Article(id=1240950905248469809, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240950898113966774, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202311470, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1700841600000, receivedDateStr=2023-11-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773795351564, onlineDateStr=2026-03-18, pubDate=1712678400000, pubDateStr=2024-04-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773795351564, onlineIssueDateStr=2026-03-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773795351564, creator=13701087609, updateTime=1773795351564, updator=13701087609, issue=Issue{id=1240950898113966774, tenantId=1146029695717560320, journalId=1227665162245664772, year='2024', volume='51', issue='7', pageStart='1153', pageEnd='1344', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1773795349862, creator=13701087609, updateTime=1773795519367, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1240951609136567133, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240950898113966774, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1240951609136567134, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240950898113966774, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1222, endPage=1228, ext={EN=ArticleExt(id=1240950905533682490, articleId=1240950905248469809, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Association of vegetable and fruit intake with gut microbiota during the first trimester of pregnancy, columnId=1228016568949474136, journalTitle=Modern Preventive Medicine, columnName=Child and Adolescent Health, Maternal and Child Health, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the relationship between the intake of vegetables and fruits and the composition and diversity ofgut microbiota during the first trimester of pregnancy in Chengdu.
Methods In total 104 early pregnant women in Chengdu were enrolled in this study. Dietary frequency questionnaire was used to collect the intake of vegetables and fruits. According to the median intake of vegetables and fruits, the early pregnant women were divided into high intake group and low intake group. The intestinal microflora of fecal samples of early pregnant women was detected by 16S rRNA highthroughput sequencing, and the differences of intestinal microflora between groups were compared. Multiple linear regression was used to explore the relationship between vegetable and fruit intake and intestinal flora in early pregnant women.
Results The median intake of vegetables and fruits in early pregnant women was 90.0 g/d and 200.0 g/d, respectively. There was no significant difference in intestinal microflora α and β diversity between high and low intake of vegetables and fruits in early pregnancy. LEfSe analysis showed that the relative abundance of multiple intestinal microflorae in early pregnant women was significantly different between the groups with high and low intake of vegetables and fruits. Multiple linear regression analysis