首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1241025210837684931, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241025201983508979, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202411471, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1732464000000, receivedDateStr=2024-11-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773813067397, onlineDateStr=2026-03-18, pubDate=1744214400000, pubDateStr=2025-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773813067397, onlineIssueDateStr=2026-03-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773813067397, creator=13701087609, updateTime=1773813067397, updator=13701087609, issue=Issue{id=1241025201983508979, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='7', pageStart='1153', pageEnd='1344', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1773813065285, creator=13701087609, updateTime=1773815493878, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1241035388320543403, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241025201983508979, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1241035388320543404, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241025201983508979, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1324, endPage=1327, ext={EN=ArticleExt(id=1241025211114509008, articleId=1241025210837684931, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Analysis of the epidemiological characteristics of hepatitis A and E in Huai’an city, Jiangsu Province from 2004 to 2023, columnId=1228016573156360233, journalTitle=Modern Preventive Medicine, columnName=Disease Control and Prevention, runingTitle=null, highlight=null, articleAbstract=
Objective

To analyze the epidemiological characteristics of Hepatitis A (HA) and Hepatitis E (HE) in Huai’an City,Jiangsu Province from 2004 to 2023, providing a scientific basis for infectious disease prevention and control in the region.

Methods

Case report data for HA and HE from 2004 to 2023 in Huai’an city were extracted from the Chinese Disease Prevention and Control Information System for descriptive analysis.

Results

From 2004 to 2023, a total of 1 956 cases of HA were reported in Huai’an city, accounting for 4.14% of viral hepatitis cases, with an average annual incidence rate of 1.97 per 100 000 population.Join point regression analysis indicated a significant overall declining trend in HA incidence from 2004 to 2023, with an Average Annual Percentage Change (AAPC) of -12.816% (P=0.016), with inflection points identified in 2006, 2015, and 2018. The peak months for HA cases were March to June and August; the male-to-female incidence ratio was 2.04, with the highest number of cases reported in the age group of 50 to <55 years. Farmers constituted the largest occupational group, accounting for 72.65% (1 421 cases). During the same period, a total of 3 097 cases of HE was reported, accounting for 6.55% of viral hepatitis cases, with an average annual incidence rate of 3.12 per 100 000 population. Join point regression analysis showed a significant overall increasing trend in HE incidence from 2004 to 2023, with an AAPC of 9.266% (P=0.001) and inflection points in 2011 and 2020.The peak months for HE cases were January to May; the male-to-female incidence ratio was 2.93, with the highest number of cases reported in the age group of 55 to <60 years. Farmers also represented the highest occupational group, accounting for 74.91%(2 320 cases).

Conclusion

From 2004 to 2023, HA showed a declining trend while HE exhibited an increasing trend in Huai’an city. Future efforts should focus on implementing vaccination strategies and prioritizing farmers as a key population for comprehensive prevention and control measures to effectively manage the spread of HA and HE.

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Lei XU, Qiang GAO, Zheng ZHANG, Yong-li CAI, En-chun PAN), CN=ArticleExt(id=1241025212125336324, articleId=1241025210837684931, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=2004—2023年江苏省淮安市甲型、戊型病毒性肝炎流行病学特征分析, columnId=1228016573844226129, journalTitle=现代预防医学, columnName=疾病预防控制, runingTitle=null, highlight=null, articleAbstract=
目的

分析2004—2023年江苏省淮安市甲型病毒性肝炎（简称甲肝）、戊型病毒性肝炎（简称戊肝）的流行病学特征，为本地区传染病防控工作提供科学依据。

方法

提取中国疾病预防控制信息系统中淮安市2004—2023年的甲肝、戊肝病例报告数据进行描述分析。

结果

2004—2023年淮安市累积报告甲肝1 956例，占病毒性肝炎4.14%，年平均报告发病率为1.97/10万。Joinpoint回归分析提示，甲肝在2004—2023年发病率总体呈下降趋势，平均年度变化百分比（AAPC）为-12.816%，差异具有统计学意义（P=0.016），在2006、2015和2018年出现拐点；3—6月、8月为甲肝高发月份；男性与女性的发病数比值为2.04；报告发病最多的为50～<55岁年龄组；职业以农民构成比最高，1 421例，占72.65%。2004—2023年淮安市累积报告戊肝3 097例，占病毒性肝炎6.55%，年平均报告发病率为3.12/10万。Joinpoint回归分析提示，戊肝在2004—2023年发病率总体呈上升趋势，AAPC=9.266%，差异具有统计学意义（P=0.001），在2011和2020年出现拐点。1—5月为戊肝高发月份；男性与女性的发病数比值为2.93；报告发病最多的为55～<60岁年龄组；职业以农民构成比最高，2 320例，占74.91%。

结论

2004—2023年淮安市甲肝呈现下降、戊肝呈现上升趋势，今后应进一步落实疫苗接种策略，并将农民作为重点防控人群，实施综合防控措施，有效控制甲肝、戊肝的流行。

, correspAuthors=null, authorNote=null, correspAuthorsNote=
张正，E-mail:
, copyrightStatement=本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=lGNeFj99FgYYFjKh+Z7NPg==, magXml=Z/bRmBV7S+NXxaZVbmOYDQ==, pdfUrl=null, pdf=bxu75Geo12URf8pV5nk+/A==, pdfFileSize=578279, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=fl/cY6wSWpUZGobZqxxh8g==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=vrdXfoomia4SnWFlYxRPfA==, mapNumber=null, authorCompany=null, fund=null, authors=

许磊（1995—），男，硕士，主管医师，研究方向：传染病防控

, authorsList=许磊, 高强, 张正, 蔡永丽, 潘恩春)}, authors=[Author(id=1241025212590904103, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241025212720927538, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025212590904103, language=EN, stringName=Lei XU, firstName=Lei, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241025212867728184, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025212590904103, language=CN, stringName=许磊, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.淮安市疾病预防控制中心，江苏 淮安 223003, bio={"content":"

