污染和膳食暴露的分布情况。采用χ2 检验评估毒素检出率的显著性差异(α=0.05)。
如表1所示,玉米及制品中真菌毒素污染呈现显著差异性分布特征。FBs以91.3%的检出率最高,其平均浓度(1 506.1 μg/kg)和最大值(17 661.0 μg/kg)均显著高于其他毒素;tDON次之,检出率89.6%,均值91.7 μg/kg;ZEN检出率72.8%,均值41.1 μg/kg,而AFs和OTA污染水平较低,检出率分别为24.3%和4.62%。依据GB 2761—2017《食品安全国家标准-食品中真菌毒素限量》进行评价,其中AFB1、DON无超标样本,有30份样品的ZEN超标,超标率17.3%。
多重污染现象普遍存在,91.9%的样品存在两类及以上毒素共存。其中:双毒素共存占比26.0%,主要组合为FBs+tDON(18.5%);三毒素共存占比49.1%,典型组合为FBs+tDON+ZEN(43.3%);四毒素共存占比16.8%,以FBs+tDON+ZEN+AFT(13.9%)复合污染为主。
比较了12个区县玉米及制品中检出最多的真菌毒素组合tDON、FBs和ZEN的污染特征。三类毒素在12个区县的玉米及制品中同时检出比例最高的是历城区(72.7%),其次是槐荫区(42.7%)和长清区(40.8%),各地区同时检出的检出率与污染水平之间没有相关性。FBs污染水平较高的是莱芜区(2 653.7 μg/kg),其次为商河县(2 273.4 μg/kg),平阴县(1 793.9 μg/kg)和长清区(1 702.5 μg/kg);tDON污染水平较高的是槐荫区(259.6 μg/kg),其次为市中区(188.5 μg/kg);而ZEN污染水平都相对较低,污染水平最高的槐荫区仅为60.3 μg/kg。Kruskal-Wallis检验结果表明,12区县的tDON、FBs和ZEN的污染水平均值(MB)分别都有显著性差异(P<0.001)。
不同年龄段人群对于玉米及制品三个亚类的消费量存在明显差异,总体18~59岁人群的消费量最高,男性高于女性。玉米碾磨制品的消费量(52.0 g/d)明显高于玉米/玉米粒(15.2 g/d)和玉米面制品(14.2 g/d)。在平均消费水平下,玉米/玉米粒消费量最高的是13~17岁人群(45.4 g/d),玉米碾磨制品消费量最高的是18~59岁人群(56.1 g/d),而玉米面制品消费量最高的是≥60岁人群(18.7 g/d)(图1)。
基于玉米及制品中tDON、FBs和ZEN的平均含量的中值(表1),对济南市不同年龄组人群进行累积暴露评估,如表2所示:在平均消费水平下,各人群累积暴露边界值(MOE)均低于100参考阈值,表明济南市居民对玉米及玉米制品中真菌毒素累积暴露需要予以关注,低年龄组人群因每日玉米及制品摄入量占体重比例较高,且代谢解毒能力相对较弱,因此其累积暴露相较于其他年龄组要高,需重点关注“摄入量控制”,性别间暴露风险差异无统计学意义。FBs贡献率最高(93.6%),其平均暴露量达2.050 0 μg/(kg·bw·d),成为主要风险因子。
三个亚类玉米及制品分析表明,玉米碾磨制品是主要暴露来源(贡献率67%),其消费量与毒素暴露量呈正相关。18~60岁成年人通过该类制品摄入的毒素占比最高(67%),而3~6岁和13~17岁儿童因玉米/玉米粒消费量显著高于其他两个亚类,导致其总暴露量中玉米/玉米粒贡献占比分别达74%和73%。性别差异方面,男性摄入玉米碾磨制品的总暴露贡献率(64%)略高于女性(56%)(图2)。
本研究系统揭示了济南市玉米及制品中FBs、tDON和ZEN的共污染特征及其人群暴露风险。结果显示,FBs污染情况相对突出,与山东省[20]及全国数据[7]趋势一致,其高污染水平与高温高湿储存条件促进镰刀菌繁殖相关[21]。共污染现象普遍,tDON-FBs-ZEN组合占比最高,提示共污染是主要风险。ZEN虽均值较低,但其检出率72.8% 高于全国数据(46%)[7],超标率17.3%,需警惕其作为雌激素类毒素的潜在内分泌干扰作用。
基于消费数据的累积风险评估显示,济南市居民存在对玉米及制品中真菌毒素的累积暴露的相关情况。除历下区和市中区外,其余区县MOE均低于参考阈值,低年龄组人群的相关膳食暴露指标相对偏高。玉米碾磨制品为主要暴露来源,其消费量与毒素暴露量正相关。年龄特异性分析表明3~17岁儿童暴露量相对较高,因其单位体重摄入量高且代谢系统未发育完全;老年人因玉米面制品摄入比例高需关注慢性暴露风险。性别差异较小,男性玉米碾磨制品的暴露贡献率(64.0%)略高于女性(55.9%),可能与男性更多从事粮食加工相关职业有关。
本研究存在若干不确定性。首先,研究仅采用 2022—2023 年的样本进行调查,且样本量较小,可能导致评估结果存在不确定性。其次,暴露评估使用的是 2012 年山东省的消费数据,而居民生活习惯的改变会造成消费量差异,这可能使评估结果偏高或偏低。第三,在对玉米粒及玉米原粮进行评估时,未纳入加工因素的影响,加工过程可能会不同程度降低毒素含量,进而导致暴露水平被高估。第四,本研究对tDON、FBs和ZEN的共污染物组合进行累积风险评估,采用来源于不同作用模式的毒性分离点(BMDL5、BMDL10和NOALE值),以及缺乏关于真菌毒素之间潜在相互作用的数据(即协同/相加或拮抗作用)。例如,玉米赤霉烯酮(ZEN)与脱氧雪腐镰刀菌烯醇(tDON)的协同毒性,可能通过雌激素受体和炎症通路交互作用加剧生殖毒性[22],但本研究未对此进行毒理学验证,这可能导致低估或高估多种真菌毒素的累积风险。未来需结合生物监测(如血清毒素标志物)和生理药代动力学(PBTK)模型,进一步细化风险评估。
  • 济南市卫生健康委员会科技计划项目(20240307007)
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2026年第53卷第6期
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doi: 10.20043/j.cnki.MPM.202509134
  • 接收时间:2025-09-08
  • 首发时间:2026-11-02
  • 出版时间:2026-03-25
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  • 收稿日期:2025-09-08
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济南市卫生健康委员会科技计划项目(20240307007)
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    济南市疾病预防控制中心理化检验所,山东 济南 250021

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2种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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