首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1240722571180691617, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202504461, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1745596800000, receivedDateStr=2025-04-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773740912480, onlineDateStr=2026-03-17, pubDate=1760025600000, pubDateStr=2025-10-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773740912480, onlineIssueDateStr=2026-03-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773740912480, creator=13701087609, updateTime=1773740912480, updator=13701087609, issue=Issue{id=1240722566957027366, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='19', pageStart='3457', pageEnd='3648', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=0, createTime=1773740911472, creator=13701087609, updateTime=1773740981732, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1240722861736906836, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1240722861736906837, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=3471, endPage=3477, ext={EN=ArticleExt(id=1240722571457515705, articleId=1240722571180691617, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Construction and validation of a death risk prediction model for Klebsiella pneumoniae infection patients, columnId=1240413921954295836, journalTitle=Modern Preventive Medicine, columnName=Epidemiology and Statistical Methods, runingTitle=null, highlight=null, articleAbstract=

Objective To establish a prediction model to assess the risk of death in patients with Klebsiella pneumoniae (Kp) infection, and to provide a reference for the development of targeted prevention and control strategies for nosocomial infections. Methods Patients with Klebsiella pneumoniae(Kp) infection at the Affiliated Hospital of Guizhou Medical University from January 2020 to December 2022 were used as the training dataset. LASSO-logistic regression was applied to identify independent risk factors for death in Kp-infected patients, and a mortality risk nomogram was constructed. Patients with Kp infection from January 2023 to December 2023 were used as the validation dataset. Model discrimination, accuracy, and clinical utility were comprehensively evaluated using the area under the receiver operating characteristic curve (ROC), the calibration curve, and the decision analysis curve. Results A total of 1 972 Kp-infected patients were included in the training dataset, of which 234 Kp-infected patients died with a mortality rate of 11.87%. A total of 1 148 Kp-infected patients were included in the validation dataset, of which 126 Kp-infected patients died with a mortality rate of 10.98%. The results of LASSO-logistic regression modeling showed that patients aged >70 years, carbapenem resistance, mechanical ventilation, indwelling urinary catheter, diabetes mellitus, hematologic infections, white blood cell count >10×109/L and hemoglobin <115 g/L were all associated factors for death in patients with Kp infection (OR=24.6, 95% CI: 16.56-39.38; OR=2.44, 95% CI: 1.70-3.52; OR=4.97, 95% CI: 3.08-8.21; OR=2.99, 95% CI: 1.75-5.19; OR=18.24, 95% CI: 9.27-38.12; OR=2.75, 95% CI: 1.69-4.49; OR=4.18, 95% CI: 2.88-6.09; OR=2.65, 95% CI: 1.79-3.93). The areas under the ROC curve of the training dataset and validation dataset were 0.900 (95% CI: 0.876-0.924) and 0.843 (95% CI: 0.812-0.874), respectively. The calibration curve was close to the baseline curve, and the decision analysis curve was close to the upper right corner. Conclusion By analyzing the factors related to the death of Kp-infected patients, we constructed a nomogram prediction model of the risk of death of Kp-infected patients, which has good accuracy, discrimination, and clinical utility, and according to which targeted nosocomial infection prevention and control measures can be implemented.

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Min CHEN, Jun-lin YANG, Jing-jing LI, Xi YANG), CN=ArticleExt(id=1240722573454004544, articleId=1240722571180691617, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=肺炎克雷伯菌感染患者死亡风险预测模型的构建与验证, columnId=1228016567632462653, journalTitle=现代预防医学, columnName=流行病与统计方法, runingTitle=null, highlight=null, articleAbstract=

目的 建立预测模型评估肺炎克雷伯菌（Klebsiella pneumoniae，Kp）感染患者死亡风险，为制定院内感染针对性防控策略提供参考。方法 选取2020年1月-2022年12月贵州医科大学附属医院的Kp感染患者为训练数据集，采用LASSO-logistic回归分析探索引起Kp感染患者死亡的独立危险因素，绘制Kp感染患者死亡风险列线图。选取2023年1月-2023年12月该院Kp感染患者为验证数据集，通过受试者工作特征曲线（receiver operating characteristic curve，ROC）及曲线下面积、校准曲线和决策分析曲线对模型的区分度、准确度和临床实用性进行综合评估。结果 训练数据集共纳入1 972例Kp感染患者，其中234例Kp感染患者死亡，死亡率为11.87%；验证数据集共纳入1 148例Kp感染患者，其中126例Kp感染患者死亡，死亡率为10.98%。LASSO-logistic回归模型结果显示患者年龄>70岁、碳青霉烯类药物耐药、机械通气、留置尿管、糖尿病、血液系统感染、白细胞计数>10×109/L和血红蛋白<115 g/L均是Kp感染患者死亡的相关因素（OR=24.6、2.44、4.97、2.99、18.24、2.75、4.18、2.65, 95%CI:16.56～39.38、1.70～3.52、3.08～8.21、1.75～5.19、9.27～38.12、1.69～4.49、2.88～6.09、1.79～3.93），训练数据集和验证数据集ROC曲线下面积分别为0.900（95%CI: 0.876～0.924）和0.843（95%CI:0.812～0.874），校准曲线靠近基准曲线，决策分析曲线靠近右上角。结论 通过分析Kp感染患者死亡的相关因素，构建Kp感染患者死亡风险列线图预测模型，该模型的准确度、区分度和临床实用性良好，可据此模型实施有针对性的院内感染防控措施。

, correspAuthors=null, authorNote=null, correspAuthorsNote=
杨俊林，E-mail:
, copyrightStatement=本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=bkajcLnU1i7mA8xxq0Mrgg==, magXml=qj6e6cGJB/hPmeGfx4PvOg==, pdfUrl=null, pdf=/wzn9u2dV+T2LInoPNu11A==, pdfFileSize=994106, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=O0JyhBGfRDv7kHcqxG22mg==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=j1rTSyCaVljoQ/qBxNSnDQ==, mapNumber=null, authorCompany=null, fund=null, authors=

陈敏（1991—），女，硕士，主管技师，研究方向：医院感染管理

, authorsList=陈敏, 杨俊林, 李晶晶, 杨曦)}, authors=[Author(id=1240933498677154329, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933498756846109, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, authorId=1240933498677154329, language=EN, stringName=Min CHEN, firstName=Min, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933498828149280, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, authorId=1240933498677154329, language=CN, stringName=陈敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004, bio={"content":"

