Article(id=1322607964129706523, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1322607837742747790, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202505342, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1748188800000, receivedDateStr=2025-05-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793263911516, onlineDateStr=2026-10-29, pubDate=1761321600000, pubDateStr=2025-10-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793263911516, onlineIssueDateStr=2026-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793263911516, creator=13701087609, updateTime=1793263911516, updator=13701087609, issue=Issue{id=1322607837742747790, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='20', pageStart='3649', pageEnd='3840', issueExtLink='null', onlineDate='null', pubDate='1761321600000', pubDateStr='2025-10-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793263881383, creator='13701087609', updateTime=1793264238791, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322609336933794638, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1322607837742747790, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322609336933794639, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1322607837742747790, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3693, endPage=3697, ext={EN=ArticleExt(id=1322607966222664220, articleId=1322607964129706523, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Association between comsumption amount of Tibetan traditional food Tsampa and biological age acceleration, columnId=1228016572783063333, journalTitle=Modern Preventive Medicine, columnName=Nutrition and Food Hygiene, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the association between Tsampa consumption and biological age acceleration.
Methods Utilizing baseline data from the China Multi-Ethnic Cohort study (CMEC), a composite biomarker-based biological age was constructed using the Klemera-Doubal Method (Biological age based on Klemera and Doubal’s method, KDM-BA). Biological aging was quantified as the difference between KDM-BA and chronological age. Tsampa consumption information was obtained via a Food Frequency Questionnaire (FFQ). Weekly intake was calculated based on consumption frequency and gram weight, and participants were categorized into four groups: non-consumption, low, moderate, and high, based on the 25th and 75th percentiles. Multiple linear regression was employed to analyze the association between Tsampa consumption and biological age acceleration. Stratified analyses were conducted using sex, age, smoking, alcohol consumption, and BMI as stratification factors.
Results A total of 4 335 participants were included. Compared to non-consumption, Tsampa consumption showed a negative association with biological age acceleration(β=-0.66,95% CI:-0.99- -0.327). A statistically significant association was found for moderate Tsampa consumption (700-1 400 grams)(β=-1.24,95% CI: -2.04- -0.44). Associations for low and high consumption levels were not statistically significant [Low:(β=0.11, 95% CI:-0.67-0.88); High:(β=-0.39,95% CI:-1.37-0.60)]. The protective effect of Tsampa consumption against biological age acceleration was stronger in males than in females [Males: (β=-0.83, 95% CI: -1.24- -0.43); Females:(β=-0.61,95% CI:-1.08- -0.13)].
Conclusion Tsampa consumption is negatively associated with biological age acceleration, suggesting its potential beneficial role in promoting healthy aging in the Tibetan region.