showed that after adjusting age, pre-pregnancy body mass index, and energy intake, early pregnant women’s vegetable intake was directly proportional to the relative abundance of Eubacterium siraeum group (β=0.007, P=0.012), inversely proportional to the relative abundance of Bacteroides (β=-0.167, P=0.023), and fruit intake was proportional to the relative abundance of Ruminococcus gnavus group (β=0.004, P=0.034), inversely proportional to the relative abundance of Agathobacter (β=0.004, P=0.044).
Conclusion The intake of vegetables and fruits in early pregnancy leads to the change of relative abundance of intestinal flora. This study provides a new scientific basis for dietary regulation of gut microbiota during pregnancy.
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目的 探讨成都市孕早期妇女蔬菜和水果摄入与肠道菌群组成及多样性之间的关系。
方法 本研究纳入104例成都市孕早期妇女,使用膳食频率问卷收集其蔬菜和水果摄入情况,并分别依据蔬菜、水果摄入量中位数将孕早期妇女分为摄入量高组和摄入量低组。使用16S rRNA高通量测序检测孕早期妇女粪便样本肠道菌群,比较组间肠道菌群差异。采用多重线性回归探讨蔬菜、水果摄入和孕早期妇女肠道菌群的关系。
结果 孕早期妇女蔬菜和水果摄入量中位数分别是90.0 g/d和200.0 g/d。孕早期蔬菜、水果摄入高低组孕早期妇女肠道菌群α多样性和β多样性无统计学差异。LEfSe分析显示,孕早期妇女多个肠道菌群的相对丰度在蔬菜、水果摄入量高低组间存在显著差异(P<0.01)。多重线性回归分析显示,在调整了年龄、孕前体质指数和能量摄入后,孕早期妇女蔬菜摄入量与Eubacterium siraeum group相对丰度呈正比(β=0.007, P=0.012),与Bacteroides相对丰度呈反比(β=-0.167, P=0.023);水果摄入量与Ruminococcus gnavus group相对丰度呈正比(β=0.004, P=0.034),与Agathobacter相对丰度呈反比(β=0.004, P=0.044)。
结论 孕早期蔬菜、水果摄入引起肠道菌群相对丰度的变化,本研究为孕期膳食调控肠道菌群提供新的科学依据。
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点,除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=KkSnPZ/ewocvIr6dNhrImA==, magXml=p55Cm2XwHWMiKug1MBb22A==, pdfUrl=null, pdf=piK/hAfpUtbMOe07SZKOjw==, pdfFileSize=1063608, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=3z2xEerABnhgpL2pGD7HAw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=lbfsS5521/DBCNp5IR02Iw==, mapNumber=null, authorCompany=null, fund=null, authors=
张可馨(1998—),女,硕士在读,研究方向:流行病与卫生统计学
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18(2): 101-116., articleTitle=Dietary fibre in gastrointestinal health and disease, refAbstract=null)], funds=[Fund(id=1240972176506023940, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, awardId=2020YFC2006300, language=CN, fundingSource=国家重点研发计划项目(2020YFC2006300), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1240972166561329616, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, xref=1., ext=[AuthorCompanyExt(id=1240972166565523921, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, companyId=1240972166561329616, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=West China School of Public Health, Sichuan University/West China Fourth Hospital, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1240972166573912531, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, companyId=1240972166561329616, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.四川大学华西公共卫生学院/华西第四医院,四川 成都 610041)]), AuthorCompany(id=1240972166737490404, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, xref=2., ext=[AuthorCompanyExt(id=1240972166745879014, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, companyId=1240972166737490404, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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3.四川大学华西护理学院,四川 成都 610041)])], figs=[ArticleFig(id=1240972173733589944, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=EN, label=Figure 1, caption=
