首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1241522926629999320, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241522919977841545, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202311279, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1699891200000, receivedDateStr=2023-11-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773931732089, onlineDateStr=2026-03-19, pubDate=1710000000000, pubDateStr=2024-03-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773931732089, onlineIssueDateStr=2026-03-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773931732089, creator=13701087609, updateTime=1773931732089, updator=13701087609, issue=Issue{id=1241522919977841545, tenantId=1146029695717560320, journalId=1227665162245664772, year='2024', volume='51', issue='5', pageStart='769', pageEnd='960', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1773931730503, creator=13701087609, updateTime=1773931880386, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1241523548695622547, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241522919977841545, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1241523548695622548, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241522919977841545, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=836, endPage=841, ext={EN=ArticleExt(id=1241522927246562032, articleId=1241522926629999320, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=The relationship between hormone replacement therapy and biological aging in postmenopausal women: a cross-sectional study based on the UK Biobank, columnId=1228016568949474136, journalTitle=Modern Preventive Medicine, columnName=Child and Adolescent Health, Maternal and Child Health, runingTitle=null, highlight=null, articleAbstract=
Objective

To explore the relationship between hormone replacement therapy (HRT) and the time period when postmenopausal women received HRT and accelerated biological aging.

Methods

Based on the biochemical and anthropometric data collected from the UK Biobank baseline survey, the biological age (BA) and BA acceleration index were constructed by Klemera Doubal method (KDM). The subjects were divided into 5 groups according to the status of receiving HRT: no, 10 years before menopause, 0-10 years before menopause, 0-10 years after menopause, and 10 years after menopause. Multivariate linear regression model was used to explore the relationship between HRT and BA acceleration. The characteristic factors of the population were taken as stratified factors for stratified analysis.

Results

A total of 96 889 subjects were included. Compared with people who did not receive HRT, there was a correlation for starting HRT 0-10 years before menopause (β=-0.28, 95%CI:-0.36 to -0.19) and starting HRT postmenopausal 0-10 years (β=-0.39, 95%CI: -0.46 to -0.31) with the delayed accelerated aging. The effect of HRT on delaying and accelerating aging was more obvious in postmenopausal women less than 60 years old.

Conclusion

Receiving HRT slows biological aging and is more effective when used within 10 years of menopause in postmenopausal women under 60 years of age.

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Zi-tong HUANG, Hong-mei ZHANG, Jun WEI, Jia-jie CAI, Hong-xiang CHEN, Yu-jie LIU, Hao XU, Qiang ZHANG, Xiong XIAO), CN=ArticleExt(id=1241522927967982361, articleId=1241522926629999320, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=绝经妇女激素补充治疗与生物衰老的关系——基于英国生物银行的横断面研究, columnId=1228016570031604578, journalTitle=现代预防医学, columnName=儿少卫生与妇幼保健, runingTitle=null, highlight=null, articleAbstract=
目的

探究绝经后妇女接受激素补充治疗（hormone replacement therapy, HRT）及开始治疗的时间段与生物衰老加速之间的关联。

方法

基于英国生物银行（UK Biobank，UKB）基线调查采集的生化检测与人体测量数据，采用Klemera Doubal（KDM）算法构建生物年龄（biological age，BA）和BA加速指标。将研究对象按接受HRT情况分为五组：未曾、绝经前10年以前开始、绝经前0～10年开始、绝经后0～10年开始和绝经后10年以后开始接受HRT。使用多因素线性回归模型探究HRT情况与BA加速之间的关联。并将人群特征因素作为分层因素进行分层分析。

结果

共纳入96 889名研究对象。与未接受HRT的人相比，绝经前0～10年开始（β=-0.28, 95%CI=-0.36～-0.19）和绝经后0～10年开始（β=-0.39, 95%CI=-0.46～-0.31）接受HRT与延缓加速衰老间存在关联。年龄小于60岁的绝经后妇女接受HRT延缓加速衰老的效应更明显。

结论

接受HRT会延缓生物衰老，且60岁以下绝经后妇女在绝经后10年内使用效果更明显。

, correspAuthors=null, authorNote=null, correspAuthorsNote=
肖雄，E-mail:
, copyrightStatement=本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=DVTft+uIhAARyE6ExJNG8g==, magXml=68t76hTHEcCd87TD6pah/Q==, pdfUrl=null, pdf=j+uZOBBHcIJeiWUIMyCzhQ==, pdfFileSize=713435, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=v9BZDN8KbfrLhMDOpIVddw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=GTy4ahqmurDCTzuVleYGTw==, mapNumber=null, authorCompany=null, fund=null, authors=

黄子桐（1997—），女，硕士在读，研究方向：公共卫生

, authorsList=黄子桐, 张红梅, 魏君, 蔡佳洁, 陈鸿祥, 刘钰杰, 徐浩, 张强, 肖雄)}, authors=[Author(id=1241678289857728590, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678290344267863, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678289857728590, language=EN, stringName=Zi-tong HUANG, firstName=Zi-tong, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678292353339488, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678289857728590, language=CN, stringName=黄子桐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio={"content":"

