首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1240722568534093922, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202503554, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1743264000000, receivedDateStr=2025-03-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773740911849, onlineDateStr=2026-03-17, pubDate=1760025600000, pubDateStr=2025-10-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773740911849, onlineIssueDateStr=2026-03-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773740911849, creator=13701087609, updateTime=1773740911849, updator=13701087609, issue=Issue{id=1240722566957027366, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='19', pageStart='3457', pageEnd='3648', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=0, createTime=1773740911472, creator=13701087609, updateTime=1773740981732, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1240722861736906836, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1240722861736906837, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240722566957027366, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=3496, endPage=3502, ext={EN=ArticleExt(id=1240722568798335077, articleId=1240722568534093922, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Influencing factors of anemia and anemia exacerbation in people living with HIV/AIDS and their impact on prognosis: a retrospective cohort study, columnId=1240413921954295836, journalTitle=Modern Preventive Medicine, columnName=Epidemiology and Statistical Methods, runingTitle=null, highlight=null, articleAbstract=

Objective To investigate the influencing factors of anemia and anemia exacerbation in people living with HIV/AIDS (PLWHA) during antiretroviral therapy (ART), as well as the impact of anemia on the prognosis of PLWHA. Methods This retrospective cohort study collected baseline and follow-up data for PLHIV who initiated ART at a specialized infectious-disease hospital in Guangzhou from February 10, 2004 to March 29, 2019. A generalized linear mixed-effects model was used to analyze the factors influencing anemia during long-term ART in PLWHA without anemia at baseline. The Cox proportional hazards model was used to analyze both the influencing factors of anemia exacerbation in those with baseline anemia and the impact of baseline anemia and follow-up anemia on the prognosis. Results There were 11 688 PLWHA, of whom 3 853(32.97%) had anemia at baseline. Among 7 835 PLWHA without anemia at baseline, 1 695 (21.63%) developed anemia during the follow-up. Among 3 470 PLWHA with mild or moderate anemia at baseline, 845 (24.35%) had anemia exacerbation during the follow-up. Risk factors for follow-up anemia in PLWHA included being female, aged ≥50 years at ART initiation, being married/cohabiting, being divorced/separated/widowed, blood transmission, baseline opportunistic infections, higher number of baseline clinical symptoms, the initial ART regimen containing Zidovudine (AZT), CD4 cell count <200 cells/μL, and abnormal serum creatinine. Risk factors for anemia exacerbation included being female, being married/cohabiting, being divorced/separated/widowed, an interval of ≥6 months from diagnosis to ART initiation, ≥2 categories of baseline clinical symptoms, an initial ART regimen containing AZT, and abnormal serum creatinine. The risk of death in PLWHA without anemia at baseline but developing anemia during the follow-up was 5.02 times (95% CI: 2.45-10.27) than that among those without anemia at both baseline and during the follow-up. The risk of death with anemia at both baseline and during the follow-up was 6.00 times (95%CI: 3.04-11.85) than that among those without anemia at both baseline and during the follow-up. Conclusion Follow-up anemia and anemia exacerbation during ART are affected by multiple factors. Baseline anemia and follow-up anemia are important risk factors for the prognosis of PLWHA. Anemia screening for high-risk groups should be strengthened to strive for early detection, early diagnosis, and early treatment, thereby reducing the risk of death of PLWHA.

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Jing LIN, Li-hui FENG, Yan-qiu LI, Jun-qi OU, Xin ZHOU, Yue-ping LI, Wei-dong JIA, Yan-hui GAO, Li-xia LI), CN=ArticleExt(id=1240722569427480690, articleId=1240722568534093922, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=HIV/AIDS患者贫血、贫血加重的影响因素及其对预后的影响——一项回顾性队列研究, columnId=1228016567632462653, journalTitle=现代预防医学, columnName=流行病与统计方法, runingTitle=null, highlight=null, articleAbstract=

目的 探讨HIV/AIDS患者在抗逆转录病毒治疗（antiretroviral therapy，ART）过程中贫血、贫血加重的影响因素，及贫血对患者预后的影响。方法 回顾性收集广州市某传染病专科医院2004年2月10日—2019年3月29日首次接受ART的HIV/AIDS患者基线和随访数据，采用广义线性混合效应模型分析基线无贫血患者长期ART过程中随访贫血的影响因素，采用Cox比例风险回归模型分析基线贫血患者贫血加重的影响因素及基线贫血和随访贫血对患者预后的影响。结果 HIV/AIDS患者11 688例，基线贫血3 853例（32.97%）；7 835例基线无贫血患者在随访过程中发生贫血1 695例（21.63%），3 470例轻、中度贫血患者在随访中贫血加重845例（24.35%）。随访贫血的危险因素包括女性、开始ART年龄≥50岁、已婚/同居、离异/分居/丧偶、血液传播、基线机会性感染、基线临床症状种类数越多、初始ART方案含齐多夫定（Zidovudine，AZT）、CD4细胞计数<200个/μl、血肌酐异常。女性、已婚/同居、离异/分居/丧偶、确诊到开始ART间隔时间≥6个月、基线临床症状种类数≥2种、初始ART方案含AZT、血肌酐异常是贫血加重的危险因素。基线无贫血而随访过程中贫血患者的死亡风险是基线、随访过程中均无贫血者的5.02倍（95%CI：2.45～10.27）；基线、随访过程中均贫血患者的死亡风险是基线、随访均无贫血者的6.00倍（95%CI：3.04～11.85）。结论 患者在ART过程中随访贫血、贫血加重受多种因素影响，基线贫血和随访贫血是HIV/AIDS患者预后的重要危险因素，应加强高危人群贫血筛查，力求做到早发现、早诊断、早治疗，从而降低患者的死亡风险。

, correspAuthors=null, authorNote=null, correspAuthorsNote=
李丽霞，E-mail:；
郜艳晖，E-mail:
, copyrightStatement=本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=c4vvVCs8occ+TvcFCE7Qhw==, magXml=ll8SZb9vi/yMFLcm8p+v8A==, pdfUrl=null, pdf=c3ssFpBVhDc4ACl5h0tDLQ==, pdfFileSize=723106, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=iJ4Iw7cH9AMJ1G38O3r0eQ==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=A+V8Abb0IpbjMm/0N7ibCw==, mapNumber=null, authorCompany=null, fund=null, authors=

李丽霞与郜艳晖为共同通信作者

林婧（1999—），女，硕士在读，研究方向：疾病预防控制

, authorsList=林婧, 冯立慧, 李燕秋, 欧峻祺, 周馨, 李粤平, 贾卫东, 郜艳晖, 李丽霞)}, authors=[Author(id=1240933496710033568, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933496819085477, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933496710033568, language=EN, stringName=Jing LIN, firstName=Jing, middleName=null, lastName=LIN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933496882000038, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933496710033568, language=CN, stringName=林婧, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广东药科大学公共卫生学院，广东 广州 510310, bio={"content":"

