Article(id=1324077645033517232, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202511335, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1763654400000, receivedDateStr=2025-11-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793614310749, onlineDateStr=2026-11-02, pubDate=1774368000000, pubDateStr=2026-03-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793614310749, onlineIssueDateStr=2026-11-02, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793614310749, creator=13701087609, updateTime=1793614310749, updator=13701087609, issue=Issue{id=1324077560820282023, tenantId=1146029695717560320, journalId=1227665162245664772, year='2026', volume='53', issue='6', pageStart='961', pageEnd='1152', issueExtLink='null', onlineDate='null', pubDate='1774368000000', pubDateStr='2026-03-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793614290671, creator='13701087609', updateTime=1793614391469, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1324077983656444429, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1324077983660638734, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324077560820282023, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1113, endPage=1118, ext={EN=ArticleExt(id=1324077645255815345, articleId=1324077645033517232, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Long-term trend analysis of incidence and mortality of legally notifiable rodent-borne infectious diseases, China, 1950-2020, columnId=1228016573156360233, journalTitle=Modern Preventive Medicine, columnName=Disease Control and Prevention, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the long-term trends in the incidence and mortality of four rodent-borne notifiable infectious diseases (plague, HFRS, leptospirosis, and typhus) in China from 1950 to 2020, providing a basis for understanding the epidemiological patterns and scientific prevention and control of these diseases.
Methods Data on the annual incidence and mortality of plague, HFRS, leptospirosis (data available since 1955), and typhus from 1950 to 2020 were collected from the Public Health Science Data Center. Joinpoint regression was used for trend analysis. Five indicators—number of cases, incidence rate, number of deaths, mortality rate, and case fatality rate—were used to evaluate trends in incidence and mortality.
Results Plague: From 1950 to 2020, a total of 8 409 cases and 2 761 deaths were reported, with an incidence rate of 1.64×10-4 per 100 000 and a case fatality rate of 32.83%. The number of cases, deaths, and incidence rate showed an overall declining trend (APC<0, P<0.05), while the decline in case fatality rate (AAPC=-3.50%, 95% CI: -7.29% to 0.43%) was not statistically significant. After 2002, the annual number of reported cases fluctuated between 0 and 68 (APC<0, P<0.05), with case fatality rates ranging from 0% to 100%. HFRS: From 1950 to 2020, a total of 1 684 077 cases and 48 390 deaths were reported, with an average annual incidence rate of 2.34 per 100 000 and a case fatality rate of 2.87%. The number of cases, incidence rate, number of deaths, mortality rate, and case fatality rate initially fluctuated upward and then declined. The number of cases peaked in 1986 (115 807 cases) and then fluctuated downward (APC=-6.66%, 95% CI: -8.15% to -5.13%). From 2007 to 2020, the number of cases fluctuated between 8 121 and 13 308. The number of deaths dropped below 200 after 2006 and below 100 after 2013. The case fatality rate remained between 0.46% and 1.31% after 1995. Leptospirosis: From 1955 to 2020, a total of 2 523 008 cases and 27 730 deaths were reported, with an average annual incidence rate of 3.64 per 100 000 and a case fatality rate of 1.10%. The mortality rate showed an overall declining trend (APC=-8.71%, 95% CI: -13.54% to -3.62%), while the trends in the number of cases, deaths, incidence rate, and case fatality rate were not statistically significant (APC>0, P>0.05). After 1999, the number of cases dropped below 10 000, and after 2006, it dropped below 1 000. The number of deaths dropped below 1 000 after 1988, below 100 after 2002, and below 10 after 2011. The case fatality rate showed an initial decline followed by an increase, ranging from 0% to 3.96% after 2000. Typhus: From 1950 to 2020, a total of 450 080 cases and 7 327 deaths were reported, with an average annual incidence rate of 0.62 per 100 000 and a case fatality rate of 1.63%. The number of cases, deaths, mortality rate, and case fatality rate showed an overall declining trend (APC<0, P<0.05).
Conclusion During 1950-2020, China made remarkable progress in controlling rodent-borne infectious diseases, with the incidence and mortality of the four notifiable diseases reduced to low levels; nevertheless, the prevention and control of these diseases remains a serious challenge.