黄子桐（1997—），女，硕士在读，研究方向：公共卫生

"}, bioImg=null, bioContent=

黄子桐（1997—），女，硕士在读，研究方向：公共卫生

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1241678292927959152, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678293393526916, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678292927959152, language=EN, stringName=Hong-mei ZHANG, firstName=Hong-mei, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678293796180111, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678292927959152, language=CN, stringName=张红梅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1241678294618263710, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678295121580202, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678294618263710, language=EN, stringName=Jun WEI, firstName=Jun, middleName=null, lastName=WEI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678297264869559, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678294618263710, language=CN, stringName=魏君, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1241678297650745535, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678298032427209, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678297650745535, language=EN, stringName=Jia-jie CAI, firstName=Jia-jie, middleName=null, lastName=CAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678298430886100, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678297650745535, language=CN, stringName=蔡佳洁, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1241678299282329831, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678302918791412, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678299282329831, language=EN, stringName=Hong-xiang CHEN, firstName=Hong-xiang, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678303396942082, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678299282329831, language=CN, stringName=陈鸿祥, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1241678303921230089, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678306429423895, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678303921230089, language=EN, stringName=Yu-jie LIU, firstName=Yu-jie, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678306748191010, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678303921230089, language=CN, stringName=刘钰杰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1241678306899185966, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678307247313211, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678306899185966, language=EN, stringName=Hao XU, firstName=Hao, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678307784184136, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678306899185966, language=CN, stringName=徐浩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.四川大学华西口腔医院国家口腔疾病临床医学研究中心，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678289257943109, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=2., ext=[AuthorCompanyExt(id=1241678289278914630, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678289257943109, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.四川大学华西口腔医院国家口腔疾病临床医学研究中心，四川 成都 610041)])]), Author(id=1241678308576907602, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678310967660893, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678308576907602, language=EN, stringName=Qiang ZHANG, firstName=Qiang, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678311470977380, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678308576907602, language=CN, stringName=张强, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1241678311806521716, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=xiaoxiong.scu@scu.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241678315484926340, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678311806521716, language=EN, stringName=Xiong XIAO, firstName=Xiong, middleName=null, lastName=XIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241678316583833996, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, authorId=1241678311806521716, language=CN, stringName=肖雄, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])])], keywords=[Keyword(id=1241678319897334179, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=EN, orderNo=1, keyword=Hormone replacement therapy), Keyword(id=1241678320320958892, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=EN, orderNo=2, keyword=Aging), Keyword(id=1241678320794915253, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=EN, orderNo=3, keyword=Biological age), Keyword(id=1241678321549889983, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=CN, orderNo=1, keyword=激素补充治疗), Keyword(id=1241678321977708995, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=CN, orderNo=2, keyword=衰老), Keyword(id=1241678322397139404, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=CN, orderNo=3, keyword=生物年龄)], refs=[Reference(id=1241678328298525231, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2015, volume=1, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Davis SR, Lambrinoudaki I, Lumsden M, journalName=Nature Reviews Disease Primers, refType=null, unstructuredReference=Davis SR, Lambrinoudaki I, Lumsden M, et al. Menopause[J]. Nature Reviews Disease Primers, 2015, 1: 15004., articleTitle=Menopause, refAbstract=null), Reference(id=1241678328646652472, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2015, volume=44, issue=3, pageStart=497, pageEnd=515, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Santoro N, Epperson CN, Mathews SB, journalName=Endocrinology and Metabolism Clinics of North America, refType=null, unstructuredReference=Santoro N, Epperson CN, Mathews SB. Menopausal symptoms and their management[J]. Endocrinology and Metabolism Clinics of North America, 2015, 44(3): 497-515., articleTitle=Menopausal symptoms and their management, refAbstract=null), Reference(id=1241678329456153149, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2022, volume=10, issue=6, pageStart=457, pageEnd=470, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Lobo RA, Gompel A, journalName=Lancet Diabetes Endocrinol, refType=null, unstructuredReference=Lobo RA, Gompel A. Management of menopause: a view towards prevention[J]. Lancet Diabetes Endocrinol, 2022, 10(6): 457-470., articleTitle=Management of menopause: a view towards prevention, refAbstract=null), Reference(id=1241678329913332296, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2016, volume=113, issue=33, pageStart=9327, pageEnd=9332, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=Levine ME, Lu AT, Chen BH, journalName=Proceedings of the National Academy of Sciences of the United States of America, refType=null, unstructuredReference=Levine ME, Lu AT, Chen BH, et al. Menopause accelerates biological aging[J]. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(33): 9327-9332., articleTitle=Menopause accelerates biological aging, refAbstract=null), Reference(id=1241678330311791182, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2019, volume=55, issue=9, pageStart=602, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=Cagnacci A, Venier M, journalName=Medicina (Kaunas, Lithuania), refType=null, unstructuredReference=Cagnacci A, Venier M. The controversial history of hormone replacement therapy[J]. Medicina (Kaunas, Lithuania), 2019, 55(9):602., articleTitle=The controversial history of hormone replacement therapy, refAbstract=null), Reference(id=1241678330680889940, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2023, volume=147, issue=7, pageStart=597, pageEnd=610, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=Cho L, Kaunitz AM, Faubion SS, journalName=Circulation, refType=null, unstructuredReference=Cho L, Kaunitz AM, Faubion SS, et al. Rethinking menopausal hormone therapy: for whom, what, when, and how long?[J]. Circulation, 2023, 147(7): 597-610., articleTitle=Rethinking menopausal hormone therapy: for whom, what, when, and how long?, refAbstract=null), Reference(id=1241678330991268444, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2012, volume=19, issue=3, pageStart=257, pageEnd=271, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=North American Menopause Society, journalName=Menopause (New York, N.Y.), refType=null, unstructuredReference=North American Menopause Society. The 2012 hormone therapy position statement of: the north American menopause society[J].Menopause (New York, N.Y.), 2012, 19(3): 257-271., articleTitle=The 2012 hormone therapy position statement of: the north American menopause society, refAbstract=null), Reference(id=1241678331221955173, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2000, volume=87, issue=11, pageStart=956, pageEnd=960, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Mendelsohn ME, journalName=Circulation Research, refType=null, unstructuredReference=Mendelsohn ME. Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean?[J]. Circulation Research, 2000, 87(11): 956-960., articleTitle=Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean?, refAbstract=null), Reference(id=1241678331540722282, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2005, volume=308, issue=5728, pageStart=1583, pageEnd=1587, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=Mendelsohn ME, Karas RH, journalName=Science, refType=null, unstructuredReference=Mendelsohn ME, Karas RH. Molecular and cellular basis of cardio-vascular gender differences[J]. Science, 2005, 308(5728): 1583-1587., articleTitle=Molecular and cellular basis of cardio-vascular gender differences, refAbstract=null), Reference(id=1241678331918209651, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2005, volume=46, issue=4, pageStart=471, pageEnd=479, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=Lee DC, Im JA, Kim JH, journalName=Yonsei Medical Journal, refType=null, unstructuredReference=Lee DC, Im JA, Kim JH, et al. Effect of long-term hormone therapy on telomere length in postmenopausal women[J]. Yonsei Medical Journal, 2005, 46(4): 471-479., articleTitle=Effect of long-term hormone therapy on telomere length in postmenopausal women, refAbstract=null), Reference(id=1241678332207616634, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2013, volume=68, issue=6, pageStart=667, pageEnd=674, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=Levine ME, journalName=The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences, refType=null, unstructuredReference=Levine ME. Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?[J]. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences, 2013, 68(6): 667-674., articleTitle=Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?, refAbstract=null), Reference(id=1241678332509606526, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2015, volume=12, issue=3, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=Sudlow C, Gallacher J, Allen N, journalName=PLOS Medicine, refType=null, unstructuredReference=Sudlow C, Gallacher J, Allen N, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age[J]. PLOS Medicine, 2015, 12(3):e1001779., articleTitle=UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age, refAbstract=null), Reference(id=1241678332962591366, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2006, volume=127, issue=3, pageStart=240, pageEnd=248, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=Klemera P, Doubal S, journalName=Mechanisms of Ageing and Development, refType=null, unstructuredReference=Klemera P, Doubal S. A new approach to the concept and computation of biological age[J]. Mechanisms of Ageing and Development,2006, 127(3): 240-248., articleTitle=A new approach to the concept and computation of biological age, refAbstract=null), Reference(id=1241678334669673101, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2011, volume=30, issue=4, pageStart=377, pageEnd=399, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=White IR, Royston P, Wood AM, journalName=Medicine Statistics, refType=null, unstructuredReference=White IR, Royston P, Wood AM. Multiple imputation using chained equations: Issues and guidance for practice[J]. Medicine Statistics,2011, 30(4): 377-399., articleTitle=Multiple imputation using chained equations: Issues and guidance for practice, refAbstract=null), Reference(id=1241678335298818709, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2017, volume=167, issue=4, pageStart=268, pageEnd=274, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=Vanderweele TJ, Ding P, journalName=Annals of Internal Medicine, refType=null, unstructuredReference=Vanderweele TJ, Ding P. Sensitivity analysis in observational research: introducing the E-Value[J]. Annals of Internal Medicine,2017, 167(4): 268-274., articleTitle=Sensitivity analysis in observational research: introducing the E-Value, refAbstract=null), Reference(id=1241678335479173789, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2013, volume=8, issue=2, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=Jacobs EG, Kroenke C, Lin J, journalName=PLOS One, refType=null, unstructuredReference=Jacobs EG, Kroenke C, Lin J, et al. Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use[J]. PLOS One, 2013, 8(2): e54713., articleTitle=Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use, refAbstract=null), Reference(id=1241678335646945954, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2015, volume=350, issue=6265, pageStart=1193, pageEnd=1198, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=Blackburn EH, Epel ES, Lin J, journalName=Science, refType=null, unstructuredReference=Blackburn EH, Epel ES, Lin J. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection[J]. Science, 2015, 350(6265): 1193-1198., articleTitle=Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection, refAbstract=null), Reference(id=1241678336028627622, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2017, volume=21, issue=null, pageStart=29, pageEnd=36, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=Jylhävä J, journalName=EBioMedicine, refType=null, unstructuredReference=Jylhävä J. Pedersen NL,Hägg S.biological age predictors[J]. EBioMedicine, 2017, 21: 29-36., articleTitle=Pedersen NL,Hägg S.biological age predictors, refAbstract=null), Reference(id=1241678336313840300, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2013, volume=239, issue=null, pageStart=34, pageEnd=45, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=Luine V, Frankfurt M, journalName=Neuroscience, refType=null, unstructuredReference=Luine V, Frankfurt M. Interactions between estradiol, BDNF and dendritic spines in promoting memory[J]. Neuroscience, 2013, 239:34-45., articleTitle=Interactions between estradiol, BDNF and dendritic spines in promoting memory, refAbstract=null), Reference(id=1241678336708104888, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2023, volume=58, issue=1, pageStart=4, pageEnd=21, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=中华医学会妇产科学分会绝经学组, journalName=中华妇产科杂志, refType=null, unstructuredReference=中华医学会妇产科学分会绝经学组.中国绝经管理与绝经激素治疗指南2023版[J].中华妇产科杂志，2023，58（1）：4-21., articleTitle=中国绝经管理与绝经激素治疗指南2023版, refAbstract=null), Reference(id=1241678337295307453, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2023, volume=58, issue=1, pageStart=4, pageEnd=21, url=null, language=null, rfNumber=[20], rfOrder=20, authorNames=Menopause Group, Obstetrics and Gynecology Branch, Chinese Medical Association, journalName=Chinese Journal of Obstetrics and Gynecology, refType=null, unstructuredReference=Menopause Group, Obstetrics and Gynecology Branch, Chinese Medical Association. 2023 Chinese guideline on menopause management and menopause hormone therapy[J]. Chinese Journal of Obstetrics and Gynecology,2023, 58(1): 4-21., articleTitle=2023 Chinese guideline on menopause management and menopause hormone therapy, refAbstract=null), Reference(id=1241678337588908741, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2017, volume=13, issue=4, pageStart=220, pageEnd=231, url=null, language=null, rfNumber=[21], rfOrder=21, authorNames=Lobo RA, journalName=Nature Reviews Endocrinology, refType=null, unstructuredReference=Lobo RA. Hormone-replacement therapy: current thinking[J]. Nature Reviews Endocrinology, 2017, 13(4): 220-231., articleTitle=Hormone-replacement therapy: current thinking, refAbstract=null), Reference(id=1241678339417625292, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2015, volume=100, issue=12, pageStart=4456, pageEnd=4462, url=null, language=null, rfNumber=[22], rfOrder=22, authorNames=Pereira RI, Casey BA, Swibas TA, journalName=Journal of Clinical Endocrinology & Metabolism, refType=null, unstructuredReference=Pereira RI, Casey BA, Swibas TA, et al. Timing of estradiol treatment after menopause May determine benefit or harm to insulin action[J]. Journal of Clinical Endocrinology & Metabolism, 2015, 100(12):4456-4462., articleTitle=Timing of estradiol treatment after menopause May determine benefit or harm to insulin action, refAbstract=null), Reference(id=1241678340193571543, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=1998, volume=280, issue=7, pageStart=605, pageEnd=613, url=null, language=null, rfNumber=[23], rfOrder=23, authorNames=Hulley S, Grady D, Bush T, journalName=JAMA: the Journal of the American Medical Association, refType=null, unstructuredReference=Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group[J]. JAMA: the Journal of the American Medical Association, 1998, 280(7): 605-613., articleTitle=Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group, refAbstract=null), Reference(id=1241678340478784219, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2014, volume=17, issue=5, pageStart=540, pageEnd=556, url=null, language=null, rfNumber=[24], rfOrder=24, authorNames=Lobo RA, Davis SR, De VT, journalName=Climacteric, refType=null, unstructuredReference=Lobo RA, Davis SR, De VT, et al. Prevention of diseases after menopause[J]. Climacteric, 2014, 17(5): 540-556., articleTitle=Prevention of diseases after menopause, refAbstract=null), Reference(id=1241678340839494368, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2012, volume=15, issue=2, pageStart=105, pageEnd=114, url=null, language=null, rfNumber=[25], rfOrder=25, authorNames=Harlow SD, Gass M, Hall JE, journalName=Climacteric, refType=null, unstructuredReference=Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging[J]. Climacteric, 2012, 15(2): 105-114., articleTitle=Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging, refAbstract=null), Reference(id=1241678341250536164, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2022, volume=29, issue=7, pageStart=767, pageEnd=794, url=null, language=null, rfNumber=[26], rfOrder=26, authorNames=“The 2022 Hormone Therapy Position Statement of The North American Menopause Society” Advisory Panel, journalName=Menopause (New York, N.Y.), refType=null, unstructuredReference=“The 2022 Hormone Therapy Position Statement of The North American Menopause Society” Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society[J]. Menopause (New York, N.Y.), 2022, 29(7): 767-794., articleTitle=The 2022 hormone therapy position statement of The North American Menopause Society, refAbstract=null), Reference(id=1241678341636412138, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2019, volume=34, issue=20, pageStart=4718, pageEnd=4722, url=null, language=null, rfNumber=[27], rfOrder=27, authorNames=姚玲, journalName=中国妇幼保健, refType=null, unstructuredReference=姚玲.社区妇女围绝经期保健现状及需求情况分析[J].中国妇幼保健，2019，34（20）：4718-4722., articleTitle=社区妇女围绝经期保健现状及需求情况分析, refAbstract=null), Reference(id=1241678342043259632, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, doi=null, pmid=null, pmcid=null, year=2019, volume=34, issue=20, pageStart=4718, pageEnd=4722, url=null, language=null, rfNumber=[27], rfOrder=28, authorNames=Yao L, journalName=Maternal & Child Health Care of China, refType=null, unstructuredReference=Yao L. Analysis of the current situation and needs of perimenopausal health care for women in the community[J]. Maternal & Child Health Care of China, 2019, 34(20): 4718-4722., articleTitle=Analysis of the current situation and needs of perimenopausal health care for women in the community, refAbstract=null)], funds=[Fund(id=1241678327019262492, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, awardId=82273740, language=CN, fundingSource=国家自然科学基金(82273740), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1241678288788181046, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=1., ext=[AuthorCompanyExt(id=1241678288796569655, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1241678288800763960, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678288788181046, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)]), AuthorCompany(id=1241678289257943109, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, xref=2., ext=[AuthorCompanyExt(id=1241678289278914630, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, companyId=1241678289257943109, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.四川大学华西口腔医院国家口腔疾病临床医学研究中心，四川 成都 610041)])], figs=[ArticleFig(id=1241678323378606560, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=EN, label=Figure 1, caption=Results of the association between hormone replacement therapy use and biological aging acceleration, figureFileSmall=/ikTMI1LcRTB73a0rL+a+Q==, figureFileBig=hHn/9hhNiYopnPtpmDWsbg==, tableContent=null), ArticleFig(id=1241678323819008483, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=CN, label=图1, caption=HRT开始使用情况与BA加速之间的关联结果

