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Article(id=1240722576431968814, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202502135, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1739203200000, receivedDateStr=2025-02-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773740913732, onlineDateStr=2026-03-17, pubDate=1760025600000, pubDateStr=2025-10-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773740913732, onlineIssueDateStr=2026-03-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773740913732, creator=13701087609, updateTime=1773740913732, updator=13701087609, issue=Issue{id=1240722566957027366, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='19', pageStart='3457', pageEnd='3648', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=0, createTime=1773740911472, creator=13701087609, updateTime=1773740981732, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1240722861736906836, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1240722861736906837, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=3637, endPage=3642, ext={EN=ArticleExt(id=1240722576780096076, articleId=1240722576431968814, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Investigation on the knowledge of hepatitis C and its influencing factors among clinical doctors in Hebei Province, columnId=1228016573156360233, journalTitle=Modern Preventive Medicine, columnName=Disease Control and Prevention, runingTitle=null, highlight=null, articleAbstract=

Objective To evaluate the extent to which clinical doctors in Hebei Province have mastered the knowledge associated with the prevention and control of viral hepatitis C and its influencing factors, and supply a scientific basis to further improve and perfect the prevention and control strategies of hepatitis C. Methods The on-site investigation adopted the "Questionnaire on Hepatitis C Prevention and Treatment Knowledge for Clinical Doctors" devised by the National AIDS Prevention and Control Center. Its components involved demographic traits, fundamental prevention and treatment knowledge, diagnosis and treatment standards, as well as case reporting requirements, and others. Categorical variables were described using proportions and rates.The influencing factors of awareness of hepatitis C knowledge were studied by using the χ2 test and multivariable logistic regression method. Results This survey obtained 2 858 questionnaires in total, and every single one of them was valid. The awareness rate of basic knowledge and professional knowledge was 95.31% (2 724/2 858) and 14.49% (414/2 858), respectively.In terms of basic knowledge content, the correct answer rate for "Hepatitis C can be cured" was the lowest, at 86.28%, while the correct answer rates for other questions were all above 90%. Regarding professional knowledge, 50% (8/16) of the questions had a correct answer rate below 50%. Among these, the question on "Diagnostic basis for diagnosing hepatitis C" had the lowest correct answer rate, at 13.89%. The educational background, department, hospital level and type of clinical doctor, as well as whether they have received hepatitis C knowledge training in the past year, all have an impact on their knowledge of hepatitis C. Doctors with a master’s degree or above had higher knowledge levels than those with a master’s degree or below (OR=2.324, 95% CI:1.706-3.166). Doctors in infectious diseases had higher knowledge levels than those in non-infectious diseases such as internal medicine (OR=0.275, 95% CI: 0.159-0.475). Doctors in tertiary hospitals had higher knowledge levels than those in secondary and lower-level hospitals (OR=1.462, 95% CI: 1.044-2.048). Doctors in provincial hospitals were better than those in county and municipal hospitals (OR=2.869, 95% CI: 1.978-4.161). Doctors who have received prevention and treatment knowledge training in the past year were higher than those who have not received training (OR=3.144, 95% CI: 2.386-4.143). Conclusion While many clinical doctors in Hebei Province have mastered the fundamental knowledge about hepatitis C prevention and treatment quite well, the level of their professional knowledge needs to be improved. Attention should be paid to strengthening the training on diagnosis, treatment and case reporting, etc. At the same time, differentiated training programs should be formulated for different groups to effectively improve the diagnosis and treatment level of clinicians.

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目的 了解河北省临床医生对于丙型病毒性肝炎（简称丙肝）防治知识的掌握情况及其影响因素，为进一步优化防控措施提供科学依据。方法 现场调查采用中国疾病预防控制中心性病艾滋病预防控制中心制定的《临床医生丙肝防治知识调查表》，调查内容包括人群特征、基础防治知识、诊断治疗标准和病例报告要求等，采用构成比、率对计数资料进行描述。采用χ2检验和多因素logistic回归方法研究丙肝知识知晓情况的影响因素。结果 回收的2 858份问卷均为有效问卷。防治基础知识的知晓率为95.31%(2 724/2 858)，专业知识的知晓率为14.49%（414/2 858）。在基础知识内容中，回答正确率最低的是“丙肝可以治愈”，为86.28%，其余题目回答正确率均高于90%。在专业知识内容中，50%（8/16）的题目回答正确率在50%以下，回答正确率最低的是“临床诊断病例的诊断依据”，为13.89%。临床医生的学历、所在科室、医院等级和类型以及近一年参加丙肝知识培训情况均对丙肝专业知识知晓情况有影响。硕士及以上学历医生高于其以下（OR= 2.324,95%CI: 1.706～3.166），感染科医生高于内科等非感染科室（OR=0.275,95%CI: 0.159～0.475），三级医院医生优于二级及以下医院（OR=1.462，95%CI: 1.044～2.048），省级医院医生优于县市级（OR=2.869，95%CI：1.978～4.161），近一年来接受过防治知识培训的医生高于未接受培训者（OR=3.144,95%CI: 2.386～4.143）。结论 河北省部分临床医生丙肝防治基础知识水平较高，但专业知识水平仍待提高。应注意加强诊断治疗及病例报告等内容培训，同时针对不同群体制定差异化培训方案，切实提高临床医生诊疗水平。