, authors=Tian LIU
1, Quan XIANG
1, Xu-hua GUAN
2, Zhou QIN
1, Yang WU
2, De-xin RUAN
1, Yi-xiong ZHAN
3, Jing ZHAO
4, authorsList=Tian LIU, Quan XIANG, Xu-hua GUAN, Zhou QIN, Yang WU, De-xin RUAN, Yi-xiong ZHAN, Jing ZHAO, authorCompany=null, correspAuthors=Jing ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1324077646321168570, articleId=1324077645033517232, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=1950—2020年全国鼠传法定传染病发病及死亡长期趋势分析, columnId=1228016573844226129, journalTitle=现代预防医学, columnName=疾病预防控制, runingTitle=null, highlight=null, articleAbstract=
目的 对1950—2020年全国鼠疫、肾综合征出血热、钩端螺旋体病、斑疹伤寒4种鼠传法定传染病发病及死亡长期趋势进行分析,为认识鼠传传染病流行规律并科学防控提供依据。
方法 自公共卫生科学数据中心收集1950—2020年全国鼠疫、肾综合征出血热、钩端螺旋体病(1955年起有数据)、斑疹伤寒逐年发病及死亡数据。Joinpoint回归用于趋势分析;从发病数、发病率、死亡数、死亡率和病死率5个指标评价发病及死亡趋势变化。
结果 1950—2020年全国鼠疫累计报告8 409例,死亡2 761例,发病率1.64×10-4/10万,病死率32.83%。发病数、死亡数和发病率总体呈下降趋势(APC<0,P<0.05),病死率(AAPC=-3.50%,95% CI: -7.29%~0.43%)下降趋势无统计学意义。2002年后年报告发病数维持在0~68例波动(APC<0,P<0.05);病死率介于0~100.00%。1950—2020年全国肾综合征出血热累计报告1 684 077例,死亡48 390例,年均发病率2.34/10万,病死率2.87%;发病数、发病率、死亡数、死亡率及病死率均呈先波动上升后波动下降的趋势;发病数在1986年达到最高峰(115 807例),随后波动下降(APC=-6.66%,95% CI:-8.15%~-5.13%),2007—2020年发病数维持在8 121~13 308例波动;2006年后死亡数降至200例内,2013年后死亡数降至100例内;1995年后病死率维持在0.46%~1.31%水平。1955—2020年全国钩端螺旋体病累计报告2 523 008例,死亡27 730例,年均发病率3.64/10万,病死率1.10%;死亡率总体呈下降趋势(APC=-8.71%,95% CI:-13.54%~-3.62%),发病数、死亡数、发病率、病死率下降趋势无统计学意义(APC>0,P>0.05)。1999年后发病数降至10 000例以内,2006年后发病数降至1 000以内;死亡数自1988年后降至1 000以内,2002年后降至100以内,2011年后降至10以内;病死率呈先降后升的变化趋势,2000年后病死率介于0~3.96%。1950—2020年全国斑疹伤寒累计报告450 080例,死亡7 327例,年均发病率0.62/10万,病死率1.63%;发病数、死亡数、死亡率、病死率总体呈下降趋势(APC<0,P<0.05)。
结论 1950—2020年我国鼠类传染病防制效果显著,4种法定鼠传传染病发病及死亡均降至较低水平,但4种鼠传传染病防控形势仍然严峻。
, authors=刘天
1, 向泉
1, 官旭华
2, 秦周
1, 吴杨
2, 阮德欣
1, 詹益雄
3, 赵婧
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刘天(1991—),男,本科,副主任医师,研究方向:急性传染病防制工作
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点,除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=YzyYFKaszrdxVLDczlzGqQ==, magXml=MXAOoVqZ5fAXJef9vsXIXQ==, pdfUrl=null, pdf=ira7lS2AwgG0xsDjgvfGoA==, pdfFileSize=1330429, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=jJSq4/cFTCW7aBLiyHKSdw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=YYYTPjo3fPIywfzKWQN6zw==, mapNumber=null, fund=null)}, authors=[Author(id=1324077646941925573, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324077647021617351, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, authorId=1324077646941925573, language=EN, stringName=Tian LIU, firstName=Tian, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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19(1): e0012729., articleTitle=The first direct detection of spotted fever group Rickettsia spp. diversity in ticks from Ningxia, northwestern