陈敏（1991—），女，硕士，主管技师，研究方向：医院感染管理

"}, bioImg=null, bioContent=

陈敏（1991—），女，硕士，主管技师，研究方向：医院感染管理

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933498568102414, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, xref=null, ext=[AuthorCompanyExt(id=1240933498576491023, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China), AuthorCompanyExt(id=1240933498584879633, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004)])]), Author(id=1240933498941395498, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yangjlrh@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933499042058801, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, authorId=1240933498941395498, language=EN, stringName=Jun-lin YANG, firstName=Jun-lin, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933499142722100, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, authorId=1240933498941395498, language=CN, stringName=杨俊林, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933498568102414, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, xref=null, ext=[AuthorCompanyExt(id=1240933498576491023, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China), AuthorCompanyExt(id=1240933498584879633, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004)])]), Author(id=1240933499293717054, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933499394380356, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, authorId=1240933499293717054, language=EN, stringName=Jing-jing LI, firstName=Jing-jing, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933499545375307, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, authorId=1240933499293717054, language=CN, stringName=李晶晶, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933498568102414, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, xref=null, ext=[AuthorCompanyExt(id=1240933498576491023, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China), AuthorCompanyExt(id=1240933498584879633, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004)])]), Author(id=1240933499633455700, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933499713147482, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, authorId=1240933499633455700, language=EN, stringName=Xi YANG, firstName=Xi, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933499801227874, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, authorId=1240933499633455700, language=CN, stringName=杨曦, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933498568102414, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, xref=null, ext=[AuthorCompanyExt(id=1240933498576491023, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China), AuthorCompanyExt(id=1240933498584879633, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004)])])], keywords=[Keyword(id=1240933500023525996, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, orderNo=1, keyword=Klebsiella pneumoniae), Keyword(id=1240933500145160818, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, orderNo=2, keyword=LASSO-logistic regression), Keyword(id=1240933500224852597, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, orderNo=3, keyword=Nomogram), Keyword(id=1240933500342293115, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, orderNo=4, keyword=Risk factors), Keyword(id=1240933500434567808, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, orderNo=1, keyword=肺炎克雷伯菌), Keyword(id=1240933500518453895, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, orderNo=2, keyword=LASSO-logistic回归), Keyword(id=1240933500640088715, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, orderNo=3, keyword=列线图), Keyword(id=1240933500774306448, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, orderNo=4, keyword=危险因素)], refs=[Reference(id=1240933503009870634, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=14, issue=3, pageStart=167, pageEnd=181, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Opoku-Temeng C, Malachowa N, Kobayashi SD, journalName=Journal of Innate Immunity, refType=null, unstructuredReference=Opoku-Temeng C, Malachowa N, Kobayashi SD, et al. Innate host defense against klebsiella pneumoniae and the outlook for development of immunotherapies[J]. Journal of Innate Immunity,2022, 14(3): 167-181., articleTitle=Innate host defense against klebsiella pneumoniae and the outlook for development of immunotherapies, refAbstract=null), Reference(id=1240933503131505462, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=11, issue=2, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Jiang MX, Li H, Liu X, journalName=Microbiol Spectr, refType=null, unstructuredReference=Jiang MX, Li H, Liu X, et al. Genomic analysis revealed the international and domestic transmission of Carbapenem-Resistant klebsiella pneumoniae in Chinese pediatric patients[J].Microbiol Spectr, 2023, 11(2): e0321322., articleTitle=Genomic analysis revealed the international and domestic transmission of Carbapenem-Resistant klebsiella pneumoniae in Chinese pediatric patients, refAbstract=null), Reference(id=1240933503232168766, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=400, issue=10369, pageStart=2221, pageEnd=2248, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=GBD 2019 Antimicrobial Resistance Collaborators, journalName=Lancet, refType=null, unstructuredReference=GBD 2019 Antimicrobial Resistance Collaborators. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet,2022, 400(10369): 2221-2248., articleTitle=Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019, refAbstract=null), Reference(id=1240933503349609285, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=22, issue=6, pageStart=680, pageEnd=687, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=黄丽萍, 林嘉萍, 余雪莹, journalName=中国感染与化疗杂志, refType=null, unstructuredReference=黄丽萍，林嘉萍，余雪莹，等.114例成人肺炎克雷伯菌血流感染的临床特征及预后[J].中国感染与化疗杂志，2022，22（6）：680-687., articleTitle=114例成人肺炎克雷伯菌血流感染的临床特征及预后, refAbstract=null), Reference(id=1240933503454466893, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=22, issue=6, pageStart=680, pageEnd=687, url=null, language=null, rfNumber=[4], rfOrder=4, authorNames=Huang LP, Lin JP, Yu XY, journalName=Chinese Journal of Infection and Chemotherapy, refType=null, unstructuredReference=Huang LP, Lin JP, Yu XY, et al. Clinical characteristics and outcomes of 114 bloodstream infections caused by Klebsiella pneumoniae in adult patients[J]. Chinese Journal of Infection and Chemotherapy, 2022, 22(6):680-687.(In Chinese), articleTitle=Clinical characteristics and outcomes of 114 bloodstream infections caused by Klebsiella pneumoniae in adult patients, refAbstract=null), Reference(id=1240933503567713109, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=23, issue=30, pageStart=3789, pageEnd=3797, url=null, language=null, rfNumber=[5], rfOrder=5, authorNames=刘小婷, 杨欢, 姚红, journalName=中国全科医学, refType=null, unstructuredReference=刘小婷，杨欢，姚红，等.碳青霉烯类耐药肺炎克雷伯菌感染死亡风险预测模型的建立及其对患者预后的预测价值研究[J].中国全科医学，2020，23（30）：3789-3797., articleTitle=碳青霉烯类耐药肺炎克雷伯菌感染死亡风险预测模型的建立及其对患者预后的预测价值研究, refAbstract=null), Reference(id=1240933503689347930, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=23, issue=30, pageStart=3789, pageEnd=3797, url=null, language=null, rfNumber=[5], rfOrder=6, authorNames=Liu XT, Yang H, Yao H, journalName=Chinese General Practice, refType=null, unstructuredReference=Liu XT, Yang H, Yao H, et al. Development and prognostic value of a mortality risk prediction model in patients with carbapenem-resistant klebsiella pneumoniae infection[J]. Chinese General Practice, 2020, 23(30): 3789-3797.(In Chinese), articleTitle=Development and prognostic value of a mortality risk prediction model in patients with carbapenem-resistant klebsiella pneumoniae infection, refAbstract=null), Reference(id=1240933503815177061, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=28, issue=1, pageStart=10, pageEnd=18, url=null, language=null, rfNumber=[6], rfOrder=7, authorNames=Tran TN, Vu DH, Nguyen HA, journalName=Journal of Infection and Chemotherapy, refType=null, unstructuredReference=Tran TN, Vu DH, Nguyen HA, et al. Predicting mortality in intensive care unit patients infected with Klebsiella pneumoniae: A retrospective cohort study[J]. Journal of Infection and Chemotherapy,2022, 28(1): 10-18., articleTitle=Predicting mortality in intensive care unit patients infected with Klebsiella pneumoniae: A retrospective cohort study, refAbstract=null), Reference(id=1240933503928423278, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=55, issue=1, pageStart=101, pageEnd=113, url=null, language=null, rfNumber=[7], rfOrder=8, authorNames=Giacobbe DR, Di Pilato V, Karaiskos I, journalName=Annals of Medicine, refType=null, unstructuredReference=Giacobbe DR, Di Pilato V, Karaiskos I, et al.Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades[J].Annals of Medicine, 2023, 55(1): 101-113., articleTitle=Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades, refAbstract=null), Reference(id=1240933504041669496, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2024, volume=15, issue=null, pageStart=1439116, pageEnd=1439127, url=null, language=null, rfNumber=[8], rfOrder=9, authorNames=Yao HJ, Yang Y, Yao HM, journalName=Frontiers in Pharmacology, refType=null, unstructuredReference=Yao HJ, Yang Y, Yao HM, et al. Development of prediction models for carbapenem-resistant Klebsiella pneumoniae acquisition and prognosis in adult patients[J]. Frontiers in Pharmacology, 2024,15: 1439116-1439127., articleTitle=Development of prediction models for carbapenem-resistant Klebsiella pneumoniae acquisition and prognosis in adult patients, refAbstract=null), Reference(id=1240933504142332799, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=13, issue=null, pageStart=1157010, pageEnd=1157019, url=null, language=null, rfNumber=[9], rfOrder=10, authorNames=Li D, Huang XN, Rao HY, journalName=Frontiers in Cellular and Infection Microbiology, refType=null, unstructuredReference=Li D, Huang XN, Rao HY, et al. Klebsiella pneumoniae bacteremia mortality: a systematic review and meta-analysis[J]. Frontiers in Cellular and Infection Microbiology, 2023, 13: 1157010-1157019., articleTitle=Klebsiella pneumoniae bacteremia mortality: a systematic review and meta-analysis, refAbstract=null), Reference(id=1240933504280744839, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=177, issue=null, pageStart=106026, pageEnd=106037, url=null, language=null, rfNumber=[10], rfOrder=11, authorNames=Chen Q, Wang M, Han MX, journalName=Microbial Pathogenesis, refType=null, unstructuredReference=Chen Q, Wang M, Han MX, et al. Molecular basis of Klebsiella pneumoniae colonization in host[J]. Microbial Pathogenesis, 2023, 177: 106026-106037., articleTitle=Molecular basis of Klebsiella pneumoniae colonization in host, refAbstract=null), Reference(id=1240933504435934092, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2025, volume=18, issue=null, pageStart=1611, pageEnd=1628, url=null, language=null, rfNumber=[11], rfOrder=12, authorNames=Jin SS, Wang WQ, Jiang YH, journalName=Infection and Drug Resistance, refType=null, unstructuredReference=Jin SS, Wang WQ, Jiang YH, et al. A comprehensive overview of klebsiella pneumoniae: resistance dynamics, clinical manifestations,and therapeutic options[J]. Infection and Drug Resistance, 2025, 18:1611-1628., articleTitle=A comprehensive overview of klebsiella pneumoniae: resistance dynamics, clinical manifestations,and therapeutic options, refAbstract=null), Reference(id=1240933504532403092, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=41, issue=12, pageStart=791, pageEnd=796, url=null, language=null, rfNumber=[12], rfOrder=13, authorNames=秦家元, 匡欢, 吕晓菊, journalName=中华传染病杂志, refType=null, unstructuredReference=秦家元， 匡欢， 吕晓菊.碳青霉烯耐药肺炎克雷伯菌分子流行病学与感染防治的研究进展[J].中华传染病杂志，2023，41（12）：791-796., articleTitle=碳青霉烯耐药肺炎克雷伯菌分子流行病学与感染防治的研究进展, refAbstract=null), Reference(id=1240933504633066395, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=41, issue=12, pageStart=791, pageEnd=796, url=null, language=null, rfNumber=[12], rfOrder=14, authorNames=Qin JY, Kuang H, Lv XJ, journalName=Chinese Journal of Infectious Diseases, refType=null, unstructuredReference=Qin JY, Kuang H, Lv XJ. Molecular epidemiology and infection control advances in carbapenem-resistant klebsiella pneumoniae[J]. Chinese Journal of Infectious Diseases, 2023, 41(12): 791-796.