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马琳，E-mail:
, copyrightStatement=本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=TtMgMKCiuOGHl2wlwoizJA==, magXml=HUqQEdMBF+4XtrDoLZ3h1w==, pdfUrl=null, pdf=eLKOQJmNV8vBOIDTUzlenQ==, pdfFileSize=656067, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=unXxC4rC+OHrWAzzdWIvfg==, mapNumber=null, authorCompany=null, fund=null, authors=

张亚丽（1978—），女，硕士，副主任技师，研究方向：丙肝性病艾滋病防治

, authorsList=张亚丽, 马琳, 孙悦, 王伟, 吴小雪, 王敬丘, 成效莹, 路新利)}, authors=[Author(id=1240933504205255122, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933504339472856, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, authorId=1240933504205255122, language=EN, stringName=Ya-li ZHANG, firstName=Ya-li, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=Institute for AIDS/STD Control and Prevention, Hebei Province Center for Disease Control and Prevention, Shijiazhuang, Hebei 050021, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933504431747549, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, authorId=1240933504205255122, language=CN, stringName=张亚丽, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.河北省疾病预防控制中心性病艾滋病防治所，河北 石家庄 050021, bio={"content":"

张亚丽（1978—），女，硕士，副主任技师，研究方向：丙肝性病艾滋病防治

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张亚丽（1978—），女，硕士，副主任技师，研究方向：丙肝性病艾滋病防治

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Analysis of data quality of Hepatitis C case reports in Guangxi from 2019 to 2022[J]. 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From treatable to curable to eliminated--a decade of research progress in the diagnosis and treatment of hepatitis C[J]. 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Exploring the Efficacy of Direct-Acting Antiviral Drugs in the Treatment of Chronic Hepatitis C[J]. Medical Diet and Health, 2021, 19(8):60-61.(In Chinese), articleTitle=Exploring the Efficacy of Direct-Acting Antiviral Drugs in the Treatment of Chronic Hepatitis C, refAbstract=null), Reference(id=1240933512744858548, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, doi=null, pmid=null, pmcid=null, year=2018, volume=24, issue=10, pageStart=1054, pageEnd=1055, url=null, language=null, rfNumber=[17], rfOrder=30, authorNames=王百锁, 尤海菲, 胡婷, journalName=中国艾滋病性病, refType=null, unstructuredReference=王百锁，尤海菲，胡婷，等.陕西省医务人员丙型肝炎相关知识认知情况调查[J].中国艾滋病性病，2018，24（10）：1054-1055., articleTitle=陕西省医务人员丙型肝炎相关知识认知情况调查, refAbstract=null), Reference(id=1240933512845521848, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, doi=null, pmid=null, pmcid=null, year=2018, volume=24, issue=10, pageStart=1054, pageEnd=1055, url=null, language=null, rfNumber=[17], rfOrder=31, authorNames=Wang BS, You HF, Hu T, journalName=Chinese Journal of AIDS & STD, refType=null, unstructuredReference=Wang BS, You HF, Hu T, et al. 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Chinese Journal of AIDS & STD, 2018, 24(10): 1054-1055.(In Chinese), articleTitle=Investigation on cognitive status of Hepatitis C-related knowledge among clinical doctors in Shaanxi Province, refAbstract=null), Reference(id=1240933512950379452, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, doi=null, pmid=null, pmcid=null, year=2018, volume=24, issue=1, pageStart=40, pageEnd=43, url=null, language=null, rfNumber=[18], rfOrder=32, authorNames=戴色莺, 程晓莉, 刘爱文, journalName=安徽预防医学杂志, refType=null, unstructuredReference=戴色莺，程晓莉，刘爱文，等.安徽省医疗机构医务人员丙肝防治知识培训效果评估[J].安徽预防医学杂志，2018，24（1）：40-43., articleTitle=安徽省医疗机构医务人员丙肝防治知识培训效果评估, refAbstract=null), Reference(id=1240933513030071232, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, doi=null, pmid=null, pmcid=null, year=2018, volume=24, issue=1, pageStart=40, pageEnd=43, url=null, language=null, rfNumber=[18], rfOrder=33, authorNames=Dai SY, Cheng XL, Liu AW, journalName=Anhui Journal of Preventive Medicine, refType=null, unstructuredReference=Dai SY, Cheng XL, Liu AW, et al. Effect evaluation of knowledge training in the prevention and treatment of hepatitis C among medical staff of Anhui medical institutions[J]. Anhui Journal of Preventive Medicine, 2018, 24(1):40-43.(In Chinese), articleTitle=Effect evaluation of knowledge training in the prevention and treatment of hepatitis C among medical staff of Anhui medical institutions, refAbstract=null)], funds=[Fund(id=1240933509167117076, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, awardId=172777185, language=CN, fundingSource=河北省重点研发计划自筹项目(172777185), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1240933503941013946, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, xref=1., ext=[AuthorCompanyExt(id=1240933503961985471, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, companyId=1240933503941013946, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Institute for AIDS/STD Control and Prevention, Hebei Province Center for Disease Control and Prevention, Shijiazhuang, Hebei 050021, China), AuthorCompanyExt(id=1240933503970374080, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, companyId=1240933503941013946, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.河北省疾病预防控制中心性病艾滋病防治所，河北 石家庄 050021)]), AuthorCompany(id=1240933504058454468, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, xref=2., ext=[AuthorCompanyExt(id=1240933504071037383, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, companyId=1240933504058454468, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.河北医科大学公共卫生学院)])], figs=[ArticleFig(id=1240933507929797342, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=EN, label=Table 1, caption=