注：图A为未调整协变量的模型1；图B为调整了一般社会因素、生活行为和心理因素的模型2,；图C为调整了一般社会因素、生活行为和心理因素模型、生殖史因素的模型3。

, figureFileSmall=/ikTMI1LcRTB73a0rL+a+Q==, figureFileBig=hHn/9hhNiYopnPtpmDWsbg==, tableContent=null), ArticleFig(id=1241678324456542708, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=EN, label=Table 1, caption=

Baseline characteristics of study participants ［M（P25，P75），n（%）］

, figureFileSmall=null, figureFileBig=null, tableContent=
基线特征全人群
（n=96 889）		未曾接受过HRT
（n=55 678）		绝经前10年以前开始接受HRT
（n=1 404）		绝经前0～10年开始接受HRT
（n=15 250）		绝经后0～10年开始接受HRT
（n=23 274）		绝经后10年以后开始接受HRT
（n=1 283）
BA加速(岁)-0.09(-3.97, 4.06)0.16(-3.70, 4.34)0.94(-3.10, 5.15)-0.17(-4.00, 3.84)-0.63(-4.56, 3.51)0.16(-3.70, 4.34)
年龄(岁)60.83(56.50, 64.67)59.75(55.42, 64.00)62.42(59.58, 65.42)61.67(58.50, 64.75)62.08(58.17, 65.50)59.75(55.42, 64.00)
种族
白人92 916(96.1)52 822(95.1)1 377(98.3)14 939(98.1)22 534(97.0)52 822(95.1)
非白人3 737(3.9)2 695(4.9)24(1.7)286(1.9)695(3.0)2 695(4.9)
受教育程度
初中及以下19 406(20.2)10 378(18.8)435(31.3)3 293(21.8)4 920(21.3)10 378(18.8)
高中48 156(50.2)27 462(49.8)707(50.9)7 775(51.4)11 569(50.1)27 462(49.8)
大学及以上28 419(29.6)17 268(31.3)246(17.7)4 068(26.9)6 590(28.6)17 268(31.3)
职业
待业47 891(49.9)24 554(44.6)854(61.4)8 468(55.9)13 116(56.8)24 554(44.6)
在业48 123(50.1)30 558(55.4)536(38.6)6 680(44.1)9 970(43.2)30 558(55.4)
剥夺指数-2.30(-3.71, 0.13)-2.28(-3.70, 0.17)-2.20(-3.63, 0.39)-2.39(-3.75, -0.08)-2.29(-3.71, 0.18)-2.28(-3.70, 0.17)
吸烟状况
不吸烟89 014(92.2)51 504(92.8)1 245(88.9)13 903(91.5)21 205(91.4)51 504(92.8)
曾经吸烟7 556(7.8)3 993(7.2)156(11.1)1 291(8.5)1 998(8.6)3 993(7.2)
饮酒状况
现在不饮酒9 050(9.3)5 671(10.2)130(9.3)1 154(7.6)1 963(8.4)5 671(10.2)
现在饮酒87 763(90.7)49 957(89.8)1 273(90.7)14 088(92.4)21 295(91.6)49 957(89.8)
饮茶状况
现在不饮茶13 536(14.0)7 941(14.3)209(14.9)2 032(13.3)3 153(13.6)7 941(14.3)
现在饮茶83 190(86.0)47 612(85.7)1 193(85.1)13 205(86.7)20 098(86.4)47 612(85.7)
饮咖啡状况
现在不饮咖啡20 925(21.6)12 204(22.0)340(24.3)3 156(20.7)4 928(21.2)12 204(22.0)
现在饮咖啡75 829(78.4)43 375(78.0)1 062(75.7)12 082(79.3)18 324(78.8)43 375(78.0)
体力活动
(MET-h/week)		30.62(14.53, 60.43)30.07(14.25, 59.10)33.51(14.60, 73.55)30.92(14.40, 61.54)31.55(14.95, 62.60)30.07(14.25, 59.10)
BMI (kg/m2)26.07(23.49, 29.49)26.04(23.42, 29.60)27.12(24.35, 30.76)26.39(23.88, 29.64)25.84(23.35, 29.05)26.04(23.42, 29.60)
失眠状况
不失眠15 443(15.9)9 603(17.3)187(13.3)1 995(13.1)3 468(14.9)9 603(17.3)
失眠81 393(84.1)46 035(82.7)1 217(86.7)13 249(86.9)19 799(85.1)46 035(82.7)
焦虑状况
不焦虑89 210(96.0)51 153(96.1)1 285(94.1)14 136(96.1)21 464(95.8)51 153(96.1)
焦虑3 739(4.0)2 059(3.9)81(5.9)581(3.9)947(4.2)2 059(3.9)
抑郁状况
不抑郁85 982(95.0)49 277(95.2)1 216(92.3)13 608(95.1)20 744(94.6)49 277(95.2)
抑郁4 557(5.0)2 511(4.8)102(7.7)694(4.9)1 173(5.4)2 511(4.8)
初潮年龄(岁)13(12, 14)13(12, 14)13(12, 14)13(12, 14)13(12, 14)13(12, 14)
初产年龄(岁)25(22, 29)26(23, 29)23(21, 27)25(22, 28)25(22, 28)26(23, 29)
口服避孕药
未曾使用21 067(21.8)13 442(24.2)260(18.5)2 569(16.9)4 449(19.1)13 442(24.2)
曾使用75 649(78.2)42 108(75.8)1 143(81.5)12 666(83.1)18 797(80.9)42 108(75.8)
自然流产史
无67 591(69.8)39 158(70.3)956(68.1)10 438(68.4)16 134(69.3)39 158(70.3)
有29 298(30.2)16 520(29.7)448(31.9)4 812(31.6)7 140(30.7)16 520(29.7)
人工流产史
无67 714(69.9)39 226(70.5)958(68.2)10 463(68.6)16 163(69.4)39 226(70.5)
有29 175(30.1)16 452(29.5)446(31.8)4 787(31.4)7 111(30.6)16 452(29.5)
), ArticleFig(id=1241678324762726909, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=CN, label=表1, caption=

研究对象的基线特征汇总［M（P25，P75），n（%）］

, figureFileSmall=null, figureFileBig=null, tableContent=
基线特征全人群
（n=96 889）		未曾接受过HRT
（n=55 678）		绝经前10年以前开始接受HRT
（n=1 404）		绝经前0～10年开始接受HRT
（n=15 250）		绝经后0～10年开始接受HRT
（n=23 274）		绝经后10年以后开始接受HRT
（n=1 283）
BA加速(岁)-0.09(-3.97, 4.06)0.16(-3.70, 4.34)0.94(-3.10, 5.15)-0.17(-4.00, 3.84)-0.63(-4.56, 3.51)0.16(-3.70, 4.34)
年龄(岁)60.83(56.50, 64.67)59.75(55.42, 64.00)62.42(59.58, 65.42)61.67(58.50, 64.75)62.08(58.17, 65.50)59.75(55.42, 64.00)
种族
白人92 916(96.1)52 822(95.1)1 377(98.3)14 939(98.1)22 534(97.0)52 822(95.1)
非白人3 737(3.9)2 695(4.9)24(1.7)286(1.9)695(3.0)2 695(4.9)
受教育程度
初中及以下19 406(20.2)10 378(18.8)435(31.3)3 293(21.8)4 920(21.3)10 378(18.8)
高中48 156(50.2)27 462(49.8)707(50.9)7 775(51.4)11 569(50.1)27 462(49.8)
大学及以上28 419(29.6)17 268(31.3)246(17.7)4 068(26.9)6 590(28.6)17 268(31.3)
职业
待业47 891(49.9)24 554(44.6)854(61.4)8 468(55.9)13 116(56.8)24 554(44.6)
在业48 123(50.1)30 558(55.4)536(38.6)6 680(44.1)9 970(43.2)30 558(55.4)
剥夺指数-2.30(-3.71, 0.13)-2.28(-3.70, 0.17)-2.20(-3.63, 0.39)-2.39(-3.75, -0.08)-2.29(-3.71, 0.18)-2.28(-3.70, 0.17)
吸烟状况
不吸烟89 014(92.2)51 504(92.8)1 245(88.9)13 903(91.5)21 205(91.4)51 504(92.8)
曾经吸烟7 556(7.8)3 993(7.2)156(11.1)1 291(8.5)1 998(8.6)3 993(7.2)
饮酒状况
现在不饮酒9 050(9.3)5 671(10.2)130(9.3)1 154(7.6)1 963(8.4)5 671(10.2)
现在饮酒87 763(90.7)49 957(89.8)1 273(90.7)14 088(92.4)21 295(91.6)49 957(89.8)
饮茶状况
现在不饮茶13 536(14.0)7 941(14.3)209(14.9)2 032(13.3)3 153(13.6)7 941(14.3)
现在饮茶83 190(86.0)47 612(85.7)1 193(85.1)13 205(86.7)20 098(86.4)47 612(85.7)
饮咖啡状况
现在不饮咖啡20 925(21.6)12 204(22.0)340(24.3)3 156(20.7)4 928(21.2)12 204(22.0)
现在饮咖啡75 829(78.4)43 375(78.0)1 062(75.7)12 082(79.3)18 324(78.8)43 375(78.0)
体力活动
(MET-h/week)		30.62(14.53, 60.43)30.07(14.25, 59.10)33.51(14.60, 73.55)30.92(14.40, 61.54)31.55(14.95, 62.60)30.07(14.25, 59.10)
BMI (kg/m2)26.07(23.49, 29.49)26.04(23.42, 29.60)27.12(24.35, 30.76)26.39(23.88, 29.64)25.84(23.35, 29.05)26.04(23.42, 29.60)
失眠状况
不失眠15 443(15.9)9 603(17.3)187(13.3)1 995(13.1)3 468(14.9)9 603(17.3)
失眠81 393(84.1)46 035(82.7)1 217(86.7)13 249(86.9)19 799(85.1)46 035(82.7)
焦虑状况
不焦虑89 210(96.0)51 153(96.1)1 285(94.1)14 136(96.1)21 464(95.8)51 153(96.1)
焦虑3 739(4.0)2 059(3.9)81(5.9)581(3.9)947(4.2)2 059(3.9)
抑郁状况
不抑郁85 982(95.0)49 277(95.2)1 216(92.3)13 608(95.1)20 744(94.6)49 277(95.2)
抑郁4 557(5.0)2 511(4.8)102(7.7)694(4.9)1 173(5.4)2 511(4.8)
初潮年龄(岁)13(12, 14)13(12, 14)13(12, 14)13(12, 14)13(12, 14)13(12, 14)
初产年龄(岁)25(22, 29)26(23, 29)23(21, 27)25(22, 28)25(22, 28)26(23, 29)
口服避孕药
未曾使用21 067(21.8)13 442(24.2)260(18.5)2 569(16.9)4 449(19.1)13 442(24.2)
曾使用75 649(78.2)42 108(75.8)1 143(81.5)12 666(83.1)18 797(80.9)42 108(75.8)
自然流产史
无67 591(69.8)39 158(70.3)956(68.1)10 438(68.4)16 134(69.3)39 158(70.3)
有29 298(30.2)16 520(29.7)448(31.9)4 812(31.6)7 140(30.7)16 520(29.7)
人工流产史
无67 714(69.9)39 226(70.5)958(68.2)10 463(68.6)16 163(69.4)39 226(70.5)
有29 175(30.1)16 452(29.5)446(31.8)4 787(31.4)7 111(30.6)16 452(29.5)
), ArticleFig(id=1241678324959859203, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=EN, label=Table 2, caption=