, authors=Danzengwangjiu
1, Yu-ling JIANG
2, Zi-jun SONG
2, Jia-jie CAI
2, Cirenzhuoga
1, Labaciren
1, Nimaqucuo
1, Silangyangzong
1, Rui-feng HE
1, Nimazhuoga
1, authorsList=Danzengwangjiu, Yu-ling JIANG, Zi-jun SONG, Jia-jie CAI, Cirenzhuoga, Labaciren, Nimaqucuo, Silangyangzong, Rui-feng HE, Nimazhuoga, authorCompany=null, correspAuthors=Nimazhuoga, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322607970832204326, articleId=1322607964129706523, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=藏族传统饮食糌粑食用量与生物年龄加速的关联研究, columnId=1228016573034721597, journalTitle=现代预防医学, columnName=营养与食品卫生, runingTitle=null, highlight=null, articleAbstract=
方法 利用中国西南区域自然人群队列研究（The China Multi-Ethnic Cohort study，CMEC）基线调查数据，采用Klemera-Doubal Method方法构建复合生物指标类生物年龄（Biological age based on Klemera and Doubal’s method，KDM-BA）。以KDM-BA与实足年龄差值量化生物衰老。通过食物频率问卷（Food Frequency Questionnaire，FFQ）获得糌粑食用信息。以食用频率与克重计算周摄入量，并按第25%和75% 百分位数分为不吃、低、中、高 4 组。运用多重线性回归分析糌粑食用量与生物年龄加速的关联，并以性别、年龄、吸烟、饮酒、BMI 为分层因素开展分层分析。
结果 共纳入4 335名研究对象。与不食用糌粑相比，食用糌粑与生物年龄加速呈现负向关联（β=-0.66，95% CI:-0.99~-0.327），中等水平糌粑食用量（700~1 400 g）与生物年龄加速的关联差异具有统计学意义（β =-1.24，95% CI: -2.04~-0.44），低水平和高水平糌粑食用量与生物年龄加速的关联，差异没有统计学意义[低水平:（β=0.11，95% CI:-0.67~0.88），高水平:（β=-0.39，95% CI:-1.37~0.60）]。糌粑食用量对生物年龄加速的保护作用在男性中比女性中更强 [男性:（β=-0.83, 95% CI: -1.24~-0.43），女性:（β=-0.61，95% CI:-1.08~-0.13）]。
结论 糌粑食用量与生物年龄加速呈负向关联，提示食用糌粑在促进西藏地区健康老龄化的潜在有益作用。
, authors=旦珍旺久
1, 姜玉玲
2, 宋子君
2, 蔡佳洁
2, 次仁卓嘎
1, 拉巴次仁
1, 尼玛曲措
1, 四郎央宗
1, 何瑞峰
1, 尼玛卓嘎
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旦珍旺久（1991—），男，本科，主管医师，研究方向：传染病防控
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=Ro0LgU+5rymcQ/5MVEKEdQ==, magXml=5Po6EEIejY9xxblQVyGgGA==, pdfUrl=null, pdf=tS35H7XubphtlfR55PbDmQ==, pdfFileSize=925808, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=rnEPheyObDBflbH3nLqb/A==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=vb+Qihf6Beoh8iAmrzjUDw==, mapNumber=null, fund=null)}, authors=[Author(id=1322607974711935533, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322607975055868463, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, authorId=1322607974711935533, language=EN, stringName=Danzengwangjiu, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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9 (5): 436-447., articleTitle=Epigenetic signatures of cigarette smoking, refAbstract=null)], funds=[Fund(id=1322607990138585714, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, awardId=2017YFC0907300，2017YFC0907302, language=CN, fundingSource=国家重点研发计划(2017YFC0907300，2017YFC0907302), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1322607973004853799, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, xref=1., ext=[AuthorCompanyExt(id=1322607973025825320, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, companyId=1322607973004853799, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Tibet Center for Disease Control and Prevention, Lhasa, Tibet 850000, China), AuthorCompanyExt(id=1322607973034213929, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, companyId=1322607973004853799, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.西藏自治区疾病预防控制中心应急办，西藏 拉萨 850000)]), AuthorCompany(id=1322607974628049450, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, xref=2., ext=[AuthorCompanyExt(id=1322607974653215275, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, companyId=1322607974628049450, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.四川大学华西公共卫生学院/华西第四医院)])], figs=[ArticleFig(id=1322607985977836137, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, language=EN, label=Fig.1, caption=