Basic demographic characteristics of survey subjects (n=2 858)

, figureFileSmall=null, figureFileBig=null, tableContent=
基本特征调查人数构成比(%)
性别
男1 27944.75
女1 57955.25
年龄（岁）
20～29802.80
30～391 17341.04
40～491 11438.98
50～5944615.61
≥60451.57
学历
本科及以下2 22077.68
硕士及以上63822.32
职称
初级65222.81
中级1 32546.36
副高级71024.84
正高级1715.98
工作年限（年）
≤554719.14
6～1084229.46
11～2096933.90
>2048917.11
科室部门
门诊部83229.11
住院部2 02670.89
科室类别
内科1 01535.51
外科61921.66
妇产科34512.07
儿科2047.14
皮肤性病672.34
五官科1324.62
中医科782.73
感染性疾病科692.41
其他32911.51
过去一个月是否开
过丙肝抗体或核酸
检测化验单
是1 56654.79
否1 28044.79
医院类型
县级1 80763.23
地市级80628.20
省级2458.57
医院等级
二级及以下2 00270.05
三级85629.95
), ArticleFig(id=1240933508068209381, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=CN, label=表1, caption=

调查对象的基础人口学特征（n=2 858）

, figureFileSmall=null, figureFileBig=null, tableContent=
基本特征调查人数构成比(%)
性别
男1 27944.75
女1 57955.25
年龄（岁）
20～29802.80
30～391 17341.04
40～491 11438.98
50～5944615.61
≥60451.57
学历
本科及以下2 22077.68
硕士及以上63822.32
职称
初级65222.81
中级1 32546.36
副高级71024.84
正高级1715.98
工作年限（年）
≤554719.14
6～1084229.46
11～2096933.90
>2048917.11
科室部门
门诊部83229.11
住院部2 02670.89
科室类别
内科1 01535.51
外科61921.66
妇产科34512.07
儿科2047.14
皮肤性病672.34
五官科1324.62
中医科782.73
感染性疾病科692.41
其他32911.51
过去一个月是否开
过丙肝抗体或核酸
检测化验单
是1 56654.79
否1 28044.79
医院类型
县级1 80763.23
地市级80628.20
省级2458.57
医院等级
二级及以下2 00270.05
三级85629.95
), ArticleFig(id=1240933508189844204, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=EN, label=Table 2, caption=

Mastery of basic knowledge on hepatitis C among survey subjects (n=2 858)

, figureFileSmall=null, figureFileBig=null, tableContent=
丙肝防治基本知识回答正确人数正确率(%)
1.丙肝感染可能无症状，需检测确诊2 64392.48
2.接触含丙肝病毒的血液、体液、分泌物或器械可能感染2 68693.98
3.丙肝可以通过性行为传播2 60591.15
4.丙肝感染孕妇可能出现胎传2 73195.56
5.输入含丙肝病毒血液会感染2 81998.64
6.街头创伤美容有感染风险2 78197.31
7.慢性病例有进展为肝硬化、肝癌风险2 73095.52
8.丙肝可以治愈2 46686.28
), ArticleFig(id=1240933508290507504, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=CN, label=表2, caption=

调查对象丙肝基本知识掌握情况（n=2 858）

, figureFileSmall=null, figureFileBig=null, tableContent=
丙肝防治基本知识回答正确人数正确率(%)
1.丙肝感染可能无症状，需检测确诊2 64392.48
2.接触含丙肝病毒的血液、体液、分泌物或器械可能感染2 68693.98
3.丙肝可以通过性行为传播2 60591.15
4.丙肝感染孕妇可能出现胎传2 73195.56
5.输入含丙肝病毒血液会感染2 81998.64
6.街头创伤美容有感染风险2 78197.31
7.慢性病例有进展为肝硬化、肝癌风险2 73095.52
8.丙肝可以治愈2 46686.28
), ArticleFig(id=1240933508399559414, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=EN, label=Table 3, caption=

Mastery of professional knowledge on hepatitis C among survey subjects (n=2 858)