林婧（1999—），女，硕士在读，研究方向：疾病预防控制

"}, bioImg=null, bioContent=

林婧（1999—），女，硕士在读，研究方向：疾病预防控制

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496466763922, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=1., ext=[AuthorCompanyExt(id=1240933496470958227, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China), AuthorCompanyExt(id=1240933496479346836, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广东药科大学公共卫生学院，广东 广州 510310)])]), Author(id=1240933496940720297, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933497028800686, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933496940720297, language=EN, stringName=Li-hui FENG, firstName=Li-hui, middleName=null, lastName=FENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933497133658287, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933496940720297, language=CN, stringName=冯立慧, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广东药科大学公共卫生学院，广东 广州 510310, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496466763922, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=1., ext=[AuthorCompanyExt(id=1240933496470958227, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China), AuthorCompanyExt(id=1240933496479346836, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广东药科大学公共卫生学院，广东 广州 510310)])]), Author(id=1240933497221738674, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933497326596277, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933497221738674, language=EN, stringName=Yan-qiu LI, firstName=Yan-qiu, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933497402093752, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933497221738674, language=CN, stringName=李燕秋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广东药科大学公共卫生学院，广东 广州 510310, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496466763922, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=1., ext=[AuthorCompanyExt(id=1240933496470958227, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China), AuthorCompanyExt(id=1240933496479346836, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广东药科大学公共卫生学院，广东 广州 510310)])]), Author(id=1240933497481785531, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933497553088702, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933497481785531, language=EN, stringName=Jun-qi OU, firstName=Jun-qi, middleName=null, lastName=OU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933497641169089, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933497481785531, language=CN, stringName=欧峻祺, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广东药科大学公共卫生学院，广东 广州 510310, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496466763922, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=1., ext=[AuthorCompanyExt(id=1240933496470958227, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China), AuthorCompanyExt(id=1240933496479346836, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广东药科大学公共卫生学院，广东 广州 510310)])]), Author(id=1240933497699889347, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933497804746952, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933497699889347, language=EN, stringName=Xin ZHOU, firstName=Xin, middleName=null, lastName=ZHOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933497901215949, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933497699889347, language=CN, stringName=周馨, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广东药科大学公共卫生学院，广东 广州 510310, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496466763922, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=1., ext=[AuthorCompanyExt(id=1240933496470958227, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China), AuthorCompanyExt(id=1240933496479346836, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广东药科大学公共卫生学院，广东 广州 510310)])]), Author(id=1240933497968324816, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933498052210899, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933497968324816, language=EN, stringName=Yue-ping LI, firstName=Yue-ping, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933498123514071, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933497968324816, language=CN, stringName=李粤平, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.广州医科大学附属市八医院感染ICU, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496563232919, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=2., ext=[AuthorCompanyExt(id=1240933496571621529, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496563232919, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.广州医科大学附属市八医院感染ICU)])]), Author(id=1240933498224177370, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933498320646365, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933498224177370, language=EN, stringName=Wei-dong JIA, firstName=Wei-dong, middleName=null, lastName=JIA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933498446475492, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933498224177370, language=CN, stringName=贾卫东, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, address=2.广州医科大学附属市八医院感染ICU, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496563232919, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=2., ext=[AuthorCompanyExt(id=1240933496571621529, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496563232919, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.广州医科大学附属市八医院感染ICU)])]), Author(id=1240933498509390056, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=gao_yanhui@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933498610053356, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933498509390056, language=EN, stringName=Yan-hui GAO, firstName=Yan-hui, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=null, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933498723299566, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933498509390056, language=CN, stringName=郜艳晖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=3, address=3.暨南大学基础医学与公共卫生学院公共卫生与预防医学系，广东 广州 510632, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496630341788, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=3., ext=[AuthorCompanyExt(id=1240933496638730397, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496630341788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.暨南大学基础医学与公共卫生学院公共卫生与预防医学系，广东 广州 510632)])]), Author(id=1240933498819768563, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, orderNo=8, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=llx19@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1240933498949791991, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933498819768563, language=EN, stringName=Li-xia LI, firstName=Li-xia, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1240933499033678074, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, authorId=1240933498819768563, language=CN, stringName=李丽霞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.广东药科大学公共卫生学院，广东 广州 510310, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1240933496466763922, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=1., ext=[AuthorCompanyExt(id=1240933496470958227, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China), AuthorCompanyExt(id=1240933496479346836, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广东药科大学公共卫生学院，广东 广州 510310)])])], keywords=[Keyword(id=1240933499289530621, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, orderNo=1, keyword=People living with HIV/AIDS), Keyword(id=1240933499398582529, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, orderNo=2, keyword=Anemia), Keyword(id=1240933499545383172, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, orderNo=3, keyword=Anemia exacerbation), Keyword(id=1240933499625074950, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, orderNo=4, keyword=Generalized linear mixed-effects model), Keyword(id=1240933499700572424, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, orderNo=1, keyword=HIV/AIDS患者), Keyword(id=1240933499788652816, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, orderNo=2, keyword=贫血), Keyword(id=1240933499914481944, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, orderNo=3, keyword=贫血加重), Keyword(id=1240933500015145243, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, orderNo=4, keyword=广义线性混合效应模型)], refs=[Reference(id=1240933501621563741, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=null, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=The Joint United Nations Programme on HIV/AIDS, journalName=null, refType=null, unstructuredReference=The Joint United Nations Programme on HIV/AIDS. The path that ends AIDS: UNAIDS Global AIDS update 2023[EB/OL]. [2025-08-10]. https://www.unaids.org/sites/default/files/media_asset/2023-unaids-global-aids-update_en.pdf., articleTitle=The path that ends AIDS: UNAIDS Global AIDS update 2023, refAbstract=null), Reference(id=1240933501709644127, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2022, volume=44, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Cao GY, Wang YP, Wu Y, journalName=EClinicalMedicine, refType=null, unstructuredReference=Cao GY, Wang YP, Wu Y, et al. Prevalence of anemia among People living with HIV: a systematic review and meta-analysis[J].EClinicalMedicine, 2022, 44: 101283., articleTitle=Prevalence of anemia among People living with HIV: a systematic review and meta-analysis, refAbstract=null), Reference(id=1240933501810307428, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2020, volume=11, issue=5, pageStart=1334, pageEnd=1363, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Abioye Ai, Andersen CT, Sudfeld CR, journalName=Advances in Nutrition, refType=null, unstructuredReference=Abioye Ai, Andersen CT, Sudfeld CR, et al. Anemia, iron status,and HIV: a systematic review of the evidence[J]. Advances in Nutrition, 2020, 11(5): 1334-1363., articleTitle=Anemia, iron status,and HIV: a systematic review of the evidence, refAbstract=null), Reference(id=1240933501885804903, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2022, volume=28, issue=10, pageStart=1215, pageEnd=1218, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=霍岩, 丁海波, 耿文清, journalName=中国艾滋病性病, refType=null, unstructuredReference=霍岩， 丁海波， 耿文清.HIV感染者贫血的发病机制和临床管理策略[J].中国艾滋病性病，2022，28（10）：1215-1218., articleTitle=HIV感染者贫血的发病机制和临床管理策略, refAbstract=null), Reference(id=1240933501973885292, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2022, volume=28, issue=10, pageStart=1215, pageEnd=1218, url=null, language=null, rfNumber=[4], rfOrder=4, authorNames=Huo Y, Ding HB, Geng WQ, journalName=Chinese Journal of AIDS& STD, refType=null, unstructuredReference=Huo Y, Ding HB, Geng WQ. Pathogenesis and clinical management strategies of anemia in HIV-infected patients[J]. Chinese Journal of AIDS& STD, 2022, 28(10): 1215-1218.(In Chinese), articleTitle=Pathogenesis and clinical management strategies of anemia in HIV-infected patients, refAbstract=null), Reference(id=1240933502070354286, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2016, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=5, authorNames=中国疾病预防控制中心性病艾滋病预防控制中心, journalName=国家免费艾滋病抗病毒药物治疗手册, refType=null, unstructuredReference=中国疾病预防控制中心性病艾滋病预防控制中心.国家免费艾滋病抗病毒药物治疗手册[M].4版.北京：人民卫生出版社，2016., articleTitle=null, refAbstract=null), Reference(id=1240933502191989106, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2016, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=6, authorNames=National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, journalName=National free AIDS antiviral drug treatment manual, refType=null, unstructuredReference=National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention. National free AIDS antiviral drug treatment manual[M]. 4th ed. Beijing: People's Medical Publishing House,2016.(In Chinese), articleTitle=null, refAbstract=null), Reference(id=1240933502292652405, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2021, volume=42, issue=7, pageStart=1218, pageEnd=1224, url=null, language=null, rfNumber=[6], rfOrder=7, authorNames=姚仕堂, 何春燕, 曹东冬, journalName=中华流行病学杂志, refType=null, unstructuredReference=姚仕堂，何春燕，曹东冬，等.