The final constructed directed acyclic graph (DAG), figureFileSmall=CgxjvcRcRo+8wrYsrneQyQ==, figureFileBig=rnEPheyObDBflbH3nLqb/A==, tableContent=null), ArticleFig(id=1322607986372100714, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, language=CN, label=图1, caption=
图1 最终构建的有向无环图, figureFileSmall=CgxjvcRcRo+8wrYsrneQyQ==, figureFileBig=rnEPheyObDBflbH3nLqb/A==, tableContent=null), ArticleFig(id=1322607988167262827, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, language=EN, label=Fig.2, caption=
Stratified analysis by population characteristics [β (95% CI)], figureFileSmall=Ac7bIxJ2PKLX9CQ4i0pduw==, figureFileBig=GYM5GAgP89a6qD4EZJecag==, tableContent=null), ArticleFig(id=1322607988523778668, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, language=CN, label=图2, caption=
基于人群特征的分层分析[β (95% CI)], figureFileSmall=Ac7bIxJ2PKLX9CQ4i0pduw==, figureFileBig=GYM5GAgP89a6qD4EZJecag==, tableContent=null), ArticleFig(id=1322607988880294509, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, language=EN, label=Table 1, caption=
Baseline characteristics of the study participants [Median (P25, P75), n(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 人群特征 | 总人群(n=4 335) | 糌粑食用量分组 |
|---|
| 0 (n=180) | 1 (n=2 156) | 2 (n=1 702) | 3 (n=297) |
|---|
| 生物年龄加速（岁） | 3.3(0.1, 6.7) | 4.6(1.0, 7.8) | 4.0(0.8, 7.0) | 2.2(-0.8, 5.7) | 3.4(0.6, 7.5) |
| 年龄（岁） | 48.8(39.7, 56.9) | 39.8(34.3, 47.0) | 48.4(39.0, 56.1) | 50.3(41.3, 58.2) | 50.2(41.1, 58.4) |
| 性别 | | | | | |
| 男性 | 1 663(38.4) | 76(42.2) | 801(37.2) | 653(38.4) | 133(44.8) |
| 女性 | 2 672(61.6) | 104(57.8) | 1 355(62.8) | 1 049(61.6) | 164(55.2) |
| 饮酒 | | | | | |
| 从不或几乎从不饮酒 | 2 966(68.4) | 87(48.3) | 1 386(64.3) | 1 284(75.4) | 209(70.4) |
| 特殊场合下偶尔喝酒 | 861(19.9) | 61(33.9) | 482(22.4) | 270(15.9) | 48(16.2) |
| 一年中特定月份喝酒 | 77(1.8) | 8(4.4) | 47(2.2) | 20(1.2) | 2(0.7) |
| 频率不足每周一次 | 140(3.2) | 6(3.3) | 81(3.8) | 41(2.4) | 12(4.0) |
| 每周至少喝一次 | 291(6.7) | 18(10.0) | 160(7.4) | 87(5.1) | 26(8.8) |
| 受教育程度 | | | | | |
| 未正规上学 | 2 412(55.6) | 59(32.8) | 1 118(51.9) | 1 082(63.6) | 153(51.5) |
| 小学 | 1 310(30.2) | 64(35.6) | 738(34.2) | 398(23.4) | 110(37.0) |
| 初中及高中 | 505(11.6) | 45(25.0) | 260(12.1) | 167(9.8) | 33(11.1) |
| 大专及大学（包括研究生） | 108(2.5) | 12(6.7) | 40(1.9) | 55(3.2) | 1(0.3) |
| 吸烟状况 | | | | | |
| 不吸烟 | 3 332(76.9) | 116(64.4) | 1 631(75.6) | 1 376(80.8) | 209(70.4) |
| 吸烟 | 791(18.2) | 61(33.9) | 423(19.6) | 240(14.1) | 67(22.6) |
| 戒烟 | 212(4.9) | 3(1.7) | 102(4.7) | 86(5.1) | 21(7.1) |
| 睡眠状况 | | | | | |
| 非失眠 | 2 765(63.8) | 130(72.2) | 1 422(66.0) | 1 027(60.3) | 186(62.6) |
| 失眠 | 1 570(36.2) | 50(27.8) | 734(34.0) | 675(39.7) | 111(37.4) |
| 抑郁状况 | | | | | |
| 非抑郁 | 4 243(97.9) | 176(97.8) | 2 117(98.2) | 1 662(97.6) | 288(97.0) |
| 抑郁 | 92(2.1) | 4(2.2) | 39(1.8) | 40(2.4) | 9(3.0) |
| 体力活动（MET-h/周） | 16.1(8.0, 28.5) | 16.6(7.6, 29.7) | 16.0(8.0, 28.2) | 15.8(7.9, 28.6) | 17.1(9.7, 28.9) |
| BMI(kg/m2) | | | | | |
| <18.5 | 64(1.5) | 1(0.6) | 25(1.2) | 34(2.0) | 4(1.3) |
| 18.5~24.9 | 1 036(23.9) | 32(17.8) | 500(23.2) | 456(26.8) | 48(16.2) |
| 25~29.9 | 2 456(56.7) | 110(61.1) | 1 271(59.0) | 858(50.4) | 217(73.1) |
| ≥30 | 779(18.0) | 37(20.6) | 360(16.7) | 354(20.8) | 28(9.4) |