, figureFileSmall=null, figureFileBig=null, tableContent=
丙肝专业知识回答错误人数部分回答正确人数完全回答正确人数正确率(%)
1.引起丙肝的病原体a479—2 37983.24
2.丙肝特点b1 3602231 27544.61
3.传播途径b6104551 79362.74
4.高风险人群b1 08990486530.27
5.建议丙肝筛查的人群b584222 37883.21
6.实验室检测适用人群b7502941 81463.47
7.血液抗-HCV阳性的意义b501 5691 23943.35
8.慢性丙肝是感染丙肝病毒几个月以上a662—2 19676.84
诊断知识1645.74
9.丙肝病例的诊断分类b2 8148059420.78
10.临床诊断病例的诊断依据b2 03642539713.89
11.确诊病例的诊断依据a649—2 20977.29
12.病例诊断后正确的做法b531 7951 01035.34
治疗知识60821.27
13.目前治疗丙肝最有效的方法a1 430—1 42849.97
14.需抗病毒治疗的病例包括b97195593232.61
病例报告
15.诊断病例法定报告时限a798—2 06072.08
相关政策
16.抗病毒治疗药品纳入国家医保报销范畴a699—2 15975.54
), ArticleFig(id=1240933508525388537, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=CN, label=表3, caption=

调查对象的丙肝专业知识掌握情况（n=2 858）

, figureFileSmall=null, figureFileBig=null, tableContent=
丙肝专业知识回答错误人数部分回答正确人数完全回答正确人数正确率(%)
1.引起丙肝的病原体a479—2 37983.24
2.丙肝特点b1 3602231 27544.61
3.传播途径b6104551 79362.74
4.高风险人群b1 08990486530.27
5.建议丙肝筛查的人群b584222 37883.21
6.实验室检测适用人群b7502941 81463.47
7.血液抗-HCV阳性的意义b501 5691 23943.35
8.慢性丙肝是感染丙肝病毒几个月以上a662—2 19676.84
诊断知识1645.74
9.丙肝病例的诊断分类b2 8148059420.78
10.临床诊断病例的诊断依据b2 03642539713.89
11.确诊病例的诊断依据a649—2 20977.29
12.病例诊断后正确的做法b531 7951 01035.34
治疗知识60821.27
13.目前治疗丙肝最有效的方法a1 430—1 42849.97
14.需抗病毒治疗的病例包括b97195593232.61
病例报告
15.诊断病例法定报告时限a798—2 06072.08
相关政策
16.抗病毒治疗药品纳入国家医保报销范畴a699—2 15975.54
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Mastery of professional knowledge on hepatitis C and analysis of influencing factors among clinical doctors in Hebei Province (n=2 858)

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特征调查人数回答正确人数
（正确率，%）		χ2值P值
性别0.0180.892
男1 279184(14.4)
女1 579230(14.6)
年龄（岁）3.0610.548
20～298010(12.5)
30～391 173172(14.7)
40～491 114154(13.8)
50～5944668(15.2)
≥604510(21.7)
学历40.045<0.001
本科及以下2 220272(12.3)
硕士及以上638142(22.3)
职称1.8710.600
初级65296(14.7)
中级1 325201(15.2)
副高级71092(13.0)
正高级17125(14.6)
科室部门0.0320.859
门诊部832119(14.3)
住院部2 026295(14.6)
科室类别42.6540.000
感染性疾病科6925(36.2)
内科1 015132(13.0)
外科61980(12.9)
妇产科34558(16.8)
儿科20438(18.6)
皮肤性病科6716(23.9)
五官科13214(10.6)
中医科7813(16.7)
其他32938(11.6)
工作年限（年）1.5340.674
≤554778(14.3)
6～10842114(13.5)
11～20969143(14.8)
>2048978(16.0)
所在医院等级26.0680.000
二级及以下2 002246(12.3)
三级856168(19.6)
医院类型56.2600.000
县、地市级医院2613339(13.0)
省级医院24575(30.6)
近1年内接受培训情况72.2580.000
否1 01971(7.0)
是1 839343(18.7)
), ArticleFig(id=1240933508739298051, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=CN, label=表4, caption=

河北省部分临床医生专业知识掌握情况及影响因素分析（n=2 858）

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特征调查人数回答正确人数
（正确率，%）		χ2值P值
性别0.0180.892
男1 279184(14.4)
女1 579230(14.6)
年龄（岁）3.0610.548
20～298010(12.5)
30～391 173172(14.7)
40～491 114154(13.8)
50～5944668(15.2)
≥604510(21.7)
学历40.045<0.001
本科及以下2 220272(12.3)
硕士及以上638142(22.3)
职称1.8710.600
初级65296(14.7)
中级1 325201(15.2)
副高级71092(13.0)
正高级17125(14.6)
科室部门0.0320.859
门诊部832119(14.3)
住院部2 026295(14.6)
科室类别42.6540.000
感染性疾病科6925(36.2)
内科1 015132(13.0)
外科61980(12.9)
妇产科34558(16.8)
儿科20438(18.6)
皮肤性病科6716(23.9)
五官科13214(10.6)
中医科7813(16.7)
其他32938(11.6)
工作年限（年）1.5340.674
≤554778(14.3)
6～10842114(13.5)
11～20969143(14.8)
>2048978(16.0)
所在医院等级26.0680.000
二级及以下2 002246(12.3)
三级856168(19.6)
医院类型56.2600.000
县、地市级医院2613339(13.0)
省级医院24575(30.6)
近1年内接受培训情况72.2580.000
否1 01971(7.0)
是1 839343(18.7)
), ArticleFig(id=1240933508839961350, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=EN, label=Table 5, caption=