(In Chinese), articleTitle=Molecular epidemiology and infection control advances in carbapenem-resistant klebsiella pneumoniae, refAbstract=null), Reference(id=1240933504754701221, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2019, volume=63, issue=7, pageStart=e00355, pageEnd=19, url=null, language=null, rfNumber=[13], rfOrder=15, authorNames=Diekema DJ, Hsueh PR, Mendes RE, journalName=Antimicrobial Agents and Chemotherapy, refType=null, unstructuredReference=Diekema DJ, Hsueh PR, Mendes RE, et al. The microbiology of bloodstream infection: 20-Year trends from the SENTRY antimicrobial surveillance program[J]. Antimicrobial Agents and Chemotherapy, 2019, 63(7): e00355-19., articleTitle=The microbiology of bloodstream infection: 20-Year trends from the SENTRY antimicrobial surveillance program, refAbstract=null), Reference(id=1240933504834393006, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=1997, volume=350, issue=9080, pageStart=783, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=16, authorNames=Mackenzie FM, Forbes KJ, Dorai-John T, journalName=Lancet, refType=null, unstructuredReference=Mackenzie FM, Forbes KJ, Dorai-John T, et al. Emergence of a carbapenem-resistant Klebsiella pneumoniae[J]. Lancet, 1997, 350(9080): 783., articleTitle=Emergence of a carbapenem-resistant Klebsiella pneumoniae, refAbstract=null), Reference(id=1240933504951833526, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2024, volume=24, issue=1, pageStart=465, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=17, authorNames=Wu CY, Huang Y, Zhou PY, journalName=BMC Microbiology, refType=null, unstructuredReference=Wu CY, Huang Y, Zhou PY, et al. Emergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae from 2014 - 2021 in Central and Eastern China: a molecular, biological, and epidemiological study[J]. BMC Microbiology, 2024, 24(1): 465., articleTitle=Emergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae from 2014 - 2021 in Central and Eastern China: a molecular, biological, and epidemiological study, refAbstract=null), Reference(id=1240933505060885434, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=11, issue=1, pageStart=17, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=18, authorNames=Chen YB, Ji JR, Ying CQ, journalName=Antimicrobial Resistance and Infection Control, refType=null, unstructuredReference=Chen YB, Ji JR, Ying CQ, et al.Blood bacterial resistant investigation collaborative system (BRICS) report: a National surveillance in China from 2014 to 2019[J]. Antimicrobial Resistance and Infection Control, 2022, 11(1): 17., articleTitle=Blood bacterial resistant investigation collaborative system (BRICS) report: a National surveillance in China from 2014 to 2019, refAbstract=null), Reference(id=1240933505157354432, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2017, volume=111, issue=5, pageStart=240, pageEnd=246, url=null, language=null, rfNumber=[17], rfOrder=19, authorNames=Veeraraghavan B, Shankar C, Karunasree S, journalName=Pathogens and Global Health, refType=null, unstructuredReference=Veeraraghavan B, Shankar C, Karunasree S, et al. Carbapenem resistant Klebsiella pneumoniae isolated from bloodstream infection:Indian experience[J]. Pathogens and Global Health, 2017, 111(5):240-246., articleTitle=Carbapenem resistant Klebsiella pneumoniae isolated from bloodstream infection:Indian experience, refAbstract=null), Reference(id=1240933505287377868, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=22, issue=1, pageStart=573, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=20, authorNames=Chen YL, Chen Y, Liu PJ, journalName=BMC Geriatrics, refType=null, unstructuredReference=Chen YL, Chen Y, Liu PJ, et al. Risk factors and mortality for elderly patients with bloodstream infection of carbapenem resistance Klebsiella pneumoniae: a 10-year longitudinal study[J]. BMC Geriatrics, 2022, 22(1): 573., articleTitle=Risk factors and mortality for elderly patients with bloodstream infection of carbapenem resistance Klebsiella pneumoniae: a 10-year longitudinal study, refAbstract=null), Reference(id=1240933505404818386, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=9, issue=1, pageStart=79, pageEnd=null, url=null, language=null, rfNumber=[19], rfOrder=21, authorNames=Li YY, Li JH, Hu T, journalName=Antimicrobial Resistance and Infection Control, refType=null, unstructuredReference=Li YY, Li JH, Hu T, et al. Five-year change of prevalence and risk factors for infection and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary hospital in North China[J]. Antimicrobial Resistance and Infection Control, 2020, 9(1):79., articleTitle=Five-year change of prevalence and risk factors for infection and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary hospital in North China, refAbstract=null), Reference(id=1240933505530647511, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2012, volume=55, issue=7, pageStart=943, pageEnd=950, url=null, language=null, rfNumber=[20], rfOrder=22, authorNames=Tumbarello M, Viale P, Viscoli C, journalName=Clinical Infectious Diseases, refType=null, unstructuredReference=Tumbarello M, Viale P, Viscoli C, et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy[J]. Clinical Infectious Diseases, 2012, 55(7):943-950., articleTitle=Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy, refAbstract=null), Reference(id=1240933505627116508, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2008, volume=29, issue=12, pageStart=1099, pageEnd=1106, url=null, language=null, rfNumber=[21], rfOrder=23, authorNames=Patel G, Huprikar S, Factor SH, journalName=Infection Control and Hospital Epidemiology: the Official Journal of the Society of Hospital Epidemiologists of America, refType=null, unstructuredReference=Patel G, Huprikar S, Factor SH, et al. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies[J]. Infection Control and Hospital Epidemiology: the Official Journal of the Society of Hospital Epidemiologists of America, 2008, 29(12): 1099-1106., articleTitle=Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies, refAbstract=null), Reference(id=1240933505761334243, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=29, issue=1, pageStart=43, pageEnd=48, url=null, language=null, rfNumber=[22], rfOrder=24, authorNames=刘秀凤, 肖志军, 唐群力, journalName=老年医学与保健, refType=null, unstructuredReference=刘秀凤，肖志军，唐群力，等.老年住院患者感染肺炎克雷伯菌的临床特点及耐药性分析[J].老年医学与保健，2023，29（1）：43-48., articleTitle=老年住院患者感染肺炎克雷伯菌的临床特点及耐药性分析, refAbstract=null), Reference(id=1240933505870386154, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=29, issue=1, pageStart=43, pageEnd=48, url=null, language=null, rfNumber=[22], rfOrder=25, authorNames=Liu XF, Xiao ZJ, Tang QL, journalName=Geriatrics & Health Care, refType=null, unstructuredReference=Liu XF, Xiao ZJ, Tang QL, et al. Analysis of clinical characteristics and drug resistance of Klebsiella pneumoniae infection in elderly inpatients[J].Geriatrics & Health Care, 2023, 29(1): 43-48.(In Chinese), articleTitle=Analysis of clinical characteristics and drug resistance of Klebsiella pneumoniae infection in elderly inpatients, refAbstract=null), Reference(id=1240933506038158322, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2024, volume=24, issue=2, pageStart=162, pageEnd=170, url=null, language=null, rfNumber=[23], rfOrder=26, authorNames=李晓君, 黄兴辉, 周晓红, journalName=中国感染与化疗杂志, refType=null, unstructuredReference=李晓君，黄兴辉，周晓红，等.老年患者碳青霉烯类耐药肺炎克雷伯菌血流感染危险因素及预后分析[J].中国感染与化疗杂志，2024，24（2）：162-170., articleTitle=老年患者碳青霉烯类耐药肺炎克雷伯菌血流感染危险因素及预后分析, refAbstract=null), Reference(id=1240933506205930491, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2024, volume=24, issue=2, pageStart=162, pageEnd=170, url=null, language=null, rfNumber=[23], rfOrder=27, authorNames=Li XJ, Huang XH, Zhou XH, journalName=Chinese Journal of Infection and Chemotherapy, refType=null, unstructuredReference=Li XJ, Huang XH, Zhou XH, et al. Risk factors and prognosis of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in elderly patients[J]. Chinese Journal of Infection and Chemotherapy, 2024,24(2): 162-170.(In Chinese), articleTitle=Risk factors and prognosis of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in elderly patients, refAbstract=null), Reference(id=1240933506432421892, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2009, volume=122, issue=3, pageStart=315, pageEnd=318, url=null, language=null, rfNumber=[24], rfOrder=28, authorNames=Wang S, Li D, Chu YZ, journalName=Chin Med J(Engl), refType=null, unstructuredReference=Wang S, Li D, Chu YZ, et al. Determination of oropharyngeal pathogenic colonization in the elderly community[J]. Chin Med J(Engl), 2009, 122(3): 315-318., articleTitle=Determination of oropharyngeal pathogenic colonization in the elderly community, refAbstract=null), Reference(id=1240933506570833929, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=33, issue=11, pageStart=972, pageEnd=975, url=null, language=null, rfNumber=[25], rfOrder=29, authorNames=张婧, 薛恒怡, 李妍妍, journalName=武警医学, refType=null, unstructuredReference=张婧，薛恒怡，李妍妍，等.高龄患者住院期间死亡的影响因素探讨[J].武警医学，2022，33（11）：972-975., articleTitle=高龄患者住院期间死亡的影响因素探讨, refAbstract=null), Reference(id=1240933506692468750, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=33, issue=11, pageStart=972, pageEnd=975, url=null, language=null, rfNumber=[25], rfOrder=30, authorNames=Zhang J, Xue HY, Li YY, journalName=Medical Journal of the Chinese People's Armed Police Forces, refType=null, unstructuredReference=Zhang J, Xue HY, Li YY, et al. Influencing factors of in-hospital mortality of aged patients[J]. Medical Journal of the Chinese People's Armed Police Forces, 2022, 33(11): 972-975.(In Chinese), articleTitle=Influencing factors of in-hospital mortality of aged patients, refAbstract=null), Reference(id=1240933506793132052, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=22, issue=5, pageStart=538, pageEnd=539, url=null, language=null, rfNumber=[26], rfOrder=31, authorNames=陈镇凡, 许桂英, 董凤英, journalName=中华保健医学杂志, refType=null, unstructuredReference=陈镇凡，许桂英，董凤英，等.住院老年患者贫血与衰弱表型的相关性研究[J].中华保健医学杂志，2020，22（5）：538-539., articleTitle=住院老年患者贫血与衰弱表型的相关性研究, refAbstract=null), Reference(id=1240933506960904221, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=22, issue=5, pageStart=538, pageEnd=539, url=null, language=null, rfNumber=[26], rfOrder=32, authorNames=Chen ZF, Xu GY, Dong FY, journalName=Chinese Journal of Health Care and Medicine, refType=null, unstructuredReference=Chen ZF, Xu GY, Dong FY, et al. Association between anemia and frailty phenotype in hospitalized elderly patients[J]. Chinese Journal of Health Care and Medicine, 2020, 22(5): 538-539.(In Chinese), articleTitle=Association between anemia and frailty phenotype in hospitalized elderly patients, refAbstract=null), Reference(id=1240933507032207393, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=33, authorNames=刘思宏, journalName=null, refType=null, unstructuredReference=刘思宏.WBC与PCT联合检测对泌尿系感染进展为尿源性脓毒血症的早期预测价值[D].广州：广州医科大学，2023., articleTitle=WBC与PCT联合检测对泌尿系感染进展为尿源性脓毒血症的早期预测价值, refAbstract=null), Reference(id=1240933507128676393, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2023, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=34, authorNames=Liu SH, journalName=null, refType=null, unstructuredReference=Liu SH. Combined detection of WBC and PCT for early prediction of progression from urinary tract infection to urosepsis[D]. Guangzhou:Guangzhou Medical University, 2023.(In Chinese), articleTitle=Combined detection of WBC and PCT for early prediction of progression from urinary tract infection to urosepsis, refAbstract=null), Reference(id=1240933507225145390, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=21, issue=null, pageStart=306, pageEnd=313, url=null, language=null, rfNumber=[28], rfOrder=35, authorNames=Li JH, Li YY, Song N, journalName=Journal of Global Antimicrobial Resistance, refType=null, unstructuredReference=Li JH, Li YY, Song N, et al. Risk factors for carbapenem-resistant Klebsiella pneumoniae infection: A meta-analysis[J].Journal of Global Antimicrobial Resistance, 2020, 21: 306-313., articleTitle=Risk factors for carbapenem-resistant Klebsiella pneumoniae infection: A meta-analysis, refAbstract=null), Reference(id=1240933507313225775, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=13, issue=5, pageStart=784, pageEnd=790, url=null, language=null, rfNumber=[29], rfOrder=36, authorNames=Chang H, Wei J, Zhou W, journalName=Journal of Infection and Public Health, refType=null, unstructuredReference=Chang H, Wei J, Zhou W, et al.Risk factors and mortality for patients with Bloodstream infections of Klebsiella pneumoniae during 2014-2018: Clinical impact of carbapenem resistance in a large tertiary hospital of China[J]. Journal of Infection and Public Health,2020, 13(5): 784-790., articleTitle=Risk factors and mortality for patients with Bloodstream infections of Klebsiella pneumoniae during 2014-2018: Clinical impact of carbapenem resistance in a large tertiary hospital of China, refAbstract=null), Reference(id=1240933507430666292, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2022, volume=9, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[30], rfOrder=37, authorNames=Cheng SY, Wang H, Lin SH, journalName=Front Cardiovasc Med, refType=null, unstructuredReference=Cheng SY, Wang H, Lin SH, et al. Association of admission hyperglycemia and all-cause mortality in acute myocardial infarction with percutaneous coronary intervention: A dose-response meta-analysis[J]. Front Cardiovasc Med, 2022, 9: 932716., articleTitle=Association of admission hyperglycemia and all-cause mortality in acute myocardial infarction with percutaneous coronary intervention: A dose-response meta-analysis, refAbstract=null), Reference(id=1240933507552301116, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=12, issue=4, pageStart=348, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=38, authorNames=Yang YT, Liu XD, journalName=Pharmaceutics, refType=null, unstructuredReference=Yang YT, Liu XD.Imbalance of drug Transporter-CYP450s interplay by diabetes and its clinical significance[J]. Pharmaceutics,2020, 12(4): 348., articleTitle=Imbalance of drug Transporter-CYP450s interplay by diabetes and its clinical significance, refAbstract=null), Reference(id=1240933507690713148, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, doi=null, pmid=null, pmcid=null, year=2020, volume=21, issue=null, pageStart=924556, pageEnd=924563, url=null, language=null, rfNumber=[32], rfOrder=39, authorNames=Ray A, Sharma S, Atal S, journalName=American Journal of Case Reports, refType=null, unstructuredReference=Ray A, Sharma S, Atal S, et al. Tigecycline-Induced severe hypoglycemia in a Non-Diabetic individual: a case report and brief review of Tigecycline-Induced severe hypoglycemia[J].American Journal of Case Reports, 2020, 21: 924556-924563., articleTitle=Tigecycline-Induced severe hypoglycemia in a Non-Diabetic individual: a case report and brief review of Tigecycline-Induced severe hypoglycemia, refAbstract=null)], funds=[Fund(id=1240933502552691459, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, awardId=黔教技[2024]104号, language=CN, fundingSource=贵州省教育厅高等学校自然科学研究项目(黔教技[2024]104号), fundOrder=null, country=null), Fund(id=1240933502632383244, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, awardId=黔科合基础[2024]青年282, language=CN, fundingSource=贵州省科技厅基础研究计划（自然科学）青年引导项目(黔科合基础[2024]青年282), fundOrder=null, country=null), Fund(id=1240933502716269333, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, awardId=2024116K, language=CN, fundingSource=贵州医科大学附属医院IIT项目(2024116K), fundOrder=null, country=null), Fund(id=1240933502816932636, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, awardId=研究者GE2023YGK-259, language=CN, fundingSource=贵州医科大学附属医院GCP项目(研究者GE2023YGK-259), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1240933498568102414, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, xref=null, ext=[AuthorCompanyExt(id=1240933498576491023, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China), AuthorCompanyExt(id=1240933498584879633, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, companyId=1240933498568102414, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004)])], figs=[ArticleFig(id=1240933501013381791, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, label=Figure 1, caption=The cross-validation curve and coefficient path plot of LASSO regression analysis, figureFileSmall=pagEMh+O5uoF+PJKlGz7Yg==, figureFileBig=TJxTh7WN34WuBcwmywusRQ==, tableContent=null), ArticleFig(id=1240933501135016615, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, label=图1, caption=LASSO回归分析交叉验证曲线LASSO系数路径图