PCoA plots based on Bray-Curtis distance for groups according to low and high intakes of vegetable and fruit in the first trimester of pregnancy (n=104), figureFileSmall=lCpFKsxUh2J08eGzf3C+sw==, figureFileBig=3vIDQU3jo6+2dPUc3R698g==, tableContent=null), ArticleFig(id=1240972173859419072, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=CN, label=图1, caption=
孕早期蔬菜水果不同摄入量组肠道菌群β多样性PCoA分析(n=104)注:根据蔬菜、水果摄入量中位数,将研究对象分为摄入量低组和摄入量高组;图A为蔬菜摄入量高低组间比较;图B为水果摄入量高低组间比较。
, figureFileSmall=lCpFKsxUh2J08eGzf3C+sw==, figureFileBig=3vIDQU3jo6+2dPUc3R698g==, tableContent=null), ArticleFig(id=1240972175377757132, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=EN, label=Figure 2, caption=
LEfSe analysis to identify enriched bacteria according to low and high intakes of vegetable and fruit in the first trimester of pregnancy (n=104), figureFileSmall=BHWRGgGr9UU5oENvh/L4Xg==, figureFileBig=mKYLr2jtoOnIH/ReXI9cvQ==, tableContent=null), ArticleFig(id=1240972175491003345, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=CN, label=图2, caption=
孕早期蔬菜水果摄入量肠道菌群物种差异的LEfSe分析(n=104)注:根据蔬菜、水果摄入量中位数,将研究对象分为摄入量低组和摄入量高组;图A为蔬菜摄入量高低组间比较;图B为水果摄入量高低组间比较。
, figureFileSmall=BHWRGgGr9UU5oENvh/L4Xg==, figureFileBig=mKYLr2jtoOnIH/ReXI9cvQ==, tableContent=null), ArticleFig(id=1240972175608443864, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=EN, label=Table 1, caption=
Basic characteristics of the study participants stratified by vegetable and fruit intake (n=104)
, figureFileSmall=null, figureFileBig=null, tableContent=
| 特征 | 蔬菜摄入量b | χ2/Z值 | P值 | 水果摄入量b | χ2/Z值 | P值 |
|---|
| 低 (n=52) | 高 (n=52) | 低 (n=52) | 高 (n=52) |
|---|
| 年龄(岁) | | | 2.869 | 0.238 | | | 1.046 | 0.593 |
| <30 | 11 (21.15) | 9 (17.31) | | | 8 (15.38) | 12 (23.08) | | |
| 30~34 | 27 (51.92) | 35 (67.31) | | | 32 (61.54) | 30 (57.69) | | |
| ≥35 | 14 (26.92) | 8 (15.38) | | | 12 (23.08) | 10 (19.23) | | |
| 孕前BMI(kg/m2)c | | | 0.144 | 0.931 | | | 0.970 | 0.616 |
| <18.5 | 7 (13.46) | 8 (15.38) | | | 8 (15.38) | 7 (13.46) | | |
| 18.5~23.9 | 38 (73.08) | 38 (73.08) | | | 36 (69.23) | 40 (76.92) | | |
| ≥24 | 7 (13.46) | 6 (11.54) | | | 8 (15.38) | 5 (9.62) | | |
| 孕妇最高学历 | | | 5.518 | 0.063 | | | 5.518 | 0.063 |
| 高中及以下 | 1 (1.92) | 5 (9.62) | | | 3 (5.77) | 3 (5.77) | | |
| 大专/大学 | 42 (80.77) | 32 (61.54) | | | 32 (61.54) | 42 (80.77) | | |
| 研究生及以上 | 9 (17.31) | 15 (28.85) | | | 17 (32.69) | 7 (13.46) | | |
| 家庭人均月收入(元)d | | | 2.920 | 0.232 | | | 9.280 | 0.010 |
| <6 000 | 3 (5.77) | 6 (11.54) | | | 6 (11.54) | 3 (5.77) | | |
| 6 000~8 000 | 13 (25.00) | 7 (13.46) | | | 4 (7.69) | 16 (30.77) | | |
| >8 000 | 36 (69.23) | 39 (75.00) | | | 42 (80.77) | 33 (63.46) | | |