云南省德宏傣族景颇族自治州2004-2018年启动抗病毒治疗后HIV/AIDS贫血发病及危险因素回顾性队列研究[J].中华流行病学杂志，2021，42（7）：1218-1224., articleTitle=云南省德宏傣族景颇族自治州2004-2018年启动抗病毒治疗后HIV/AIDS贫血发病及危险因素回顾性队列研究, refAbstract=null), Reference(id=1240933502389121402, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2021, volume=42, issue=7, pageStart=1218, pageEnd=1224, url=null, language=null, rfNumber=[6], rfOrder=8, authorNames=Yao ST, He CY, Cao DD, journalName=Chinese Journal of Epidemiology, refType=null, unstructuredReference=Yao ST, He CY, Cao DD, et al. A retrospective cohort study of incidence of anemia and risk factors in HIV/AIDS patients with access to antiretroviral therapy in Dehong Jingpo and Dai Autonomous Prefecture in Yunnan province, 2004-2018[J]. Chinese Journal of Epidemiology, 2021, 42(7):1218-1224.(In Chinese), articleTitle=A retrospective cohort study of incidence of anemia and risk factors in HIV/AIDS patients with access to antiretroviral therapy in Dehong Jingpo and Dai Autonomous Prefecture in Yunnan province, 2004-2018, refAbstract=null), Reference(id=1240933502477201791, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2015, volume=26, issue=3, pageStart=156, pageEnd=164, url=null, language=null, rfNumber=[7], rfOrder=9, authorNames=Mijiti Peu, Yuexin Z, Min L, journalName=International Journal of STD & AIDS, refType=null, unstructuredReference=Mijiti Peu, Yuexin Z, Min L, et al. Prevalence and predictors of anaemia in patients with HIV infection at the initiation of combined antiretroviral therapy in Xinjiang, China[J]. International Journal of STD & AIDS, 2015, 26(3): 156-164., articleTitle=Prevalence and predictors of anaemia in patients with HIV infection at the initiation of combined antiretroviral therapy in Xinjiang, China, refAbstract=null), Reference(id=1240933502582059397, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2024, volume=38, issue=1, pageStart=73, pageEnd=77, url=null, language=null, rfNumber=[8], rfOrder=10, authorNames=李畅, 谢亚莉, 汪剡灵, journalName=中国初级卫生保健, refType=null, unstructuredReference=李畅，谢亚莉，汪剡灵，等.台州市HIV感染者启动抗病毒治疗后贫血发病发展情况及影响因素分析[J].中国初级卫生保健，2024，38（1）：73-77., articleTitle=台州市HIV感染者启动抗病毒治疗后贫血发病发展情况及影响因素分析, refAbstract=null), Reference(id=1240933502699499915, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2024, volume=38, issue=1, pageStart=73, pageEnd=77, url=null, language=null, rfNumber=[8], rfOrder=11, authorNames=Li C, Xie YL, Wang SL, journalName=Chinese Primary Health Care, refType=null, unstructuredReference=Li C, Xie YL, Wang SL, et al. Incidence and risk factors of anemia after initiation of ART among HIV-Infected individuals in Taizhou[J]. Chinese Primary Health Care, 2024, 38(1): 73-77.(In Chinese), articleTitle=Incidence and risk factors of anemia after initiation of ART among HIV-Infected individuals in Taizhou, refAbstract=null), Reference(id=1240933502816940432, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2023, volume=37, issue=2, pageStart=287, pageEnd=298, url=null, language=null, rfNumber=[9], rfOrder=12, authorNames=Lang R, Gill MJ, Coburn SB, journalName=AIDS, refType=null, unstructuredReference=Lang R, Gill MJ, Coburn SB, et al. The changing prevalence of anemia and risk factors in People with HIV in North America who have initiated ART, 2007-2017[J]. AIDS, 2023, 37(2): 287-298., articleTitle=The changing prevalence of anemia and risk factors in People with HIV in North America who have initiated ART, 2007-2017, refAbstract=null), Reference(id=1240933502946963864, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2023, volume=23, issue=1, pageStart=704, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=13, authorNames=Wei L, Zhao Y, Gan XM, journalName=BMC Infectious Diseases, refType=null, unstructuredReference=Wei L, Zhao Y, Gan XM, et al. The burden of anemia among Chinese HIV-infected patients following the initiation of antiretroviral therapy in the treat-all era: a nationwide cohort study[J]. BMC Infectious Diseases, 2023, 23(1): 704., articleTitle=The burden of anemia among Chinese HIV-infected patients following the initiation of antiretroviral therapy in the treat-all era: a nationwide cohort study, refAbstract=null), Reference(id=1240933503056015771, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2020, volume=21, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[11], rfOrder=14, authorNames=Manaye Y, Asrat A, Mengesha EW, journalName=BioMed Research International, refType=null, unstructuredReference=Manaye Y, Asrat A, Mengesha EW. Time to development of anemia and predictors among HIV-infected patients initiating ART at Felege Hiwot Referral Hospital, Northwest Ethiopia: a retrospective follow-up study[J]. BioMed Research International, 2020, 21: 7901241., articleTitle=Time to development of anemia and predictors among HIV-infected patients initiating ART at Felege Hiwot Referral Hospital, Northwest Ethiopia: a retrospective follow-up study, refAbstract=null), Reference(id=1240933503127318944, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2020, volume=9, issue=3, pageStart=337, pageEnd=349, url=null, language=null, rfNumber=[12], rfOrder=15, authorNames=Isabirye N, Ezeamama AE, Kyeyune-Bakyayita R, journalName=Int J MCH AIDS, refType=null, unstructuredReference=Isabirye N, Ezeamama AE, Kyeyune-Bakyayita R, et al.Dietary micronutrients and gender, body mass index and viral suppression among HIV-Infected patients in Kampala, Uganda[J]. Int J MCH AIDS, 2020, 9(3): 337-349., articleTitle=Dietary micronutrients and gender, body mass index and viral suppression among HIV-Infected patients in Kampala, Uganda, refAbstract=null), Reference(id=1240933503223787940, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2022, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=16, authorNames=霍岩, journalName=null, refType=null, unstructuredReference=霍岩.HIV感染者贫血发病率,危险因素及临床预后:一项回顾性队列研究[D].沈阳：中国医科大学，2022., articleTitle=HIV感染者贫血发病率,危险因素及临床预后:一项回顾性队列研究, refAbstract=null), Reference(id=1240933503358005671, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2022, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=17, authorNames=Huo Y, journalName=null, refType=null, unstructuredReference=Huo Y. Incidence, risk factors, and clinical prognosis of anemia in HIV-infected patients: a retrospective cohort study[D]. Shenyang: China Medical University, 2022.(In Chinese), articleTitle=Incidence, risk factors, and clinical prognosis of anemia in HIV-infected patients: a retrospective cohort study, refAbstract=null), Reference(id=1240933503446086057, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2023, volume=35, issue=4, pageStart=362, pageEnd=368, url=null, language=null, rfNumber=[14], rfOrder=18, authorNames=郎晶晶, 陈盼盼, 朱黎丹, journalName=上海预防医学, refType=null, unstructuredReference=郎晶晶，陈盼盼，朱黎丹，等.艾滋病病毒感染者启动高效抗逆转录病毒疗法对贫血发病的影响[J].上海预防医学，2023，35（4）：362-368., articleTitle=艾滋病病毒感染者启动高效抗逆转录病毒疗法对贫血发病的影响, refAbstract=null), Reference(id=1240933503567720876, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2023, volume=35, issue=4, pageStart=362, pageEnd=368, url=null, language=null, rfNumber=[14], rfOrder=19, authorNames=Lang JJ, Chen PP, Zhu LD, journalName=Shanghai Journal of Preventive Medicine, refType=null, unstructuredReference=Lang JJ, Chen PP, Zhu LD, et al. Starting effect of highly active antiretroviral therapy on the incidence of anemia in HIV-infected patients[J]. Shanghai Journal of Preventive Medicine, 2023, 35(4): 362-368.(In Chinese), articleTitle=Starting effect of highly active antiretroviral therapy on the incidence of anemia in HIV-infected patients, refAbstract=null), Reference(id=1240933503697744306, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2022, volume=17, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=20, authorNames=Tigabu A, Beyene Y, Getaneh T, journalName=PLOS One, refType=null, unstructuredReference=Tigabu A, Beyene Y, Getaneh T, et al. Incidence and predictors of anemia among adults on HIV care at South Gondar Zone Public General Hospital Northwest Ethiopia, 2020; retrospective cohort study[J]. PLOS One, 2022, 17(1): e0259944., articleTitle=Incidence and predictors of anemia among adults on HIV care at South Gondar Zone Public General Hospital Northwest Ethiopia, 2020; retrospective cohort study, refAbstract=null), Reference(id=1240933503836156342, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2021, volume=101, issue=20, pageStart=1463, pageEnd=1502, url=null, language=null, rfNumber=[16], rfOrder=21, authorNames=中国医师协会肾脏内科医师分会肾性贫血指南工作组, journalName=中华医学杂志, refType=null, unstructuredReference=中国医师协会肾脏内科医师分会肾性贫血指南工作组.中国肾性贫血诊治临床实践指南[J].中华医学杂志，2021，101（20）：1463-1502., articleTitle=中国肾性贫血诊治临床实践指南, refAbstract=null), Reference(id=1240933503945208251, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2021, volume=101, issue=20, pageStart=1463, pageEnd=1502, url=null, language=null, rfNumber=[16], rfOrder=22, authorNames=Working Group on Guidelines for Renal Anemia, Chinese Nephrologist Association, journalName=National Medical Journal of China, refType=null, unstructuredReference=Working Group on Guidelines for Renal Anemia, Chinese Nephrologist Association. Clinical practice guideline for the diagnosis and treatment of renal anemia in China[J]. National Medical Journal of China, 2021, 101(20): 1463-1502.(In Chinese), articleTitle=Clinical practice guideline for the diagnosis and treatment of renal anemia in China, refAbstract=null), Reference(id=1240933504050065859, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, doi=null, pmid=null, pmcid=null, year=2024, volume=154, issue=6, pageStart=1927, pageEnd=1935, url=null, language=null, rfNumber=[17], rfOrder=23, authorNames=Abioye Ai, Sudfeld CR, Noor RA, journalName=Journal of Nutrition, refType=null, unstructuredReference=Abioye Ai, Sudfeld CR, Noor RA, et al. Anemia and Iron supplementation in relation to viral load and mortality among 70,442 People living with human immunodeficiency virus in Tanzania[J].Journal of Nutrition, 2024, 154(6): 1927-1935., articleTitle=Anemia and Iron supplementation in relation to viral load and mortality among 70,442 People living with human immunodeficiency virus in Tanzania, refAbstract=null)], funds=[Fund(id=1240933501369905496, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, awardId=202206010009, language=CN, fundingSource=广州市科技计划项目(202206010009), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1240933496466763922, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=1., ext=[AuthorCompanyExt(id=1240933496470958227, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China), AuthorCompanyExt(id=1240933496479346836, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496466763922, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.广东药科大学公共卫生学院，广东 广州 510310)]), AuthorCompany(id=1240933496563232919, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=2., ext=[AuthorCompanyExt(id=1240933496571621529, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496563232919, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.广州医科大学附属市八医院感染ICU)]), AuthorCompany(id=1240933496630341788, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, xref=3., ext=[AuthorCompanyExt(id=1240933496638730397, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, companyId=1240933496630341788, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.暨南大学基础医学与公共卫生学院公共卫生与预防医学系，广东 广州 510632)])], figs=[ArticleFig(id=1240933500237443364, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, label=Figure 1, caption=Prevalence of anemia among people living with HIV/AIDS during ART, figureFileSmall=Eac0mgi/DvQfPdm68TOi2A==, figureFileBig=ENbwJbFD8BBJs1i2FbS35g==, tableContent=null), ArticleFig(id=1240933500405215527, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, label=图1, caption=ART过程中HIV/AIDS患者贫血患病情况, figureFileSmall=Eac0mgi/DvQfPdm68TOi2A==, figureFileBig=ENbwJbFD8BBJs1i2FbS35g==, tableContent=null), ArticleFig(id=1240933500501684524, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, label=Table 1, caption=

