Article(id=1241023930715140512, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241023927812682133, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202409313, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1726761600000, receivedDateStr=2024-09-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773812762191, onlineDateStr=2026-03-18, pubDate=1739116800000, pubDateStr=2025-02-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773812762191, onlineIssueDateStr=2026-03-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773812762191, creator=13701087609, updateTime=1773812762191, updator=13701087609, issue=Issue{id=1241023927812682133, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='3', pageStart='385', pageEnd='576', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1773812761500, creator=13701087609, updateTime=1773812858867, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1241024336258200259, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241023927812682133, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1241024336258200260, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1241023927812682133, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=526, endPage=532, ext={EN=ArticleExt(id=1241023930996158888, articleId=1241023930715140512, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Optimization of VNTR loci screening and its application in MLVA typing of mycobacterium tuberculosis in Guizhou province, columnId=1228016572065837304, journalTitle=Modern Preventive Medicine, columnName=Experimental Technology and Applications, runingTitle=null, highlight=null, articleAbstract=
Objective To conduct genetic typing of Mycobacterium tuberculosis (MTB) in Guizhou Province using the MLVA technique based on 24 VNTR loci, to identify VNTR typing loci suitable for Guizhou MTB strains, and to establish a high-resolution, user-friendly MLVA typing model for MTB. This model will provide technical means for tracing the sources, transmission, and prevention and control of tuberculosis in Guizhou Province.
Methods A total of 124 MTB strains were collected from Guizhou Province. PCR amplification was performed using 24 internationally recognized VNTR loci for MTB, followed by analysis of the amplification products using capillary electrophoresis. The number of repeats at each locus was counted, and allele polymorphism and the discriminatory index for each locus were calculated. Clustering analysis of the tested strains was conducted using BIONUMERICS 8.0 to explore the typing characteristics of MTB in Guizhou Province based on 24-VNTR, 15-VNTR, 12-VNTR, and 8-VNTR.
Results The allele polymorphism and discriminatory index of the 24 VNTR loci indicated that seven loci, including QUB-11b, had high discriminatory power, eleven loci, including MIRU-10, had moderate power, and six loci, including MIRU-20, had low power. Furthermore, clustering analysis revealed that the 24-VNTR typing exhibited the highest discriminatory ability at 95.16% (118/124), approaching the level of single strain identification, followed by 15-VNTR at 91.13% (113/124), 12-VNTR at 90.32% (112/124), and 8-VNTR at 83.06% (103/124). All four VNTR typing models successfully categorized the 124 MTB strains into four clusters.
Conclusion This study identified six high-resolution loci, including QUB-11b, as the preferred VNTR loci for MLVA typing of MTB strains in Guizhou Province, with other loci ranked according to their discriminatory power as supplementary typing methods. The 24-VNTR, 15-VNTR, and 12-VNTR methods demonstrated high typing capabilities, providing technical support for molecular tracing of tuberculosis in Guizhou Province.
