Article(id=1324077658128130277, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202510041, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1759939200000, receivedDateStr=2025-10-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793614313871, onlineDateStr=2026-11-02, pubDate=1774368000000, pubDateStr=2026-03-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793614313871, onlineIssueDateStr=2026-11-02, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793614313871, creator=13701087609, updateTime=1793614313871, updator=13701087609, issue=Issue{id=1324077560820282023, tenantId=1146029695717560320, journalId=1227665162245664772, year='2026', volume='53', issue='6', pageStart='961', pageEnd='1152', issueExtLink='null', onlineDate='null', pubDate='1774368000000', pubDateStr='2026-03-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793614290671, creator='13701087609', updateTime=1793614391469, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1324077983656444429, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1324077983660638734, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1009, endPage=1016, ext={EN=ArticleExt(id=1324077658342039782, articleId=1324077658128130277, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Influencing factors and construction of a nomogram prediction model for secondary fungal infection in pneumoconiosis patients with bacterial pneumonia, columnId=1228016570660745413, journalTitle=Modern Preventive Medicine, columnName=Environmental and Occupational Health, runingTitle=null, highlight=null, articleAbstract=
Objective To identify risk factors for secondary fungal infection in patients with pneumoconiosis complicated by bacterial pneumonia and to develop a nomogram prediction model.
Methods Clinical data of patients admitted to a tertiary occupational disease hospital between December 2021 and July 2024 were retrospectively analyzed and randomly divided into training and testing sets (7:3). Variables were selected using LASSO and multivariable logistic regression to construct a nomogram. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis (DCA).
Results Among 641 patients, 213 developed secondary pulmonary fungal infection. Multivariable analysis showed that invasive procedures (OR=3.440, 95% CI:2.111-5.699), elevated immature granulocyte percentage (OR=2.294, 95% CI:1.254-4.402), systemic glucocorticoid use (OR=2.196, 95% CI:1.114-4.327), repeated hospitalization (OR=2.094, 95% CI:1.280-3.464), and increasing age (OR=1.059, 95% CI:1.034-1.085) were associated with increased risk, whereas higher large platelet count was associated with reduced risk (OR=0.980, 95% CI:0.968-0.992). The nomogram achieved AUCs of 0.818 (95% CI:0.777-0.858) in the training set and 0.797 (95% CI:0.688-0.906) in the testing set. Calibration and DCA demonstrated good agreement and clinical net benefit.