注：图A为交叉验证曲线；图B为LASSO系数路径图。

, figureFileSmall=pagEMh+O5uoF+PJKlGz7Yg==, figureFileBig=TJxTh7WN34WuBcwmywusRQ==, tableContent=null), ArticleFig(id=1240933501311177399, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, label=Figure 2, caption=Nomogram for predicting mortality risk in patients with Kp infection, figureFileSmall=IUXZFFvFgainI5BF5lJ1dg==, figureFileBig=rNXNm96L7npheCab7+j1IA==, tableContent=null), ArticleFig(id=1240933501508309693, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, label=图2, caption=Kp感染患者死亡风险列线图

注：HGB为血红蛋白。

, figureFileSmall=IUXZFFvFgainI5BF5lJ1dg==, figureFileBig=rNXNm96L7npheCab7+j1IA==, tableContent=null), ArticleFig(id=1240933501629944519, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, label=Figure 3, caption=ROC curve for mortality risk prediction in patients with Kp infection, figureFileSmall=rhhzLV41AG0bBhqqGZrDWQ==, figureFileBig=7dNGvS9m4pFdrOsB/ffcKA==, tableContent=null), ArticleFig(id=1240933501718024910, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, label=图3, caption=Kp感染患者死亡风险ROC曲线, figureFileSmall=rhhzLV41AG0bBhqqGZrDWQ==, figureFileBig=7dNGvS9m4pFdrOsB/ffcKA==, tableContent=null), ArticleFig(id=1240933501818688214, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, label=Figure 4, caption=Calibration curves for mortality risk prediction in Kp-infected patients, figureFileSmall=qACNwLYhtO2dCignP0jOqg==, figureFileBig=0YzjNps5EVYE0bgeVXgsOA==, tableContent=null), ArticleFig(id=1240933501919351517, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, label=图4, caption=Kp感染患者死亡风险校准曲线

注：图A训练数据集；图B验证数据集。

, figureFileSmall=qACNwLYhtO2dCignP0jOqg==, figureFileBig=0YzjNps5EVYE0bgeVXgsOA==, tableContent=null), ArticleFig(id=1240933502003237601, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, label=Figure 5, caption=Decision curve analysis for mortality risk prediction in Kp-infected patients, figureFileSmall=1DOoNnovthI4exBkVJPRrg==, figureFileBig=m2plVIKNaGdRK2f1a56eDg==, tableContent=null), ArticleFig(id=1240933502129066728, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, label=图5, caption=Kp感染患者死亡风险DCA曲线