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目的 应用基于24个VNTR位点的多基因座可变数量串联重复序列分析（MLVA）技术对贵州省结核分枝杆菌进行基因分型研究，筛选出适合贵州结核分枝杆菌菌株的VNTR分型基因座，建立分辨力高、操作简便的结核分枝杆菌MLVA分型模型，为贵州省结核病传染源的追踪溯源、传播及防控提供技术手段。
方法 收集来自贵州省的124株结核分枝杆菌菌株，采用结核分枝杆菌国际通用的24个VNTR基因座进行PCR扩增，应用毛细管电泳法对扩增产物进行分析，统计各基因座的重复数，计算等位基因多态性及各基因座分辨指数，使用BIONUMERICS 8.0对受试菌株进行聚类分析，探索贵州省结核分枝杆菌的24-VNTR、15-VNTR、12-VNTR、8-VNTR分型特征。
结果 24个VNTR基因座等位基因多态性及分辨指数显示：分辨力高的基因座基因有QUB-11b等7个基因座，分辨力中等的有MIRU-10等11个基因座，分辨力低的有MIRU-20等6个基因座；此外，聚类分析显示：24-VNTR分型能力最强，分辨力高达95.16%（118/124），接近单菌株鉴定水平，依次15-VNTR分辨力为91.13%（113/124）、12-VNTR分辨力为90.32%（112/124）、8-VNTR分辨力为83.06%（103/124）。以上4种VNTR分型模型均能将124株结核分枝杆菌菌株分为4个种群。
结论 本研究评估筛选出了以QUB-11b等6个高分辨力基因座为贵州省结核分枝杆菌菌株MLVA分型首选，其他基因座依据其分辨力排序作为补充的分型方法。其中24-VNTR、15-VNTR及12-VNTR具有较高分型能力，可为贵州省结核病分子溯源提供技术支持。
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=qwqhXORFpkTUxWOykk87lg==, magXml=HHXPngwNFILG6uGRoSUElw==, pdfUrl=null, pdf=fiVvTeIApTDjY222OoT3ZQ==, pdfFileSize=1137134, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=HfLG+OYFLY2mffPtH9MrYw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=nejXgty5JB1M2TxbPoAlfw==, mapNumber=null, authorCompany=null, fund=null, authors=
陈依江（1973—），女，本科，副主任医师，研究方向：病原微生物研究
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3.贵州医科大学公共卫生与健康学院，贵州 贵阳 550004)])], figs=[ArticleFig(id=1241023939846140678, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=EN, label=Figure 1, caption=
The cluster tree in different VNTR loci model for 124 MTB strains, figureFileSmall=FXYzojLMjlpgKZ555S598w==, figureFileBig=HfLG+OYFLY2mffPtH9MrYw==, tableContent=null), ArticleFig(id=1241023939992941328, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=CN, label=图1, caption=
124株结核分枝杆菌不同VNTR基因座的MLVA分型聚类, figureFileSmall=FXYzojLMjlpgKZ555S598w==, figureFileBig=HfLG+OYFLY2mffPtH9MrYw==, tableContent=null), ArticleFig(id=1241023940240405281, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=EN, label=Figure 2, caption=
The composition characteristics of strains after cluster tree analysis in 4 VNTR loci model for 124 MTB strains, figureFileSmall=WI+s0FQpiLcOYnvVi1ul4Q==, figureFileBig=GjwPWZYYqyBwAfjSqQkbqA==, tableContent=null), ArticleFig(id=1241023940345262889, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=CN, label=图2, caption=
124株结核分枝杆菌4种VNTR基因座模型聚类分析各基因群的菌株组成特征, figureFileSmall=WI+s0FQpiLcOYnvVi1ul4Q==, figureFileBig=GjwPWZYYqyBwAfjSqQkbqA==, tableContent=null), ArticleFig(id=1241023940479480631, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=EN, label=Figure 3, caption=
Note: The small black arrows indicate clusters of strains in the same genotype, figureFileSmall=ZGNlmRd0ytaqsMwu6Pbrcw==, figureFileBig=Ua4ib0qhwpwtJY2hOWL2pw==, tableContent=null), ArticleFig(id=1241023940580143935, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=CN, label=图3, caption=