Logistic regression analysis of professional knowledge mastery

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特征调查人数回答正确人数（正确率，%）OR值（95%CI）P值
学历
本科及以下2 220272(12.3)1.000（参照组）
硕士及以上638142(22.3)2.324(1.706～3.166)<0.001
科室类别
感染性疾病科6925(36.2)1.000（参照组）
内科1 015132(13.0)0.275(0.159～0.475)0.000
外科61980(12.9)0.247(0.140～0.435)0.000
妇产科34558(16.8)0.384(0.213～0.691)0.001
儿科20438(18.6)0.472(0.253～0.881)0.018
皮肤性病科6716(23.9)0.546(0.247～1.207)0.135
五官科13214(10.6)0.234(0.109～0.500)0.000
中医科7813(16.7)0.422(0.189～0.941)0.035
其他32938(11.6)0.281(0.152～0.520)0.000
所在医院等级
二级及以下2 002246(12.3)1.000（参照组）
三级856168(19.6)1.462(1.044～2.048)0.027
医院类型
县、地市级医院2613339(13.0)1.000（参照组）
省级医院24575(30.6)2.869(1.978～4.161)0.000
近1年内接受培训情况
否1 01971(7.0)1.000（参照组）
是1 839343(18.7)3.144(2.386～4.143)0.000
), ArticleFig(id=1240933508936430347, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722576431968814, language=CN, label=表5, caption=

专业知识掌握情况logistic回归

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特征调查人数回答正确人数（正确率，%）OR值（95%CI）P值
学历
本科及以下2 220272(12.3)1.000（参照组）
硕士及以上638142(22.3)2.324(1.706～3.166)<0.001
科室类别
感染性疾病科6925(36.2)1.000（参照组）
内科1 015132(13.0)0.275(0.159～0.475)0.000
外科61980(12.9)0.247(0.140～0.435)0.000
妇产科34558(16.8)0.384(0.213～0.691)0.001
儿科20438(18.6)0.472(0.253～0.881)0.018
皮肤性病科6716(23.9)0.546(0.247～1.207)0.135
五官科13214(10.6)0.234(0.109～0.500)0.000
中医科7813(16.7)0.422(0.189～0.941)0.035
其他32938(11.6)0.281(0.152～0.520)0.000
所在医院等级
二级及以下2 002246(12.3)1.000（参照组）
三级856168(19.6)1.462(1.044～2.048)0.027
医院类型
县、地市级医院2613339(13.0)1.000（参照组）
省级医院24575(30.6)2.869(1.978～4.161)0.000
近1年内接受培训情况
否1 01971(7.0)1.000（参照组）
是1 839343(18.7)3.144(2.386～4.143)0.000
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河北省临床医生丙型肝炎知识知晓情况调查及影响因素分析
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张亚丽 1 , 马琳 1 , 孙悦 2 , 王伟 1 , 吴小雪 1 , 王敬丘 1 , 成效莹 1 , 路新利 1
现代预防医学 | 疾病预防控制 2025,52(19): 3637-3642
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现代预防医学 | 疾病预防控制 2025, 52(19): 3637-3642
河北省临床医生丙型肝炎知识知晓情况调查及影响因素分析
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张亚丽1, 马琳1 , 孙悦2, 王伟1, 吴小雪1, 王敬丘1, 成效莹1, 路新利1
作者信息
  • 1.河北省疾病预防控制中心性病艾滋病防治所，河北 石家庄 050021
  • 2.河北医科大学公共卫生学院

    • 张亚丽（1978—），女，硕士，副主任技师，研究方向：丙肝性病艾滋病防治

通讯作者:

马琳，E-mail:
Investigation on the knowledge of hepatitis C and its influencing factors among clinical doctors in Hebei Province
Ya-li ZHANG1, Lin MA1 , Yue SUN2, Wei WANG1, Xiao-xue WU1, Jing-qiu WANG1, Xiao-ying CHENG1, Xin-li LU1
Affiliations
  • Institute for AIDS/STD Control and Prevention, Hebei Province Center for Disease Control and Prevention, Shijiazhuang, Hebei 050021, China
出版时间: 2025-10-10 doi: 10.20043/j.cnki.MPM.202502135
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摘要
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目的 了解河北省临床医生对于丙型病毒性肝炎（简称丙肝）防治知识的掌握情况及其影响因素，为进一步优化防控措施提供科学依据。方法 现场调查采用中国疾病预防控制中心性病艾滋病预防控制中心制定的《临床医生丙肝防治知识调查表》，调查内容包括人群特征、基础防治知识、诊断治疗标准和病例报告要求等，采用构成比、率对计数资料进行描述。采用χ2检验和多因素logistic回归方法研究丙肝知识知晓情况的影响因素。结果 回收的2 858份问卷均为有效问卷。防治基础知识的知晓率为95.31%(2 724/2 858)，专业知识的知晓率为14.49%（414/2 858）。在基础知识内容中，回答正确率最低的是“丙肝可以治愈”，为86.28%，其余题目回答正确率均高于90%。在专业知识内容中，50%（8/16）的题目回答正确率在50%以下，回答正确率最低的是“临床诊断病例的诊断依据”，为13.89%。临床医生的学历、所在科室、医院等级和类型以及近一年参加丙肝知识培训情况均对丙肝专业知识知晓情况有影响。硕士及以上学历医生高于其以下（OR= 2.324,95%CI: 1.706～3.166），感染科医生高于内科等非感染科室（OR=0.275,95%CI: 0.159～0.475），三级医院医生优于二级及以下医院（OR=1.462，95%CI: 1.044～2.048），省级医院医生优于县市级（OR=2.869，95%CI：1.978～4.161），近一年来接受过防治知识培训的医生高于未接受培训者（OR=3.144,95%CI: 2.386～4.143）。结论 河北省部分临床医生丙肝防治基础知识水平较高，但专业知识水平仍待提高。应注意加强诊断治疗及病例报告等内容培训，同时针对不同群体制定差异化培训方案，切实提高临床医生诊疗水平。

丙型肝炎  /  临床医生  /  知晓率  /  调查

Objective To evaluate the extent to which clinical doctors in Hebei Province have mastered the knowledge associated with the prevention and control of viral hepatitis C and its influencing factors, and supply a scientific basis to further improve and perfect the prevention and control strategies of hepatitis C. Methods The on-site investigation adopted the "Questionnaire on Hepatitis C Prevention and Treatment Knowledge for Clinical Doctors" devised by the National AIDS Prevention and Control Center. Its components involved demographic traits, fundamental prevention and treatment knowledge, diagnosis and treatment standards, as well as case reporting requirements, and others. Categorical variables were described using proportions and rates.The influencing factors of awareness of hepatitis C knowledge were studied by using the χ2 test and multivariable logistic regression method. Results This survey obtained 2 858 questionnaires in total, and every single one of them was valid. The awareness rate of basic knowledge and professional knowledge was 95.31% (2 724/2 858) and 14.49% (414/2 858), respectively.In terms of basic knowledge content, the correct answer rate for "Hepatitis C can be cured" was the lowest, at 86.28%, while the correct answer rates for other questions were all above 90%. Regarding professional knowledge, 50% (8/16) of the questions had a correct answer rate below 50%. Among these, the question on "Diagnostic basis for diagnosing hepatitis C" had the lowest correct answer rate, at 13.89%. The educational background, department, hospital level and type of clinical doctor, as well as whether they have received hepatitis C knowledge training in the past year, all have an impact on their knowledge of hepatitis C. Doctors with a master’s degree or above had higher knowledge levels than those with a master’s degree or below (OR=2.324, 95% CI:1.706-3.166). Doctors in infectious diseases had higher knowledge levels than those in non-infectious diseases such as internal medicine (OR=0.275, 95% CI: 0.159-0.475). Doctors in tertiary hospitals had higher knowledge levels than those in secondary and lower-level hospitals (OR=1.462, 95% CI: 1.044-2.048). Doctors in provincial hospitals were better than those in county and municipal hospitals (OR=2.869, 95% CI: 1.978-4.161). Doctors who have received prevention and treatment knowledge training in the past year were higher than those who have not received training (OR=3.144, 95% CI: 2.386-4.143). Conclusion While many clinical doctors in Hebei Province have mastered the fundamental knowledge about hepatitis C prevention and treatment quite well, the level of their professional knowledge needs to be improved. Attention should be paid to strengthening the training on diagnosis, treatment and case reporting, etc. At the same time, differentiated training programs should be formulated for different groups to effectively improve the diagnosis and treatment level of clinicians.