Conclusion The nomogram accurately predicts secondary fungal infection risk in this population, demonstrating favorable performance and potential for early risk stratification and targeted intervention.
, authors=Yi-fei WANG, Yun-di JIANG, Wen DU, Li-jun PENG, Yu-qin YAO, Qin ZHANG, Ding-zi ZHOU, authorsList=Yi-fei WANG, Yun-di JIANG, Wen DU, Li-jun PENG, Yu-qin YAO, Qin ZHANG, Ding-zi ZHOU, authorCompany=null, correspAuthors=Ding-zi ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1324077660082675957, articleId=1324077658128130277, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=尘肺合并细菌性肺炎患者继发真菌感染的影响因素分析及列线图预测模型构建, columnId=1228016571273113811, journalTitle=现代预防医学, columnName=环境与职业卫生, runingTitle=null, highlight=null, articleAbstract=
目的 探究尘肺病合并细菌性肺炎继发真菌感染的危险因素并构建列线图预测模型。
方法 回顾分析2021年12月至2024年7月某三甲职业病防治院尘肺合并细菌性肺炎患者临床资料，按7:3随机分为训练集与测试集。经LASSO及多因素logistic回归筛选变量并构建列线图模型，采用ROC曲线下面积（AUC）、校准曲线与决策曲线分析（DCA）评估模型的区分度、校准度及临床实用性。
结果 共纳入641例尘肺合并细菌性肺炎患者，其中继发肺真菌感染213例。多因素logistic回归分析显示：侵入性操作（OR=3.440，95% CI:2.111~5.699）、未成熟粒细胞百分比升高（OR=2.294，95% CI:1.254~4.402）、全身性糖皮质激素使用（OR=2.196，95% CI:1.114~4.327）、重复住院史（OR=2.094，95% CI:1.280~3.464）及年龄增加（OR=1.059，95% CI:1.034~1.085）与继发肺真菌感染风险升高相关，而大血小板数升高与风险降低相关（OR=0.980，95% CI:0.968~0.992）。基于上述变量构建的列线图模型在训练集与测试集AUC分别为0.818（95% CI:0.777~0.858）和0.797（95% CI:0.688~0.906）。校准曲线显示预测与实测一致性良好, DCA显示模型在较宽阈值概率范围内具有临床净获益。
结论 本研究构建的列线图模型能有效预测尘肺合并细菌性肺炎患者继发真菌感染的风险，具有良好的预测性能与临床实用价值，有助于早期识别高危患者并指导干预。
, authors=王艺霏, 江云笛, 杜文, 彭莉君, 姚于勤, 张勤, 周丁子, authorsList=王艺霏, 江云笛, 杜文, 彭莉君, 姚于勤, 张勤, 周丁子, authorCompany=null, correspAuthors=周丁子, authorNote=
王艺霏（2000—），女，硕士在读，研究方向：劳动卫生与环境卫生学
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=hQLOhsl1xkWCBgRxkUCceQ==, magXml=r03L1FYn9jLI5j/LalMQBA==, pdfUrl=null, pdf=wwSYIDIV9NpelwWCaqHr9g==, pdfFileSize=1226917, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=RDkWkKVvnuxI8XlLrB4T0Q==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=1YmQ8HSudC+J0VpvPvnUPA==, mapNumber=null, fund=null)}, authors=[Author(id=1324077660414025978, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324077660506300668, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, authorId=1324077660414025978, language=EN, stringName=Yi-fei WANG, firstName=Yi-fei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=West China School of Public Health (West China Fourth Hospital), Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324077660577603837, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, authorId=1324077660414025978, language=CN, stringName=王艺霏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院（华西第四医院），华西职业性尘肺病队列工作组，成都 610041, bio={"content":"