124株结核分枝杆菌不同VNTR基因座的MLVA分型最小间距图注：黑色小箭头所指的为成簇的相同基因型菌株。
, figureFileSmall=ZGNlmRd0ytaqsMwu6Pbrcw==, figureFileBig=Ua4ib0qhwpwtJY2hOWL2pw==, tableContent=null), ArticleFig(id=1241023940701778762, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=EN, label=Table 1, caption=
Table 1 The basic information of 24 VNTR loci for MTB
, figureFileSmall=null, figureFileBig=null, tableContent=
| 基因座 | PCR引物序列及荧光标记位置 (5’ to 3’) | 重复单元长度 | H37Rv重复单元数 | 别名 |
|---|
| MIRU-04 | GCGCGAGAGCCCGAACTGC(FAM) | 77 | 3 | ETR-D |
| GCGCAGCAGAAACGCCAGC | | | |
| MIRU-26 | TAGGTCTACCGTCGAAATCTGTGAC | 51 | 3 | |
| CATAGGCGACCAGGCGAATAG(VIC) | | | |
| MIRU-40 | GGGTTGCTGGATGACAACGTGT(NED) | 54 | 1 | |
| GGGTGATCTCGGCGAAATCAGATA | | | |
| MIRU-10 | GTTCTTGACCAACTGCAGTCGTCC | 53 | 3 | |
| GCCACCTTGGTGATCAGCTACCT(FAM) | | | |
| MIRU-16 | TCGGTGATCGGGTCCAGTCCAAGTA | 53 | 2 | |
| CCCGTCGTGCAGCCCTGGTAC(VIC) | | | |
| MIRU-31 | ACTGATTGGCTTCATACGGCTTTA | 53 | 3 | ETR-E |
| GTGCCGACGTGGTCTTGAT(NED) | | | |
| VNTR-42 | CTTGGCCGGCATCAAGCGCATTATT | 51 | 2 | Mtub04 |
| GGCAGCAGAGCCCGGGATTCTTC(FAM) | | | |
| VNTR-43 | CGAGAGTGGCAGTGGCGGTTATCT(VIC) | 58 | 4 | ETR-C |
| AATGACTTGAACGCGCAAATTGTGA | | | |
| ETR-A | AAATCGGTCCCATCACCTTCTTAT(NED) | 75 | 3 | |
| CGAAGCCTGGGGTGCCCGCGATTT | | | |
| VNTR-47 | CTTGAAGCCCCGGTCTCATCTGT(FAM) | 58 | 2 | Mtub30 |
| ACTTGAACCCCCACGCCCATTAGTA | | | |
| VNTR-52 | CGGTGGAGGCGATGAACGTCTTC(VIC) | 58 | 5 | Mtub39 |
| TAGAGCGGCACGGGGGAAAGCTTAG | | | |
| VNTR-53 | TGACCACGGATTGCTCTAGT | 59 | 2 | QUB-4156c |
| GCCGGCGTCCATGTT(NED) | | | |
| QUB-11b | CGTAAGGGGGATGCGGGAAATAGG | 69 | 5 | |
| CGAAGTGAATGGTGGCAT(FAM) | | | |
| VNTR-1955 | AGATCCCAGTTGTCGTCGTC(VIC) | 57 | 2 | Mtub21 |
| CAACATCGCCTGGTTCTGTA | | | |
| QUB-26 | AACGCTCAGCTGTCGGAT(NED) | 111 | 5 | |
| CGGCCGTGCCGGCCAGGTCCTTCCCGAT | | | |
| MIRU-02 | TGGACTTGCAGCAATGGACCAACT | 52 | 2 | |
| TACTCGGACGCCGGCTCAAAAT(FAM) | | | |
| MIRU-23 | CTGTCGATGGCCGCAACAAAACG(VIC) | 53 | 6 | |
| AGCTCAACGGGTTCGCCCTTTTGTC | | | |
| MIRU-39 | CGCATCGACAAACTGGAGCCAAAC | 53 | 2 | |
| CGGAAACGTCTACGCCCCACACAT(NED) | | | |
| MIRU-20 | TCGGAGAGATGCCCTTCGAGTTAG(FAM) | 77 | 2 | |
| GGAGACCGCGACCAGGTACTTGTA | | | |
| MIRU-24 | CGACCAAGATGTGCAGGAATACAT | 54 | 1 | |
| GGGCGAGTTGAGCTCACAGAA(VIC) | | | |
| MIRU-27 | TCGAAAGCCTCTGCGTGCCAGTAA | 53 | 3 | QUB-5 |
| GCGATGTGAGCGTGCCACTCAA(NED) | | | |
| VNTR-46 | GCCAGCCGCCGTGCATAAACCT(FAM) | 57 | 4 | Mtub29 |
| AGCCACCCGGTGTGCCTTGTATGAC | | | |
| VNTR-48 | ATGGCCACCCGATACCGCTTCAGT(VIC) | 57 | 3 | ETR-B |
| CGACGGGCCATCTTGGATCAGCTAC | | | |
| VNTR-49 | GGTGCGCACCTGCTCCAGATAA(NED) | 54 | 3 | Mtub34 |