Hepatitis C  /  Clinicians  /  Awareness rate  /  Investigation
张亚丽, 马琳, 孙悦, 王伟, 吴小雪, 王敬丘, 成效莹, 路新利. 河北省临床医生丙型肝炎知识知晓情况调查及影响因素分析. 现代预防医学, 2025 , 52 (19) : 3637 -3642 . DOI: 10.20043/j.cnki.MPM.202502135
Ya-li ZHANG, Lin MA, Yue SUN, Wei WANG, Xiao-xue WU, Jing-qiu WANG, Xiao-ying CHENG, Xin-li LU. Investigation on the knowledge of hepatitis C and its influencing factors among clinical doctors in Hebei Province[J]. Modern Preventive Medicine, 2025 , 52 (19) : 3637 -3642 . DOI: 10.20043/j.cnki.MPM.202502135
正文
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丙型病毒性肝炎（简称丙肝）因感染丙型肝炎病毒（hepatitis C virus，HCV）所导致，血液传播、性接触传播及母婴垂直传播为其主要传播途径。感染 HCV后，若未及时干预，极易进展为慢性肝炎，并逐步发展为肝硬化、肝功能衰竭，甚至演变为肝癌[1]。据既往我国流行病学调查数据，60岁以下人群中HCV抗体阳性检出率达4.3‰，且考虑到高危人群及高发区域的抗体阳性率要高于一般人群，推算我国总感染人数可达1 000万例[2]，HCV感染已经成为公共卫生的重要问题。在丙肝防治工作中，临床医生对丙肝防治知识的掌握程度，直接关系到临床诊疗工作的质量与效果[3]。世界卫生组织（WHO）的相关报告指出，在全球范围内，许多国家的医生在丙肝领域存在认知短板，对于丙肝诊断标准以及新型抗病毒药物（如DAA）的了解程度不足。在发展中国家，这种知晓率低的情况尤为显著，严重阻碍了丙肝的有效防控与患者的及时诊治[4]。为系统评估河北省临床医生在丙肝防治方面对基础知识、诊断以及病例报告标准的掌握情况，本研究开展了专项调查，旨在为制定科学精准的区域防治策略提供量化依据，这对于提升河北省丙肝防治能力、推动实现消除丙肝公共卫生危害目标具有重要的现实意义。
1　对象与方法
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1.1　调查对象
本次调查共覆盖河北省11个设区市，每个市均按照整群随机原则选取3家综合性医院，分别为省级、地市级和县级医院各1家。以选中医院的门诊部和住院部所有临床科室为抽样单元实施单纯随机抽样：若人数≤5人，随机抽取1名；若人数>5人且≤10人，随机抽取2名；若人数>10人，则随机抽取3名。最终共对33家医院的2 858名临床医生进行了调查，且所有调查对象均在充分了解研究目的和内容后签署了知情同意书。
1.2　调查内容
应用《临床医生丙肝防治知识调查表》开展问卷调查，该调查表由中国疾病预防控制中心性病艾滋病预防控制中心制发。内容主要包含人群特征、基础防治知识和专业知识三个部分。其中，基础知识部分设置了8道题目，专业知识部分则有16道题目（题目类型包括单选题和多选题，多选题需选对全部才能判定为正确，选对部分判定为部分正确，选错则直接判定为错误）。在丙肝的诊断及报告内容方面，严格遵循《丙型肝炎诊断标准（WS 213 -2018）》[5]执行。
1.3　指标定义
丙肝知识知晓率的定义为调查对象中知晓丙肝知识的人数所占调查人数的比例。其中，基础知识知晓情况以答对至少6道基础知识题目为知晓标准，计算公式为：（答对6道及以上人数/总人数）×100%；专业知识知晓情况则以答对至少12道专业知识题目为知晓标准，计算公式为：（答对12道及以上人数/总人数）×100% 。
1.4　统计学分析
数据整理及分析分别运用Excel 2016和SPSS 21.0软件。采用构成比、率对计数资料进行描述。采用χ2检验比较组间的差异，若P<0.05，则认为差异有统计学意义。采用χ2检验和多因素logistic回归方法研究丙肝知识知晓情况的影响因素。检验水准α=0.05。
2　结果
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2.1　调查对象基本信息
本次共调查临床医生2 858人，男女性别比为1∶1.2。年龄范围为20～69岁，平均年龄（41.62±7.73）岁，以30～50岁占比最高，占80.02%；学历以本科及以下为主，占77.68%；职称以中级为主，占46.36%；工作年限在11～20年者最多，为33.90%；内科（35.51%）和外科（21.66%）样本量较多；医院类型中63.23%为县级医院；二级及以下医院为主，占70.05%。54.79%的医生过去一个月开过丙肝相关检测化验单。见表1。
2.2　丙肝基础知识掌握情况
基础知识全部题目中回答正确6道及以上的临床医生为2 724人，知晓率为95.31%。所有题目均答对2 031人，占71.06%；所有题目均答错5人，占0.17%。题目回答正确比例低于90%的仅有“丙肝可以治愈”这一知识点，正确率最高的为输血问题。见表2。
2.3　丙肝专业知识掌握情况
专业知识全部题目中回答正确12道及以上的临床医生仅有414人，正确掌握比例为14.49%。所有题目均答对40人，占1.40%；所有题目均答错14人，占0.49%。在16道题中，仅有两道题的正确率高于80%，有8道题的正确率低于50%，涉及丙肝诊断知识和治疗内容的题目正确率均低于30%。见表3。
2.4　接受丙肝培训情况