Stratified analysis according to characteristics of study participants [β, 95%CI]

, figureFileSmall=null, figureFileBig=null, tableContent=
人群特征未曾接受HRT绝经前10年前开始HRT绝经前0～10年开始HRT绝经后0～10年开始HRT绝经后10年后开始HRT
年龄(岁)
<60(n=42 395)0(ref)-0.21(-0.69～0.28)-0.37(-0.52～-0.23)-0.61(-0.74～-0.49)-0.27(-0.85～0.30)
≥60(n=54 494)0(ref)0.11(-0.18～0.41)-0.34(-0.45～-0.24)-0.34(-0.44～-0.25)-0.18(-0.48～0.11)
吸烟
现在不吸(n=89 014)0(ref)0.15(-0.12～0.41)-0.26(-0.35～-0.17)-0.39(-0.47～-0.32)-0.02(-0.29～0.26)
现在吸(n=7 556)0(ref)-0.39(-1.17～0.39)-0.51(-0.82～-0.2)-0.36(-0.63～-0.09)-0.69(-1.58～0.20)
抑郁症状
无(n=85 982)0(ref)0.15(-0.11～0.42)-0.3(-0.39～-0.21)-0.37(-0.45～-0.29)-0.12(-0.39～0.16)
有(n=4 557)0(ref)-0.82(-1.84～0.19)-0.21(-0.65～0.23)-0.64(-1.00～-0.28)0.36(-0.81～1.52)
BMI (kg/m2)
<25(n=38 579)0(ref)-0.04(-0.50～0.41)-0.24(-0.38～-0.09)-0.58(-0.70～-0.46)-0.13(-0.58～0.33)
≥25(n=58 290)0(ref)0.30(-0.07～0.67)-0.39(-0.51～-0.26)-0.52(-0.63～-0.41)-0.13(-0.52～0.27)
口服避孕药
未使用(n=21 067)0(ref)0.28(-0.30～0.86)-0.31(-0.51～-0.11)-0.35(-0.51～-0.18)-0.26(-0.76～0.25)
使用过(n=75 649)0(ref)0.04(-0.23～0.32)-0.28(-0.38～-0.19)-0.40(-0.48～-0.32)-0.02(-0.32～0.28)
自然流产史
无(n=67 591)0(ref)0.03(-0.27～0.33)-0.27(-0.38～-0.17)-0.36(-0.45～-0.27)-0.11(-0.42～0.20)
有(n=29 298)0(ref)0.23(-0.21～0.67)-0.31(-0.47～-0.16)-0.46(-0.59～-0.32)-0.02(-0.50～0.46)
), ArticleFig(id=1241678325333152266, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241522926629999320, language=CN, label=表2, caption=

基于人群特征的分层分析[β（95%CI）]

, figureFileSmall=null, figureFileBig=null, tableContent=
人群特征未曾接受HRT绝经前10年前开始HRT绝经前0～10年开始HRT绝经后0～10年开始HRT绝经后10年后开始HRT
年龄(岁)
<60(n=42 395)0(ref)-0.21(-0.69～0.28)-0.37(-0.52～-0.23)-0.61(-0.74～-0.49)-0.27(-0.85～0.30)
≥60(n=54 494)0(ref)0.11(-0.18～0.41)-0.34(-0.45～-0.24)-0.34(-0.44～-0.25)-0.18(-0.48～0.11)
吸烟
现在不吸(n=89 014)0(ref)0.15(-0.12～0.41)-0.26(-0.35～-0.17)-0.39(-0.47～-0.32)-0.02(-0.29～0.26)
现在吸(n=7 556)0(ref)-0.39(-1.17～0.39)-0.51(-0.82～-0.2)-0.36(-0.63～-0.09)-0.69(-1.58～0.20)
抑郁症状
无(n=85 982)0(ref)0.15(-0.11～0.42)-0.3(-0.39～-0.21)-0.37(-0.45～-0.29)-0.12(-0.39～0.16)
有(n=4 557)0(ref)-0.82(-1.84～0.19)-0.21(-0.65～0.23)-0.64(-1.00～-0.28)0.36(-0.81～1.52)
BMI (kg/m2)
<25(n=38 579)0(ref)-0.04(-0.50～0.41)-0.24(-0.38～-0.09)-0.58(-0.70～-0.46)-0.13(-0.58～0.33)
≥25(n=58 290)0(ref)0.30(-0.07～0.67)-0.39(-0.51～-0.26)-0.52(-0.63～-0.41)-0.13(-0.52～0.27)
口服避孕药
未使用(n=21 067)0(ref)0.28(-0.30～0.86)-0.31(-0.51～-0.11)-0.35(-0.51～-0.18)-0.26(-0.76～0.25)
使用过(n=75 649)0(ref)0.04(-0.23～0.32)-0.28(-0.38～-0.19)-0.40(-0.48～-0.32)-0.02(-0.32～0.28)
自然流产史
无(n=67 591)0(ref)0.03(-0.27～0.33)-0.27(-0.38～-0.17)-0.36(-0.45～-0.27)-0.11(-0.42～0.20)
有(n=29 298)0(ref)0.23(-0.21～0.67)-0.31(-0.47～-0.16)-0.46(-0.59～-0.32)-0.02(-0.50～0.46)
)], attaches=null, journal=Journal(id=1227664546253402114, delFlag=0, nameCn=现代预防医学, nameEn=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, issn=1003-8507, eissn=null, cn=51-1365/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=IeiuPXEZi6AA+k0VfvoiOQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Modern Preventive Medicine, journalRemark=null, publicationField=null, createdTime=1770627636734, updatedTime=1770628902248, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=IeiuPXEZi6AA+k0VfvoiOQ==, picEn=/9iTl8/ndms4tBz1fL28Pg==, jcr=null, cjcr=null, exts=[JournalExt(id=1227669854342280188, language=CN, name=现代预防医学, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1770628902278, updatedTime=1770628902278, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1227669854396806141, language=EN, name=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1770628902291, updatedTime=1770628902291, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1227665162245664772, websiteList=[Website(id=1227687234141352800, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/CN, language=CN, createTime=1770633045945, createBy=18614031015, updateTime=1770633090526, updateBy=18614031015, name=现代预防医学-中文, tplId=1146099689490845704, title=现代预防医学, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687735088051072, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=articleTextType, value=kx, createTime=1770633165380, updateTime=1770633165380, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735071273853, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=banner, value=null, createTime=1770633165376, updateTime=1770633165376, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735113216899, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=grayFlag, value=0, createTime=1770633165386, updateTime=1770633165386, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735062885244, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633165374, updateTime=1770633165374, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735125799813, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=minRunFlag, value=0, createTime=1770633165389, updateTime=1770633165389, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735083856767, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic, createTime=1770633165379, updateTime=1770633165379, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735121605508, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=silenceFlag, value=0, createTime=1770633165388, updateTime=1770633165388, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735079662462, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1770633165378, updateTime=1770633165378, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735096439681, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeColor, value=null, createTime=1770633165382, updateTime=1770633165382, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735104828290, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeStyle, value=null, createTime=1770633165384, updateTime=1770633165384, creator=18614031015, updator=18614031015)]), Website(id=1227687234338485094, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/EN, language=EN, createTime=1770633045992, createBy=18614031015, updateTime=1770633115374, updateBy=18614031015, name=现代预防医学-英文, tplId=1146101810881728533, title=Modern Preventive Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687709129507332, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=articleTextType, value=kx, createTime=1770633159191, updateTime=1770633159191, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709108535809, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=banner, value=null, createTime=1770633159186, updateTime=1770633159186, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709167256071, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=grayFlag, value=0, createTime=1770633159200, updateTime=1770633159200, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709095952896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633159183, updateTime=1770633159183, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709179838985, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=minRunFlag, value=0, createTime=1770633159203, updateTime=1770633159203, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709121118723, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic, createTime=1770633159189, updateTime=1770633159189, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709171450376, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=silenceFlag, value=0, createTime=1770633159201, updateTime=1770633159201, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709112730114, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1770633159187, updateTime=1770633159187, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709133701637, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeColor, value=null, createTime=1770633159192, updateTime=1770633159192, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709154673158, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeStyle, value=null, createTime=1770633159197, updateTime=1770633159197, creator=18614031015, updator=18614031015)])], journalTitle=现代预防医学, weixinUrl=null, journalUrl=http://xdyfyxzz.paperopen.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Modern Preventive Medicine, journalPhotoCn=IeiuPXEZi6AA+k0VfvoiOQ==, journalPhotoEn=/9iTl8/ndms4tBz1fL28Pg==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202311279, detailUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/10.20043/j.cnki.MPM.202311279, pdfUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/PDF/10.20043/j.cnki.MPM.202311279, pdfUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/PDF/10.20043/j.cnki.MPM.202311279, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
绝经妇女激素补充治疗与生物衰老的关系——基于英国生物银行的横断面研究
收藏切换
PDF下载
黄子桐 1 , 张红梅 1 , 魏君 1 , 蔡佳洁 1 , 陈鸿祥 1 , 刘钰杰 1 , 徐浩 2 , 张强 1 , 肖雄 1
现代预防医学 | 儿少卫生与妇幼保健 2024,51(5): 836-841
收起
收藏切换
现代预防医学 | 儿少卫生与妇幼保健 2024, 51(5): 836-841
绝经妇女激素补充治疗与生物衰老的关系——基于英国生物银行的横断面研究
全屏
黄子桐1, 张红梅1, 魏君1, 蔡佳洁1, 陈鸿祥1, 刘钰杰1, 徐浩2, 张强1, 肖雄1
作者信息
  • 1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041
  • 2.四川大学华西口腔医院国家口腔疾病临床医学研究中心，四川 成都 610041