| GGCTCTCATTGCTGGAGGGTTGTAC | | | |
), ArticleFig(id=1241023940831802196, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=CN, label=表1, caption=
结核分枝杆菌24个VNTR基因座基本信息
, figureFileSmall=null, figureFileBig=null, tableContent=
| 基因座 | PCR引物序列及荧光标记位置 (5’ to 3’) | 重复单元长度 | H37Rv重复单元数 | 别名 |
|---|
| MIRU-04 | GCGCGAGAGCCCGAACTGC(FAM) | 77 | 3 | ETR-D |
| GCGCAGCAGAAACGCCAGC | | | |
| MIRU-26 | TAGGTCTACCGTCGAAATCTGTGAC | 51 | 3 | |
| CATAGGCGACCAGGCGAATAG(VIC) | | | |
| MIRU-40 | GGGTTGCTGGATGACAACGTGT(NED) | 54 | 1 | |
| GGGTGATCTCGGCGAAATCAGATA | | | |
| MIRU-10 | GTTCTTGACCAACTGCAGTCGTCC | 53 | 3 | |
| GCCACCTTGGTGATCAGCTACCT(FAM) | | | |
| MIRU-16 | TCGGTGATCGGGTCCAGTCCAAGTA | 53 | 2 | |
| CCCGTCGTGCAGCCCTGGTAC(VIC) | | | |
| MIRU-31 | ACTGATTGGCTTCATACGGCTTTA | 53 | 3 | ETR-E |
| GTGCCGACGTGGTCTTGAT(NED) | | | |
| VNTR-42 | CTTGGCCGGCATCAAGCGCATTATT | 51 | 2 | Mtub04 |
| GGCAGCAGAGCCCGGGATTCTTC(FAM) | | | |
| VNTR-43 | CGAGAGTGGCAGTGGCGGTTATCT(VIC) | 58 | 4 | ETR-C |
| AATGACTTGAACGCGCAAATTGTGA | | | |
| ETR-A | AAATCGGTCCCATCACCTTCTTAT(NED) | 75 | 3 | |
| CGAAGCCTGGGGTGCCCGCGATTT | | | |
| VNTR-47 | CTTGAAGCCCCGGTCTCATCTGT(FAM) | 58 | 2 | Mtub30 |
| ACTTGAACCCCCACGCCCATTAGTA | | | |
| VNTR-52 | CGGTGGAGGCGATGAACGTCTTC(VIC) | 58 | 5 | Mtub39 |
| TAGAGCGGCACGGGGGAAAGCTTAG | | | |
| VNTR-53 | TGACCACGGATTGCTCTAGT | 59 | 2 | QUB-4156c |
| GCCGGCGTCCATGTT(NED) | | | |
| QUB-11b | CGTAAGGGGGATGCGGGAAATAGG | 69 | 5 | |
| CGAAGTGAATGGTGGCAT(FAM) | | | |
| VNTR-1955 | AGATCCCAGTTGTCGTCGTC(VIC) | 57 | 2 | Mtub21 |
| CAACATCGCCTGGTTCTGTA | | | |
| QUB-26 | AACGCTCAGCTGTCGGAT(NED) | 111 | 5 | |
| CGGCCGTGCCGGCCAGGTCCTTCCCGAT | | | |
| MIRU-02 | TGGACTTGCAGCAATGGACCAACT | 52 | 2 | |
| TACTCGGACGCCGGCTCAAAAT(FAM) | | | |
| MIRU-23 | CTGTCGATGGCCGCAACAAAACG(VIC) | 53 | 6 | |
| AGCTCAACGGGTTCGCCCTTTTGTC | | | |
| MIRU-39 | CGCATCGACAAACTGGAGCCAAAC | 53 | 2 | |
| CGGAAACGTCTACGCCCCACACAT(NED) | | | |
| MIRU-20 | TCGGAGAGATGCCCTTCGAGTTAG(FAM) | 77 | 2 | |
| GGAGACCGCGACCAGGTACTTGTA | | | |
| MIRU-24 | CGACCAAGATGTGCAGGAATACAT | 54 | 1 | |
| GGGCGAGTTGAGCTCACAGAA(VIC) | | | |
| MIRU-27 | TCGAAAGCCTCTGCGTGCCAGTAA | 53 | 3 | QUB-5 |
| GCGATGTGAGCGTGCCACTCAA(NED) | | | |
| VNTR-46 | GCCAGCCGCCGTGCATAAACCT(FAM) | 57 | 4 | Mtub29 |
| AGCCACCCGGTGTGCCTTGTATGAC | | | |
| VNTR-48 | ATGGCCACCCGATACCGCTTCAGT(VIC) | 57 | 3 | ETR-B |
| CGACGGGCCATCTTGGATCAGCTAC | | | |
| VNTR-49 | GGTGCGCACCTGCTCCAGATAA(NED) | 54 | 3 | Mtub34 |
| GGCTCTCATTGCTGGAGGGTTGTAC | | | |
), ArticleFig(id=1241023940974408544, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=EN, label=Table 2, caption=
The repeat numbers and allelic diversity of 24 VNTR loci for 124 MTB strains
, figureFileSmall=null, figureFileBig=null, tableContent=