许磊（1995—），男，硕士，主管医师，研究方向：传染病防控

"}, bioImg=null, bioContent=

许磊（1995—），男，硕士，主管医师，研究方向：传染病防控

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241025212364411663, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, xref=1., ext=[AuthorCompanyExt(id=1241025212372800272, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China), AuthorCompanyExt(id=1241025212381188883, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.淮安市疾病预防控制中心，江苏 淮安 223003)])]), Author(id=1241025214394454858, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241025214503506768, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025214394454858, language=EN, stringName=Qiang GAO, firstName=Qiang, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241025214616752989, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025214394454858, language=CN, stringName=高强, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.淮安市疾病预防控制中心，江苏 淮安 223003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241025212364411663, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, xref=1., ext=[AuthorCompanyExt(id=1241025212372800272, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China), AuthorCompanyExt(id=1241025212381188883, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.淮安市疾病预防控制中心，江苏 淮安 223003)])]), Author(id=1241025214734193510, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=hacdczz@126.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241025214834856816, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025214734193510, language=EN, stringName=Zheng ZHANG, firstName=Zheng, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241025214952297336, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025214734193510, language=CN, stringName=张正, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.淮安市疾病预防控制中心，江苏 淮安 223003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241025212364411663, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, xref=1., ext=[AuthorCompanyExt(id=1241025212372800272, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China), AuthorCompanyExt(id=1241025212381188883, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.淮安市疾病预防控制中心，江苏 淮安 223003)])]), Author(id=1241025215061349250, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241025215174595476, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025215061349250, language=EN, stringName=Yong-li CAI, firstName=Yong-li, middleName=null, lastName=CAI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241025215275258776, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025215061349250, language=CN, stringName=蔡永丽, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.淮阴师范学院, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241025212481852187, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, xref=2., ext=[AuthorCompanyExt(id=1241025212502823709, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212481852187, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.淮阴师范学院)])]), Author(id=1241025215367533474, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1241025215484974001, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025215367533474, language=EN, stringName=En-chun PAN, firstName=En-chun, middleName=null, lastName=PAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1241025215606608827, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, authorId=1241025215367533474, language=CN, stringName=潘恩春, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.淮安市疾病预防控制中心，江苏 淮安 223003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1241025212364411663, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, xref=1., ext=[AuthorCompanyExt(id=1241025212372800272, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China), AuthorCompanyExt(id=1241025212381188883, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.淮安市疾病预防控制中心，江苏 淮安 223003)])])], keywords=[Keyword(id=1241025215778575297, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=EN, orderNo=1, keyword=Hepatitis A), Keyword(id=1241025215916987338, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=EN, orderNo=2, keyword=Hepatitis E), Keyword(id=1241025216130896855, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=EN, orderNo=3, keyword=Incidence), Keyword(id=1241025216269308904, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=EN, orderNo=4, keyword=Epidemiological characteristics), Keyword(id=1241025216365777906, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=CN, orderNo=1, keyword=甲型病毒性肝炎), Keyword(id=1241025216487412732, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=CN, orderNo=2, keyword=戊型病毒性肝炎), Keyword(id=1241025216604852233, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=CN, orderNo=3, keyword=发病率), Keyword(id=1241025216739069979, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=CN, orderNo=4, keyword=流行特征)], refs=[Reference(id=1241025219616362663, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2021, volume=13, issue=10, pageStart=1900, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Migueres M, Lhomme S, Izopet J, journalName=Viruses, refType=null, unstructuredReference=Migueres M, Lhomme S, Izopet J. Hepatitis A:Epidemiology, high-risk groups, prevention and research on antiviral treatment[J]. Viruses, 2021, 13(10): 1900., articleTitle=Hepatitis A:Epidemiology, high-risk groups, prevention and research on antiviral treatment, refAbstract=null), Reference(id=1241025219754774705, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2022, volume=30, issue=8, pageStart=820, pageEnd=831, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=中华医学会肝病学分会, journalName=中华肝脏病杂志, refType=null, unstructuredReference=中华医学会肝病学分会.戊型肝炎防治共识[J].中华肝脏病杂志，2022，30（8）：820-831., articleTitle=戊型肝炎防治共识, refAbstract=null), Reference(id=1241025219901575356, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2022, volume=30, issue=8, pageStart=820, pageEnd=831, url=null, language=null, rfNumber=[2], rfOrder=2, authorNames=Chinese Society of Hepatology, Chinese Medical Association, journalName=Chinese Journal of Hepatology, refType=null, unstructuredReference=Chinese Society of Hepatology， Chinese Medical Association. Consensus on prevention and treatment of hepatitis E[J]. Chinese Journal of Hepatology，2022， 30(8): 820-831.(In Chinese), articleTitle=Consensus on prevention and treatment of hepatitis E, refAbstract=null), Reference(id=1241025220006432964, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=31, issue=5, pageStart=455, pageEnd=459, url=null, language=null, rfNumber=[3], rfOrder=3, authorNames=杨心悦, 何启瑜, 王麟, journalName=中华肝脏病杂志, refType=null, unstructuredReference=杨心悦， 何启瑜， 王麟.戊型肝炎的流行病学进展[J].中华肝脏病杂志，2023，31（5）：455-459., articleTitle=戊型肝炎的流行病学进展, refAbstract=null), Reference(id=1241025220170010830, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=31, issue=5, pageStart=455, pageEnd=459, url=null, language=null, rfNumber=[3], rfOrder=4, authorNames=Yang XY, He QY, Wang L, journalName=Chinese Journal of Hepatology, refType=null, unstructuredReference=Yang XY， He QY， Wang L. Advances in hepatitis E epidemiology[J].Chinese Journal of Hepatology， 2023， 31(5): 455-459.(In Chinese), articleTitle=Advances in hepatitis E epidemiology, refAbstract=null), Reference(id=1241025220287451351, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2020, volume=40, issue=7, pageStart=1516, pageEnd=1528, url=null, language=null, rfNumber=[4], rfOrder=5, authorNames=Li P, Liu J, Li Y, journalName=Liver International, refType=null, unstructuredReference=Li P, Liu J, Li Y, et al. The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis[J]. Liver International, 2020, 40(7): 1516-1528., articleTitle=The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis, refAbstract=null), Reference(id=1241025220400697572, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=31, issue=5, pageStart=460, pageEnd=465, url=null, language=null, rfNumber=[5], rfOrder=6, authorNames=熊晓妍, 刘杏, 尹鑫, journalName=中华肝脏病杂志, refType=null, unstructuredReference=熊晓妍， 刘杏， 尹鑫.戊型肝炎病原学研究进展[J].中华肝脏病杂志，2023，31（5）：460-465., articleTitle=戊型肝炎病原学研究进展, refAbstract=null), Reference(id=1241025220518138093, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=31, issue=5, pageStart=460, pageEnd=465, url=null, language=null, rfNumber=[5], rfOrder=7, authorNames=Xiong XY, Liu X, Yin X, journalName=Chinese Journal of Hepatology, refType=null, unstructuredReference=Xiong XY， Liu X， Yin X. Research progress in the etiology of hepatitis type E virus[J]. Chinese Journal of Hepatology， 2023， 31(5): 460-465.(In Chinese), articleTitle=Research progress in the etiology of hepatitis type E virus, refAbstract=null), Reference(id=1241025220606218487, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2024, volume=35, issue=3, pageStart=42, pageEnd=45, url=null, language=null, rfNumber=[6], rfOrder=8, authorNames=许磊, 高强, 蔡永丽, journalName=公共卫生与预防医学, refType=null, unstructuredReference=许磊，高强，蔡永丽，等.2009-2022年江苏省淮安市手足口病长期流行特征及病原监测分析[J].