在2 858名临床医生中，近一年来接受过丙肝知识培训的共1 839人，占比64.35%。其中，以参加过一次培训的人数最多，占比达84.91%。关于培训必要性的认知调查显示，81.39%（2 326人）认为培训必要性非常大，6.72%（192人）认为比较必要，11.62%（332人）认为有必要，仅0.28%（8人）持否定态度。
2.5　丙肝专业知识掌握情况及影响因素分析
专业知识调查表中答对至少12道题目认为知识知晓，答对12道题目以下认为不知晓。经χ2检验得出不同的学历、科室类别、医院等级和类型及近一年接受培训情况在知识知晓情况的差异具有统计学意义（P<0.05）。将这些因素进行多因素logistic回归分析。结果显示，硕士及以上高于其以下学历者（OR= 2.324,95%CI: 1.706～3.166）；相比于非感染性科室，感染科医生的丙肝专业知识掌握度高；三级医院的医生丙肝专业知识掌握情况优于二级及以下医院（OR=1.462，95%CI: 1.044～2.048）；省级医院的医生丙肝知识掌握情况优于县市级（OR=2.869，95%CI：1.978～4.161）；近一年来接受过防治知识培训的临床医生专业知识知晓率高（OR= 3.144,95%CI: 2.386～4.143）。见表4、5。
3　讨论
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由于HCV感染具有隐匿性，在感染早期，患者通常无明显症状和体征，这使得疾病早期诊断难度较大，患者往往难以察觉自身感染情况[6]。现有的状况使得临床医生在诊疗和病例上报方面，必须具备更强的专业能力。同时国家也把丙肝知识掌握情况纳入衡量《消除丙型肝炎公共卫生危害行动工作方案（2021-2030年）》[7]执行效果的关键指标中。
本次调查结果显示，河北省临床医生关于丙肝相关基础知识的内容掌握程度高于武汉市、扬州市的相关研究结果[8-9]。然而，在专业知识掌握方面，河北省低于重庆市[10]、重庆万州区[11]、上海市黄浦区[12]的调查结果。特别是在涉及丙肝病例诊断分类及临床诊断病例诊断依据这些方面，正确率较低，这与之前河北省158家医院的调查结果[13]以及广西省丙肝相关研究结果[14]一致。提示河北省临床医生对2018年新颁布的版丙肝诊断标准的认知较为模糊，其掌握水平需进一步提升，建议进一步强化对丙肝诊断标准相关内容的学习，并加大考核力度。
随着直接抗病毒药物的研发成功并广泛推广，显著提高了丙肝的治疗效果，使其成为一种可以治愈的疾病[15]。而且，临床实践表明，规范治疗越早，治愈率越高。为了让丙肝患者能够获得有效、及时且经济可负担的治疗[16]，我国已将部分DAAs纳入国家医保，大幅降低了药物费用。但本次调查发现，河北省仍有部分临床医生对”丙肝可以治愈"这一事实认识不足，半数医生不知道 “直接抗病毒药物是治疗丙肝最有效的方法”，还有部分医生对医院关于治疗药物的报销政策了解不够。这反映出部分医生未能及时跟进丙肝相关的研究进展和政策变化，建议临床医生及时学习，拓宽自身在丙肝防治领域的知识面。
本次调查中超过80%的调查对象表示有培训需求，因此，定期开展专业培训十分必要。另外，三级医院的临床医生知晓率高于二级及以下医院，这可能是因为三级医院接诊病例数量较多，为医生提供的培训与学习机会也更为丰富，使得医生的专业知识储备更加充足。
本研究发现，临床医生的丙肝防治专业知识掌握程度与学历、科室类别、医院等级和类型以及近一年是否参加丙肝培训密切相关，这与陕西省的研究结果存在部分差异[17]。一般来说，临床医生学历越高，接受系统教育的机会越多，接触和学习丙肝相关知识的渠道也更为广泛，因此知晓率更高。感染性疾病科医生由于日常工作中接触和诊断的丙肝病例较多，且承担着丙肝病例的后续治疗和随访工作，其专业知识知晓率相对较高，这就提示我们应更加重视对非感染科科室医生的培训。同时，从临床医生接受丙肝相关知识培训角度看，接受过的专业知识掌握程度高于未接受培训人员，这与其他研究结果一致[18]。
综上所述，河北省临床医生在丙肝专业知识方面，尤其是诊断和治疗方面，存在较大提升空间。医疗机构应加大培训力度，特别是针对基层临床医生。培训内容应全面涵盖丙肝病原学基础知识、诊断标准、治疗方案以及政策要求等方面。同时，建立完善的丙肝诊疗标准考核机制，以考核促进更深一层学习。卫生行政主管部门也要建立常态化督导机制，加强对医疗机构丙肝诊断规范宣传执行情况的监督检查，促使各医疗机构充分认识到丙肝防治工作的重要性，以此推动丙肝防治工作整体水平的显著提升。
基金
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  • 河北省重点研发计划自筹项目(172777185)
文献
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2025年第52卷第19期
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doi: 10.20043/j.cnki.MPM.202502135
  • 接收时间：2025-02-11
  • 首发时间：2026-03-17
  • 出版时间：2025-10-10
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  • 收稿日期：2025-02-11
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河北省重点研发计划自筹项目(172777185)
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    1.河北省疾病预防控制中心性病艾滋病防治所，河北 石家庄 050021
    2.河北医科大学公共卫生学院

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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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