| 序号 | VNTR
基因座 | 拷贝数 | h | HDGI |
|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | None |
|---|
| 1 | QUB-11b | 11 | 13 | 24 | 20 | 20 | 25 | 10 | 1 | 0 | 0 | 0 | 0 | 0 | | 0.843 | 0.851 |
| 2 | VNTR-1955 | 0 | 22 | 2 | 45 | 30 | 22 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | | 0.744 | 0.752 |
| 3 | VNTR-53 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 36 | 49 | 17 | 0 | 21 | 0.739 | 0.745 |
| 4 | MIRU-26 | 0 | 0 | 1 | 0 | 0 | 10 | 4 | 3 | 16 | 30 | 53 | 4 | 2 | 1 | 0.730 | 0.739 |
| 5 | MIRU-31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 51 | 10 | 49 | 4 | 0.658 | 0.667 |
| 6 | ETR-A | 1 | 0 | 0 | 18 | 43 | 58 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.637 | 0.647 |
| 7 | VNTR-42 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 36 | 17 | 66 | | 0.609 | 0.617 |
| 8 | MIRU-10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 61 | 52 | 9 | 0 | | 0.573 | 0.581 |
| 9 | MIRU-40 | 0 | 0 | 0 | 0 | 0 | 0 | 15 | 36 | 72 | 1 | 0 | 0 | 0 | | 0.560 | 0.568 |
| 10 | VNTR-52 | 0 | 0 | 0 | 0 | 27 | 08 | 10 | 5 | 2 | 0 | 0 | 0 | 0 | | 0.524 | 0.532 |
| 11 | MIRU-39 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 70 | 50 | 1 | | 0.514 | 0.522 |
| 12 | VNTR-47 | 0 | 0 | 0 | 0 | 59 | 1 | 64 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.504 | 0.511 |
| 13 | VNTR-43 | 0 | 0 | 0 | 0 | 38 | 86 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.420 | 0.427 |
| 14 | MIRU-16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 92 | 3 | 5 | 0.407 | 0.415 |
| 15 | VNTR-48 | 0 | 0 | 0 | 0 | 0 | 31 | 93 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.370 | 0.378 |
| 16 | MIRU-04 | 0 | 0 | 1 | 98 | 8 | 15 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | | 0.351 | 0.359 |
| 17 | MIRU-27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 23 | 97 | 2 | 0 | | 0.348 | 0.356 |
| 18 | QUB-26 | 0 | 102 | 1 | 3 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.309 | 0.317 |
| 19 | MIRU-20 | 0 | 0 | 0 | 0 | 0 | 5 | 114 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.146 | 0.154 |
| 20 | VNTR-46 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 114 | 3 | 3 | 0 | 0 | | 0.146 | 0.154 |
| 21 | MIRU-23 | 0 | 0 | 0 | 1 | 0 | 2 | 118 | 3 | 0 | 0 | 0 | 0 | 0 | | 0.086 | 0.094 |
| 22 | VNTR-49 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 118 | 1 | 0 | 0 | 0 | 0 | | 0.086 | 0.094 |
| 23 | MIRU-24 | 0 | 0 | 0 | 0 | 0 | 0 | 121 | 3 | 0 | 0 | 0 | 0 | 0 | | 0.039 | 0.048 |
| 24 | MIRU-02 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 123 | 0 | 0 | 0 | 0 | | 0.008 | 0.016 |
), ArticleFig(id=1241023941117014894, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1241023930715140512, language=CN, label=表2, caption=