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54(11): 2595-2610.e7., articleTitle=Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization, refAbstract=null)], funds=[Fund(id=1324077666302828858, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, awardId=U22A20359; 82373548, language=CN, fundingSource=国家自然科学基金项目(U22A20359; 82373548), fundOrder=null, country=null), Fund(id=1324077666395103547, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, awardId=24QNMP072, language=CN, fundingSource=四川省卫健委科技计划项目(24QNMP072), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1324077660304974070, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, xref=null, ext=[AuthorCompanyExt(id=1324077660313362679, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, companyId=1324077660304974070, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=West China School of Public Health (West China Fourth Hospital), Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324077660321751288, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, companyId=1324077660304974070, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院（华西第四医院），华西职业性尘肺病队列工作组，成都 610041)])], figs=[ArticleFig(id=1324077664478306598, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Fig.1, caption=
Flowchart of study population selection and model development, figureFileSmall=Md7j6h7l6P5mfBlNnr81SA==, figureFileBig=RDkWkKVvnuxI8XlLrB4T0Q==, tableContent=null), ArticleFig(id=1324077664557998375, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=图1, caption=
研究人群筛选与模型构建流程图, figureFileSmall=Md7j6h7l6P5mfBlNnr81SA==, figureFileBig=RDkWkKVvnuxI8XlLrB4T0Q==, tableContent=null), ArticleFig(id=1324077664784490792, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Fig.2, caption=
LASSO regression coefficient path (a) and cross-validation (b) results, figureFileSmall=Ntnz3yuXz8KUJQMS8JL/ow==, figureFileBig=fRrJ41HGUWxUQDMGraXR8Q==, tableContent=null), ArticleFig(id=1324077664872571178, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=图2, caption=
LASSO回归系数路径(a)与交叉验证(b)结果, figureFileSmall=Ntnz3yuXz8KUJQMS8JL/ow==, figureFileBig=fRrJ41HGUWxUQDMGraXR8Q==, tableContent=null), ArticleFig(id=1324077665044537644, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Fig.3, caption=
Risk prediction nomogram for secondary pulmonary fungal infection, figureFileSmall=pHi5O/944ci0eZMdwHCZBA==, figureFileBig=YiK/OwuXKdX7APoaGRK8bw==, tableContent=null), ArticleFig(id=1324077665132618029, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=图3, caption=
尘肺合并细菌性肺炎患者继发肺真菌感染风险预测列线图, figureFileSmall=pHi5O/944ci0eZMdwHCZBA==, figureFileBig=YiK/OwuXKdX7APoaGRK8bw==, tableContent=null), ArticleFig(id=1324077665199726894, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Fig.4, caption=