公共卫生与预防医学，2024，35（3）：42-45., articleTitle=2009-2022年江苏省淮安市手足口病长期流行特征及病原监测分析, refAbstract=null), Reference(id=1241025220673327360, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2024, volume=35, issue=3, pageStart=42, pageEnd=45, url=null, language=null, rfNumber=[6], rfOrder=9, authorNames=Xu L, Gao Q, Cai YL, journalName=Journal of Public Health and Preventive Medicine, refType=null, unstructuredReference=Xu L，Gao Q，Cai YL， et al. Long-term epidemiological and etiological characteristics of hand， foot， and mouth disease in Huai’an， Jiangsu Province， 2009-2022[J]. Journal of Public Health and Preventive Medicine， 2024， 35(3): 42-45.(In Chinese), articleTitle=Long-term epidemiological and etiological characteristics of hand， foot， and mouth disease in Huai’an， Jiangsu Province， 2009-2022, refAbstract=null), Reference(id=1241025220790767879, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2024, volume=50, issue=7, pageStart=604, pageEnd=607， 612, url=null, language=null, rfNumber=[7], rfOrder=10, authorNames=张家玮, 周敏, 苏永健, journalName=华南预防医学, refType=null, unstructuredReference=张家玮，周敏，苏永健，等.基于Joinpoint回归模型分析2005—2021我国甲型肝炎发病趋势[J].华南预防医学，2024，50（7）：604-607， 612., articleTitle=基于Joinpoint回归模型分析2005—2021我国甲型肝炎发病趋势, refAbstract=null), Reference(id=1241025220895625489, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2024, volume=50, issue=7, pageStart=604, pageEnd=607， 612, url=null, language=null, rfNumber=[7], rfOrder=11, authorNames=Zhang JW, Zhou M, Su YJ, journalName=South China Journal of Preventive Medicine, refType=null, unstructuredReference=Zhang JW，Zhou M，Su YJ， et al. Incidence trend of hepatitis A in China from 2005 to 2021:an analysis based on Joinpoint regression model[J].South China Journal of Preventive Medicine， 2024， 50(7): 604-607， 612.(In Chinese), articleTitle=Incidence trend of hepatitis A in China from 2005 to 2021:an analysis based on Joinpoint regression model, refAbstract=null), Reference(id=1241025220975317274, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2019, volume=36, issue=5, pageStart=787, pageEnd=791, url=null, language=null, rfNumber=[8], rfOrder=12, authorNames=曾四清, journalName=中国卫生统计, refType=null, unstructuredReference=曾四清.Joinpoint回归模型及其在传染病流行趋势分析中的应用[J].中国卫生统计，2019，36（5）：787-791., articleTitle=Joinpoint回归模型及其在传染病流行趋势分析中的应用, refAbstract=null), Reference(id=1241025221059203363, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2019, volume=36, issue=5, pageStart=787, pageEnd=791, url=null, language=null, rfNumber=[8], rfOrder=13, authorNames=Zeng SQ, journalName=Chinese Journal of Health Statistics, refType=null, unstructuredReference=Zeng SQ. Joinpoint regression model and its application in the analysis of epidemic trend of infectious diseases[J]. Chinese Journal of Health Statistics， 2019， 36(5): 787-791.(In Chinese), articleTitle=Joinpoint regression model and its application in the analysis of epidemic trend of infectious diseases, refAbstract=null), Reference(id=1241025221130506538, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2017, volume=51, issue=12, pageStart=1091, pageEnd=1096, url=null, language=null, rfNumber=[9], rfOrder=14, authorNames=孙校金, 王富珍, 郑徽, journalName=中华预防医学杂志, refType=null, unstructuredReference=孙校金，王富珍，郑徽，等.2004—2015年中国甲型病毒性肝炎流行病学特征分析[J].中华预防医学杂志，2017，51（12）：1091-1096., articleTitle=2004—2015年中国甲型病毒性肝炎流行病学特征分析, refAbstract=null), Reference(id=1241025221239558449, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2017, volume=51, issue=12, pageStart=1091, pageEnd=1096, url=null, language=null, rfNumber=[9], rfOrder=15, authorNames=Sun JJ, Wang FZ, Zheng H, journalName=Chinese Journal of Preventive Medicine, refType=null, unstructuredReference=Sun JJ，Wang FZ，Zheng H， et al. Epidemiological analysis of viral hepatitis A in China， 2004-2015[J]. Chinese Journal of Preventive Medicine， 2017，51(12): 1091-1096.(In Chinese), articleTitle=Epidemiological analysis of viral hepatitis A in China， 2004-2015, refAbstract=null), Reference(id=1241025221348610360, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2024, volume=39, issue=3, pageStart=296, pageEnd=300, url=null, language=null, rfNumber=[10], rfOrder=16, authorNames=毛星棋, 姜辉, 薛士银, journalName=疾病监测, refType=null, unstructuredReference=毛星棋，姜辉，薛士银，等.2005-2022年江苏省甲型肝炎流行病学特征[J].疾病监测，2024，39（3）：296-300., articleTitle=2005-2022年江苏省甲型肝炎流行病学特征, refAbstract=null), Reference(id=1241025221432496447, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2024, volume=39, issue=3, pageStart=296, pageEnd=300, url=null, language=null, rfNumber=[10], rfOrder=17, authorNames=Mao XQ, Jiang H, Xue SY, journalName=Disease Surveillance, refType=null, unstructuredReference=Mao XQ，Jiang H，Xue SY， et al. Epidemiological characteristics of hepatitis A in Jiangsu，2005-2022[J]. Disease Surveillance， 2024， 39(3):296-300.(In Chinese), articleTitle=Epidemiological characteristics of hepatitis A in Jiangsu，2005-2022, refAbstract=null), Reference(id=1241025221545742663, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=24, issue=12, pageStart=1265, pageEnd=1276, url=null, language=null, rfNumber=[11], rfOrder=18, authorNames=中国肝炎防治基金会, 陈园生, 庄辉, journalName=中国预防医学杂志, refType=null, unstructuredReference=中国肝炎防治基金会， 陈园生， 庄辉.成人甲型肝炎疫苗接种专家建议[J].中国预防医学杂志，2023，24（12）:1265-1276., articleTitle=成人甲型肝炎疫苗接种专家建议, refAbstract=null), Reference(id=1241025221638017356, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=24, issue=12, pageStart=1265, pageEnd=1276., url=null, language=null, rfNumber=[11], rfOrder=19, authorNames=China Foundation for Hepatitis Prevention and Control, Chen YS, Zhuang H, journalName=Chinese Preventive Medicine, refType=null, unstructuredReference=China Foundation for Hepatitis Prevention and Control， Chen YS， Zhuang H. Expert recommendations on hepatitis A vaccination for adults[J].Chinese Preventive Medicine， 2023， 24(12): 1265-1276. (In Chinese)., articleTitle=Expert recommendations on hepatitis A vaccination for adults, refAbstract=null), Reference(id=1241025221742874961, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2020, volume=26, issue=2, pageStart=136, pageEnd=141, url=null, language=null, rfNumber=[12], rfOrder=20, authorNames=丁显香, 张丽杰, 孙校金, journalName=中国疫苗和免疫, refType=null, unstructuredReference=丁显香，张丽杰，孙校金，等.2004-2018年中国戊型病毒性肝炎发病趋势和空间聚集性[J].中国疫苗和免疫，2020，26（2）：136-141., articleTitle=2004-2018年中国戊型病毒性肝炎发病趋势和空间聚集性, refAbstract=null), Reference(id=1241025221965173080, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2020, volume=26, issue=2, pageStart=136, pageEnd=141, url=null, language=null, rfNumber=[12], rfOrder=21, authorNames=Ding XX, Zhang LJ, Sun JJ, journalName=Chinese Journal of Vaccines and Immunization, refType=null, unstructuredReference=Ding XX，Zhang LJ，Sun JJ， et al. Trends in incidence and spatial clustering of hepatitis E in China， 2004-2018[J]. Chinese Journal of Vaccines and Immunization， 2020， 26(2): 136-141.(In Chinese), articleTitle=Trends in incidence and spatial clustering of hepatitis E in China， 2004-2018, refAbstract=null), Reference(id=1241025223324127582, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2022, volume=28, issue=4, pageStart=417, pageEnd=421, url=null, language=null, rfNumber=[13], rfOrder=22, authorNames=黄澳迪, 唐林, 王晓琪, journalName=中国疫苗和免疫, refType=null, unstructuredReference=黄澳迪，唐林，王晓琪，等.中国2011-2021年戊型病毒性肝炎发病趋势和时空聚集性[J].中国疫苗和免疫，2022，28（4）：417-421., articleTitle=中国2011-2021年戊型病毒性肝炎发病趋势和时空聚集性, refAbstract=null), Reference(id=1241025223424790884, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2022, volume=28, issue=4, pageStart=417, pageEnd=421, url=null, language=null, rfNumber=[13], rfOrder=23, authorNames=Huang AD, Tang L, Wang XQ, journalName=Chinese Journal of Vaccines and Immunization, refType=null, unstructuredReference=Huang AD，Tang L，Wang XQ， et al. Hepatitis E incidence trends and spatial-temporal clustering in China，2011-2021[J]. Chinese Journal of Vaccines and Immunization， 2022， 28(4): 417-421.(In Chinese), articleTitle=Hepatitis E incidence trends and spatial-temporal clustering in China，2011-2021, refAbstract=null), Reference(id=1241025223504482666, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2021, volume=10, issue=1, pageStart=91, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=24, authorNames=Yang M, Cheng XQ, Zhao ZY, journalName=Infectious Diseases of Poverty, refType=null, unstructuredReference=Yang M, Cheng XQ, Zhao ZY, et al. Feasibility of controlling hepatitis E in Jiangsu Province, China: a modelling study[J]. Infectious Diseases of Poverty, 2021, 10(1): 91., articleTitle=Feasibility of controlling hepatitis E in Jiangsu Province, China: a modelling study, refAbstract=null), Reference(id=1241025223626117488, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2022, volume=33, issue=2, pageStart=153, pageEnd=157, url=null, language=null, rfNumber=[15], rfOrder=25, authorNames=田华, 张雪峰, 付建光, journalName=江苏预防医学, refType=null, unstructuredReference=田华，张雪峰，付建光，等.2015—2020年江苏省戊型肝炎病毒流行病学特征及分子进化研究[J].