124株结核分枝杆菌24个VNTR基因座重复单位及多态性分布
, figureFileSmall=null, figureFileBig=null, tableContent=
| 序号 | VNTR
基因座 | 拷贝数 | h | HDGI |
|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | None |
|---|
| 1 | QUB-11b | 11 | 13 | 24 | 20 | 20 | 25 | 10 | 1 | 0 | 0 | 0 | 0 | 0 | | 0.843 | 0.851 |
| 2 | VNTR-1955 | 0 | 22 | 2 | 45 | 30 | 22 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | | 0.744 | 0.752 |
| 3 | VNTR-53 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 36 | 49 | 17 | 0 | 21 | 0.739 | 0.745 |
| 4 | MIRU-26 | 0 | 0 | 1 | 0 | 0 | 10 | 4 | 3 | 16 | 30 | 53 | 4 | 2 | 1 | 0.730 | 0.739 |
| 5 | MIRU-31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10 | 51 | 10 | 49 | 4 | 0.658 | 0.667 |
| 6 | ETR-A | 1 | 0 | 0 | 18 | 43 | 58 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.637 | 0.647 |
| 7 | VNTR-42 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 36 | 17 | 66 | | 0.609 | 0.617 |
| 8 | MIRU-10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 61 | 52 | 9 | 0 | | 0.573 | 0.581 |
| 9 | MIRU-40 | 0 | 0 | 0 | 0 | 0 | 0 | 15 | 36 | 72 | 1 | 0 | 0 | 0 | | 0.560 | 0.568 |
| 10 | VNTR-52 | 0 | 0 | 0 | 0 | 27 | 08 | 10 | 5 | 2 | 0 | 0 | 0 | 0 | | 0.524 | 0.532 |
| 11 | MIRU-39 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 70 | 50 | 1 | | 0.514 | 0.522 |
| 12 | VNTR-47 | 0 | 0 | 0 | 0 | 59 | 1 | 64 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.504 | 0.511 |
| 13 | VNTR-43 | 0 | 0 | 0 | 0 | 38 | 86 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.420 | 0.427 |
| 14 | MIRU-16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 92 | 3 | 5 | 0.407 | 0.415 |
| 15 | VNTR-48 | 0 | 0 | 0 | 0 | 0 | 31 | 93 | 0 | 0 | 0 | 0 | 0 | 0 | | 0.370 | 0.378 |
| 16 | MIRU-04 | 0 | 0 | 1 | 98 | 8 | 15 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | | 0.351 | 0.359 |
| 17 | MIRU-27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 23 | 97 | 2 | 0 | | 0.348 | 0.356 |
| 18 | QUB-26 | 0 | 102 | 1 | 3 | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.309 | 0.317 |
| 19 | MIRU-20 | 0 | 0 | 0 | 0 | 0 | 5 | 114 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.146 | 0.154 |
| 20 | VNTR-46 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 114 | 3 | 3 | 0 | 0 | | 0.146 | 0.154 |
| 21 | MIRU-23 | 0 | 0 | 0 | 1 | 0 | 2 | 118 | 3 | 0 | 0 | 0 | 0 | 0 | | 0.086 | 0.094 |
| 22 | VNTR-49 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 118 | 1 | 0 | 0 | 0 | 0 | | 0.086 | 0.094 |
| 23 | MIRU-24 | 0 | 0 | 0 | 0 | 0 | 0 | 121 | 3 | 0 | 0 | 0 | 0 | 0 | | 0.039 | 0.048 |
| 24 | MIRU-02 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 123 | 0 | 0 | 0 | 0 | | 0.008 | 0.016 |
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