| 怀孕次数(次) | | | 0.386 | 0.824 | | | 1.334 | 0.513 |
| 1 | 25 (48.08) | 28 (53.85) | | | 24 (46.15) | 29 (55.77) | | |
| 2 | 15 (28.85) | 14 (26.92) | | | 17 (32.69) | 12 (23.08) | | |
| ≥3 | 12 (23.08) | 10 (19.23) | | | 11 (21.15) | 11 (21.15) | | |
| 生产次数(次) | | | 0.232 | 0.891 | | | 2.778 | 0.249 |
| 1 | 39 (75.00) | 41 (78.85) | | | 39 (75.00) | 41 (78.85) | | |
| 2 | 12 (23.08) | 10 (19.23) | | | 13 (25.00) | 9 (17.31) | | |
| ≥3 | 1 (1.92) | 1 (1.92) | | | 0 | 2 (3.85) | | |
| 谷类摄入量(g/d) | 170.5 (92.6, 226.1) | 157.0 (111.4, 243.7) | -1.080 | 0.280 | 146.9 (103.6, 231.4) | 181.8 (111.4, 233.1) | -1.047 | 0.295 |
| 薯类摄入量(g/d) | 29.3 (10.0, 64.1) | 27.7 (11.0, 66.1) | -0.003 | 0.997 | 26.1 (9.3, 50.3) | 32.3 (11.6, 86.1) | -1.314 | 0.189 |
| 肉类摄入量(g/d) | 72.2 (46.4, 103.6) | 84.3 (51.8, 128.6) | -0.388 | 0.579 | 71.5 (46.5, 119.3) | 56.1 (31.7, 94.4) | 1.278 | 0.201 |
| 水产摄入量(g/d) | 35.7 (14.2, 60.5) | 42.0 (17.2, 141.3) | -1.375 | 0.170 | 40.0 (14.2, 92.4) | 37.4 (16.4, 104.5) | -0.341 | 0.733 |
| 蔬菜摄入量(g/d) | 45.0 (35.0, 64.3) | 146.0 (105.0, 190.2) | -8.745 | <0.001 | 101.4 (58.6, 115.7) | 76.1 (42.9, 132.1) | 1.776 | 0.076 |
| 水果摄入量(g/d) | 200.0 (80.0, 228.6) | 144.1 (94.9, 209.7) | 0.407 | 0.684 | 89.1 (52.08, 112.5) | 221.0 (203.1, 305.7) | -8.758 | <0.001 |
| 坚果摄入量(g/d) | 8.8 (1.4, 18.0) | 5.3 (0.6, 16.5) | 0.849 | 0.396 | 4.9 (1.9, 11.5) | 10.0 (0.5, 22.3) | -1.183 | 0.237 |
| 奶及奶制品摄入量(g/d) | 220.0 (111.4, 300.0) | 250.0 (128.6, 300.0) | -0.873 | 0.383 | 200.0 (85.7, 300.0) | 250.0 (150.0, 300.0) | -1.917 | 0.056 |
| 豆及豆制品摄入量(g/d) | 8.7 (3.2, 18.9) | 9.6 (3.0, 16.9) | -0.127 | 0.900 | 8.4 (3.1, 17.0) | 9.1 (3.2, 18.1) | -0.289 | 0.772 |
| 蛋类摄入量(g/d) | 60.0 (30.0, 60.0) | 60.0 (42.9, 60.0) | -1.080 | 0.280 | 60.1 (42.9, 60.0) | 60.0 (27.9, 60.0) | 0.192 | 0.848 |
| 能量摄入(kcal/d) | 1 456.5 (1 197.8, 1 878.6) | 1 706.1 (1 343.4, 2 155.7) | -2.220 | 0.026 | 1 530.4 (1 156.2, 1 882.7) | 1 568.6 (1 416.6, 1 959.8) | -1.232 | 0.218 |
), ArticleFig(id=1240972175738467294, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=CN, label=表1, caption=
研究对象基本信息(n=104)a
, figureFileSmall=null, figureFileBig=null, tableContent=
| 特征 | 蔬菜摄入量b | χ2/Z值 | P值 | 水果摄入量b | χ2/Z值 | P值 |
|---|
| 低 (n=52) | 高 (n=52) | 低 (n=52) | 高 (n=52) |
|---|
| 年龄(岁) | | | 2.869 | 0.238 | | | 1.046 | 0.593 |
| <30 | 11 (21.15) | 9 (17.31) | | | 8 (15.38) | 12 (23.08) | | |
| 30~34 | 27 (51.92) | 35 (67.31) | | | 32 (61.54) | 30 (57.69) | | |
| ≥35 | 14 (26.92) | 8 (15.38) | | | 12 (23.08) | 10 (19.23) | | |
| 孕前BMI(kg/m2)c | | | 0.144 | 0.931 | | | 0.970 | 0.616 |
| <18.5 | 7 (13.46) | 8 (15.38) | | | 8 (15.38) | 7 (13.46) | | |
| 18.5~23.9 | 38 (73.08) | 38 (73.08) | | | 36 (69.23) | 40 (76.92) | | |
| ≥24 | 7 (13.46) | 6 (11.54) | | | 8 (15.38) | 5 (9.62) | | |
| 孕妇最高学历 | | | 5.518 | 0.063 | | | 5.518 | 0.063 |
| 高中及以下 | 1 (1.92) | 5 (9.62) | | | 3 (5.77) | 3 (5.77) | | |
| 大专/大学 | 42 (80.77) | 32 (61.54) | | | 32 (61.54) | 42 (80.77) | | |
| 研究生及以上 | 9 (17.31) | 15 (28.85) | | | 17 (32.69) | 7 (13.46) | | |