Baseline characteristics in people living with HIV/AIDS (n=11 688)

, figureFileSmall=null, figureFileBig=null, tableContent=
变量人数(%)
性别
男性9 603(82.16)
女性2 085(17.84)
开始ART年龄（岁）
<5010 092(86.34)
≥501 596(13.66)
婚姻状况
未婚5 375(45.99)
已婚/同居5 607(47.97)
离异/分居/丧偶706(6.04)
BMI分级
正常7 503(64.19)
偏瘦2 273(19.45)
超重1 600(13.69)
肥胖312(2.67)
开始ART年份（年）
2004—20111 349(11.54)
2012—20155 608(47.98)
2016—20194 731(40.48)
确诊到开始ART间隔时间（月）
<68 609(73.66)
≥63 079(26.34)
感染途径
性传播10 679(91.37)
血液传播622(5.32)
其他387(3.31)
WHO临床分期
Ⅰ/Ⅱ期298(2.55)
Ⅲ/Ⅳ期11 390(97.45)
基线机会性感染
无10 191(87.19)
有1 497(12.81)
基线临床症状种类数（种）
08 023(68.64)
11 964(16.81)
≥21 701(14.55)
抗结核治疗史
否11 044(94.49)
是644(5.51)
复方新诺明服用史
否7 508(64.24)
是4 180(35.76)
初始ART方案含AZT
否10 489(89.74)
是1 199(10.26)
CD4细胞计数（个/μl）
≥500596(5.10)
350～4991 751(14.98)
200～3494 183(35.79)
<2005 158(44.13)
CD4/CD8比值
<111 541(98.74)
≥1147(1.26)
血肌酐*
正常10 778(93.27)
异常778(6.73)
), ArticleFig(id=1240933500610736434, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, label=表1, caption=

HIV/AIDS患者基线特征分布（n=11 688）

, figureFileSmall=null, figureFileBig=null, tableContent=
变量人数(%)
性别
男性9 603(82.16)
女性2 085(17.84)
开始ART年龄（岁）
<5010 092(86.34)
≥501 596(13.66)
婚姻状况
未婚5 375(45.99)
已婚/同居5 607(47.97)
离异/分居/丧偶706(6.04)
BMI分级
正常7 503(64.19)
偏瘦2 273(19.45)
超重1 600(13.69)
肥胖312(2.67)
开始ART年份（年）
2004—20111 349(11.54)
2012—20155 608(47.98)
2016—20194 731(40.48)
确诊到开始ART间隔时间（月）
<68 609(73.66)
≥63 079(26.34)
感染途径
性传播10 679(91.37)
血液传播622(5.32)
其他387(3.31)
WHO临床分期
Ⅰ/Ⅱ期298(2.55)
Ⅲ/Ⅳ期11 390(97.45)
基线机会性感染
无10 191(87.19)
有1 497(12.81)
基线临床症状种类数（种）
08 023(68.64)
11 964(16.81)
≥21 701(14.55)
抗结核治疗史
否11 044(94.49)
是644(5.51)
复方新诺明服用史
否7 508(64.24)
是4 180(35.76)
初始ART方案含AZT
否10 489(89.74)
是1 199(10.26)
CD4细胞计数（个/μl）
≥500596(5.10)
350～4991 751(14.98)
200～3494 183(35.79)
<2005 158(44.13)
CD4/CD8比值
<111 541(98.74)
≥1147(1.26)
血肌酐*
正常10 778(93.27)
异常778(6.73)
), ArticleFig(id=1240933500723982649, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, label=Table 2, caption=

Analysis of influencing factors of anemia during follow-up in people living with HIV/AIDS without baseline anemia (n=7 835)

, figureFileSmall=null, figureFileBig=null, tableContent=
因素ORa（95%CI）Pa值ORb（95%CI）Pb值
ART治疗时间0.01(0.01～0.02)<0.0010.08(0.07～0.11)<0.001
性别
男性1.001.00
女性3.71(3.38～4.08)<0.0012.61(2.35～2.91)<0.001
开始ART年龄（岁）
<501.001.00
≥502.21(1.97～2.48)<0.0011.73(1.52～1.96)<0.001
婚姻状况
未婚1.001.00
已婚/同居3.35(3.05～3.67)<0.0011.66(1.49～1.85)<0.001
离异/分居/丧偶2.67(2.23～3.19)<0.0011.31(1.07～1.60)0.008
BMI分级
正常1.001.00
偏瘦0.92(0.81～1.05)0.2131.00(0.88～1.15)0.956
超重0.75(0.67～0.85)<0.0010.77(0.68～0.88)<0.001
肥胖0.84(0.65～1.07)0.1570.84(0.64～1.10)0.211
开始ART年份（年）
2004—20111.001.00
2012—20150.20(0.18～0.22)<0.0010.66(0.58～0.75)<0.001
2016—20190.07(0.06～0.08)<0.0010.47(0.40～0.56)<0.001
确诊到开始ART间隔时间（月）
<61.001.00
≥61.46(1.34～1.59)<0.0011.05(0.95～1.16)0.319
感染途径
性传播1.001.00
血液传播3.14(2.69～3.67)<0.0011.80(1.52～2.14)<0.001
其他0.96(0.73～1.27)0.7921.22(0.91～1.64)0.184
WHO临床分期
Ⅰ/Ⅱ期1.001.00
Ⅲ/Ⅳ期0.56(0.45～0.70)<0.0010.79(0.62～1.01)0.061
基线机会性感染
无1.001.00
有2.22(1.92～2.56)<0.0011.22(1.01～1.47)0.039
基线临床症状种类数（种）
01.001.00
12.05(1.84～2.28)<0.0011.30(1.16～1.47)<0.001
≥22.64(2.36～2.97)<0.0011.31(1.15～1.49)<0.001
抗结核治疗史
否1.001.00
是2.05(1.59～2.64)<0.0011.17(0.85～1.62)0.327
复方新诺明服用史
否1.001.00
是1.56(1.42～1.71)<0.0010.99(0.87～1.14)0.929
初始ART方案含AZT
否1.001.00
是9.95(9.09～10.90)<0.0016.18(5.53～6.90)<0.001
CD4细胞计数（个/μl）
≥5001.001.00
350～4991.46(1.11～1.93)0.0081.22(0.92～1.61)0.169
200～3492.37(1.83～3.07)<0.0011.20(0.92～1.57)0.175
<2004.23(3.26～5.48)<0.0011.89(1.43～2.49)<0.001
CD4/CD8比值
<11.001.00
≥10.64(0.42～0.99)0.0470.63(0.39～1.01)0.055
血肌酐
正常1.001.00
异常2.20(1.84～2.63)<0.0011.77(1.46～2.16)<0.001
), ArticleFig(id=1240933500799480128, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, label=表2, caption=

基线无贫血HIV/AIDS患者随访期间贫血的影响因素分析（n=7 835）

, figureFileSmall=null, figureFileBig=null, tableContent=
因素ORa（95%CI）Pa值ORb（95%CI）Pb值
ART治疗时间0.01(0.01～0.02)<0.0010.08(0.07～0.11)<0.001
性别
男性1.001.00
女性3.71(3.38～4.08)<0.0012.61(2.35～2.91)<0.001
开始ART年龄（岁）
<501.001.00
≥502.21(1.97～2.48)<0.0011.73(1.52～1.96)<0.001
婚姻状况
未婚1.001.00
已婚/同居3.35(3.05～3.67)<0.0011.66(1.49～1.85)<0.001
离异/分居/丧偶2.67(2.23～3.19)<0.0011.31(1.07～1.60)0.008
BMI分级
正常1.001.00
偏瘦0.92(0.81～1.05)0.2131.00(0.88～1.15)0.956
超重0.75(0.67～0.85)<0.0010.77(0.68～0.88)<0.001
肥胖0.84(0.65～1.07)0.1570.84(0.64～1.10)0.211
开始ART年份（年）
2004—20111.001.00
2012—20150.20(0.18～0.22)<0.0010.66(0.58～0.75)<0.001
2016—20190.07(0.06～0.08)<0.0010.47(0.40～0.56)<0.001
确诊到开始ART间隔时间（月）
<61.001.00
≥61.46(1.34～1.59)<0.0011.05(0.95～1.16)0.319
感染途径
性传播1.001.00
血液传播3.14(2.69～3.67)<0.0011.80(1.52～2.14)<0.001
其他0.96(0.73～1.27)0.7921.22(0.91～1.64)0.184
WHO临床分期
Ⅰ/Ⅱ期1.001.00
Ⅲ/Ⅳ期0.56(0.45～0.70)<0.0010.79(0.62～1.01)0.061
基线机会性感染
无1.001.00
有2.22(1.92～2.56)<0.0011.22(1.01～1.47)0.039
基线临床症状种类数（种）
01.001.00
12.05(1.84～2.28)<0.0011.30(1.16～1.47)<0.001
≥22.64(2.36～2.97)<0.0011.31(1.15～1.49)<0.001
抗结核治疗史
否1.001.00
是2.05(1.59～2.64)<0.0011.17(0.85～1.62)0.327
复方新诺明服用史
否1.001.00
是1.56(1.42～1.71)<0.0010.99(0.87～1.14)0.929
初始ART方案含AZT
否1.001.00
是9.95(9.09～10.90)<0.0016.18(5.53～6.90)<0.001
CD4细胞计数（个/μl）
≥5001.001.00
350～4991.46(1.11～1.93)0.0081.22(0.92～1.61)0.169
200～3492.37(1.83～3.07)<0.0011.20(0.92～1.57)0.175
<2004.23(3.26～5.48)<0.0011.89(1.43～2.49)<0.001
CD4/CD8比值
<11.001.00
≥10.64(0.42～0.99)0.0470.63(0.39～1.01)0.055
血肌酐
正常1.001.00
异常2.20(1.84～2.63)<0.0011.77(1.46～2.16)<0.001
), ArticleFig(id=1240933500891754822, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, label=Table 3, caption=