注：图A训练数据集；图B验证数据集。

, figureFileSmall=1DOoNnovthI4exBkVJPRrg==, figureFileBig=m2plVIKNaGdRK2f1a56eDg==, tableContent=null), ArticleFig(id=1240933502233924335, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=EN, label=Table 1, caption=

Baseline characteristics of the training and validation sets ［n（%）］

, figureFileSmall=null, figureFileBig=null, tableContent=
项目数据集人数t/χ2值P值
训练集(n=1 972)验证集(n=1 148)
性别男1 304 (66.1)786 (68.5)1.7980.180
女668 (33.9)362 (31.5)
年龄>70岁是850 (43.1)562 (49.0)10.0270.002
否1 122 (56.9)586 (51.0)
CRKP是486 (24.6)263 (22.9)1.1980.274
否1 486 (75.4)885 (77.1)
手术是834 (42.3)467 (40.7)0.7760.378
否1 138 (57.7)681 (59.3)
机械通气是612 (31.0)300 (26.1)8.4290.004
否1 360 (69.0)848 (73.9)
留置尿管是888 (45.0)409 (35.6)26.414<0.001
否1 084 (55.0)739 (64.4)
留置血管导管是800 (40.6)408 (35.5)7.7310.005
否1 172 (59.4)740 (64.5)
高血压是1 160 (58.8)693 (60.4)0.7160.398
否812 (41.2)455 (39.6)
糖尿病是728 (36.9)474 (41.3)5.8570.016
否1 244 (63.1)674 (58.7)
感染部位呼吸系统1 188 (60.2)717 (62.5)8.2850.141
血液系统164 (8.3)83 (7.2)
泌尿系统242 (12.3)132 (11.5)
胸腹腔180 (9.1)83 (7.2)
皮肤软组织168 (8.5)119 (10.4)
其他30 (1.5)14 (1.2)
WBC（×109/L）<4135 (6.8)66 (5.7)2.6220.270
>10484 (24.5)305 (26.6)
4～101 353 (68.6)777 (67.7)
白蛋白（g/L）<40867 (44.0)290 (25.3)117.867<0.001
40～551 101 (55.8)844 (73.5)
>554 (0.2)14 (1.2)
血红蛋白（g/L）<115472 (23.9)208 (18.1)14.940<0.001
115～1501 176 (59.6)561 (48.9)
>150324(16.4)379(33.0)
), ArticleFig(id=1240933502359753465, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722571180691617, language=CN, label=表1, caption=

训练数据集和验证数据集的基线特征［n（%）］

, figureFileSmall=null, figureFileBig=null, tableContent=
项目数据集人数t/χ2值P值
训练集(n=1 972)验证集(n=1 148)
性别男1 304 (66.1)786 (68.5)1.7980.180
女668 (33.9)362 (31.5)
年龄>70岁是850 (43.1)562 (49.0)10.0270.002
否1 122 (56.9)586 (51.0)
CRKP是486 (24.6)263 (22.9)1.1980.274
否1 486 (75.4)885 (77.1)
手术是834 (42.3)467 (40.7)0.7760.378
否1 138 (57.7)681 (59.3)
机械通气是612 (31.0)300 (26.1)8.4290.004
否1 360 (69.0)848 (73.9)
留置尿管是888 (45.0)409 (35.6)26.414<0.001
否1 084 (55.0)739 (64.4)
留置血管导管是800 (40.6)408 (35.5)7.7310.005
否1 172 (59.4)740 (64.5)
高血压是1 160 (58.8)693 (60.4)0.7160.398
否812 (41.2)455 (39.6)
糖尿病是728 (36.9)474 (41.3)5.8570.016
否1 244 (63.1)674 (58.7)
感染部位呼吸系统1 188 (60.2)717 (62.5)8.2850.141
血液系统164 (8.3)83 (7.2)
泌尿系统242 (12.3)132 (11.5)
胸腹腔180 (9.1)83 (7.2)
皮肤软组织168 (8.5)119 (10.4)
其他30 (1.5)14 (1.2)
WBC（×109/L）<4135 (6.8)66 (5.7)2.6220.270
>10484 (24.5)305 (26.6)
4～101 353 (68.6)777 (67.7)
白蛋白（g/L）<40867 (44.0)290 (25.3)117.867<0.001
40～551 101 (55.8)844 (73.5)
>554 (0.2)14 (1.2)
血红蛋白（g/L）<115472 (23.9)208 (18.1)14.940<0.001
115～1501 176 (59.6)561 (48.9)
>150324(16.4)379(33.0)
)], attaches=null, journal=Journal(id=1227664546253402114, delFlag=0, nameCn=现代预防医学, nameEn=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, issn=1003-8507, eissn=null, cn=51-1365/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=IeiuPXEZi6AA+k0VfvoiOQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Modern Preventive Medicine, journalRemark=null, publicationField=null, createdTime=1770627636734, updatedTime=1770628902248, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=IeiuPXEZi6AA+k0VfvoiOQ==, picEn=/9iTl8/ndms4tBz1fL28Pg==, jcr=null, cjcr=null, exts=[JournalExt(id=1227669854342280188, language=CN, name=现代预防医学, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1770628902278, updatedTime=1770628902278, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1227669854396806141, language=EN, name=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1770628902291, updatedTime=1770628902291, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1227665162245664772, websiteList=[Website(id=1227687234141352800, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/CN, language=CN, createTime=1770633045945, createBy=18614031015, updateTime=1770633090526, updateBy=18614031015, name=现代预防医学-中文, tplId=1146099689490845704, title=现代预防医学, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687735088051072, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=articleTextType, value=kx, createTime=1770633165380, updateTime=1770633165380, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735071273853, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=banner, value=null, createTime=1770633165376, updateTime=1770633165376, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735113216899, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=grayFlag, value=0, createTime=1770633165386, updateTime=1770633165386, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735062885244, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633165374, updateTime=1770633165374, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735125799813, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=minRunFlag, value=0, createTime=1770633165389, updateTime=1770633165389, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735083856767, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic, createTime=1770633165379, updateTime=1770633165379, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735121605508, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=silenceFlag, value=0, createTime=1770633165388, updateTime=1770633165388, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735079662462, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1770633165378, updateTime=1770633165378, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735096439681, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeColor, value=null, createTime=1770633165382, updateTime=1770633165382, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735104828290, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeStyle, value=null, createTime=1770633165384, updateTime=1770633165384, creator=18614031015, updator=18614031015)]), Website(id=1227687234338485094, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/EN, language=EN, createTime=1770633045992, createBy=18614031015, updateTime=1770633115374, updateBy=18614031015, name=现代预防医学-英文, tplId=1146101810881728533, title=Modern Preventive Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687709129507332, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=articleTextType, value=kx, createTime=1770633159191, updateTime=1770633159191, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709108535809, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=banner, value=null, createTime=1770633159186, updateTime=1770633159186, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709167256071, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=grayFlag, value=0, createTime=1770633159200, updateTime=1770633159200, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709095952896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633159183, updateTime=1770633159183, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709179838985, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=minRunFlag, value=0, createTime=1770633159203, updateTime=1770633159203, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709121118723, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic, createTime=1770633159189, updateTime=1770633159189, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709171450376, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=silenceFlag, value=0, createTime=1770633159201, updateTime=1770633159201, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709112730114, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1770633159187, updateTime=1770633159187, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709133701637, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeColor, value=null, createTime=1770633159192, updateTime=1770633159192, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709154673158, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeStyle, value=null, createTime=1770633159197, updateTime=1770633159197, creator=18614031015, updator=18614031015)])], journalTitle=现代预防医学, weixinUrl=null, journalUrl=http://xdyfyxzz.paperopen.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Modern Preventive Medicine, journalPhotoCn=IeiuPXEZi6AA+k0VfvoiOQ==, journalPhotoEn=/9iTl8/ndms4tBz1fL28Pg==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202504461, detailUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/10.20043/j.cnki.MPM.202504461, pdfUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/PDF/10.20043/j.cnki.MPM.202504461, pdfUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/PDF/10.20043/j.cnki.MPM.202504461, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
肺炎克雷伯菌感染患者死亡风险预测模型的构建与验证
收藏切换
PDF下载
陈敏 , 杨俊林 , 李晶晶 , 杨曦
现代预防医学 | 流行病与统计方法 2025,52(19): 3471-3477
收起
收藏切换
现代预防医学 | 流行病与统计方法 2025, 52(19): 3471-3477
肺炎克雷伯菌感染患者死亡风险预测模型的构建与验证
全屏
陈敏, 杨俊林 , 李晶晶, 杨曦
作者信息
  • 贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004

    • 陈敏（1991—），女，硕士，主管技师，研究方向：医院感染管理

通讯作者:

杨俊林，E-mail:
Construction and validation of a death risk prediction model for Klebsiella pneumoniae infection patients
Min CHEN, Jun-lin YANG , Jing-jing LI, Xi YANG
Affiliations
  • Department of Hospital Infection Management, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004,China
出版时间: 2025-10-10 doi: 10.20043/j.cnki.MPM.202504461
文章导航
收藏切换
摘要
收起