China, refAbstract=null)], funds=[Fund(id=1324077654659444994, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, awardId=102393220020010000017, language=CN, fundingSource=中国疾病预防控制中心公共卫生应急反应机制的运行(102393220020010000017), fundOrder=null, country=null), Fund(id=1324077654743331075, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, awardId=2023-2026, language=CN, fundingSource=国家疾病预防控制局公共卫生人才培养支持项目(2023-2026), fundOrder=null, country=null), Fund(id=1324077654869160196, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, awardId=2021-2025, language=CN, fundingSource=湖北省公共卫生领军人才项目(2021-2025), fundOrder=null, country=null), Fund(id=1324077654944657669, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, awardId=WJ2025Q080, language=CN, fundingSource=2025-2026年度湖北省卫生健康科技项目(WJ2025Q080), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1324077646560243899, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, xref=1., ext=[AuthorCompanyExt(id=1324077646564438204, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, companyId=1324077646560243899, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department for Infectious Disease Control and Prevention, Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei 434000, China), AuthorCompanyExt(id=1324077646572826813, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, companyId=1324077646560243899, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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Joinpoint regression analysis of the cases of plague, HFRS, leptospirosis, and typhus since the founding of the People’s Republic of China, figureFileSmall=RrajRzKFzRLVvbU8HFsiCg==, figureFileBig=jJSq4/cFTCW7aBLiyHKSdw==, tableContent=null), ArticleFig(id=1324077653396959479, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=CN, label=图1, caption=
1950—2020年鼠疫、肾综合征出血热、钩端螺旋体病和斑疹伤寒发病数Joinpoint回归分析, figureFileSmall=RrajRzKFzRLVvbU8HFsiCg==, figureFileBig=jJSq4/cFTCW7aBLiyHKSdw==, tableContent=null), ArticleFig(id=1324077653690560760, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=EN, label=Fig.2, caption=
Joinpoint regression analysis of the incidence rate of plague, HFRS, leptospirosis, and typhus since the founding of the People’s Republic of China, figureFileSmall=rv0DkSu6/1/iYkMXsWeycA==, figureFileBig=imMD2LXNsNwv8H3R0G7i5A==, tableContent=null), ArticleFig(id=1324077653812195577, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=CN, label=图2, caption=
1950—2020年鼠疫、肾综合征出血热、钩端螺旋体病和斑疹伤寒发病率Joinpoint回归分析, figureFileSmall=rv0DkSu6/1/iYkMXsWeycA==, figureFileBig=imMD2LXNsNwv8H3R0G7i5A==, tableContent=null), ArticleFig(id=1324077653891887354, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=EN, label=Fig.3, caption=
Joinpoint regression analysis of mortality rates for plague, HFRS, leptospirosis, and typhus, 1950-2020, figureFileSmall=j+uEFDiSfGT6RCqvLgUbLQ==, figureFileBig=vTOmR1aO6HCuUVmUnZGt4A==, tableContent=null), ArticleFig(id=1324077653971579131, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=CN, label=图3, caption=
1950—2020鼠疫、肾综合征出血热、钩端螺旋体病和斑疹伤寒死亡率Joinpoint回归分析, figureFileSmall=j+uEFDiSfGT6RCqvLgUbLQ==, figureFileBig=vTOmR1aO6HCuUVmUnZGt4A==, tableContent=null), ArticleFig(id=1324077654084825340, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=EN, label=Fig.4, caption=