Analysis of influencing factors for anemia exacerbation during follow-up in people living with HIV/AIDS (n=3 470)

, figureFileSmall=null, figureFileBig=null, tableContent=
因素HRa（95%CI）Pa值HRb（95%CI）Pb值
性别
男性1.001.00
女性1.56(1.36～1.79)<0.0011.29(1.10～1.50)0.002
开始ART年龄（岁）
<501.00——
≥501.15(0.98～1.34)0.089——
婚姻状况
未婚1.001.00
已婚/同居1.37(1.16～1.61)<0.0011.20(1.01～1.44)0.041
离异/分居/丧偶1.67(1.28～2.17)<0.0011.32(1.01～1.74)0.046
BMI分级
正常1.001.00
偏瘦0.93(0.79～1.08)0.3290.96(0.82～1.13)0.654
超重1.34(1.06～1.70)0.0131.16(0.91～1.48)0.230
肥胖1.00(0.59～1.70)0.9940.90(0.52～1.53)0.684
开始ART年份（年）
2004—20111.001.00
2012—20150.74(0.63～0.86)<0.0011.02(0.86～1.22)0.810
2016—20190.55(0.45～0.67)<0.0010.92(0.73～1.16)0.464
确诊到开始ART间隔时间（月）
<61.001.00
≥61.49(1.29～1.73)<0.0011.24(1.05～1.45)0.010
感染途径
性传播1.001.00
血液传播1.37(1.11～1.69)0.0031.23(0.97～1.54)0.083
其他0.86(0.59～1.24)0.4091.01(0.68～1.49)0.970
WHO临床分期
Ⅰ/Ⅱ期1.001.00
Ⅲ/Ⅳ期0.65(0.44～0.97)0.0340.82(0.54～1.23)0.331
机会性感染史
否1.001.00
是0.78(0.66～0.91)0.0020.87(0.70～1.08)0.211
基线临床症状种类数（种）
01.001.00
11.09(0.92～1.29)0.3351.12(0.93～1.34)0.225
≥21.24(1.06～1.46)0.0081.25(1.05～1.49)0.011
抗结核治疗史
否1.001.00
是0.72(0.58～0.90)0.0030.89(0.66～1.20)0.439
复方新诺明服用史
否1.001.00
是0.77(0.67～0.88)<0.0010.95(0.81～1.10)0.478
初始ART方案含AZT
否1.001.00
是3.14(2.67～3.70)<0.0012.52(2.08～3.05)<0.001
CD4细胞计数（个/μl）
≥5001.00——
350～4990.97(0.60～1.59)0.914
200～3490.99(0.64～1.54)0.967
<2000.85(0.55～1.30)0.446
CD4/CD8比值
<11.00
≥11.16(0.64～2.10)0.632——
血肌酐
正常1.001.00
异常1.35(1.11～1.63)0.0031.25(1.03～1.53)0.025
), ArticleFig(id=1240933500992418124, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, label=表3, caption=

HIV/AIDS患者随访期间贫血加重影响因素分析（n=3 470）

, figureFileSmall=null, figureFileBig=null, tableContent=
因素HRa（95%CI）Pa值HRb（95%CI）Pb值
性别
男性1.001.00
女性1.56(1.36～1.79)<0.0011.29(1.10～1.50)0.002
开始ART年龄（岁）
<501.00——
≥501.15(0.98～1.34)0.089——
婚姻状况
未婚1.001.00
已婚/同居1.37(1.16～1.61)<0.0011.20(1.01～1.44)0.041
离异/分居/丧偶1.67(1.28～2.17)<0.0011.32(1.01～1.74)0.046
BMI分级
正常1.001.00
偏瘦0.93(0.79～1.08)0.3290.96(0.82～1.13)0.654
超重1.34(1.06～1.70)0.0131.16(0.91～1.48)0.230
肥胖1.00(0.59～1.70)0.9940.90(0.52～1.53)0.684
开始ART年份（年）
2004—20111.001.00
2012—20150.74(0.63～0.86)<0.0011.02(0.86～1.22)0.810
2016—20190.55(0.45～0.67)<0.0010.92(0.73～1.16)0.464
确诊到开始ART间隔时间（月）
<61.001.00
≥61.49(1.29～1.73)<0.0011.24(1.05～1.45)0.010
感染途径
性传播1.001.00
血液传播1.37(1.11～1.69)0.0031.23(0.97～1.54)0.083
其他0.86(0.59～1.24)0.4091.01(0.68～1.49)0.970
WHO临床分期
Ⅰ/Ⅱ期1.001.00
Ⅲ/Ⅳ期0.65(0.44～0.97)0.0340.82(0.54～1.23)0.331
机会性感染史
否1.001.00
是0.78(0.66～0.91)0.0020.87(0.70～1.08)0.211
基线临床症状种类数（种）
01.001.00
11.09(0.92～1.29)0.3351.12(0.93～1.34)0.225
≥21.24(1.06～1.46)0.0081.25(1.05～1.49)0.011
抗结核治疗史
否1.001.00
是0.72(0.58～0.90)0.0030.89(0.66～1.20)0.439
复方新诺明服用史
否1.001.00
是0.77(0.67～0.88)<0.0010.95(0.81～1.10)0.478
初始ART方案含AZT
否1.001.00
是3.14(2.67～3.70)<0.0012.52(2.08～3.05)<0.001
CD4细胞计数（个/μl）
≥5001.00——
350～4990.97(0.60～1.59)0.914
200～3490.99(0.64～1.54)0.967
<2000.85(0.55～1.30)0.446
CD4/CD8比值
<11.00
≥11.16(0.64～2.10)0.632——
血肌酐
正常1.001.00
异常1.35(1.11～1.63)0.0031.25(1.03～1.53)0.025
), ArticleFig(id=1240933501093081425, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=EN, label=Table 4, caption=

Analysis of the influencing factors of anemia on prognosis in people living with HIV/AIDS (n=11 688)

, figureFileSmall=null, figureFileBig=null, tableContent=
基线贫血随访过程中贫血人数死亡人数（%）HRa（95%CI）Pa值HRb（95%CI）Pb值
否否6 14011(0.18)1.001.00
否是1 69534(2.01)7.53(3.80～14.90)<0.0015.02(2.45～10.27)<0.001
是否4772(0.42)2.38(0.53～10.75)0.2591.63(0.36～7.43)0.531
是是3 376115(3.41)14.22(7.63～26.47)<0.0016.00(3.04～11.85)<0.001
), ArticleFig(id=1240933501189550422, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240722568534093922, language=CN, label=表4, caption=