    • 黄子桐（1997—），女，硕士在读，研究方向：公共卫生

通讯作者:

肖雄，E-mail:
The relationship between hormone replacement therapy and biological aging in postmenopausal women: a cross-sectional study based on the UK Biobank
Zi-tong HUANG1, Hong-mei ZHANG1, Jun WEI1, Jia-jie CAI1, Hong-xiang CHEN1, Yu-jie LIU1, Hao XU2, Qiang ZHANG1, Xiong XIAO1
Affiliations
  • Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China
出版时间: 2024-03-10 doi: 10.20043/j.cnki.MPM.202311279
文章导航
收藏切换
摘要
收起
目的

探究绝经后妇女接受激素补充治疗（hormone replacement therapy, HRT）及开始治疗的时间段与生物衰老加速之间的关联。

方法

基于英国生物银行（UK Biobank，UKB）基线调查采集的生化检测与人体测量数据，采用Klemera Doubal（KDM）算法构建生物年龄（biological age，BA）和BA加速指标。将研究对象按接受HRT情况分为五组：未曾、绝经前10年以前开始、绝经前0～10年开始、绝经后0～10年开始和绝经后10年以后开始接受HRT。使用多因素线性回归模型探究HRT情况与BA加速之间的关联。并将人群特征因素作为分层因素进行分层分析。

结果

共纳入96 889名研究对象。与未接受HRT的人相比，绝经前0～10年开始（β=-0.28, 95%CI=-0.36～-0.19）和绝经后0～10年开始（β=-0.39, 95%CI=-0.46～-0.31）接受HRT与延缓加速衰老间存在关联。年龄小于60岁的绝经后妇女接受HRT延缓加速衰老的效应更明显。

结论

接受HRT会延缓生物衰老，且60岁以下绝经后妇女在绝经后10年内使用效果更明显。

激素补充治疗  /  衰老  /  生物年龄
Objective

To explore the relationship between hormone replacement therapy (HRT) and the time period when postmenopausal women received HRT and accelerated biological aging.

Methods

Based on the biochemical and anthropometric data collected from the UK Biobank baseline survey, the biological age (BA) and BA acceleration index were constructed by Klemera Doubal method (KDM). The subjects were divided into 5 groups according to the status of receiving HRT: no, 10 years before menopause, 0-10 years before menopause, 0-10 years after menopause, and 10 years after menopause. Multivariate linear regression model was used to explore the relationship between HRT and BA acceleration. The characteristic factors of the population were taken as stratified factors for stratified analysis.

Results

A total of 96 889 subjects were included. Compared with people who did not receive HRT, there was a correlation for starting HRT 0-10 years before menopause (β=-0.28, 95%CI:-0.36 to -0.19) and starting HRT postmenopausal 0-10 years (β=-0.39, 95%CI: -0.46 to -0.31) with the delayed accelerated aging. The effect of HRT on delaying and accelerating aging was more obvious in postmenopausal women less than 60 years old.

Conclusion

Receiving HRT slows biological aging and is more effective when used within 10 years of menopause in postmenopausal women under 60 years of age.

