Article(id=1311350427556344098, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1311350363295417204, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202603337, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1774022400000, receivedDateStr=2026-03-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1790579905641, onlineDateStr=2026-09-28, pubDate=1787587200000, pubDateStr=2026-08-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1790579905641, onlineIssueDateStr=2026-09-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1790579905641, creator=13701087609, updateTime=1790579905641, updator=13701087609, issue=Issue{id=1311350363295417204, tenantId=1146029695717560320, journalId=1227665162245664772, year='2026', volume='53', issue='16', pageStart='2881', pageEnd='3072', issueExtLink='null', onlineDate='null', pubDate='1787587200000', pubDateStr='2026-08-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1790579890321, creator='13701087609', updateTime=1790584112451, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1311368072267653663, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1311350363295417204, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1311368072267653664, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1311350363295417204, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2909, endPage=2913, ext={EN=ArticleExt(id=1311350427812196643, articleId=1311350427556344098, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Research progress on the effects of heavy metal exposure on gut microbiota and probiotic intervention, columnId=1228016570660745413, journalTitle=Modern Preventive Medicine, columnName=Environmental and Occupational Health, runingTitle=null, highlight=null, articleAbstract=

Heavy metal pollution is a major global public health issue. Long-term low-dose exposure to heavy metals can induce multisystem damage and increase the risk of chronic diseases. Conventional chelation therapy is associated with adverse effects such as organ injury; therefore, safer and more effective intervention strategies are still needed. Increasing evidence has shown that heavy metal exposure can markedly disrupt the composition and function of the gut microbiota, thereby aggravating toxic effects. Probiotics may reduce heavy metal toxicity through multiple mechanisms by influencing the metabolism of heavy metals in vivo. However, previous reviews have mainly focused on the detoxification effects of traditional probiotics, while relatively few have discussed the recent advances in next-generation probiotics (NGPs). Accordingly, this review summarizes the effects of lead, mercury, cadmium, and arsenic exposure on gut microbiota composition and microbial metabolites, discusses the mechanisms by which traditional probiotics alleviate heavy metal toxicity, and further explores the potential applications of NGPs in heavy metal detoxification, with the aim of providing a theoretical basis for developing probiotic-based intervention strategies against heavy metal exposure.

, authors=Zhi-yu WANG¹, Jing ZHANG¹, Jun-zhao LIU¹, Ming-yang YANG¹, Song-bai HE¹, Yu DU^{1, 2}, authorsList=Zhi-yu WANG, Jing ZHANG, Jun-zhao LIU, Ming-yang YANG, Song-bai HE, Yu DU, authorCompany=null, correspAuthors=Yu DU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1311350428164518181, articleId=1311350427556344098, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=重金属暴露对肠道菌群的影响及益生菌干预的研究进展, columnId=1228016571273113811, journalTitle=现代预防医学, columnName=环境与职业卫生, runingTitle=null, highlight=null, articleAbstract=

重金属污染是全球重大公共卫生问题，长期低剂量重金属暴露可引发多系统损伤，并增加慢性疾病发生风险。传统螯合剂疗法存在脏器损伤等不良反应，故仍需探索安全有效的新型干预手段。研究表明，重金属暴露可显著扰乱肠道菌群组成与功能，进而加剧毒性损伤，益生菌则可通过多种途径影响重金属的体内代谢并降低其毒性。然而，既往综述多局限于传统益生菌的解毒作用，较少涉及下一代益生菌（Next-generation probiotics, NGPs）的相关研究进展。鉴于此，本文以铅、汞、镉、砷四种常见重金属为例，综述重金属暴露对肠道菌群组成及代谢产物的影响，传统益生菌缓解重金属毒性的机制，并探讨NGPs在重金属解毒中的应用潜力，旨在为开发基于益生菌干预的重金属暴露防治策略提供理论依据。

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