HIV/AIDS患者贫血对预后的影响因素分析（n=11 688）

, figureFileSmall=null, figureFileBig=null, tableContent=
基线贫血随访过程中贫血人数死亡人数（%）HRa（95%CI）Pa值HRb（95%CI）Pb值
否否6 14011(0.18)1.001.00
否是1 69534(2.01)7.53(3.80～14.90)<0.0015.02(2.45～10.27)<0.001
是否4772(0.42)2.38(0.53～10.75)0.2591.63(0.36～7.43)0.531
是是3 376115(3.41)14.22(7.63～26.47)<0.0016.00(3.04～11.85)<0.001
)], attaches=null, journal=Journal(id=1227664546253402114, delFlag=0, nameCn=现代预防医学, nameEn=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, issn=1003-8507, eissn=null, cn=51-1365/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=IeiuPXEZi6AA+k0VfvoiOQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Modern Preventive Medicine, journalRemark=null, publicationField=null, createdTime=1770627636734, updatedTime=1770628902248, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=IeiuPXEZi6AA+k0VfvoiOQ==, picEn=/9iTl8/ndms4tBz1fL28Pg==, jcr=null, cjcr=null, exts=[JournalExt(id=1227669854342280188, language=CN, name=现代预防医学, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1770628902278, updatedTime=1770628902278, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1227669854396806141, language=EN, name=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1770628902291, updatedTime=1770628902291, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1227665162245664772, websiteList=[Website(id=1227687234141352800, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/CN, language=CN, createTime=1770633045945, createBy=18614031015, updateTime=1770633090526, updateBy=18614031015, name=现代预防医学-中文, tplId=1146099689490845704, title=现代预防医学, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687735088051072, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=articleTextType, value=kx, createTime=1770633165380, updateTime=1770633165380, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735071273853, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=banner, value=null, createTime=1770633165376, updateTime=1770633165376, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735113216899, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=grayFlag, value=0, createTime=1770633165386, updateTime=1770633165386, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735062885244, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633165374, updateTime=1770633165374, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735125799813, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=minRunFlag, value=0, createTime=1770633165389, updateTime=1770633165389, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735083856767, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic, createTime=1770633165379, updateTime=1770633165379, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735121605508, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=silenceFlag, value=0, createTime=1770633165388, updateTime=1770633165388, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735079662462, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1770633165378, updateTime=1770633165378, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735096439681, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeColor, value=null, createTime=1770633165382, updateTime=1770633165382, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735104828290, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeStyle, value=null, createTime=1770633165384, updateTime=1770633165384, creator=18614031015, updator=18614031015)]), Website(id=1227687234338485094, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/EN, language=EN, createTime=1770633045992, createBy=18614031015, updateTime=1770633115374, updateBy=18614031015, name=现代预防医学-英文, tplId=1146101810881728533, title=Modern Preventive Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687709129507332, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=articleTextType, value=kx, createTime=1770633159191, updateTime=1770633159191, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709108535809, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=banner, value=null, createTime=1770633159186, updateTime=1770633159186, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709167256071, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=grayFlag, value=0, createTime=1770633159200, updateTime=1770633159200, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709095952896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633159183, updateTime=1770633159183, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709179838985, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=minRunFlag, value=0, createTime=1770633159203, updateTime=1770633159203, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709121118723, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic, createTime=1770633159189, updateTime=1770633159189, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709171450376, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=silenceFlag, value=0, createTime=1770633159201, updateTime=1770633159201, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709112730114, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1770633159187, updateTime=1770633159187, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709133701637, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeColor, value=null, createTime=1770633159192, updateTime=1770633159192, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709154673158, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeStyle, value=null, createTime=1770633159197, updateTime=1770633159197, creator=18614031015, updator=18614031015)])], journalTitle=现代预防医学, weixinUrl=null, journalUrl=http://xdyfyxzz.paperopen.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Modern Preventive Medicine, journalPhotoCn=IeiuPXEZi6AA+k0VfvoiOQ==, journalPhotoEn=/9iTl8/ndms4tBz1fL28Pg==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202503554, detailUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/10.20043/j.cnki.MPM.202503554, pdfUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/PDF/10.20043/j.cnki.MPM.202503554, pdfUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/PDF/10.20043/j.cnki.MPM.202503554, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
HIV/AIDS患者贫血、贫血加重的影响因素及其对预后的影响——一项回顾性队列研究
收藏切换
PDF下载
林婧 1 , 冯立慧 1 , 李燕秋 1 , 欧峻祺 1 , 周馨 1 , 李粤平 2 , 贾卫东 2 , 郜艳晖 3 , 李丽霞 1
现代预防医学 | 流行病与统计方法 2025,52(19): 3496-3502
收起
收藏切换
现代预防医学 | 流行病与统计方法 2025, 52(19): 3496-3502
HIV/AIDS患者贫血、贫血加重的影响因素及其对预后的影响——一项回顾性队列研究
全屏
林婧1, 冯立慧1, 李燕秋1, 欧峻祺1, 周馨1, 李粤平2, 贾卫东2, 郜艳晖3 , 李丽霞1
作者信息
  • 1.广东药科大学公共卫生学院，广东 广州 510310
  • 2.广州医科大学附属市八医院感染ICU
  • 3.暨南大学基础医学与公共卫生学院公共卫生与预防医学系，广东 广州 510632

    • 林婧（1999—），女，硕士在读，研究方向：疾病预防控制

通讯作者:

李丽霞，E-mail:；
郜艳晖，E-mail:
Influencing factors of anemia and anemia exacerbation in people living with HIV/AIDS and their impact on prognosis: a retrospective cohort study
Jing LIN1, Li-hui FENG1, Yan-qiu LI1, Jun-qi OU1, Xin ZHOU1, Yue-ping LI2, Wei-dong JIA2, Yan-hui GAO3 , Li-xia LI1
Affiliations
  • School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China
出版时间: 2025-10-10 doi: 10.20043/j.cnki.MPM.202503554
文章导航
收藏切换
摘要
收起

目的 探讨HIV/AIDS患者在抗逆转录病毒治疗（antiretroviral therapy，ART）过程中贫血、贫血加重的影响因素，及贫血对患者预后的影响。方法 回顾性收集广州市某传染病专科医院2004年2月10日—2019年3月29日首次接受ART的HIV/AIDS患者基线和随访数据，采用广义线性混合效应模型分析基线无贫血患者长期ART过程中随访贫血的影响因素，采用Cox比例风险回归模型分析基线贫血患者贫血加重的影响因素及基线贫血和随访贫血对患者预后的影响。结果 HIV/AIDS患者11 688例，基线贫血3 853例（32.97%）；7 835例基线无贫血患者在随访过程中发生贫血1 695例（21.63%），3 470例轻、中度贫血患者在随访中贫血加重845例（24.35%）。随访贫血的危险因素包括女性、开始ART年龄≥50岁、已婚/同居、离异/分居/丧偶、血液传播、基线机会性感染、基线临床症状种类数越多、初始ART方案含齐多夫定（Zidovudine，AZT）、CD4细胞计数<200个/μl、血肌酐异常。女性、已婚/同居、离异/分居/丧偶、确诊到开始ART间隔时间≥6个月、基线临床症状种类数≥2种、初始ART方案含AZT、血肌酐异常是贫血加重的危险因素。基线无贫血而随访过程中贫血患者的死亡风险是基线、随访过程中均无贫血者的5.02倍（95%CI：2.45～10.27）；基线、随访过程中均贫血患者的死亡风险是基线、随访均无贫血者的6.00倍（95%CI：3.04～11.85）。结论 患者在ART过程中随访贫血、贫血加重受多种因素影响，基线贫血和随访贫血是HIV/AIDS患者预后的重要危险因素，应加强高危人群贫血筛查，力求做到早发现、早诊断、早治疗，从而降低患者的死亡风险。

HIV/AIDS患者  /  贫血  /  贫血加重  /  广义线性混合效应模型

Objective To investigate the influencing factors of anemia and anemia exacerbation in people living with HIV/AIDS (PLWHA) during antiretroviral therapy (ART), as well as the impact of anemia on the prognosis of PLWHA. Methods This retrospective cohort study collected baseline and follow-up data for PLHIV who initiated ART at a specialized infectious-disease hospital in Guangzhou from February 10, 2004 to March 29, 2019. A generalized linear mixed-effects model was used to analyze the factors influencing anemia during long-term ART in PLWHA without anemia at baseline. The Cox proportional hazards model was used to analyze both the influencing factors of anemia exacerbation in those with baseline anemia and the impact of baseline anemia and follow-up anemia on the prognosis. Results There were 11 688 PLWHA, of whom 3 853(32.97%) had anemia at baseline. Among 7 835 PLWHA without anemia at baseline, 1 695 (21.63%) developed anemia during the follow-up. Among 3 470 PLWHA with mild or moderate anemia at baseline, 845 (24.35%) had anemia exacerbation during the follow-up. Risk factors for follow-up anemia in PLWHA included being female, aged ≥50 years at ART initiation, being married/cohabiting, being divorced/separated/widowed, blood transmission, baseline opportunistic infections, higher number of baseline clinical symptoms, the initial ART regimen containing Zidovudine (AZT), CD4 cell count <200 cells/μL, and abnormal serum creatinine. Risk factors for anemia exacerbation included being female, being married/cohabiting, being divorced/separated/widowed, an interval of ≥6 months from diagnosis to ART initiation, ≥2 categories of baseline clinical symptoms, an initial ART regimen containing AZT, and abnormal serum creatinine. The risk of death in PLWHA without anemia at baseline but developing anemia during the follow-up was 5.02 times (95% CI: 2.45-10.27) than that among those without anemia at both baseline and during the follow-up. The risk of death with anemia at both baseline and during the follow-up was 6.00 times (95%CI: 3.04-11.85) than that among those without anemia at both baseline and during the follow-up. Conclusion Follow-up anemia and anemia exacerbation during ART are affected by multiple factors. Baseline anemia and follow-up anemia are important risk factors for the prognosis of PLWHA. Anemia screening for high-risk groups should be strengthened to strive for early detection, early diagnosis, and early treatment, thereby reducing the risk of death of PLWHA.