江苏预防医学，2022，33（2）：153-157., articleTitle=2015—2020年江苏省戊型肝炎病毒流行病学特征及分子进化研究, refAbstract=null), Reference(id=1241025223722586486, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2022, volume=33, issue=2, pageStart=153, pageEnd=157, url=null, language=null, rfNumber=[15], rfOrder=26, authorNames=Tian H, Zhang XF, Fu JG, journalName=Jiangsu Journal of Preventive Medicine, refType=null, unstructuredReference=Tian H，Zhang XF，Fu JG， et al. Epidemiological characteristics and molecular evolution of hepatitis E virus in Jiangsu Province from 2015 to 2020[J]. Jiangsu Journal of Preventive Medicine， 2022， 33(2): 153-157.(In Chinese), articleTitle=Epidemiological characteristics and molecular evolution of hepatitis E virus in Jiangsu Province from 2015 to 2020, refAbstract=null), Reference(id=1241025223840027007, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2018, volume=32, issue=1, pageStart=32, pageEnd=33， 35, url=null, language=null, rfNumber=[16], rfOrder=27, authorNames=苏琦, 高强, 杨鹏飞, journalName=中国校医, refType=null, unstructuredReference=苏琦，高强，杨鹏飞，等.淮安市戊型病毒性肝炎人畜共患性及病毒基因型研究[J].中国校医，2018，32（1）：32-33， 35., articleTitle=淮安市戊型病毒性肝炎人畜共患性及病毒基因型研究, refAbstract=null), Reference(id=1241025223940690308, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2018, volume=32, issue=1, pageStart=32, pageEnd=33， 35, url=null, language=null, rfNumber=[16], rfOrder=28, authorNames=Su Q, Gao Q, Yang PF, journalName=Chinese Journal of School Doctor, refType=null, unstructuredReference=Su Q，Gao Q，Yang PF， et al. Study on zoonotic prevalence and virus genotype of hepatitis E virus in Huaian City[J]. Chinese Journal of School Doctor， 2018， 32(1): 32-33， 35.(In Chinese), articleTitle=Study on zoonotic prevalence and virus genotype of hepatitis E virus in Huaian City, refAbstract=null), Reference(id=1241025224041353614, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=29, issue=5, pageStart=539, pageEnd=543, url=null, language=null, rfNumber=[17], rfOrder=29, authorNames=马涛, 丁松宁, 汪君君, journalName=中国疫苗和免疫, refType=null, unstructuredReference=马涛，丁松宁，汪君君，等.2010-2022年南京市戊型病毒性肝炎流行病学特征和空间聚集性[J].中国疫苗和免疫，2023，29（5）：539-543., articleTitle=2010-2022年南京市戊型病毒性肝炎流行病学特征和空间聚集性, refAbstract=null), Reference(id=1241025224146211221, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=29, issue=5, pageStart=539, pageEnd=543, url=null, language=null, rfNumber=[17], rfOrder=30, authorNames=Ma T, Ding SN, Wang JJ, journalName=Chinese Journal of Vaccines and Immunization, refType=null, unstructuredReference=Ma T，Ding SN，Wang JJ， et al. Epidemiological characteristics and spatial clustering of hepatitis E in Nanjing city from 2010 to 2022[J]. Chinese Journal of Vaccines and Immunization， 2023， 29(5): 539-543.(In Chinese), articleTitle=Epidemiological characteristics and spatial clustering of hepatitis E in Nanjing city from 2010 to 2022, refAbstract=null), Reference(id=1241025224263651741, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=27, issue=9, pageStart=1101, pageEnd=1106, url=null, language=null, rfNumber=[18], rfOrder=31, authorNames=陈奕娟, 孙琬琬, 陈直平, journalName=中华疾病控制杂志, refType=null, unstructuredReference=陈奕娟，孙琬琬，陈直平，等.2005-2020年浙江省戊型病毒性肝炎时空特征[J].中华疾病控制杂志，2023，27（9）：1101-1106., articleTitle=2005-2020年浙江省戊型病毒性肝炎时空特征, refAbstract=null), Reference(id=1241025224456589739, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=27, issue=9, pageStart=1101, pageEnd=1106, url=null, language=null, rfNumber=[18], rfOrder=32, authorNames=Chen YJ, Sun WW, Chen ZP, journalName=Chinese Journal of Disease Control & Prevention, refType=null, unstructuredReference=Chen YJ，Sun WW，Chen ZP， et al. Spatio-temporal analysis of hepatitis E in Zhejiang Province from 2005 to 2020[J]. Chinese Journal of Disease Control & Prevention， 2023， 27(9): 1101-1106.(In Chinese), articleTitle=Spatio-temporal analysis of hepatitis E in Zhejiang Province from 2005 to 2020, refAbstract=null), Reference(id=1241025224548864433, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2022, volume=42, issue=11, pageStart=807, pageEnd=812, url=null, language=null, rfNumber=[19], rfOrder=33, authorNames=龙苏兰, 张频, 王军永, journalName=中国农村卫生事业管理, refType=null, unstructuredReference=龙苏兰，张频，王军永，等.农村地区老年人预防流行性传染病的知识、态度及行为调查[J].中国农村卫生事业管理，2022，42（11）：807-812., articleTitle=农村地区老年人预防流行性传染病的知识、态度及行为调查, refAbstract=null), Reference(id=1241025224620167608, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2022, volume=42, issue=11, pageStart=807, pageEnd=812, url=null, language=null, rfNumber=[19], rfOrder=34, authorNames=Long SL, Zhang P, Wang JY, journalName=Chinese Rural Health Service Administration, refType=null, unstructuredReference=Long SL，Zhang P，Wang JY， et al. Knowledge， attitudes and behaviors of the rural elderly in preventing epidemic infectious diseases[J]. Chinese Rural Health Service Administration， 2022， 42(11): 807-812.(In Chinese), articleTitle=Knowledge， attitudes and behaviors of the rural elderly in preventing epidemic infectious diseases, refAbstract=null), Reference(id=1241025224741802433, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=29, issue=1, pageStart=19, pageEnd=23, url=null, language=null, rfNumber=[20], rfOrder=35, authorNames=邢菲, 张雪莉, 郝萌萱, journalName=预防医学论坛, refType=null, unstructuredReference=邢菲，张雪莉，郝萌萱，等.山东省农村传染病防控素养现状及其影响因素分析[J].预防医学论坛，2023，29（1）：19-23., articleTitle=山东省农村传染病防控素养现状及其影响因素分析, refAbstract=null), Reference(id=1241025224825688520, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, doi=null, pmid=null, pmcid=null, year=2023, volume=29, issue=1, pageStart=19, pageEnd=23, url=null, language=null, rfNumber=[20], rfOrder=36, authorNames=Xing F, Zhang XL, Hao MX, journalName=Preventive Medicine Tribune, refType=null, unstructuredReference=Xing F，Zhang XL，Hao MX， et al. Analysis on current situation and influencing factors of infectious disease prevention and control literacy in rural areas of Shandong province[J]. Preventive Medicine Tribune， 2023， 29(1): 19-23.(In Chinese), articleTitle=Analysis on current situation and influencing factors of infectious disease prevention and control literacy in rural areas of Shandong province, refAbstract=null)], funds=[Fund(id=1241025219415036048, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, awardId=12071173, language=CN, fundingSource=国家自然科学基金(12071173), fundOrder=null, country=null), Fund(id=1241025219490533529, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, awardId=HAB202341, language=CN, fundingSource=淮安市自然科学基金项目(HAB202341), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1241025212364411663, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, xref=1., ext=[AuthorCompanyExt(id=1241025212372800272, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China), AuthorCompanyExt(id=1241025212381188883, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212364411663, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.淮安市疾病预防控制中心，江苏 淮安 223003)]), AuthorCompany(id=1241025212481852187, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, xref=2., ext=[AuthorCompanyExt(id=1241025212502823709, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, companyId=1241025212481852187, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.淮阴师范学院)])], figs=[ArticleFig(id=1241025216969756714, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=EN, label=Figure 1, caption=The reported incidence of hepatitis A and hepatitis E in Huai’an, 2004—2023, figureFileSmall=4JfjIIC4F6faoTmkKc1/vA==, figureFileBig=fl/cY6wSWpUZGobZqxxh8g==, tableContent=null), ArticleFig(id=1241025217074614329, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=CN, label=图1, caption=2004—2023年淮安市甲、戊肝报告病例数和发病率趋势, figureFileSmall=4JfjIIC4F6faoTmkKc1/vA==, figureFileBig=fl/cY6wSWpUZGobZqxxh8g==, tableContent=null), ArticleFig(id=1241025217301106765, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=EN, label=Figure 2, caption=Changing trend of annual reported incidence of hepatitis A and hepatitis E in Huai’an, 2004—2023, figureFileSmall=juak3o01mYERcFZIj1uAeg==, figureFileBig=BC1qSMe6hE1cuODKNYS12w==, tableContent=null), ArticleFig(id=1241025218777501783, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=CN, label=图2, caption=2004—2023年淮安市甲、戊肝发病率变化趋势, figureFileSmall=juak3o01mYERcFZIj1uAeg==, figureFileBig=BC1qSMe6hE1cuODKNYS12w==, tableContent=null), ArticleFig(id=1241025218865582175, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=EN, label=Figure 3, caption=Distribution of number of reported hepatitis A and hepatitis E cases according to age groups in Huai’an, 2004—2023, figureFileSmall=VnwgqmqykJjRNKpkY3S/Wg==, figureFileBig=QV1swzp+yJ4qAlrWd8no/g==, tableContent=null), ArticleFig(id=1241025218966245476, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=CN, label=图3, caption=2004—2023年淮安市甲、戊肝按年龄分组报告发病情况, figureFileSmall=VnwgqmqykJjRNKpkY3S/Wg==, figureFileBig=QV1swzp+yJ4qAlrWd8no/g==, tableContent=null), ArticleFig(id=1241025219108851824, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=EN, label=Table 1, caption=