Joinpoint regression analysis of case-fatality rates for plague, HFRS, leptospirosis, and typhus, 1950-2020, figureFileSmall=RcSjvDq9ibDskpZo6nEzCw==, figureFileBig=qgFBQJqdKjU0KCZ+J64GQQ==, tableContent=null), ArticleFig(id=1324077654177100029, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=CN, label=图4, caption=
1950—2020鼠疫、肾综合征出血热、钩端螺旋体病和斑疹伤寒病死率Joinpoint回归分析, figureFileSmall=RcSjvDq9ibDskpZo6nEzCw==, figureFileBig=qgFBQJqdKjU0KCZ+J64GQQ==, tableContent=null), ArticleFig(id=1324077654260986110, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=EN, label=Table 1, caption=
Incidence andmortality overview of plague, HFRS, leptospirosis, and typhus since the founding of the People’s Republic of China
, figureFileSmall=null, figureFileBig=null, tableContent=
| 病种 | 发病数 | 死亡数 | 发病率(1/10万) | 死亡率(1/10万) | 病死率(%) |
|---|
| 鼠疫 | 8 409 | 2 761 | 1.64×10-4 | 5.39×10-5 | 32.83 |
| 肾综合征出血热 | 1 684 077 | 48 390 | 2.34 | 0.07 | 2.87 |
| 钩端螺旋体病 | 2 523 008 | 27 730 | 3.64 | 0.04 | 1.10 |
| 斑疹伤寒 | 450 080 | 7 327 | 0.62 | 0.01 | 1.63 |
), ArticleFig(id=1324077654386815231, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=CN, label=表1, caption=
1950—2020年鼠疫、肾综合征出血热、钩端螺旋体病和斑疹伤寒发病和死亡概况
, figureFileSmall=null, figureFileBig=null, tableContent=
| 病种 | 发病数 | 死亡数 | 发病率(1/10万) | 死亡率(1/10万) | 病死率(%) |
|---|
| 鼠疫 | 8 409 | 2 761 | 1.64×10-4 | 5.39×10-5 | 32.83 |
| 肾综合征出血热 | 1 684 077 | 48 390 | 2.34 | 0.07 | 2.87 |
| 钩端螺旋体病 | 2 523 008 | 27 730 | 3.64 | 0.04 | 1.10 |
| 斑疹伤寒 | 450 080 | 7 327 | 0.62 | 0.01 | 1.63 |
), ArticleFig(id=1324077654466507008, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=EN, label=Table 2, caption=
Joinpoint analysis of overall incidence and mortality trends for plague, hemorrhagic fever with renal syndrome, leptospirosis, and spotted fever, 1950-2020: AAPC (%, 95% CI)
, figureFileSmall=null, figureFileBig=null, tableContent=
| 属性 | 鼠疫 | 肾综合征出血热 | 钩体病 | 斑疹伤寒 |
|---|
| 发病数 | -10.76(-18.60~-2.17) | 9.27(4.01~14.80) | -0.77(-3.83~2.38) | -3.47(-8.65~2.01) |
| 死亡数 | -7.75(-10.00~-5.44) | 7.62(5.43~9.85) | -0.92(-6.43~4.92) | -8.82(-14.65~-2.59) |
| 发病率 | -14.50(-17.89~-13.62) | 4.52(2.28~6.81) | -4.59(-12.26~3.73) | -5.38(-10.62~0.17) |
| 死亡率 | -12.34(-31.18~11.66) | 3.83(-0.26~8.08) | -8.71(-13.54~-3.62) | -12.10(-14.86~-9.24) |
| 病死率 | -3.50(-7.29~0.43) | 13.76(0.44~28.84) | -1.78(-5.03~1.58) | -13.14(-16.39~-9.76) |
), ArticleFig(id=1324077654550393089, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324077645033517232, language=CN, label=表2, caption=
1950—2020年鼠疫、肾综合征出血热、钩端螺旋体病和斑疹伤寒总体发病和死亡趋势joinpoint分析AAPC结果(%)
, figureFileSmall=null, figureFileBig=null, tableContent=
| 属性 | 鼠疫 | 肾综合征出血热 | 钩体病 | 斑疹伤寒 |
|---|
| 发病数 | -10.76(-18.60~-2.17) | 9.27(4.01~14.80) | -0.77(-3.83~2.38) | -3.47(-8.65~2.01) |
| 死亡数 | -7.75(-10.00~-5.44) | 7.62(5.43~9.85) | -0.92(-6.43~4.92) | -8.82(-14.65~-2.59) |
| 发病率 | -14.50(-17.89~-13.62) | 4.52(2.28~6.81) | -4.59(-12.26~3.73) | -5.38(-10.62~0.17) |
| 死亡率 | -12.34(-31.18~11.66) | 3.83(-0.26~8.08) | -8.71(-13.54~-3.62) | -12.10(-14.86~-9.24) |
| 病死率 | -3.50(-7.29~0.43) | 13.76(0.44~28.84) | -1.78(-5.03~1.58) | -13.14(-16.39~-9.76) |
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