Comparison of ROC curves for different models in the training (a) and test (b) sets, figureFileSmall=JZC5/329rgTyLCGGTvn9vA==, figureFileBig=O2LMWSTXO0FY3UKK9VcIqA==, tableContent=null), ArticleFig(id=1324077665304584495, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=图4, caption=
训练集(a)与测试集(b)中不同模型的ROC曲线比较, figureFileSmall=JZC5/329rgTyLCGGTvn9vA==, figureFileBig=O2LMWSTXO0FY3UKK9VcIqA==, tableContent=null), ArticleFig(id=1324077665396859184, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Fig.5, caption=
Calibration curves of the prediction model in the training (a) and test (b) sets, figureFileSmall=rs8XhjPfWLRNfURCypcdCg==, figureFileBig=YAExj40dflYerZhXNPaFwA==, tableContent=null), ArticleFig(id=1324077665480745265, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=图5, caption=
预测模型在训练集(a)与测试集(b)中的校准曲线结果, figureFileSmall=rs8XhjPfWLRNfURCypcdCg==, figureFileBig=YAExj40dflYerZhXNPaFwA==, tableContent=null), ArticleFig(id=1324077665564631346, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Fig.6, caption=
Decision curve analysis of the prediction model in the training (a) and test (b) sets, figureFileSmall=i+bep3liC67TCQS5xXA9yw==, figureFileBig=LqPzaZsuj6M0JOT3YedCFA==, tableContent=null), ArticleFig(id=1324077665640128819, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=图6, caption=
预测模型在训练集(a)与测试集(b)中的决策曲线结果, figureFileSmall=i+bep3liC67TCQS5xXA9yw==, figureFileBig=LqPzaZsuj6M0JOT3YedCFA==, tableContent=null), ArticleFig(id=1324077665715626292, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Table 1, caption=
Comparison of clinical characteristics between the training and test sets
, figureFileSmall=null, figureFileBig=null, tableContent=
| 临床特征 | 训练集(n=455) | 测试集(n=186) | 统计值(H/χ2) | P值 |
|---|
| 继发肺真菌感染[n(%)] | 157(34.5) | 56(30.1) | 0.053 | 0.818 |
| 年龄[岁,M(P25,P75)] | 56.00(51.00, 64.00) | 56.00(51.00, 65.00) | 0.056 | 0.955 |
| BMI [kg/m2,M(P25,P75)] | 22.23(19.53, 24.80) | 22.04(19.52, 25.18) | 0.244 | 0.808 |
| 总接尘工龄[年,M(P25,P75)] | 16.00(10.00, 26.00) | 18.00(10.75, 25.00) | 0.200 | 0.842 |
| 住院天数[天,M(P25,P75)] | 14.00(10.00, 18.00) | 14.00(10.00, 18.00) | 0.036 | 0.971 |
| 尘肺分期[n(%)] | | | 0.039 | 0.981 |
| 壹期 | 94(21.0) | 38(20.7) | | |
| 贰期 | 92(20.6) | 37(20.1) | | |
| 叁期 | 261(58.4) | 109(59.2) | | |
| 尘肺分型[n(%)] | | | 0.648 | 0.723 |
| 矽肺 | 360(80.5) | 148(80.4) | | |
| 煤工尘肺 | 48(10.7) | 17(9.2) | | |
| 其他类型 | 39(8.7) | 19(10.3) | | |
| 吸烟[n(%)] | | | 2.971 | 0.226 |
| 从不吸烟 | 98(21.9) | 31(16.8) | | |
| 已戒烟 | 282(63.1) | 129(70.1) | | |
| 仍在吸烟 | 67(15.0) | 24(13.0) | | |
| 氧疗[n(%)] | 342(76.5) | 134(72.8) | 0.766 | 0.381 |