Changing trend of annual reported incidence of hepatitis A and hepatitis E in Huai’an, 2004—2023

, figureFileSmall=null, figureFileBig=null, tableContent=
时间（年）AAPC/APC95%CIt值P值
甲肝2004—2023AAPC-12.816-22.023～-2.522-2.4090.016
2004—2006APC-30.246-47.304～-7.668-2.9060.017
2006—2015APC-16.064-21.126～-10.678-6.369<0.001
2015—2018APC23.312-39.729～152.2930.6620.524
2018—2023APC-17.104-30.285～-1.431-2.4500.037
戊肝2004—2023AAPC9.2663.927～14.8793.4670.001
2004—2011AAPC23.98412.814～36.2614.961<0.001
2011—2020APC-6.289-11.237～-1.065-2.6090.023
2020—2023APC28.9743.276～61.0672.4950.028
), ArticleFig(id=1241025219255652476, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241025210837684931, language=CN, label=表1, caption=

2004—2023年淮安市甲、戊肝发病率变化趋势

, figureFileSmall=null, figureFileBig=null, tableContent=
时间（年）AAPC/APC95%CIt值P值
甲肝2004—2023AAPC-12.816-22.023～-2.522-2.4090.016
2004—2006APC-30.246-47.304～-7.668-2.9060.017
2006—2015APC-16.064-21.126～-10.678-6.369<0.001
2015—2018APC23.312-39.729～152.2930.6620.524
2018—2023APC-17.104-30.285～-1.431-2.4500.037
戊肝2004—2023AAPC9.2663.927～14.8793.4670.001
2004—2011AAPC23.98412.814～36.2614.961<0.001
2011—2020APC-6.289-11.237～-1.065-2.6090.023
2020—2023APC28.9743.276～61.0672.4950.028
)], attaches=null, journal=Journal(id=1227664546253402114, delFlag=0, nameCn=现代预防医学, nameEn=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, issn=1003-8507, eissn=null, cn=51-1365/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=IeiuPXEZi6AA+k0VfvoiOQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Modern Preventive Medicine, journalRemark=null, publicationField=null, createdTime=1770627636734, updatedTime=1770628902248, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=IeiuPXEZi6AA+k0VfvoiOQ==, picEn=/9iTl8/ndms4tBz1fL28Pg==, jcr=null, cjcr=null, exts=[JournalExt(id=1227669854342280188, language=CN, name=现代预防医学, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1770628902278, updatedTime=1770628902278, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1227669854396806141, language=EN, name=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1770628902291, updatedTime=1770628902291, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1227665162245664772, websiteList=[Website(id=1227687234141352800, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/CN, language=CN, createTime=1770633045945, createBy=18614031015, updateTime=1770633090526, updateBy=18614031015, name=现代预防医学-中文, tplId=1146099689490845704, title=现代预防医学, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687735088051072, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=articleTextType, value=kx, createTime=1770633165380, updateTime=1770633165380, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735071273853, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=banner, value=null, createTime=1770633165376, updateTime=1770633165376, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735113216899, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=grayFlag, value=0, createTime=1770633165386, updateTime=1770633165386, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735062885244, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633165374, updateTime=1770633165374, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735125799813, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=minRunFlag, value=0, createTime=1770633165389, updateTime=1770633165389, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735083856767, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic, createTime=1770633165379, updateTime=1770633165379, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735121605508, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=silenceFlag, value=0, createTime=1770633165388, updateTime=1770633165388, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735079662462, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1770633165378, updateTime=1770633165378, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735096439681, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeColor, value=null, createTime=1770633165382, updateTime=1770633165382, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735104828290, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeStyle, value=null, createTime=1770633165384, updateTime=1770633165384, creator=18614031015, updator=18614031015)]), Website(id=1227687234338485094, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/EN, language=EN, createTime=1770633045992, createBy=18614031015, updateTime=1770633115374, updateBy=18614031015, name=现代预防医学-英文, tplId=1146101810881728533, title=Modern Preventive Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687709129507332, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=articleTextType, value=kx, createTime=1770633159191, updateTime=1770633159191, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709108535809, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=banner, value=null, createTime=1770633159186, updateTime=1770633159186, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709167256071, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=grayFlag, value=0, createTime=1770633159200, updateTime=1770633159200, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709095952896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633159183, updateTime=1770633159183, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709179838985, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=minRunFlag, value=0, createTime=1770633159203, updateTime=1770633159203, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709121118723, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic, createTime=1770633159189, updateTime=1770633159189, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709171450376, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=silenceFlag, value=0, createTime=1770633159201, updateTime=1770633159201, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709112730114, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1770633159187, updateTime=1770633159187, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709133701637, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeColor, value=null, createTime=1770633159192, updateTime=1770633159192, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709154673158, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeStyle, value=null, createTime=1770633159197, updateTime=1770633159197, creator=18614031015, updator=18614031015)])], journalTitle=现代预防医学, weixinUrl=null, journalUrl=http://xdyfyxzz.paperopen.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Modern Preventive Medicine, journalPhotoCn=IeiuPXEZi6AA+k0VfvoiOQ==, journalPhotoEn=/9iTl8/ndms4tBz1fL28Pg==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202411471, detailUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/10.20043/j.cnki.MPM.202411471, pdfUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/PDF/10.20043/j.cnki.MPM.202411471, pdfUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/PDF/10.20043/j.cnki.MPM.202411471, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
2004—2023年江苏省淮安市甲型、戊型病毒性肝炎流行病学特征分析
收藏切换
PDF下载
许磊 1 , 高强 1 , 张正 1 , 蔡永丽 2 , 潘恩春 1
现代预防医学 | 疾病预防控制 2025,52(7): 1324-1327
收起
收藏切换
现代预防医学 | 疾病预防控制 2025, 52(7): 1324-1327
2004—2023年江苏省淮安市甲型、戊型病毒性肝炎流行病学特征分析
全屏
许磊1, 高强1, 张正1 , 蔡永丽2, 潘恩春1
作者信息
  • 1.淮安市疾病预防控制中心，江苏 淮安 223003
  • 2.淮阴师范学院