), ArticleFig(id=1322607989299724910, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, language=CN, label=表1, caption=
研究对象的基线特征[M (P25，P75)，n(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 人群特征 | 总人群(n=4 335) | 糌粑食用量分组 |
|---|
| 0 (n=180) | 1 (n=2 156) | 2 (n=1 702) | 3 (n=297) |
|---|
| 生物年龄加速（岁） | 3.3(0.1, 6.7) | 4.6(1.0, 7.8) | 4.0(0.8, 7.0) | 2.2(-0.8, 5.7) | 3.4(0.6, 7.5) |
| 年龄（岁） | 48.8(39.7, 56.9) | 39.8(34.3, 47.0) | 48.4(39.0, 56.1) | 50.3(41.3, 58.2) | 50.2(41.1, 58.4) |
| 性别 | | | | | |
| 男性 | 1 663(38.4) | 76(42.2) | 801(37.2) | 653(38.4) | 133(44.8) |
| 女性 | 2 672(61.6) | 104(57.8) | 1 355(62.8) | 1 049(61.6) | 164(55.2) |
| 饮酒 | | | | | |
| 从不或几乎从不饮酒 | 2 966(68.4) | 87(48.3) | 1 386(64.3) | 1 284(75.4) | 209(70.4) |
| 特殊场合下偶尔喝酒 | 861(19.9) | 61(33.9) | 482(22.4) | 270(15.9) | 48(16.2) |
| 一年中特定月份喝酒 | 77(1.8) | 8(4.4) | 47(2.2) | 20(1.2) | 2(0.7) |
| 频率不足每周一次 | 140(3.2) | 6(3.3) | 81(3.8) | 41(2.4) | 12(4.0) |
| 每周至少喝一次 | 291(6.7) | 18(10.0) | 160(7.4) | 87(5.1) | 26(8.8) |
| 受教育程度 | | | | | |
| 未正规上学 | 2 412(55.6) | 59(32.8) | 1 118(51.9) | 1 082(63.6) | 153(51.5) |
| 小学 | 1 310(30.2) | 64(35.6) | 738(34.2) | 398(23.4) | 110(37.0) |
| 初中及高中 | 505(11.6) | 45(25.0) | 260(12.1) | 167(9.8) | 33(11.1) |
| 大专及大学（包括研究生） | 108(2.5) | 12(6.7) | 40(1.9) | 55(3.2) | 1(0.3) |
| 吸烟状况 | | | | | |
| 不吸烟 | 3 332(76.9) | 116(64.4) | 1 631(75.6) | 1 376(80.8) | 209(70.4) |
| 吸烟 | 791(18.2) | 61(33.9) | 423(19.6) | 240(14.1) | 67(22.6) |
| 戒烟 | 212(4.9) | 3(1.7) | 102(4.7) | 86(5.1) | 21(7.1) |
| 睡眠状况 | | | | | |
| 非失眠 | 2 765(63.8) | 130(72.2) | 1 422(66.0) | 1 027(60.3) | 186(62.6) |
| 失眠 | 1 570(36.2) | 50(27.8) | 734(34.0) | 675(39.7) | 111(37.4) |
| 抑郁状况 | | | | | |
| 非抑郁 | 4 243(97.9) | 176(97.8) | 2 117(98.2) | 1 662(97.6) | 288(97.0) |
| 抑郁 | 92(2.1) | 4(2.2) | 39(1.8) | 40(2.4) | 9(3.0) |
| 体力活动（MET-h/周） | 16.1(8.0, 28.5) | 16.6(7.6, 29.7) | 16.0(8.0, 28.2) | 15.8(7.9, 28.6) | 17.1(9.7, 28.9) |
| BMI(kg/m2) | | | | | |
| <18.5 | 64(1.5) | 1(0.6) | 25(1.2) | 34(2.0) | 4(1.3) |
| 18.5~24.9 | 1 036(23.9) | 32(17.8) | 500(23.2) | 456(26.8) | 48(16.2) |
| 25~29.9 | 2 456(56.7) | 110(61.1) | 1 271(59.0) | 858(50.4) | 217(73.1) |
| ≥30 | 779(18.0) | 37(20.6) | 360(16.7) | 354(20.8) | 28(9.4) |
), ArticleFig(id=1322607989412971119, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, language=EN, label=Table 2, caption=
Association between Zanba Consumption and Biological Age Acceleration [β (95% CI)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 模型 | 糌粑食用量分类（g/周） | 线性趋势P值 |
|---|
| 0(参考组） | >0 g/周且≤700 g/周 | >700 g/周且≤1 400 g/周 | >1 400 g |
|---|
| 模型1a | 1 (ref) | -0.62(-1.40~0.15) | -2.29(-3.08~-1.50) | -0.77(-1.72~0.28) | <0.001 |
| 模型2b | 1 (ref) | -0.20(-0.98~0.58) | -1.76(-2.55~-0.97) | -0.26(-1.21~0.69) | <0.001 |
| 模型3c | 1 (ref) | 0.11(-0.67~0.88) | -1.24(-2.04~-0.44) | -0.39(-1.37~0.60) | <0.001 |
), ArticleFig(id=1322607989782069872, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1322607964129706523, language=CN, label=表2, caption=
糌粑食用量与生物年龄加速的关联[β (95% CI)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 模型 | 糌粑食用量分类（g/周） | 线性趋势P值 |
|---|
| 0(参考组） | >0 g/周且≤700 g/周 | >700 g/周且≤1 400 g/周 | >1 400 g |
|---|
| 模型1a | 1 (ref) | -0.62(-1.40~0.15) | -2.29(-3.08~-1.50) | -0.77(-1.72~0.28) | <0.001 |
| 模型2b | 1 (ref) | -0.20(-0.98~0.58) | -1.76(-2.55~-0.97) | -0.26(-1.21~0.69) | <0.001 |
| 模型3c | 1 (ref) | 0.11(-0.67~0.88) | -1.24(-2.04~-0.44) | -0.39(-1.37~0.60) | <0.001 |
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