| 家庭人均月收入(元)d | | | 2.920 | 0.232 | | | 9.280 | 0.010 |
| <6 000 | 3 (5.77) | 6 (11.54) | | | 6 (11.54) | 3 (5.77) | | |
| 6 000~8 000 | 13 (25.00) | 7 (13.46) | | | 4 (7.69) | 16 (30.77) | | |
| >8 000 | 36 (69.23) | 39 (75.00) | | | 42 (80.77) | 33 (63.46) | | |
| 怀孕次数(次) | | | 0.386 | 0.824 | | | 1.334 | 0.513 |
| 1 | 25 (48.08) | 28 (53.85) | | | 24 (46.15) | 29 (55.77) | | |
| 2 | 15 (28.85) | 14 (26.92) | | | 17 (32.69) | 12 (23.08) | | |
| ≥3 | 12 (23.08) | 10 (19.23) | | | 11 (21.15) | 11 (21.15) | | |
| 生产次数(次) | | | 0.232 | 0.891 | | | 2.778 | 0.249 |
| 1 | 39 (75.00) | 41 (78.85) | | | 39 (75.00) | 41 (78.85) | | |
| 2 | 12 (23.08) | 10 (19.23) | | | 13 (25.00) | 9 (17.31) | | |
| ≥3 | 1 (1.92) | 1 (1.92) | | | 0 | 2 (3.85) | | |
| 谷类摄入量(g/d) | 170.5 (92.6, 226.1) | 157.0 (111.4, 243.7) | -1.080 | 0.280 | 146.9 (103.6, 231.4) | 181.8 (111.4, 233.1) | -1.047 | 0.295 |
| 薯类摄入量(g/d) | 29.3 (10.0, 64.1) | 27.7 (11.0, 66.1) | -0.003 | 0.997 | 26.1 (9.3, 50.3) | 32.3 (11.6, 86.1) | -1.314 | 0.189 |
| 肉类摄入量(g/d) | 72.2 (46.4, 103.6) | 84.3 (51.8, 128.6) | -0.388 | 0.579 | 71.5 (46.5, 119.3) | 56.1 (31.7, 94.4) | 1.278 | 0.201 |
| 水产摄入量(g/d) | 35.7 (14.2, 60.5) | 42.0 (17.2, 141.3) | -1.375 | 0.170 | 40.0 (14.2, 92.4) | 37.4 (16.4, 104.5) | -0.341 | 0.733 |
| 蔬菜摄入量(g/d) | 45.0 (35.0, 64.3) | 146.0 (105.0, 190.2) | -8.745 | <0.001 | 101.4 (58.6, 115.7) | 76.1 (42.9, 132.1) | 1.776 | 0.076 |
| 水果摄入量(g/d) | 200.0 (80.0, 228.6) | 144.1 (94.9, 209.7) | 0.407 | 0.684 | 89.1 (52.08, 112.5) | 221.0 (203.1, 305.7) | -8.758 | <0.001 |
| 坚果摄入量(g/d) | 8.8 (1.4, 18.0) | 5.3 (0.6, 16.5) | 0.849 | 0.396 | 4.9 (1.9, 11.5) | 10.0 (0.5, 22.3) | -1.183 | 0.237 |
| 奶及奶制品摄入量(g/d) | 220.0 (111.4, 300.0) | 250.0 (128.6, 300.0) | -0.873 | 0.383 | 200.0 (85.7, 300.0) | 250.0 (150.0, 300.0) | -1.917 | 0.056 |
| 豆及豆制品摄入量(g/d) | 8.7 (3.2, 18.9) | 9.6 (3.0, 16.9) | -0.127 | 0.900 | 8.4 (3.1, 17.0) | 9.1 (3.2, 18.1) | -0.289 | 0.772 |
| 蛋类摄入量(g/d) | 60.0 (30.0, 60.0) | 60.0 (42.9, 60.0) | -1.080 | 0.280 | 60.1 (42.9, 60.0) | 60.0 (27.9, 60.0) | 0.192 | 0.848 |
| 能量摄入(kcal/d) | 1 456.5 (1 197.8, 1 878.6) | 1 706.1 (1 343.4, 2 155.7) | -2.220 | 0.026 | 1 530.4 (1 156.2, 1 882.7) | 1 568.6 (1 416.6, 1 959.8) | -1.232 | 0.218 |
), ArticleFig(id=1240972175855907810, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=EN, label=Table 2, caption=
The α diversity index stratified by vegetable and fruit intake in the first trimester of pregnancy (n=104)
, figureFileSmall=null, figureFileBig=null, tableContent=
| α多样性 | 蔬菜摄入量b | Z值 | P值 | 水果摄入量b | Z值 | P值 |
|---|
| 低 (n=52) | 高 (n=52) | 低 (n=52) | 高 (n=52) |
|---|
| Chao1指数 | 396.73 (241.91, 774.34) | 525.78 (273.18, 1 292.68) | -1.041 | 0.161 | 378.72 (252.01, 1 060.21) | 520.78 (254.96, 981.28) | -0.874 | 0.382 |
| Pielou指数 | 0.67 (0.62, 0.75) | 0.71 (0.65, 0.74) | -1.180 | 0.238 | 0.70 (0.64, 0.73) | 0.70 (0.64, 0.76) | -0.670 | 0.503 |
| Shannon指数 | 5.75 (5.15, 6.77) | 6.45 (5.33, 7.39) | -1.518 | 0.129 | 5.90 (5.28, 7.00) | 6.17 (5.18, 7.01) | -0.582 | 0.561 |