| 重复住院[n(%)] | 209(46.8) | 85(46.2) | 0.002 | 0.968 |
| 无创机械通气[n(%)] | 36(8.1) | 9(4.9) | 1.520 | 0.218 |
| 侵入性操作[n(%)] | 180(40.3) | 80(43.5) | 0.430 | 0.512 |
| 使用全身性糖皮质激素 | 69(15.4) | 25(13.6) | 0.221 | 0.638 |
| 使用吸入性糖皮质激素 | 177(39.6) | 70(38.0) | 0.075 | 0.784 |
| 抗生素联合使用[n(%)] | | | 3.088 | 0.378 |
| 未使用抗生素 | 34(7.6) | 17(9.2) | | |
| 单药治疗 | 300(67.1) | 117(63.6) | | |
| 二联用药 | 89(19.9) | 34(18.5) | | |
| 三联及以上用药 | 24(5.4) | 16(8.7) | | |
| 合并症[n(%)] | | | | |
| 肺结核 | 56(12.5) | 21(11.4) | 0.065 | 0.799 |
| 肺源性心脏病 | 89(19.9) | 35(19.0) | 0.021 | 0.885 |
| 慢性阻塞性肺病 | 250(55.9) | 92(50.0) | 1.614 | 0.204 |
| 支气管哮喘 | 25(5.6) | 12(6.5) | 0.070 | 0.791 |
| 呼吸衰竭 | 57(12.8) | 21(11.4) | 0.110 | 0.740 |
| 糖尿病 | 26(5.8) | 12(6.5) | 0.024 | 0.877 |
), ArticleFig(id=1324077665820483893, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=表1, caption=
训练集和测试集患者临床特征比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 临床特征 | 训练集(n=455) | 测试集(n=186) | 统计值(H/χ2) | P值 |
|---|
| 继发肺真菌感染[n(%)] | 157(34.5) | 56(30.1) | 0.053 | 0.818 |
| 年龄[岁,M(P25,P75)] | 56.00(51.00, 64.00) | 56.00(51.00, 65.00) | 0.056 | 0.955 |
| BMI [kg/m2,M(P25,P75)] | 22.23(19.53, 24.80) | 22.04(19.52, 25.18) | 0.244 | 0.808 |
| 总接尘工龄[年,M(P25,P75)] | 16.00(10.00, 26.00) | 18.00(10.75, 25.00) | 0.200 | 0.842 |
| 住院天数[天,M(P25,P75)] | 14.00(10.00, 18.00) | 14.00(10.00, 18.00) | 0.036 | 0.971 |
| 尘肺分期[n(%)] | | | 0.039 | 0.981 |
| 壹期 | 94(21.0) | 38(20.7) | | |
| 贰期 | 92(20.6) | 37(20.1) | | |
| 叁期 | 261(58.4) | 109(59.2) | | |
| 尘肺分型[n(%)] | | | 0.648 | 0.723 |
| 矽肺 | 360(80.5) | 148(80.4) | | |
| 煤工尘肺 | 48(10.7) | 17(9.2) | | |
| 其他类型 | 39(8.7) | 19(10.3) | | |
| 吸烟[n(%)] | | | 2.971 | 0.226 |
| 从不吸烟 | 98(21.9) | 31(16.8) | | |
| 已戒烟 | 282(63.1) | 129(70.1) | | |
| 仍在吸烟 | 67(15.0) | 24(13.0) | | |
| 氧疗[n(%)] | 342(76.5) | 134(72.8) | 0.766 | 0.381 |
| 重复住院[n(%)] | 209(46.8) | 85(46.2) | 0.002 | 0.968 |
| 无创机械通气[n(%)] | 36(8.1) | 9(4.9) | 1.520 | 0.218 |
| 侵入性操作[n(%)] | 180(40.3) | 80(43.5) | 0.430 | 0.512 |
| 使用全身性糖皮质激素 | 69(15.4) | 25(13.6) | 0.221 | 0.638 |
| 使用吸入性糖皮质激素 | 177(39.6) | 70(38.0) | 0.075 | 0.784 |
| 抗生素联合使用[n(%)] | | | 3.088 | 0.378 |
| 未使用抗生素 | 34(7.6) | 17(9.2) | | |
| 单药治疗 | 300(67.1) | 117(63.6) | | |
| 二联用药 | 89(19.9) | 34(18.5) | | |
| 三联及以上用药 | 24(5.4) | 16(8.7) | | |
| 合并症[n(%)] | | | | |
| 肺结核 | 56(12.5) | 21(11.4) | 0.065 | 0.799 |
| 肺源性心脏病 | 89(19.9) | 35(19.0) | 0.021 | 0.885 |
| 慢性阻塞性肺病 | 250(55.9) | 92(50.0) | 1.614 | 0.204 |
| 支气管哮喘 | 25(5.6) | 12(6.5) | 0.070 | 0.791 |
| 呼吸衰竭 | 57(12.8) | 21(11.4) | 0.110 | 0.740 |
| 糖尿病 | 26(5.8) | 12(6.5) | 0.024 | 0.877 |
), ArticleFig(id=1324077665904369974, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Table 2, caption=
Comparison of laboratory and imaging characteristics between the training and testing sets