    • 许磊（1995—），男，硕士，主管医师，研究方向：传染病防控

通讯作者:

张正，E-mail:
Analysis of the epidemiological characteristics of hepatitis A and E in Huai’an city, Jiangsu Province from 2004 to 2023
Lei XU1, Qiang GAO1, Zheng ZHANG1 , Yong-li CAI2, En-chun PAN1
Affiliations
  • Huai’an Center for Disease Control and Prevention, Huai’an, Jiangsu 223003, China
出版时间: 2025-04-10 doi: 10.20043/j.cnki.MPM.202411471
文章导航
收藏切换
摘要
收起
目的

分析2004—2023年江苏省淮安市甲型病毒性肝炎（简称甲肝）、戊型病毒性肝炎（简称戊肝）的流行病学特征，为本地区传染病防控工作提供科学依据。

方法

提取中国疾病预防控制信息系统中淮安市2004—2023年的甲肝、戊肝病例报告数据进行描述分析。

结果

2004—2023年淮安市累积报告甲肝1 956例，占病毒性肝炎4.14%，年平均报告发病率为1.97/10万。Joinpoint回归分析提示，甲肝在2004—2023年发病率总体呈下降趋势，平均年度变化百分比（AAPC）为-12.816%，差异具有统计学意义（P=0.016），在2006、2015和2018年出现拐点；3—6月、8月为甲肝高发月份；男性与女性的发病数比值为2.04；报告发病最多的为50～<55岁年龄组；职业以农民构成比最高，1 421例，占72.65%。2004—2023年淮安市累积报告戊肝3 097例，占病毒性肝炎6.55%，年平均报告发病率为3.12/10万。Joinpoint回归分析提示，戊肝在2004—2023年发病率总体呈上升趋势，AAPC=9.266%，差异具有统计学意义（P=0.001），在2011和2020年出现拐点。1—5月为戊肝高发月份；男性与女性的发病数比值为2.93；报告发病最多的为55～<60岁年龄组；职业以农民构成比最高，2 320例，占74.91%。

结论

2004—2023年淮安市甲肝呈现下降、戊肝呈现上升趋势，今后应进一步落实疫苗接种策略，并将农民作为重点防控人群，实施综合防控措施，有效控制甲肝、戊肝的流行。

甲型病毒性肝炎  /  戊型病毒性肝炎  /  发病率  /  流行特征
Objective

To analyze the epidemiological characteristics of Hepatitis A (HA) and Hepatitis E (HE) in Huai’an City,Jiangsu Province from 2004 to 2023, providing a scientific basis for infectious disease prevention and control in the region.

Methods

Case report data for HA and HE from 2004 to 2023 in Huai’an city were extracted from the Chinese Disease Prevention and Control Information System for descriptive analysis.

Results

From 2004 to 2023, a total of 1 956 cases of HA were reported in Huai’an city, accounting for 4.14% of viral hepatitis cases, with an average annual incidence rate of 1.97 per 100 000 population.Join point regression analysis indicated a significant overall declining trend in HA incidence from 2004 to 2023, with an Average Annual Percentage Change (AAPC) of -12.816% (P=0.016), with inflection points identified in 2006, 2015, and 2018. The peak months for HA cases were March to June and August; the male-to-female incidence ratio was 2.04, with the highest number of cases reported in the age group of 50 to <55 years. Farmers constituted the largest occupational group, accounting for 72.65% (1 421 cases). During the same period, a total of 3 097 cases of HE was reported, accounting for 6.55% of viral hepatitis cases, with an average annual incidence rate of 3.12 per 100 000 population. Join point regression analysis showed a significant overall increasing trend in HE incidence from 2004 to 2023, with an AAPC of 9.266% (P=0.001) and inflection points in 2011 and 2020.The peak months for HE cases were January to May; the male-to-female incidence ratio was 2.93, with the highest number of cases reported in the age group of 55 to <60 years. Farmers also represented the highest occupational group, accounting for 74.91%(2 320 cases).

Conclusion

From 2004 to 2023, HA showed a declining trend while HE exhibited an increasing trend in Huai’an city. Future efforts should focus on implementing vaccination strategies and prioritizing farmers as a key population for comprehensive prevention and control measures to effectively manage the spread of HA and HE.