Hormone replacement therapy  /  Aging  /  Biological age
黄子桐, 张红梅, 魏君, 蔡佳洁, 陈鸿祥, 刘钰杰, 徐浩, 张强, 肖雄. 绝经妇女激素补充治疗与生物衰老的关系——基于英国生物银行的横断面研究. 现代预防医学, 2024 , 51 (5) : 836 -841 . DOI: 10.20043/j.cnki.MPM.202311279
Zi-tong HUANG, Hong-mei ZHANG, Jun WEI, Jia-jie CAI, Hong-xiang CHEN, Yu-jie LIU, Hao XU, Qiang ZHANG, Xiong XIAO. The relationship between hormone replacement therapy and biological aging in postmenopausal women: a cross-sectional study based on the UK Biobank[J]. Modern Preventive Medicine, 2024 , 51 (5) : 836 -841 . DOI: 10.20043/j.cnki.MPM.202311279
正文
收起
绝经是女性卵巢衰竭所引起的月经永久停止，其本质是雌激素缺乏[1]。在短期内，女性绝经会引起包括潮热出汗、乏力虚弱、睡眠障碍等症状的绝经综合征[2]；长远看来，它还会增加患骨质疏松、心血管疾病、代谢性疾病等年龄相关疾病的风险[3]。同时，绝经也是人体衰老的重要转折点。有研究提示绝经可能会加速生物的衰老[4]。
激素补充治疗（hormone replacement therapy,HRT）是解决绝经综合征的最有效办法，但其对心血管疾病、子宫内膜癌、乳腺癌等风险的影响一度饱受争议[5]。近20年来，研究者对其有了新的认识[6]。一些研究显示绝经后尽早（10年内）或60岁以前开始适当的HRT对治疗血管舒张症状、泌尿生殖系统症状，预防骨质疏松、心血管疾病等有重要作用，并强调了治疗开始的时间节点的重要性[7-9]。还有研究发现绝经后妇女进行长期HRT可以减轻端粒损耗[10]。HRT作为重要的预防和治疗手段，是否能延缓绝经引起的生物衰老加速，目前暂缺乏相关的流行病学研究。生物学年龄（biological age，BA）是一个综合反映身体各个器官系统的衰老状态指标，为年龄相关疾病的早期干预提供了独特的观测角度[11]。
本研究基于英国生物银行(UK Biobank, UKB)生化检测和问卷调查的基线数据，在绝经后妇女中探究了使用HRT及开始治疗的时间段与生物衰老加速(biological aging acceleration, BA加速)之间的关系。
1　对象与方法
收起
1.1　研究对象
UKB是英国一项基于人口的大型前瞻性队列研究，共招募了50多万名40～69岁的参与者[12]。调查内容包括电子通过触摸屏填写的问卷、体格测量、生化测试、表型评估和签署的知情同意书。西北多中心研究伦理委员会(MREC)为UKB研究提供了一般伦理批准。本研究在生化数据完整的基线人群(330 166)中排除了男性(153 323)、未绝经(71 648)、HRT使用情况及开始治疗时年龄数据不完整(8 306)的样本，最终纳入了96 889名研究对象。
1.2　研究方法
1.2.1　暴露测量
HRT是使用雌激素、孕激素或联合使用的对症治疗绝经综合征及预防疾病的方法，根据不同适应症和个体情况改变用药方案。HRT使用情况通过触摸屏电子问卷测量。问卷提问“您是否曾使用过HRT？”，如研究对象回答“是”则继续提问“开始使用HRT的年龄”。UKB并未在调查中详细询问参与者接受治疗的具体药物、剂量、时长。我们用开始接受HRT的年龄减去绝经年龄并据此划分开始接受治疗的时间段。最终将研究对象分为五组：未曾接受过HRT、绝经前10年以前开始接受HRT、绝经前0～10年开始接受HRT、绝经后0～10年开始接受HRT、绝经后10年以后开始接受HRT。
1.2.2　结局测量
本研究利用通过生化测试和人体测量获得的生物标志物构建了基于Klemera Doubal method (KDM)[13]的生物学年龄(KDM-BA)。该方法在预测死亡率和年龄相关疾病方面表现良好。首先，结合以往研究的指标利用情况，综合考虑生物标志物在衰老过程中的作用和数据的可及性，我们初步筛选出77个生物标志物。在对每个入选的生物标志物进行Box-Cox转换以符合正态分布后，我们对指标与实足年龄（chronological age，CA）进行了Pearson相关分析，仅保留相关系数|r|>0.1且具有统计学意义的生物标志物。然后根据先验知识，我们进一步排除了一些冗余指标。最终纳入了18个生物标志物：收缩压（SBP）、腰臀比（WHR）、体脂率（BFP）、1 s用力呼气容积（FEV1）、平均红细胞体积（MCV）、碱性磷酸酶（ALP）、天门冬氨酸氨基转移酶（AST）、C-反应蛋白（CRP）、胱抑素C（CysC）、γ-谷氨酰转肽酶（GGT）、足跟定量超声指数（QUI）、糖化血红蛋白（HBA1C）、胰岛素样生长因子1（IGF-1）、甘油三酯（TG）、尿酸盐、尿素、白蛋白（ALB）和维生素D（VD）。
基于筛选出的指标，我们利用UKB全人群基线数据分性别对CA与所有生物生物标志物进行回归训练，并根据训练得出的模型参数计算了KDM-BA。最后，生物衰老加速定义为BA与CA之差，正值表明该个体的生理年龄比基于CA的预期年龄要大，衰老程度更严重，反之亦然。
1.2.3　统计分析
根据HRT使用情况分组描述研究对象的基线特征，其中连续型变量以中位数和四分位数间距描述、分类变量用频数和构成比描述。以未曾接受过HRT为参考组，采用多因素线性回归模型来分析HRT使用情况与BA加速之间的关联。模型1为不调整任何协变量的粗模型；模型2调整了一般社会因素、生活行为和心理因素，包括年龄、种族、受教育水平、职业状况、汤森剥夺指数(Townsend deprivation index, TDI)、吸烟状况、饮酒状况、饮茶状况、饮咖啡状况、健康膳食、失眠状况、抑郁症状、焦虑症状、体力活动、身体质量指数（body mass index，BMI）、是否患有严重疾病(包括心血管疾病、糖尿病、癌症)；模型3在模型2的基础上增加调整了生殖史因素，包括初潮年龄、初产年龄、是否曾口服避孕药、自然流产史、人工流产史。为探索人群特征对HRT使用与BA加速之间关系可能的影响，本研究针对年龄、吸烟状况、抑郁症状、BMI、是否曾口服避孕药、自然流产史进行了分层分析。在上述所有分析中，采用了多重填补法（共五次）来填补协变量的缺失数据，然后根据Rubin规则对所有数据集的结果进行了汇总[14]。
为验证研究结果的稳健性，本研究进行了一些敏感性分析。首先，排除了基线自报患有严重疾病的参与者进行重复分析。其次，使用未填补的数据再次进行分析。最后，计算了E值以评估可能存在的未测量混杂变量对结果的影响[15]。
本研究采用R 4.1.2软件进行统计分析。
2　结果
收起
2.1　研究对象特征描述
本研究共纳入了96 889名研究对象，未接受过HRT的有55 678人，接受过HRT的有41 211人。在接受过HRT的人中，大多数为绝经后0～10年开始，占56%。研究对象的平均年龄为60.83(56.50, 64.67)岁，BA加速为-0.09(-3.97, 4.06)。相比于未接受过HRT和绝经前10年以前开始接受HRT的人，绝经前10年到绝经后10年开始接受HRT的人有更小的BA加速。与未接受过HRT的人相比，绝经前10年到绝经后10年开始接受HRT的人中白人、现在不饮酒、失眠、曾使用过口服避孕药的占比更高。基线特征描述见表1。
2.2　HRT使用情况与BA加速之间的关系
HRT使用情况与BA加速的关系见图1。3个模型系数的总体趋势保持一致。在调整了所有一般社会因素、生活行为因素与生殖史因素的模型3中，与未接受HRT的人相比，绝经前10年以前开始接受HRT的人有更大的BA加速但结果无统计学意义（β=0.10, 95%CI：-0.15～0.35）；绝经前0～10年开始（β=-0.28, 95%CI：-0.36～-0.19）和绝经后0～10年开始（β=-0.39,95%CI：-0.46～-0.31）的人与BA加速呈负关联，且结果具有统计学意义，其中绝经后0～10年开始的人负关联更强。而绝经后10年后与BA加速有较小的但无统计学意义的负关联（β=-0.07, 95%CI：-0.33～-0.19）。
2.3　分层分析结果
基于人群特征的分层分析的结果见表2。在绝经后0～10年开始接受HRT的人中，小于60岁及有抑郁症状的人呈现出更小的BA加速（<10岁β=-0.61，≥60岁β=-0.34；无抑郁β=-0.37，有抑郁β=-0.64）。其他人群特征未发现明显效应修饰作用。
2.4　敏感性分析结果
排除基线自报患有严重疾病的参与者或使用未填补数据进行的重复分析结果与主分析的结果相似，仅系数大小有略微浮动。另外，绝经前0～10年开始接受HRT者的β值和95%CI的E值分别为1.89和1.65，绝经后0～10年开始接受HRT者的β值和95%CI的E值分别为2.16和1.95，说明未测混杂对研究结果的影响较小。
3　讨论
收起
本研究利用UKB的基线数据探究了绝经后妇女HRT的使用情况与生物衰老加速的变化之间的关联，并探索了可能影响这一关联的人群特征因素。研究结果提示，绝经后妇女使用HRT可延缓生物衰老加速，且不同时间段开始接受治疗的效果不同。相较于不接受治疗的人，绝经后0～10年开始接受HRT延缓生物衰老加速的作用最强，绝经前0～10年开始接受HRT的次之，而绝经前过早（10年前）开始治疗可能会加剧BA加速。此外，<60岁和有抑郁症状的绝经后妇女在绝经后0～10年开始接受HRT的延缓加速衰老作用更强。
本研究结果提示绝经后妇女使用HRT或许可以延缓BA加速。既往尚未有探索HRT与生物学年龄关联的研究。有研究关注了HRT与端粒长度的关系。一项病例对照研究认为绝经后妇女长期接受HRT可以抑制端粒的损耗[10]。还有纵向队列研究显示，雌激素的使用可能对载脂蛋白-ε4（阿尔滋海默症和早死的遗传危险因素）携带者的端粒缩短有延缓作用[16]。端粒长度决定了细胞的生存寿命，端粒长度越短死亡风险越高[17]。但有研究者认为，端粒长度预测衰老相关健康结局的能力较弱[18]。而作为复合生物标志物的生物学年龄综合考虑多器官系统的生物标志物，能够反映整体的衰老状态[11]。总之，与既往研究相比，本研究从不同的维度和视角为HRT延缓绝经后妇女生物衰老提供了进一步的证据。
既往的机制学研究也支持本研究的结果。比如，在认知功能方面，雌激素在细胞和动物模型中具有神经保护作用，可以促进脑源性神经营养因子和增加海马体中的突触脊柱密度[19]。在卵巢衰竭导致大脑内源性雌激素水平降低的情况下，HRT可以缓解这一情况，预防阿尔兹海默病，进而可能达到延缓机体衰老的效果。另外，在心血管系统方面，绝经前雌激素通过一氧化氮、细胞因子和低密度脂蛋白胆固醇的氧化等机制抑制动脉粥样硬化斑块的形成[8-9]。绝经后不久提供HRT可以保持这一活性，降低心血管疾病发生的风险。而心血管系统疾病正是衰老相关结局的一大重要组成部分。
中国女性绝经的平均年龄为48～52岁[20]，本研究的研究对象主要为年龄集中在55～65岁之间的绝经后妇女，结果提示绝经前后10年内开始接受HRT均能延缓BA加速，其中绝经后0～10年效应最强。并且，分层分析的结果提示<60岁的绝经后妇女在绝经后10内开始接受HRT有更明显的延缓衰老作用。这一结果与绝经后尽早（10年内）或60岁以前开始的HRT的指南相互印证。对于<60岁的女性，绝经后短期内开始使用HRT可以提高葡萄糖处置率且有益于冠状动脉，能降低糖尿病与心血管疾病风险[21-22]。对于≥60岁的女性，一方面，随着雌激素持续缺乏时间的增加，雌激素受体功能丧失，接受HRT降低糖尿病风险的效果减弱；另一方面，其血管内可能已经形成了动脉粥样硬化斑块，在此时接受HRT会导致斑块脱落或破裂，导致严重的健康结局[23]。因此绝经后早期开始HRT是发挥雌激素有益作用的关键。此外，许多衰老相关的疾病发生在绝经后10～15年的妇女身上[24]，而绝经综合征发生在绝经前后数年内[25]，这为我们提供了宝贵的“窗口期”，HRT可以作为除生活行为方式管理之外的有效一级预防干预措施。