目的 建立预测模型评估肺炎克雷伯菌（Klebsiella pneumoniae，Kp）感染患者死亡风险，为制定院内感染针对性防控策略提供参考。方法 选取2020年1月-2022年12月贵州医科大学附属医院的Kp感染患者为训练数据集，采用LASSO-logistic回归分析探索引起Kp感染患者死亡的独立危险因素，绘制Kp感染患者死亡风险列线图。选取2023年1月-2023年12月该院Kp感染患者为验证数据集，通过受试者工作特征曲线（receiver operating characteristic curve，ROC）及曲线下面积、校准曲线和决策分析曲线对模型的区分度、准确度和临床实用性进行综合评估。结果 训练数据集共纳入1 972例Kp感染患者，其中234例Kp感染患者死亡，死亡率为11.87%；验证数据集共纳入1 148例Kp感染患者，其中126例Kp感染患者死亡，死亡率为10.98%。LASSO-logistic回归模型结果显示患者年龄>70岁、碳青霉烯类药物耐药、机械通气、留置尿管、糖尿病、血液系统感染、白细胞计数>10×109/L和血红蛋白<115 g/L均是Kp感染患者死亡的相关因素（OR=24.6、2.44、4.97、2.99、18.24、2.75、4.18、2.65, 95%CI:16.56～39.38、1.70～3.52、3.08～8.21、1.75～5.19、9.27～38.12、1.69～4.49、2.88～6.09、1.79～3.93），训练数据集和验证数据集ROC曲线下面积分别为0.900（95%CI: 0.876～0.924）和0.843（95%CI:0.812～0.874），校准曲线靠近基准曲线，决策分析曲线靠近右上角。结论 通过分析Kp感染患者死亡的相关因素，构建Kp感染患者死亡风险列线图预测模型，该模型的准确度、区分度和临床实用性良好，可据此模型实施有针对性的院内感染防控措施。

肺炎克雷伯菌  /  LASSO-logistic回归  /  列线图  /  危险因素

Objective To establish a prediction model to assess the risk of death in patients with Klebsiella pneumoniae (Kp) infection, and to provide a reference for the development of targeted prevention and control strategies for nosocomial infections. Methods Patients with Klebsiella pneumoniae(Kp) infection at the Affiliated Hospital of Guizhou Medical University from January 2020 to December 2022 were used as the training dataset. LASSO-logistic regression was applied to identify independent risk factors for death in Kp-infected patients, and a mortality risk nomogram was constructed. Patients with Kp infection from January 2023 to December 2023 were used as the validation dataset. Model discrimination, accuracy, and clinical utility were comprehensively evaluated using the area under the receiver operating characteristic curve (ROC), the calibration curve, and the decision analysis curve. Results A total of 1 972 Kp-infected patients were included in the training dataset, of which 234 Kp-infected patients died with a mortality rate of 11.87%. A total of 1 148 Kp-infected patients were included in the validation dataset, of which 126 Kp-infected patients died with a mortality rate of 10.98%. The results of LASSO-logistic regression modeling showed that patients aged >70 years, carbapenem resistance, mechanical ventilation, indwelling urinary catheter, diabetes mellitus, hematologic infections, white blood cell count >10×109/L and hemoglobin <115 g/L were all associated factors for death in patients with Kp infection (OR=24.6, 95% CI: 16.56-39.38; OR=2.44, 95% CI: 1.70-3.52; OR=4.97, 95% CI: 3.08-8.21; OR=2.99, 95% CI: 1.75-5.19; OR=18.24, 95% CI: 9.27-38.12; OR=2.75, 95% CI: 1.69-4.49; OR=4.18, 95% CI: 2.88-6.09; OR=2.65, 95% CI: 1.79-3.93). The areas under the ROC curve of the training dataset and validation dataset were 0.900 (95% CI: 0.876-0.924) and 0.843 (95% CI: 0.812-0.874), respectively. The calibration curve was close to the baseline curve, and the decision analysis curve was close to the upper right corner. Conclusion By analyzing the factors related to the death of Kp-infected patients, we constructed a nomogram prediction model of the risk of death of Kp-infected patients, which has good accuracy, discrimination, and clinical utility, and according to which targeted nosocomial infection prevention and control measures can be implemented.