, figureFileSmall=null, figureFileBig=null, tableContent=
| 检验项目/影像学特征[M(P25,P75)/例(%)] | 训练集(n=455) | 测试集(n=186) | 统计值(H/χ2) | P值 |
|---|
| 嗜酸性粒细胞百分比(%) | 1.60(0.80,3.10) | 1.75(0.88,2.90) | -0.038 | 0.970 |
| 嗜碱性粒细胞百分比(%) | 0.40(0.20, 0.50) | 0.40(0.20, 0.52) | -0.314 | 0.754 |
| 未成熟粒细胞百分比(%) | 0.20(0.10, 0.30) | 0.20(0.10, 0.40) | -0.972 | 0.331 |
| 白细胞计数(109/L) | 6.78(5.53, 8.59) | 6.92(5.79, 8.67) | -0.885 | 0.376 |
| 红细胞计数(1012/L) | 4.74(4.33, 5.09) | 4.70(4.23, 5.11) | -0.638 | 0.523 |
| 大血小板数(109/L) | 58.00(45.00, 69.00) | 57.00(46.00, 71.00) | -0.36 | 0.719 |
| 白蛋白(g/L) | 40.50(37.75, 43.00) | 40.45(37.70, 42.85) | -0.105 | 0.916 |
| 糖(mmol/L) | 5.00(4.60, 5.60) | 5.10(4.50, 5.80) | 0.346 | 0.730 |
| 超敏C反应蛋白(mg/L) | 8.07(1.96, 33.65) | 9.70(2.26, 49.49) | -1.548 | 0.122 |
| 血常规衍生复合炎症指标 | | | | |
| 预后营养指数（PNI） | 46.95(43.05, 50.30) | 46.85(42.89, 50.73) | -0.083 | 0.934 |
| 中性粒细胞与淋巴细胞比值（NLR） | 3.88(2.73, 6.36) | 4.16(2.79, 6.29) | -0.547 | 0.585 |
| 胸腔积液[n(%)] | 126(28.2) | 52(28.3) | 0.000 | 1.000 |
| 斑片影[n(%)] | 185(41.4) | 79(42.9) | 0.073 | 0.788 |
| 实变影[n(%)] | 37(8.3) | 10(5.4) | 1.143 | 0.285 |
| 磨玻璃影[n(%)] | 109(24.4) | 42(22.8) | 0.099 | 0.753 |
| 纵膈/肺门淋巴结[n(%)] | | | 0.275 | 0.872 |
| 未肿大 | 45(10.1) | 20(10.9) | | |
| 稍大/显示 | 95(21.3) | 36(19.6) | | |
| 增大/增多 | 307(68.7) | 128(69.6) | | |
| 胸膜增厚粘连[n(%)] | 375(83.9) | 154(83.7) | 0.000 | 1.000 |
| 小叶间隔增厚[n(%)] | 70(15.7) | 21(11.4) | 1.576 | 0.209 |
| 支气管扩张[n(%)] | 64(14.3) | 19(10.3) | 1.485 | 0.223 |
| 网格状影/蜂窝状影[n(%)] | 31(6.9) | 12(6.5) | 0.000 | 0.989 |
| 支气管壁增厚[n(%)] | 29(6.5) | 8(4.3) | 0.728 | 0.393 |
), ArticleFig(id=1324077665992450359, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=表2, caption=
训练集和测试集患者检验、影像特征结果比较
, figureFileSmall=null, figureFileBig=null, tableContent=
| 检验项目/影像学特征[M(P25,P75)/例(%)] | 训练集(n=455) | 测试集(n=186) | 统计值(H/χ2) | P值 |
|---|
| 嗜酸性粒细胞百分比(%) | 1.60(0.80,3.10) | 1.75(0.88,2.90) | -0.038 | 0.970 |
| 嗜碱性粒细胞百分比(%) | 0.40(0.20, 0.50) | 0.40(0.20, 0.52) | -0.314 | 0.754 |
| 未成熟粒细胞百分比(%) | 0.20(0.10, 0.30) | 0.20(0.10, 0.40) | -0.972 | 0.331 |
| 白细胞计数(109/L) | 6.78(5.53, 8.59) | 6.92(5.79, 8.67) | -0.885 | 0.376 |
| 红细胞计数(1012/L) | 4.74(4.33, 5.09) | 4.70(4.23, 5.11) | -0.638 | 0.523 |
| 大血小板数(109/L) | 58.00(45.00, 69.00) | 57.00(46.00, 71.00) | -0.36 | 0.719 |
| 白蛋白(g/L) | 40.50(37.75, 43.00) | 40.45(37.70, 42.85) | -0.105 | 0.916 |
| 糖(mmol/L) | 5.00(4.60, 5.60) | 5.10(4.50, 5.80) | 0.346 | 0.730 |
| 超敏C反应蛋白(mg/L) | 8.07(1.96, 33.65) | 9.70(2.26, 49.49) | -1.548 | 0.122 |
| 血常规衍生复合炎症指标 | | | | |
| 预后营养指数（PNI） | 46.95(43.05, 50.30) | 46.85(42.89, 50.73) | -0.083 | 0.934 |
| 中性粒细胞与淋巴细胞比值（NLR） | 3.88(2.73, 6.36) | 4.16(2.79, 6.29) | -0.547 | 0.585 |