HRT在《北美绝经协会2022年激素疗法立场声明》[26]与《中国绝经管理与绝经激素治疗指南（2023）》[20]等指南推荐中得到了再次的强调与重视。目前，我国民众对于激素治疗的了解和使用率逐渐提高[27]，但相比于发达国家仍有较大提升空间。本研究的结果作为激素治疗益处的又一证据，或许能为公共卫生指导政策与绝经后女性的预防保健工作提供科学依据。
本研究具有一定的优势。一方面，据笔者所知这是第一个研究HRT与BA加速关联的研究。另一方面，本研究具有较大样本量，且进行了多个敏感性分析以验证研究结果的稳健性。同时，本研究也存在一些局限性。首先，HRT情况来源于自填问卷，可能存在回忆偏倚和暴露错分。其次，HRT的配方、剂量和给药途径并未详细调查，这可能会影响其对生物衰老加速的作用。再次，UKB仅在基线调查时进行了全人群的生化检测，而生物学年龄的计算需要生化指标，受限于数据可及性，本研究为观察性横断面研究，尽管我们已尽量控制已测量混杂变量，仍然可能存在未测量混杂和反向因果的情况。最后，本研究样本人群仅来源于UKB，因此，研究结果在外推到其他人群时需要谨慎。
综上，本研究表明在绝经前后10年内开始接受HRT可以延缓绝经后妇女的生物衰老，并且这一效应在小于60岁的人群中更为明显。鉴于绝经是每一位妇女的必经之路且激素治疗在我国的推行仍任重而道远，本研究能为制定相关政策和指导提供科学依据。
基金
收起
  • 国家自然科学基金(82273740)
文献
收起
参考文献 引证文献
排序方式：
[1]
Davis SR, Lambrinoudaki I, Lumsden M, et al. Menopause[J]. Nature Reviews Disease Primers, 2015, 1: 15004.
[2]
Santoro N, Epperson CN, Mathews SB. Menopausal symptoms and their management[J]. Endocrinology and Metabolism Clinics of North America, 2015, 44(3): 497-515.
[3]
Lobo RA, Gompel A. Management of menopause: a view towards prevention[J]. Lancet Diabetes Endocrinol, 2022, 10(6): 457-470.
[4]
Levine ME, Lu AT, Chen BH, et al. Menopause accelerates biological aging[J]. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113(33): 9327-9332.
[5]
Cagnacci A, Venier M. The controversial history of hormone replacement therapy[J]. Medicina (Kaunas, Lithuania), 2019, 55(9):602.
[6]
Cho L, Kaunitz AM, Faubion SS, et al. Rethinking menopausal hormone therapy: for whom, what, when, and how long?[J]. Circulation, 2023, 147(7): 597-610.
[7]
North American Menopause Society. The 2012 hormone therapy position statement of: the north American menopause society[J].Menopause (New York, N.Y.), 2012, 19(3): 257-271.
[8]
Mendelsohn ME. Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean?[J]. Circulation Research, 2000, 87(11): 956-960.
[9]
Mendelsohn ME, Karas RH. Molecular and cellular basis of cardio-vascular gender differences[J]. Science, 2005, 308(5728): 1583-1587.
[10]
Lee DC, Im JA, Kim JH, et al. Effect of long-term hormone therapy on telomere length in postmenopausal women[J]. Yonsei Medical Journal, 2005, 46(4): 471-479.
[11]
Levine ME. Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?[J]. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences, 2013, 68(6): 667-674.
[12]
Sudlow C, Gallacher J, Allen N, et al. UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age[J]. PLOS Medicine, 2015, 12(3):e1001779.
[13]
Klemera P, Doubal S. A new approach to the concept and computation of biological age[J]. Mechanisms of Ageing and Development,2006, 127(3): 240-248.
[14]
White IR, Royston P, Wood AM. Multiple imputation using chained equations: Issues and guidance for practice[J]. Medicine Statistics,2011, 30(4): 377-399.
[15]
Vanderweele TJ, Ding P. Sensitivity analysis in observational research: introducing the E-Value[J]. Annals of Internal Medicine,2017, 167(4): 268-274.
[16]
Jacobs EG, Kroenke C, Lin J, et al. Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use[J]. PLOS One, 2013, 8(2): e54713.
[17]
Blackburn EH, Epel ES, Lin J. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection[J]. Science, 2015, 350(6265): 1193-1198.
[18]
Jylhävä J. Pedersen NL,Hägg S.biological age predictors[J]. EBioMedicine, 2017, 21: 29-36.
[19]
Luine V, Frankfurt M. Interactions between estradiol, BDNF and dendritic spines in promoting memory[J]. Neuroscience, 2013, 239:34-45.
[20]
中华医学会妇产科学分会绝经学组.中国绝经管理与绝经激素治疗指南2023版[J].中华妇产科杂志，2023，58（1）：4-21.
Menopause Group, Obstetrics and Gynecology Branch, Chinese Medical Association. 2023 Chinese guideline on menopause management and menopause hormone therapy[J]. Chinese Journal of Obstetrics and Gynecology,2023, 58(1): 4-21.
[21]
Lobo RA. Hormone-replacement therapy: current thinking[J]. Nature Reviews Endocrinology, 2017, 13(4): 220-231.
[22]
Pereira RI, Casey BA, Swibas TA, et al. Timing of estradiol treatment after menopause May determine benefit or harm to insulin action[J]. Journal of Clinical Endocrinology & Metabolism, 2015, 100(12):4456-4462.
[23]
Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group[J]. JAMA: the Journal of the American Medical Association, 1998, 280(7): 605-613.
[24]
Lobo RA, Davis SR, De VT, et al. Prevention of diseases after menopause[J]. Climacteric, 2014, 17(5): 540-556.
[25]
Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging[J]. Climacteric, 2012, 15(2): 105-114.
[26]
“The 2022 Hormone Therapy Position Statement of The North American Menopause Society” Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society[J]. Menopause (New York, N.Y.), 2022, 29(7): 767-794.
[27]
姚玲.社区妇女围绝经期保健现状及需求情况分析[J].中国妇幼保健，2019，34（20）：4718-4722.
Yao L. Analysis of the current situation and needs of perimenopausal health care for women in the community[J]. Maternal & Child Health Care of China, 2019, 34(20): 4718-4722.
2024年第51卷第5期
PDF下载
81
35
引用本文
BibTeX
文章信息
doi: 10.20043/j.cnki.MPM.202311279
  • 接收时间：2023-11-14
  • 首发时间：2026-03-19
  • 出版时间：2024-03-10
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2023-11-14
基金
国家自然科学基金(82273740)
作者信息
    1.四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041
    2.四川大学华西口腔医院国家口腔疾病临床医学研究中心，四川 成都 610041

通讯作者:

肖雄，E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202311279
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持