Klebsiella pneumoniae  /  LASSO-logistic regression  /  Nomogram  /  Risk factors
陈敏, 杨俊林, 李晶晶, 杨曦. 肺炎克雷伯菌感染患者死亡风险预测模型的构建与验证. 现代预防医学, 2025 , 52 (19) : 3471 -3477 . DOI: 10.20043/j.cnki.MPM.202504461
Min CHEN, Jun-lin YANG, Jing-jing LI, Xi YANG. Construction and validation of a death risk prediction model for Klebsiella pneumoniae infection patients[J]. Modern Preventive Medicine, 2025 , 52 (19) : 3471 -3477 . DOI: 10.20043/j.cnki.MPM.202504461
正文
收起
肺炎克雷伯菌(Klebsiella pneumoniae, Kp)是一种革兰阴性兼性厌氧菌，属于肠杆菌目克雷伯菌属，属机会致病菌，因其高致病性和广泛的传播性成为社区或医院感染的重要致病菌[1]。Kp携带丰富的毒力和耐药基因，感染部位广泛，易引起处在医院环境下的新生儿、老年人以及免疫功能低下人群或携带基础疾病的患者发生呼吸、泌尿和血液系统等部位的感染[2]。Kp感染率引起的疾病负担是目前医疗机构面临的主要挑战之一，《柳叶刀》发表的一项全球细菌感染负担报告显示，2019年全球因细菌感染相关死亡者约有1 370万人，占同期全球死亡人数的13.6%，其中Kp是导致死亡的最常见细菌病原体之一，全球因Kp感染死亡人数超过75万人[3]。而有研究报道Kp血流感染患者的死亡率甚至可高达42.8%[4]。早期诊断和预测Kp感染患者的死亡风险对于临床管理和降低死亡率至关重要。近年来国内外学者致力于Kp感染死亡风险预测模型构建，刘小婷等[5]基于碳青霉烯类耐药肺炎克雷伯菌（carbapenem-resistant Klebsiella pneumoniae，CRKP）感染患者构建logistic模型，但未纳入常规实验室指标，如白细胞计数（white blood cell count, WBC）、白蛋白（albumin）、血红蛋白（haemoglobin），Tran等[6]针对ICU患者开发模型，但样本量较小（n=287）且未验证临床实用性。本研究结合LASSO回归优化变量筛选避免过拟合，并且纳入常规易获指标（如白红蛋白、WBC）提升临床普适性，同时基于大样本（n=3 120）构建列线图并验证实用性。鉴于此，本文通过收集并分析临床分离的Kp感染患者的相关因素，构建Kp感染患者死亡风险预测模型，及时预警并采取相关措施，为医院Kp感染性疾病防控提供理论依据。
1　对象与方法
收起
1.1　研究对象
本研究经贵州医科大学附属医院医学伦理委员会批准（伦理批件号2024027K）。研究对象包括一个训练数据集和一个验证数据集，训练数据集为2020年1月—2022年12月在贵州医科大学附属医院住院的Kp感染患者；验证数据集为2023年1月—2023年12月在贵州医科大学附属医院住院的Kp感染患者。纳入标准：住院且有完整临床资料和实验室检查资料的Kp感染患者，Kp感染的诊断依据通过血液、痰液、尿液或引流液等的培养确诊，具有不同感染部位的感染症状，采用抗生素进行治疗[7]。排除标准：排除Kp定植患者、排除从患者身上分离的污染样本、剔除重复送检病例以及数据不完整的患者。
1.2　研究方法
本研究采用回顾性队列设计，从电子病历系统提取符合标准的Kp感染患者数据，按时间划分训练集（2020-2022年）与验证集（2023年）。预测变量基于临床重要性和文献[8-9]支持确定，涵盖人口学特征（年龄、性别）、基础疾病（糖尿病、高血压）、治疗操作（机械通气、导管留置）、病原特征（CRKP）、感染部位及实验室指标（WBC、白蛋白、血红蛋白）。结局变量为患者感染Kp后30 d内的死亡率。
1.3　统计学方法
采用SPSS 23.0软件进行统计分析，定性资料采用n(%)进行描述，组间比较采用χ2检验，正态分布的定量资料采用（）进行描述，组间比较采用独立样t检验。采用R语言建立LASSO-logistic回归模型，探索Kp感染患者死亡的的相关因素，并绘制Kp感染患者死亡风险列线图。通过内部验证数据集对模型进行验证以确保其可重复性，采用受试者工作曲线(receiver operating characteristic curve，ROC）及曲线下面积(area under the curve,AUC)来评估模型区分度，采用校准曲线(calibration curve)评估模型估计的风险与实际风险的接近程度，采用决策分析曲线(decision analysis curves, DCA)来评估模型的临床实用性。检验水准α=0.05。
2　结果
收起
2.1　基本情况
训练数据集患者和验证数据集患者在性别、年龄、CRKP、手术、机械通气、留置尿管、留置血管导管、高血压、糖尿病和感染来源方面无显著差异(P>0.05)，见表1。训练数据集共纳入1 972例Kp感染患者，其中234例Kp感染患者死亡，死亡率为11.87%；验证数据集共纳入1 148例Kp感染患者，其中126例Kp感染患者死亡，死亡率为10.98%；训练数据集和验证数据集Kp感染患者死亡率无明显差异（χ2=0.564，P=0.453）。
2.2　LASSO-logistic回归分析
以纳入的13个因素作为自变量，以Kp感染患者是否死亡作为因变量，建立LASSO-logistic回归。LASSO-logistic回归模型中变量随λ值变化的筛选情况见图1，图1A是log(λ)与自变量数目对应曲线（λ.min=0.009 547，λ.se=0.020 095），图1B是log(λ)与LASSO回归系数的关系，随着λ增大，模型的各个自变量系数估计值压缩程度增大，对因变量影响较小的自变量系数被压缩至0，自变量个数减少。本研究选择λ.se=0.020 095时为最优模型，此时LASSO-logistic回归模型纳入的自变量为年龄>70岁、CRKP、机械通气、留置尿管、糖尿病、血液系统感染、WBC >10×109/L和血红蛋白<115 g/L。LASSO-logistic回归模型结果显示，年龄>70岁(OR=24.6，95%CI:16.56～39.38)、CRKP(OR=2.44，95%CI:1.70～3.52)、机械通气(OR=4.97，95%CI:3.08～8.21)、留置尿管(OR=2.99，95%CI:1.75～5.19)、糖尿病(OR=18.24，95%CI:9.27～38.12)、血液系统感染(OR=2.75，95%CI:1.69～4.49)、WBC>10×109/L(OR=4.18，95%CI:2.88～6.09)、血红蛋白<115 g/L(OR=2.65，95%CI:1.79～3.93)均是Kp感染患者死亡的相关因素。
2.3　Kp感染患者死亡风险模型建立
使用训练数据集根据LASSO-logistic回归筛选出的独立危险因素绘制Kp感染患者死亡风险列线图，依据模型中各自变量对结局变量的影响程度，对每个自变量取值水平进行赋分，每例病人各项评分相加得到总分，根据总风险评分来计算Kp感染导致死亡的可能性，实现预测模型可视化，见图2。例如，某患者感染CRKP，感染部位为血液系统，年龄75岁，需要机械通气，WBC>10×109/L，各自变量赋分别为24、100、44和40，总和208分，根据该模型可预计患者死亡概率为52%(208/400)。
2.4　模型预测性能验证
采用验证数据集对模型进行验证，AUC值在0.5～0.75之间表明模型具有中等判别性，AUC值大于0.75表明模型具有强判别性，如图3所示，使用训练数据集和验证数据集数据计算的死亡风险AUC值分别为0.900（95%CI:0.876～0.924）和0.843（95%CI:0.812～0.874），表明模型区分度较好。校准曲线是实际发生率和预测发生率的散点图，校准曲线越接近基准线，模型预测效果越好，如图4所示，校准曲线接近基准线，并且曲线绕45°对角线摆动，表示模型准确性较强。在不同的阈值下，DCA曲线越靠近右上角，说明该模型的临床临床实用性越好，如图5所示，DCA曲线分析显示当预测概率在20% ～ 80%时，模型的临床净收益相对较高。
3　讨论
收起
Kp是临床常见的机会致病菌，也是院内感染的主要菌株之一，常定居于人体的胃肠道、呼吸道和泌尿道[10]，其致病能力强，破坏性大，该菌可引起人体多个部位包括呼吸系统、泌尿系统和血流系统等部位的感染[11]。碳青霉烯类抗生素曾是治疗Kp感染的重要抗菌药物，但近年来随着广谱抗生素的广泛应用，抗生素对Kp的杀菌效果日益消减弱，Kp感染患者的临床治疗面临巨大挑战，Kp感染患者死亡率明显升高[12-13]。
本文研究结果显示，年龄>70岁、碳青霉烯类药物耐药、血液系统感染、机械通气、留置导尿、糖尿病、WBC>10×109/L和血红蛋白<115 g/L是Kp感染患者死亡的独立危险因素。自上世纪九十年代首次报道了CRKP以来[14]，全球范围内CRKP感染呈急速上升趋势，WHO把CRKP的危险级别确定为首要等级，我国CRKP的感染形势也非常严峻[15]。其中，由CRKP引起的血流感染(bloodstream infection, BSI)发生率上升较为明显，且感染后并发症多，死亡率高，已成为临床上亟待解决的难题[16]。研究显示CRKP是Kp-BSI患者死亡相关的独立危险因素之一，Kp-BSI患者的死亡率高达14%～57%[17]，与CSKP相比，CRKP-BSI患者的死亡率更高[18]。国内的一项病例对照研究显示CRKP-BSI患者的死亡率从2014年的38%上升到2019年的74%[19]，国外研究报道也显示CRKP-BSI患者的死亡率也高达41%～68%[20-21]。我国有研究发现CRKP感染多见于老年患者且有较高的死亡率[22]，老年住院患者由于有各种潜在疾病、合并基础疾病多、营养状况差和免疫功能低下等特征，是院内感染Kp的易感人群，特别容易发生呼吸道和泌尿道感染[23]。中国老年人咽部的Kp的定植率高，或是老年人群高发病率的原因[24]，本文的研究也显示年龄>70岁的患者感染Kp后，死亡风险明显升高，表现出较强的相关性。与刘小婷等[5]研究相比，本研究发现贫血（血红蛋白<115 g/L）和白细胞升高（WBC>10×109/L）是独立危险因素，提示炎症反应与营养状态对预后的影响；一项针对高龄住院患者死亡影响因素的研究结果显示，死亡组贫血比例高达62.5%[25]，贫血可引起免疫功能下降，增加感染风险，加重心肾功能恶化，也是预测住院患者不良临床预后的因子[26]。有研究也显示WBC值可以作为泌尿系统感染进展为脓毒症的早期预测指标，具有良好的应用价值[27]。一项荟萃分析研究结果显示，留置导尿管、外科手术、中心静脉置管、机械通气等侵袭性操作是感染CRKP的危险因素[28-29]。与Tran等[6]研究结论一致的是，机械通气与CRKP均为核心预测因子，但本研究进一步证实其在不同人群（非ICU患者）中的普适性。有研究表明住院患者高血糖水平与死亡率的增加相关[30]，人体高血糖状态有利于细菌的生长繁殖，并且高血糖会导致药物运输蛋白的糖化及排泄增加，从而导致药物的利用率下降[31]，此外某些抗菌药物的应用可能会导致机体代谢紊乱影响患者的血糖[32]。因此，临床医生应重视严重感染患者的血糖水平，必要时予以相应治疗措施。
本研究采用LASSO-logistic回归选择预测变量，从而降低了过拟合的风险，通过患者的基本特征和常规实验室检测数据，很容易地确定模型中的预测变量和风险指数，进而通过电子病历系统中的自动化方法将这些变量应用于临床实践，使临床实践估计中遇到的Kp感染患者的死亡风险变得容易个体化。本次研究结果显示模型在准确度、区分度和临床实用性方面都具有良好性能。本研究模型与同类预测工具相比具有独特优势：（1）实用性：列线图整合常规指标（如血红蛋白、WBC），无需复杂检测即可快速评估风险；（2）泛化性：在非ICU患者中验证AUC达0.843，优于Tran等[6]报道的ICU专用模型（AUC=0.79）；（3）防控价值：明确机械通气与留置导管为可控因素，提示可通过减少侵入性操作降低死亡率。未来需通过多中心数据进一步验证普适性。但本研究也有不足之处，一是，本研究数据的获取或纳入的变量存在信息偏倚，并且Kp感染的影响因素仍需要进一步的探索，从而优化预测模型的变量；二是，验证数据集来自同一医疗机构，内部验证效果佳，但缺乏外部数据的验证，后续可继续扩大样本量以及进行多中心外部数据验证，建立更稳定的模型。
综上所述，碳青霉烯类药物耐药、血液系统感染、年龄>70岁、高血压、糖尿病、机械通气、留置导尿是Kp感染患者死亡的独立危险因素，基于上述指标构建的列线图具有较好的预测效能，有助于识别院内Kp感染患者死亡的风险，及时采取干预措施，加强综合诊治，提高患者救治成功率。
基金
收起
  • 贵州省教育厅高等学校自然科学研究项目(黔教技[2024]104号)
  • 贵州省科技厅基础研究计划（自然科学）青年引导项目(黔科合基础[2024]青年282)
  • 贵州医科大学附属医院IIT项目(2024116K)
  • 贵州医科大学附属医院GCP项目(研究者GE2023YGK-259)
文献
收起
参考文献 引证文献
排序方式：
[1]
Opoku-Temeng C, Malachowa N, Kobayashi SD, et al. Innate host defense against klebsiella pneumoniae and the outlook for development of immunotherapies[J]. Journal of Innate Immunity,2022, 14(3): 167-181.
[2]
Jiang MX, Li H, Liu X, et al. Genomic analysis revealed the international and domestic transmission of Carbapenem-Resistant klebsiella pneumoniae in Chinese pediatric patients[J].Microbiol Spectr, 2023, 11(2): e0321322.
[3]
GBD 2019 Antimicrobial Resistance Collaborators. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet,2022, 400(10369): 2221-2248.
[4]
黄丽萍，林嘉萍，余雪莹，等.114例成人肺炎克雷伯菌血流感染的临床特征及预后[J].中国感染与化疗杂志，2022，22（6）：680-687.
Huang LP, Lin JP, Yu XY, et al. Clinical characteristics and outcomes of 114 bloodstream infections caused by Klebsiella pneumoniae in adult patients[J]. Chinese Journal of Infection and Chemotherapy, 2022, 22(6):680-687.(In Chinese)
[5]
刘小婷，杨欢，姚红，等.碳青霉烯类耐药肺炎克雷伯菌感染死亡风险预测模型的建立及其对患者预后的预测价值研究[J].中国全科医学，2020，23（30）：3789-3797.