| 胸腔积液[n(%)] | 126(28.2) | 52(28.3) | 0.000 | 1.000 |
| 斑片影[n(%)] | 185(41.4) | 79(42.9) | 0.073 | 0.788 |
| 实变影[n(%)] | 37(8.3) | 10(5.4) | 1.143 | 0.285 |
| 磨玻璃影[n(%)] | 109(24.4) | 42(22.8) | 0.099 | 0.753 |
| 纵膈/肺门淋巴结[n(%)] | | | 0.275 | 0.872 |
| 未肿大 | 45(10.1) | 20(10.9) | | |
| 稍大/显示 | 95(21.3) | 36(19.6) | | |
| 增大/增多 | 307(68.7) | 128(69.6) | | |
| 胸膜增厚粘连[n(%)] | 375(83.9) | 154(83.7) | 0.000 | 1.000 |
| 小叶间隔增厚[n(%)] | 70(15.7) | 21(11.4) | 1.576 | 0.209 |
| 支气管扩张[n(%)] | 64(14.3) | 19(10.3) | 1.485 | 0.223 |
| 网格状影/蜂窝状影[n(%)] | 31(6.9) | 12(6.5) | 0.000 | 0.989 |
| 支气管壁增厚[n(%)] | 29(6.5) | 8(4.3) | 0.728 | 0.393 |
), ArticleFig(id=1324077666101502264, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=EN, label=Table 3, caption=
Multivariate logistic regression analysis
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 回归系数 | 标准误 | Z值 | P值 | OR（95%CI） |
|---|
| 侵入性操作 | 1.236 | 0.253 | 4.887 | <0.001 | 3.440(2.111~5.699) |
| 未成熟粒细胞百分比 | 0.830 | 0.315 | 2.640 | 0.008 | 2.294(1.254~4.402) |
| 全身性糖皮质激素使用 | 0.787 | 0.345 | 2.282 | 0.023 | 2.196(1.114~4.327) |
| 重复住院 | 0.739 | 0.253 | 2.918 | 0.004 | 2.094(1.280~3.464) |
| 呼吸衰竭 | 0.740 | 0.379 | 1.951 | 0.052 | 2.093(0.994~4.424) |
| 无创机械通气 | 0.631 | 0.497 | 1.269 | 0.204 | 1.879(0.715~5.081) |
| 胸腔积液 | 0.480 | 0.275 | 1.742 | 0.082 | 1.616(0.939~2.772) |
| 肺源性心脏病 | 0.326 | 0.322 | 1.011 | 0.312 | 1.385(0.732~2.596) |
| 糖尿病 | 0.118 | 0.073 | 1.619 | 0.105 | 1.126(0.976~1.306) |
| 年龄 | 0.057 | 0.012 | 4.695 | <0.001 | 1.059(1.034~1.085) |
| 大血小板数 | -0.020 | 0.006 | -3.196 | 0.001 | 0.980(0.968~0.992) |
| 体质量指数（BMI） | -0.065 | 0.037 | -1.749 | 0.080 | 0.937(0.871~1.007) |
), ArticleFig(id=1324077666185388345, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077658128130277, language=CN, label=表3, caption=
多因素logistic回归分析
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 回归系数 | 标准误 | Z值 | P值 | OR（95%CI） |
|---|
| 侵入性操作 | 1.236 | 0.253 | 4.887 | <0.001 | 3.440(2.111~5.699) |
| 未成熟粒细胞百分比 | 0.830 | 0.315 | 2.640 | 0.008 | 2.294(1.254~4.402) |
| 全身性糖皮质激素使用 | 0.787 | 0.345 | 2.282 | 0.023 | 2.196(1.114~4.327) |
| 重复住院 | 0.739 | 0.253 | 2.918 | 0.004 | 2.094(1.280~3.464) |
| 呼吸衰竭 | 0.740 | 0.379 | 1.951 | 0.052 | 2.093(0.994~4.424) |
| 无创机械通气 | 0.631 | 0.497 | 1.269 | 0.204 | 1.879(0.715~5.081) |
| 胸腔积液 | 0.480 | 0.275 | 1.742 | 0.082 | 1.616(0.939~2.772) |
| 肺源性心脏病 | 0.326 | 0.322 | 1.011 | 0.312 | 1.385(0.732~2.596) |
| 糖尿病 | 0.118 | 0.073 | 1.619 | 0.105 | 1.126(0.976~1.306) |
| 年龄 | 0.057 | 0.012 | 4.695 | <0.001 | 1.059(1.034~1.085) |
| 大血小板数 | -0.020 | 0.006 | -3.196 | 0.001 | 0.980(0.968~0.992) |
| 体质量指数（BMI） | -0.065 | 0.037 | -1.749 | 0.080 | 0.937(0.871~1.007) |
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