| Simpson指数 | 0.95 (0.91, 0.97) | 0.97 (0.93, 0.98) | -1.879 | 0.060 | 0.95 (0.93, 0.97) | 0.95 (0.92, 0.98) | -0.280 | 0.780 |
), ArticleFig(id=1240972175973348331, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=CN, label=表2, caption=
孕早期蔬菜水果不同摄入量组肠道菌群α多样性对比(n=104)a
, figureFileSmall=null, figureFileBig=null, tableContent=
| α多样性 | 蔬菜摄入量b | Z值 | P值 | 水果摄入量b | Z值 | P值 |
|---|
| 低 (n=52) | 高 (n=52) | 低 (n=52) | 高 (n=52) |
|---|
| Chao1指数 | 396.73 (241.91, 774.34) | 525.78 (273.18, 1 292.68) | -1.041 | 0.161 | 378.72 (252.01, 1 060.21) | 520.78 (254.96, 981.28) | -0.874 | 0.382 |
| Pielou指数 | 0.67 (0.62, 0.75) | 0.71 (0.65, 0.74) | -1.180 | 0.238 | 0.70 (0.64, 0.73) | 0.70 (0.64, 0.76) | -0.670 | 0.503 |
| Shannon指数 | 5.75 (5.15, 6.77) | 6.45 (5.33, 7.39) | -1.518 | 0.129 | 5.90 (5.28, 7.00) | 6.17 (5.18, 7.01) | -0.582 | 0.561 |
| Simpson指数 | 0.95 (0.91, 0.97) | 0.97 (0.93, 0.98) | -1.879 | 0.060 | 0.95 (0.93, 0.97) | 0.95 (0.92, 0.98) | -0.280 | 0.780 |
), ArticleFig(id=1240972176103371762, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=EN, label=Table 3, caption=
Multiple linear regression analysis of the relationship between the intake of vegetables and fruits and gut microbiota in the first trimester of pregnancy (n=104)
, figureFileSmall=null, figureFileBig=null, tableContent=
| 模型 1b | 模型 2c |
|---|
| β (95%CI) | Pd值 | β (95%CI) | Pd值 |
|---|
| 蔬菜类 | | | | |
| Eubacterium siraeum group | 0.007(0.003, 0.012) | 0.003 | 0.007(0.002, 0.012) | 0.012 |
| Bacteroides | -0.134(-0.254, -0.013) | 0.045 | -0.167(-0.300, -0.034) | 0.023 |
| Bilophila | -0.002(-0.004, 0.000 3) | 0.095 | -0.002(-0.004, 0.001) | 0.130 |
| 水果类 | | | | |
| Akkermansia | 0.002(-0.007, 0.010) | 0.725 | 0.001(-0.009, 0.010) | 0.899 |
| Ruminococcus gnavus group | 0.004(0.001, 0.007) | 0.028 | 0.004(0.001, 0.007) | 0.034 |
| Dialister | -0.014(-0.033, 0.005) | 0.187 | -0.014(-0.034, 0.006) | 0.217 |
| Agathobacter | -0.021(-0.036, -0.005) | 0.036 | -0.021(-0.037, -0.005) | 0.044 |
), ArticleFig(id=1240972176220812282, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240950905248469809, language=CN, label=表3, caption=
孕早期蔬菜水果摄入与肠道菌群关系的多重线性回归(n=104)a
, figureFileSmall=null, figureFileBig=null, tableContent=
| 模型 1b | 模型 2c |
|---|
| β (95%CI) | Pd值 | β (95%CI) | Pd值 |
|---|
| 蔬菜类 | | | | |
| Eubacterium siraeum group | 0.007(0.003, 0.012) | 0.003 | 0.007(0.002, 0.012) | 0.012 |
| Bacteroides | -0.134(-0.254, -0.013) | 0.045 | -0.167(-0.300, -0.034) | 0.023 |
| Bilophila | -0.002(-0.004, 0.000 3) | 0.095 | -0.002(-0.004, 0.001) | 0.130 |
| 水果类 | | | | |
| Akkermansia | 0.002(-0.007, 0.010) | 0.725 | 0.001(-0.009, 0.010) | 0.899 |
| Ruminococcus gnavus group | 0.004(0.001, 0.007) | 0.028 | 0.004(0.001, 0.007) | 0.034 |
| Dialister | -0.014(-0.033, 0.005) | 0.187 | -0.014(-0.034, 0.006) | 0.217 |
| Agathobacter | -0.021(-0.036, -0.005) | 0.036 | -0.021(-0.037, -0.005) | 0.044 |
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