Liu XT, Yang H, Yao H, et al. Development and prognostic value of a mortality risk prediction model in patients with carbapenem-resistant klebsiella pneumoniae infection[J]. Chinese General Practice, 2020, 23(30): 3789-3797.(In Chinese)
[6]
Tran TN, Vu DH, Nguyen HA, et al. Predicting mortality in intensive care unit patients infected with Klebsiella pneumoniae: A retrospective cohort study[J]. Journal of Infection and Chemotherapy,2022, 28(1): 10-18.
[7]
Giacobbe DR, Di Pilato V, Karaiskos I, et al.Treatment and diagnosis of severe KPC-producing Klebsiella pneumoniae infections: a perspective on what has changed over last decades[J].Annals of Medicine, 2023, 55(1): 101-113.
[8]
Yao HJ, Yang Y, Yao HM, et al. Development of prediction models for carbapenem-resistant Klebsiella pneumoniae acquisition and prognosis in adult patients[J]. Frontiers in Pharmacology, 2024,15: 1439116-1439127.
[9]
Li D, Huang XN, Rao HY, et al. Klebsiella pneumoniae bacteremia mortality: a systematic review and meta-analysis[J]. Frontiers in Cellular and Infection Microbiology, 2023, 13: 1157010-1157019.
[10]
Chen Q, Wang M, Han MX, et al. Molecular basis of Klebsiella pneumoniae colonization in host[J]. Microbial Pathogenesis, 2023, 177: 106026-106037.
[11]
Jin SS, Wang WQ, Jiang YH, et al. A comprehensive overview of klebsiella pneumoniae: resistance dynamics, clinical manifestations,and therapeutic options[J]. Infection and Drug Resistance, 2025, 18:1611-1628.
[12]
秦家元， 匡欢， 吕晓菊.碳青霉烯耐药肺炎克雷伯菌分子流行病学与感染防治的研究进展[J].中华传染病杂志，2023，41（12）：791-796.
Qin JY, Kuang H, Lv XJ. Molecular epidemiology and infection control advances in carbapenem-resistant klebsiella pneumoniae[J]. Chinese Journal of Infectious Diseases, 2023, 41(12): 791-796.(In Chinese)
[13]
Diekema DJ, Hsueh PR, Mendes RE, et al. The microbiology of bloodstream infection: 20-Year trends from the SENTRY antimicrobial surveillance program[J]. Antimicrobial Agents and Chemotherapy, 2019, 63(7): e00355-19.
[14]
Mackenzie FM, Forbes KJ, Dorai-John T, et al. Emergence of a carbapenem-resistant Klebsiella pneumoniae[J]. Lancet, 1997, 350(9080): 783.
[15]
Wu CY, Huang Y, Zhou PY, et al. Emergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae from 2014 - 2021 in Central and Eastern China: a molecular, biological, and epidemiological study[J]. BMC Microbiology, 2024, 24(1): 465.
[16]
Chen YB, Ji JR, Ying CQ, et al.Blood bacterial resistant investigation collaborative system (BRICS) report: a National surveillance in China from 2014 to 2019[J]. Antimicrobial Resistance and Infection Control, 2022, 11(1): 17.
[17]
Veeraraghavan B, Shankar C, Karunasree S, et al. Carbapenem resistant Klebsiella pneumoniae isolated from bloodstream infection:Indian experience[J]. Pathogens and Global Health, 2017, 111(5):240-246.
[18]
Chen YL, Chen Y, Liu PJ, et al. Risk factors and mortality for elderly patients with bloodstream infection of carbapenem resistance Klebsiella pneumoniae: a 10-year longitudinal study[J]. BMC Geriatrics, 2022, 22(1): 573.
[19]
Li YY, Li JH, Hu T, et al. Five-year change of prevalence and risk factors for infection and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary hospital in North China[J]. Antimicrobial Resistance and Infection Control, 2020, 9(1):79.
[20]
Tumbarello M, Viale P, Viscoli C, et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy[J]. Clinical Infectious Diseases, 2012, 55(7):943-950.
[21]
Patel G, Huprikar S, Factor SH, et al. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies[J]. Infection Control and Hospital Epidemiology: the Official Journal of the Society of Hospital Epidemiologists of America, 2008, 29(12): 1099-1106.
[22]
刘秀凤，肖志军，唐群力，等.老年住院患者感染肺炎克雷伯菌的临床特点及耐药性分析[J].老年医学与保健，2023，29（1）：43-48.
Liu XF, Xiao ZJ, Tang QL, et al. Analysis of clinical characteristics and drug resistance of Klebsiella pneumoniae infection in elderly inpatients[J].Geriatrics & Health Care, 2023, 29(1): 43-48.(In Chinese)
[23]
李晓君，黄兴辉，周晓红，等.老年患者碳青霉烯类耐药肺炎克雷伯菌血流感染危险因素及预后分析[J].中国感染与化疗杂志，2024，24（2）：162-170.
Li XJ, Huang XH, Zhou XH, et al. Risk factors and prognosis of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in elderly patients[J]. Chinese Journal of Infection and Chemotherapy, 2024,24(2): 162-170.(In Chinese)
[24]
Wang S, Li D, Chu YZ, et al. Determination of oropharyngeal pathogenic colonization in the elderly community[J]. Chin Med J(Engl), 2009, 122(3): 315-318.
[25]
张婧，薛恒怡，李妍妍，等.高龄患者住院期间死亡的影响因素探讨[J].武警医学，2022，33（11）：972-975.
Zhang J, Xue HY, Li YY, et al. Influencing factors of in-hospital mortality of aged patients[J]. Medical Journal of the Chinese People's Armed Police Forces, 2022, 33(11): 972-975.(In Chinese)
[26]
陈镇凡，许桂英，董凤英，等.住院老年患者贫血与衰弱表型的相关性研究[J].中华保健医学杂志，2020，22（5）：538-539.
Chen ZF, Xu GY, Dong FY, et al. Association between anemia and frailty phenotype in hospitalized elderly patients[J]. Chinese Journal of Health Care and Medicine, 2020, 22(5): 538-539.(In Chinese)
[27]
刘思宏.WBC与PCT联合检测对泌尿系感染进展为尿源性脓毒血症的早期预测价值[D].广州：广州医科大学，2023.
Liu SH. Combined detection of WBC and PCT for early prediction of progression from urinary tract infection to urosepsis[D]. Guangzhou:Guangzhou Medical University, 2023.(In Chinese)
[28]
Li JH, Li YY, Song N, et al. Risk factors for carbapenem-resistant Klebsiella pneumoniae infection: A meta-analysis[J].Journal of Global Antimicrobial Resistance, 2020, 21: 306-313.
[29]
Chang H, Wei J, Zhou W, et al.Risk factors and mortality for patients with Bloodstream infections of Klebsiella pneumoniae during 2014-2018: Clinical impact of carbapenem resistance in a large tertiary hospital of China[J]. Journal of Infection and Public Health,2020, 13(5): 784-790.
[30]
Cheng SY, Wang H, Lin SH, et al. Association of admission hyperglycemia and all-cause mortality in acute myocardial infarction with percutaneous coronary intervention: A dose-response meta-analysis[J]. Front Cardiovasc Med, 2022, 9: 932716.
[31]
Yang YT, Liu XD.Imbalance of drug Transporter-CYP450s interplay by diabetes and its clinical significance[J]. Pharmaceutics,2020, 12(4): 348.
[32]
Ray A, Sharma S, Atal S, et al. Tigecycline-Induced severe hypoglycemia in a Non-Diabetic individual: a case report and brief review of Tigecycline-Induced severe hypoglycemia[J].American Journal of Case Reports, 2020, 21: 924556-924563.
2025年第52卷第19期
PDF下载
85
38
引用本文
BibTeX
文章信息
doi: 10.20043/j.cnki.MPM.202504461
  • 接收时间：2025-04-26
  • 首发时间：2026-03-17
  • 出版时间：2025-10-10
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2025-04-26
基金
贵州省教育厅高等学校自然科学研究项目(黔教技[2024]104号)
贵州省科技厅基础研究计划（自然科学）青年引导项目(黔科合基础[2024]青年282)
贵州医科大学附属医院IIT项目(2024116K)
贵州医科大学附属医院GCP项目(研究者GE2023YGK-259)
作者信息
    贵州医科大学附属医院医院感染管理科，贵州 贵阳 550004

通讯作者:

杨俊林，E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202504461
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持