People living with HIV/AIDS  /  Anemia  /  Anemia exacerbation  /  Generalized linear mixed-effects model
林婧, 冯立慧, 李燕秋, 欧峻祺, 周馨, 李粤平, 贾卫东, 郜艳晖, 李丽霞. HIV/AIDS患者贫血、贫血加重的影响因素及其对预后的影响——一项回顾性队列研究. 现代预防医学, 2025 , 52 (19) : 3496 -3502 . DOI: 10.20043/j.cnki.MPM.202503554
Jing LIN, Li-hui FENG, Yan-qiu LI, Jun-qi OU, Xin ZHOU, Yue-ping LI, Wei-dong JIA, Yan-hui GAO, Li-xia LI. Influencing factors of anemia and anemia exacerbation in people living with HIV/AIDS and their impact on prognosis: a retrospective cohort study[J]. Modern Preventive Medicine, 2025 , 52 (19) : 3496 -3502 . DOI: 10.20043/j.cnki.MPM.202503554
正文
收起
随着抗逆转录病毒治疗（antiretroviral therapy，ART）的广泛应用以及AIDS防控机制的日益完善，HIV感染率得到有效控制，AIDS相关死亡率也显著降低，HIV/AIDS患者预期寿命显著延长[1]。然而贫血仍是HIV/AIDS患者较为常见的并发症，研究表明，大于或等于15岁的HIV/AIDS患者贫血患病率高达46.6%[2]。随着贫血程度加重，可出现乏力、头晕、心悸等症状，严重影响患者的生活质量和预后[3]。
国内外多数研究仅关注HIV/AIDS患者基线贫血患病情况及其对预后的影响[2-4]，但在长期治疗过程中患者可能多次发生贫血，这类重复测量的观察值之间可能存在相关，目前缺乏关于长期ART过程中随访期间患者贫血情况及其对预后影响的纵向研究。本研究采用回顾性队列研究，采用广义线性混合效应模型，探讨HIV/AIDS患者随访期间贫血、贫血加重的影响因素及其对死亡的影响，为改善患者生活质量、评估疾病进展和预后、指导临床治疗以及促进公共卫生管理提供有力支持。
1　对象与方法
收起
1.1　研究对象
数据来源于广州市某传染病专科医院HIV/AIDS患者ART数据库。纳入标准：（1）2004年2月10日—2019年3月29日启动ART；（2）开始ART时年龄≥15岁；（3）有完整的基线记录及至少进行2次随访，且时间间隔不超过2年。排除标准：（1）随访时间<6个月；（2）既往有ART史；（3）怀孕者。最终筛选出11 688例纳入本研究。患者在开始抗病毒治疗前签署知情同意书。本研究经广州医科大学附属市八医院医学伦理委员会批准（编号：AF/SC-01/01.1）。
1.2　研究方法
1.2.1　回顾性队列研究
队列起点为2004年2月10日—2019年3月29日首次开始ART的时间。针对贫血加重的研究，结局事件为基线合并贫血的HIV/AIDS患者在随访过程中发生贫血加重（轻度转中、重度贫血或中度贫血转重度贫血）。针对预后研究，结局事件为随访过程中发生死亡，包括AIDS相关死亡和非AIDS相关死亡。
删失：研究对象在随访期间未发生贫血加重（或死亡），包括在治、失访、转诊、停药或最后一次随访时患者仍然存活等情况。其研究终点为末次随访时间或随访截止时间。
队列中主要包括：（1）人口学信息：患者性别、开始ART年龄、婚姻状况等；（2）临床特征：确诊HIV感染日期、开始ART日期、感染途径、WHO临床分期、机会性感染情况、临床症状；（3）临床用药：抗结核治疗史、复方新诺明服用史、ART方案；（4）实验室指标：基线CD4+T淋巴细胞计数、CD8+T淋巴细胞计数、血肌酐水平等。
1.2.2　相关指标定义
（1）贫血：根据世界卫生组织（WHO）发布的贫血分级标准：男性血红蛋白110～129 g/L、女性血红蛋白110～119 g/L为轻度贫血；血红蛋白80～109 g/L为中度贫血；血红蛋白<80 g/L为重度贫血[2]。
（2）身体质量指数（body mass index，BMI）：偏瘦为BMI<18.5 kg/m2，正常为BMI≥18.5 kg/m2且<24 kg/m2，超重为BMI≥24 kg/m2且<28 kg/m2，肥胖为BMI≥28 kg/m2。
（3）基线机会性感染：根据《国家免费艾滋病抗病毒药物治疗手册（第4版）》[5]，HIV/AIDS患者在开始ART治疗前患有耶氏肺孢子菌肺炎、结核病、播散性非结核分枝杆菌感染等疾病。
（4）基线临床症状种类数：HIV/AIDS患者出现发热、咳嗽、咳痰、呼吸困难、胸痛、腹泻、淋巴结肿大等症状的数量。
（5）血肌酐正常参考范围：男性为53～106 μmol/L，女性为44～97 μmol/L。
1.3　统计分析
采用SAS 9.4软件进行统计分析，计数资料采用n（%）描述。采用广义线性混合效应模型分析基线无贫血HIV/AIDS患者长期ART随访过程中贫血的影响因素，采用Cox比例风险回归模型分析基线贫血患者贫血加重的影响因素及贫血对预后的影响。检验水准α=0.05。
2　结果
收起
2.1　基本情况
本研究纳入HIV/AIDS患者11 688例。男性9 603例（82.16%）；<50岁10 092例（86.34%）；未婚者5 375例（45.99%）；BMI正常7 503例（64.19%）。见表1。基线7 835例（67.03%）HIV/AIDS患者无贫血，3 853例（32.97%）合并贫血；其中1 790例（15.32%）轻度贫血，1 680例（14.37%）中度贫血，383例（3.28%）重度贫血。
2.2　基线无贫血HIV/AIDS患者ART随访期间贫血的影响因素
分析结果显示，基线无贫血HIV/AIDS患者ART期间第一、二个月贫血患病率分别为9.03%、9.23%，此后逐渐下降至4.26%，治疗第二年到第七年期间缓慢上升为7.44%。男性第一、二个月贫血患病率分别为6.75%、7.54%，贫血变化趋势与总体一致；女性第一个月贫血患病率为25.11%，随后呈下降趋势，六个月后呈缓慢上升趋势，整个随访过程中女性的贫血患病率高于男性。见图1。
以每次随访时患者是否贫血为因变量，性别、开始ART年龄、婚姻状况、BMI分级、开始ART年份等为自变量，构建广义线性混合效应模型，设截距为固定效应，ART治疗时间为随机效应。分析结果显示，女性、开始ART年龄≥50岁、已婚/同居、离异/分居/丧偶、血液传播、基线机会性感染、基线临床症状种类数越多、初始ART方案含AZT、CD4细胞计数<200个/μl、血肌酐异常是HIV/AIDS患者随访贫血的危险因素；ART治疗时间、超重、2012—2015年和2016—2019年开始ART是随访贫血的保护因素。见表2。
2.3　基线贫血HIV/AIDS患者ART期间贫血加重的影响因素
多因素Cox回归模型结果显示，女性、已婚/同居、离异/分居/丧偶、确诊到开始ART间隔时间≥6个月、基线临床症状种类数≥2种、初始ART方案含AZT、血肌酐异常者有更高的贫血加重风险，HR及95%CI见表3。
2.4　基线贫血和随访期间贫血对HIV/AIDS患者预后的影响
以患者是否死亡为因变量，采用Cox比例风险回归模型分析基线、随访期间是否贫血对HIV/AIDS患者预后的影响。多因素分析结果显示，基线无贫血而随访过程中贫血患者的死亡风险是基线、随访过程中均未贫血者的5.02倍（95%CI：2.45～10.27）；基线、随访过程中均贫血患者的死亡风险是基线、随访均无贫血者的6.00倍（95%CI：3.04～11.85）。见表4。
3　讨论
收起
本研究分析结果显示，广州市HIV/AIDS患者基线贫血患病率为32.97%。高于云南德宏州的21.2%[6]、低于新疆的38.9%[7]，亦低于全球的46.6%[2]。基线无贫血患者在随访中贫血发病密度为8.71/100人年，与台州市（8.2/100人年）相近[8]。随访期间轻、中度贫血患者贫血加重发病密度为8.00/100人年，低于台州市贫血加重发病密度（9.1/100人年）[8]。
研究发现女性是基线无贫血HIV/AIDS患者长期ART治疗过程中患贫血的危险因素，也是患者贫血加重的危险因素。多项研究显示，女性患者在ART过程中血红蛋白水平比男生低，更易并发贫血[9-11]。这可能与女性月经周期及铁、锌等微量营养素摄入较男性低有关[12]。开始ART年龄≥50岁患者在ART过程中患贫血的风险高于<50岁患者，与既往研究结果一致[4,9-10]。已婚/同居、离异/分居/丧偶是患者发生贫血或贫血加重的危险因素，与霍岩[13]研究结果一致，已婚/同居群体可能面临更高的家庭照料责任或经济压力，导致其治疗依从性下降，进而影响病毒抑制效果，间接增加免疫功能损伤与贫血风险。离异/分居/丧偶者可能因社会支持网络断裂，面临独居、经济困难或抑郁等心理健康问题，导致忽视贫血症状的早期识别，延迟贫血的诊断与干预，从而增加随访期间的贫血发生率。本研究显示，超重者贫血的风险是BMI正常者的0.77倍，即超重是贫血的保护因素，与Lang R等[9]研究结果一致，提示可以通过适当增重来预防贫血发生。
在临床特征方面，本研究发现确诊到开始ART间隔时间≥6个月的患者贫血加重的风险较高。HIV具有降低造血干细胞增殖分化为成熟血细胞的能力，确诊后较长时间未接受ART治疗，可导致患者免疫功能下降，并发感染的风险增加，这些因素都可能增加贫血加重风险[4]。分析发现，通过血液传播感染的患者发生贫血风险是性传播的1.80倍。Wei等[10]对首次开始ART的436 658名HIV/AIDS患者进行贫血影响因素研究，发现注射吸毒者患贫血的风险较同性性传播高。原因可能是经血液传播途径的患者耐药发生率和病毒学抑制失败率均高于性传播途径患者。血液传播途径的患者疾病进展速度也比性传播途径患者快，这些因素在一定程度上对患者贫血的发病产生影响。本研究发现基线合并机会性感染与贫血发生有关，与既往研究结果研究一致[13-14]，这可能与机会性感染破坏患者的骨髓系统从而引起贫血有关。此外，基线临床症状种类数越多，患者越可能发生贫血或贫血加重。霍岩[13]研究发现，持续腹泻是HIV/AIDS患者发生贫血的独立危险因素，患者出现呕吐、腹泻等症状易造成叶酸、B12、铁等营养物质减少，当这些关键营养物质供给持续减少时，会导致人体内用于血液生成的必要原材料在组织中储备量不足，继而引发巨幼细胞性贫血或缺铁性贫血。