Hepatitis A  /  Hepatitis E  /  Incidence  /  Epidemiological characteristics
许磊, 高强, 张正, 蔡永丽, 潘恩春. 2004—2023年江苏省淮安市甲型、戊型病毒性肝炎流行病学特征分析. 现代预防医学, 2025 , 52 (7) : 1324 -1327 . DOI: 10.20043/j.cnki.MPM.202411471
Lei XU, Qiang GAO, Zheng ZHANG, Yong-li CAI, En-chun PAN. Analysis of the epidemiological characteristics of hepatitis A and E in Huai’an city, Jiangsu Province from 2004 to 2023[J]. Modern Preventive Medicine, 2025 , 52 (7) : 1324 -1327 . DOI: 10.20043/j.cnki.MPM.202411471
正文
收起
甲型病毒性肝炎（简称甲肝）和戊型病毒性肝炎（简称戊肝）是由甲肝病毒（hepatitis A virus，HAV）和戊肝病毒（hepatitis E virus，HEV）感染引起的肠道传染病，临床表现以疲乏、食欲减退、肝功能异常为主[1-3]，两者均主要经粪口途径传播。随着我国公共卫生状况的明显改善，甲肝病例较以前明显减少，戊肝主要流行株也逐渐从基因型1型转变为基因型4型，即“猪戊肝病毒”，流行于我国、东南亚地区[1，4-5]。淮安市位于江苏省北部中心地域，境内河湖交织、水网密集，洪涝灾害多发，存在肠道传染病局部暴发的风险。为进一步了解淮安市甲肝、戊肝的流行特征，为地区传染病防控提供科学依据，本研究对2004—2023年淮安市长达20年的甲肝、戊肝监测数据进行分析。
1　材料与方法
收起
1.1　资料来源
来源于中国疾病预防控制信息系统中淮安市2004年1月—2023年12月按发病日期统计的甲肝、戊肝数据，包括临床诊断与确诊病例，资料包括报告病例数、报告发病率、病例年龄、性别、职业等。
1.2　基本概念
年均发病率（/10万）=年均发病数/年均人口数×10万。季节指数定义为各年同月发病的平均数与各年全部月份平均数的比值，数值≥1提示月份高发[6]。人群分布中，本研究按5岁为一个年龄段进行分组。
1.3　统计学分析
采用Joinpoint 4.9.1.0软件分析2004—2023年甲肝、戊肝报告发病率的时间趋势[7-8]，计算年度变化百分比（annual percent change， APC）、平均年度变化百分比（average annual percent change，AAPC）和95%置信区间（confidence interval， CI）。APC用来评价模型拟合出最佳拐点数量所划分的各个时间段甲肝、戊肝报告发病率的变化趋势，AAPC用来评价2004—2023年整体报告发病率的变化趋势。APC或AAPC<0表示该时间段甲肝、戊肝报告发病率呈下降趋势；APC或AAPC>0表示该时间段甲肝、戊肝报告发病率呈上升趋势；APC=AAPC则无拐点。检验水准α=0.05。
2　结果
收起
2.1　疫情概况
2004—2023年淮安市共报告甲肝1 956例，占病毒性肝炎4.14%，年平均报告发病率1.97/10万。报告病例数最多为2004年382例。2004—2023年淮安市累积报告戊肝3 097例，占病毒性肝炎6.55%，年平均报告发病率3.12/10万。报告病例数最多为2011年258例。不同年份报告甲、戊肝病例数、发病率见图1。
2.2　时间分布
Joinpoint回归分析提示，2004—2023年甲肝发病率总体呈下降趋势，AAPC=-12.816%，发病率平均每年下降12.816%（P=0.016）。在2006、2015和2018年出现拐点，其中，2004—2006年APC=-30.246%（P=0.017），2006—2015年APC=-16.064%（P<0.001），2015—2018年APC=23.312%，上升趋势无统计学意义，2018—2023年APC=-17.104%（P=0.037），见表1、图2。2004—2023年1—12月份淮安市甲肝报告季节指数分别为0.77、0.95、1.71、1.42、1.04、1.01、0.81、1.07、0.98、0.72、0.87、0.65。
Joinpoint回归分析提示，2004—2023年戊肝发病率总体呈上升趋势，AAPC=9.266%，发病率平均每年上升9.266%（P=0.001）。在2011和2020年出现拐点，其中，2004—2011年APC=23.984%（P<0.001），2011—2020年APC=-6.289%（P=0.023），2020—2023年APC=28.974%（P=0.028），见表1、图2。2004—2023年1—12月淮安市戊肝季节指数分别为1.09、1.53、1.82、1.40、1.01、0.70、0.74、0.74、0.64、0.65、0.86、0.88。
2.3　人群分布
1 956例甲肝病例中，男性1 313例，女性643例，男性、女性的发病数比为2.04∶1。病例数集中在30～74岁，占全部病例数的80.16%（1 568/1 956），以50～<55岁报告发病数最多，占比12.67%，见图3。职业构成居前三位的为农民（1 421例，占72.65%）、工人（100例，占5.11%）、家务及待业（100例，占5.11%）。
3 097例戊肝病例中，男性2 308例，女性789例，男性、女性的发病数比为2.93∶1。病例数集中在30～74岁，占全部病例数的87.63%（2714/3 097），以55～<60岁报告发病数最多，占比14.76%，见图3。职业构成居前三位的为农民（2 320例，占74.91%）、家务及待业（217例，占7.01%）、离退人员（183例，占5.91%）。
3　讨论
收起
本研究首次基于joinpoint回归模型分析了淮安市长达20年的甲肝、戊肝流行特征。结果表明，2004—2023年淮安市甲肝总体呈下降趋势（P= 0.016），与全国[9]及全省[10]报告的趋势基本一致，主要可能与近年来公共卫生状况持续改善，饮用水源中甲肝病毒污染得到逐步控制，以及甲肝疫苗推广接种[11]等因素有关。
2004—2023年淮安市戊肝发病总体呈上升趋势（P=0.001），高于全国水平，可能与医疗机构诊断水平提升、监测敏感性提高、居民就诊意识增强等有关[12-13]；但低于江苏省平均水平，可能与经济发展、人口、城市环境发展不平衡等因素有关[14]。2020年报告发病水平下降至低位，可能受新发传染病影响。近年来，因猪源污染导致戊肝病例报告增多，基于模型评估发现，江苏省戊肝发病主要与猪-人传播途径有关，而与环境-人传播途径关系不密切[15]。2015—2016年淮安市[16]戊肝监测数据均表明戊肝病例以基因型4型感染为主，病例与生猪感染的病毒高度同源。基于防控现状，建议后期开展职业暴露人群和宿主动物监测专项调查。
淮安市甲肝、戊肝病例主要集中于30～74岁，以50～60岁报告居多，男性发病高于女性，职业构成中农民占比最高，这些人群分布特征同国内研究基本一致[17-18]。中老年农民是甲肝、戊肝的高发群体，一方面可能与农村地区环境卫生、饮水卫生欠缺导致农民群体易于接触到受病毒污染的水源、猪源等有关，另一方面可能是个人卫生意识较差，包括洗手消毒不勤、加工制作菜肴生熟不分等。研究表明，农村地区老年人预防传染病的知识、态度及行为处于较低水平，年龄、文化程度低等是影响农村传染病防控素养的主要因素[19-20]。因此，应将农民作为甲肝、戊肝的重点防控人群进行健康宣教。
综上所述，2004—2023年淮安市甲肝呈现下降趋势，而戊肝总体呈上升趋势，农民是发病的重点人群，今后应继续落实疫苗接种、健康宣教等综合防控措施，以减少甲肝、戊肝发病。
基金
收起
  • 国家自然科学基金(12071173)
  • 淮安市自然科学基金项目(HAB202341)
文献
收起
参考文献 引证文献
排序方式：
[1]
Migueres M, Lhomme S, Izopet J. Hepatitis A:Epidemiology, high-risk groups, prevention and research on antiviral treatment[J]. Viruses, 2021, 13(10): 1900.
[2]
中华医学会肝病学分会.戊型肝炎防治共识[J].中华肝脏病杂志，2022，30（8）：820-831.
Chinese Society of Hepatology， Chinese Medical Association. Consensus on prevention and treatment of hepatitis E[J]. Chinese Journal of Hepatology，2022， 30(8): 820-831.(In Chinese)
[3]
杨心悦， 何启瑜， 王麟.戊型肝炎的流行病学进展[J].中华肝脏病杂志，2023，31（5）：455-459.
Yang XY， He QY， Wang L. Advances in hepatitis E epidemiology[J].Chinese Journal of Hepatology， 2023， 31(5): 455-459.(In Chinese)
[4]
Li P, Liu J, Li Y, et al. The global epidemiology of hepatitis E virus infection: A systematic review and meta-analysis[J]. Liver International, 2020, 40(7): 1516-1528.
[5]
熊晓妍， 刘杏， 尹鑫.戊型肝炎病原学研究进展[J].中华肝脏病杂志，2023，31（5）：460-465.
Xiong XY， Liu X， Yin X. Research progress in the etiology of hepatitis type E virus[J]. Chinese Journal of Hepatology， 2023， 31(5): 460-465.(In Chinese)
[6]
许磊，高强，蔡永丽，等.2009-2022年江苏省淮安市手足口病长期流行特征及病原监测分析[J].公共卫生与预防医学，2024，35（3）：42-45.
Xu L，Gao Q，Cai YL， et al. Long-term epidemiological and etiological characteristics of hand， foot， and mouth disease in Huai’an， Jiangsu Province， 2009-2022[J]. Journal of Public Health and Preventive Medicine， 2024， 35(3): 42-45.(In Chinese)
[7]
张家玮，周敏，苏永健，等.基于Joinpoint回归模型分析2005—2021我国甲型肝炎发病趋势[J].华南预防医学，2024，50（7）：604-607， 612.
Zhang JW，Zhou M，Su YJ， et al. Incidence trend of hepatitis A in China from 2005 to 2021:an analysis based on Joinpoint regression model[J].South China Journal of Preventive Medicine， 2024， 50(7): 604-607， 612.(In Chinese)
[8]
曾四清.Joinpoint回归模型及其在传染病流行趋势分析中的应用[J].中国卫生统计，2019，36（5）：787-791.
Zeng SQ. Joinpoint regression model and its application in the analysis of epidemic trend of infectious diseases[J]. Chinese Journal of Health Statistics， 2019， 36(5): 787-791.(In Chinese)
[9]
孙校金，王富珍，郑徽，等.2004—2015年中国甲型病毒性肝炎流行病学特征分析[J].中华预防医学杂志，2017，51（12）：1091-1096.
Sun JJ，Wang FZ，Zheng H， et al. Epidemiological analysis of viral hepatitis A in China， 2004-2015[J]. Chinese Journal of Preventive Medicine， 2017，51(12): 1091-1096.(In Chinese)
[10]
毛星棋，姜辉，薛士银，等.2005-2022年江苏省甲型肝炎流行病学特征[J].疾病监测，2024，39（3）：296-300.
Mao XQ，Jiang H，Xue SY， et al. Epidemiological characteristics of hepatitis A in Jiangsu，2005-2022[J]. Disease Surveillance， 2024， 39(3):296-300.(In Chinese)
[11]
中国肝炎防治基金会， 陈园生， 庄辉.成人甲型肝炎疫苗接种专家建议[J].中国预防医学杂志，2023，24（12）:1265-1276.
China Foundation for Hepatitis Prevention and Control， Chen YS， Zhuang H. Expert recommendations on hepatitis A vaccination for adults[J].Chinese Preventive Medicine， 2023， 24(12): 1265-1276. (In Chinese).
[12]
丁显香，张丽杰，孙校金，等.2004-2018年中国戊型病毒性肝炎发病趋势和空间聚集性[J].中国疫苗和免疫，2020，26（2）：136-141.
Ding XX，Zhang LJ，Sun JJ， et al. Trends in incidence and spatial clustering of hepatitis E in China， 2004-2018[J]. Chinese Journal of Vaccines and Immunization， 2020， 26(2): 136-141.(In Chinese)
[13]
黄澳迪，唐林，王晓琪，等.中国2011-2021年戊型病毒性肝炎发病趋势和时空聚集性[J].中国疫苗和免疫，2022，28（4）：417-421.
Huang AD，Tang L，Wang XQ， et al. Hepatitis E incidence trends and spatial-temporal clustering in China，2011-2021[J]. Chinese Journal of Vaccines and Immunization， 2022， 28(4): 417-421.(In Chinese)
[14]
Yang M, Cheng XQ, Zhao ZY, et al. Feasibility of controlling hepatitis E in Jiangsu Province, China: a modelling study[J]. Infectious Diseases of Poverty, 2021, 10(1): 91.
[15]
田华，张雪峰，付建光，等.2015—2020年江苏省戊型肝炎病毒流行病学特征及分子进化研究[J].江苏预防医学，2022，33（2）：153-157.
Tian H，Zhang XF，Fu JG， et al. Epidemiological characteristics and molecular evolution of hepatitis E virus in Jiangsu Province from 2015 to 2020[J]. Jiangsu Journal of Preventive Medicine， 2022， 33(2): 153-157.(In Chinese)
[16]
苏琦，高强，杨鹏飞，等.淮安市戊型病毒性肝炎人畜共患性及病毒基因型研究[J].中国校医，2018，32（1）：32-33， 35.
Su Q，Gao Q，Yang PF， et al. Study on zoonotic prevalence and virus genotype of hepatitis E virus in Huaian City[J]. Chinese Journal of School Doctor， 2018， 32(1): 32-33， 35.(In Chinese)
[17]
马涛，丁松宁，汪君君，等.2010-2022年南京市戊型病毒性肝炎流行病学特征和空间聚集性[J].中国疫苗和免疫，2023，29（5）：539-543.
Ma T，Ding SN，Wang JJ， et al. Epidemiological characteristics and spatial clustering of hepatitis E in Nanjing city from 2010 to 2022[J]. Chinese Journal of Vaccines and Immunization， 2023， 29(5): 539-543.(In Chinese)
[18]
陈奕娟，孙琬琬，陈直平，等.2005-2020年浙江省戊型病毒性肝炎时空特征[J].中华疾病控制杂志，2023，27（9）：1101-1106.
Chen YJ，Sun WW，Chen ZP， et al. Spatio-temporal analysis of hepatitis E in Zhejiang Province from 2005 to 2020[J]. Chinese Journal of Disease Control & Prevention， 2023， 27(9): 1101-1106.(In Chinese)
[19]
龙苏兰，张频，王军永，等.农村地区老年人预防流行性传染病的知识、态度及行为调查[J].中国农村卫生事业管理，2022，42（11）：807-812.
Long SL，Zhang P，Wang JY， et al. Knowledge， attitudes and behaviors of the rural elderly in preventing epidemic infectious diseases[J]. Chinese Rural Health Service Administration， 2022， 42(11): 807-812.(In Chinese)
[20]
邢菲，张雪莉，郝萌萱，等.山东省农村传染病防控素养现状及其影响因素分析[J].预防医学论坛，2023，29（1）：19-23.
Xing F，Zhang XL，Hao MX， et al. Analysis on current situation and influencing factors of infectious disease prevention and control literacy in rural areas of Shandong province[J]. Preventive Medicine Tribune， 2023， 29(1): 19-23.(In Chinese)
2025年第52卷第7期
PDF下载
48
20
引用本文
BibTeX
文章信息
doi: 10.20043/j.cnki.MPM.202411471
  • 接收时间：2024-11-25
  • 首发时间：2026-03-18
  • 出版时间：2025-04-10
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2024-11-25
基金
国家自然科学基金(12071173)
淮安市自然科学基金项目(HAB202341)
作者信息
    1.淮安市疾病预防控制中心，江苏 淮安 223003
    2.淮阴师范学院

通讯作者:

张正，E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202411471
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持