在临床用药方面，本研究显示，ART治疗时间长是HIV/AIDS患者合并贫血的保护因素，与既往研究结果一致[9-10,15]，这可能与病毒复制抑制、免疫功能恢复有关。研究发现初始ART方案含齐多夫定是患者随访期间贫血或贫血加重的危险因素。多项贫血相关因素研究显示，齐多夫定可导致骨髓抑制，从而导致感染者发生药物相关性贫血[4,8,10,14]，应慎重使用该类药物，使用齐多夫定时，应密切关注患者血红蛋白水平，预防和早期发现贫血的发生或加重。
在实验室指标方面，CD4细胞计数<200个/μl是患者随访期间贫血的危险因素，与国内外多项研究结果一致[9-10]，尽可能提高患者CD4细胞计数水平，可有效预防患者发生贫血。血肌酐异常是患者随访期间贫血或贫血加重的危险因素。埃塞俄比亚一项回顾性队列研究显示，血清肌酐大于1.1 IU/L是贫血的预测因素[15]。血肌酐异常意味着患者肾功能减弱，会导致促红细胞生成素的绝对或相对生成不足，从而引发贫血[16]。因此对血肌酐异常患者，应进行血红蛋白水平定期监测。
本研究发现，基线无贫血而随访过程中贫血患者的死亡风险是基线、随访过程中均无贫血者的5.02倍；基线、随访过程中贫血患者的死亡风险是基线、随访均无贫血者的6.00倍。Abioye等[17]对坦桑尼亚70 442名接受ART治疗的HIV/AIDS患者进行队列研究，结果显示，轻、中、重度贫血患者的死亡风险分别是无贫血患者的1.29（95%CI：1.14～1.61）、1.88（95%CI：1.62～2.17）和3.33倍（95%CI：2.75～3.99）。一项中国的队列研究显示，HIV/AIDS患者贫血状态与死亡密切相关[10]。贫血已被多项研究确定为HIV感染者死亡的预测指标[4]。
本研究存在一定的局限性，队列中缺乏患者文化程度、职业、饮食等变量，无法探究这些因素对HIV/AIDS患者贫血的影响，另外，研究数据仅限于广州市某传染病专科医院，来源单一，可能存在一定的选择偏倚。
HIV/AIDS患者在长期治疗期间往往会多次出现贫血，本研究采用大样本的队列研究，不仅着眼于患者基线贫血状况，还追踪随访期间患者的贫血情况及其对预后的影响。建议在临床治疗过程中，应针对上述高危人群进行定期监测和健康教育，以实现早预防、早发现、早诊断、早治疗，从而降低患者的死亡风险。
基金
收起
  • 广州市科技计划项目(202206010009)
文献
收起
参考文献 引证文献
排序方式：
[1]
The Joint United Nations Programme on HIV/AIDS. The path that ends AIDS: UNAIDS Global AIDS update 2023[EB/OL]. [2025-08-10]. https://www.unaids.org/sites/default/files/media_asset/2023-unaids-global-aids-update_en.pdf.
[2]
Cao GY, Wang YP, Wu Y, et al. Prevalence of anemia among People living with HIV: a systematic review and meta-analysis[J].EClinicalMedicine, 2022, 44: 101283.
[3]
Abioye Ai, Andersen CT, Sudfeld CR, et al. Anemia, iron status,and HIV: a systematic review of the evidence[J]. Advances in Nutrition, 2020, 11(5): 1334-1363.
[4]
霍岩， 丁海波， 耿文清.HIV感染者贫血的发病机制和临床管理策略[J].中国艾滋病性病，2022，28（10）：1215-1218.
Huo Y, Ding HB, Geng WQ. Pathogenesis and clinical management strategies of anemia in HIV-infected patients[J]. Chinese Journal of AIDS& STD, 2022, 28(10): 1215-1218.(In Chinese)
[5]
中国疾病预防控制中心性病艾滋病预防控制中心.国家免费艾滋病抗病毒药物治疗手册[M].4版.北京：人民卫生出版社，2016.
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention. National free AIDS antiviral drug treatment manual[M]. 4th ed. Beijing: People's Medical Publishing House,2016.(In Chinese)
[6]
姚仕堂，何春燕，曹东冬，等.云南省德宏傣族景颇族自治州2004-2018年启动抗病毒治疗后HIV/AIDS贫血发病及危险因素回顾性队列研究[J].中华流行病学杂志，2021，42（7）：1218-1224.
Yao ST, He CY, Cao DD, et al. A retrospective cohort study of incidence of anemia and risk factors in HIV/AIDS patients with access to antiretroviral therapy in Dehong Jingpo and Dai Autonomous Prefecture in Yunnan province, 2004-2018[J]. Chinese Journal of Epidemiology, 2021, 42(7):1218-1224.(In Chinese)
[7]
Mijiti Peu, Yuexin Z, Min L, et al. Prevalence and predictors of anaemia in patients with HIV infection at the initiation of combined antiretroviral therapy in Xinjiang, China[J]. International Journal of STD & AIDS, 2015, 26(3): 156-164.
[8]
李畅，谢亚莉，汪剡灵，等.台州市HIV感染者启动抗病毒治疗后贫血发病发展情况及影响因素分析[J].中国初级卫生保健，2024，38（1）：73-77.
Li C, Xie YL, Wang SL, et al. Incidence and risk factors of anemia after initiation of ART among HIV-Infected individuals in Taizhou[J]. Chinese Primary Health Care, 2024, 38(1): 73-77.(In Chinese)
[9]
Lang R, Gill MJ, Coburn SB, et al. The changing prevalence of anemia and risk factors in People with HIV in North America who have initiated ART, 2007-2017[J]. AIDS, 2023, 37(2): 287-298.
[10]
Wei L, Zhao Y, Gan XM, et al. The burden of anemia among Chinese HIV-infected patients following the initiation of antiretroviral therapy in the treat-all era: a nationwide cohort study[J]. BMC Infectious Diseases, 2023, 23(1): 704.
[11]
Manaye Y, Asrat A, Mengesha EW. Time to development of anemia and predictors among HIV-infected patients initiating ART at Felege Hiwot Referral Hospital, Northwest Ethiopia: a retrospective follow-up study[J]. BioMed Research International, 2020, 21: 7901241.
[12]
Isabirye N, Ezeamama AE, Kyeyune-Bakyayita R, et al.Dietary micronutrients and gender, body mass index and viral suppression among HIV-Infected patients in Kampala, Uganda[J]. Int J MCH AIDS, 2020, 9(3): 337-349.
[13]
霍岩.HIV感染者贫血发病率,危险因素及临床预后:一项回顾性队列研究[D].沈阳：中国医科大学，2022.
Huo Y. Incidence, risk factors, and clinical prognosis of anemia in HIV-infected patients: a retrospective cohort study[D]. Shenyang: China Medical University, 2022.(In Chinese)
[14]
郎晶晶，陈盼盼，朱黎丹，等.艾滋病病毒感染者启动高效抗逆转录病毒疗法对贫血发病的影响[J].上海预防医学，2023，35（4）：362-368.
Lang JJ, Chen PP, Zhu LD, et al. Starting effect of highly active antiretroviral therapy on the incidence of anemia in HIV-infected patients[J]. Shanghai Journal of Preventive Medicine, 2023, 35(4): 362-368.(In Chinese)
[15]
Tigabu A, Beyene Y, Getaneh T, et al. Incidence and predictors of anemia among adults on HIV care at South Gondar Zone Public General Hospital Northwest Ethiopia, 2020; retrospective cohort study[J]. PLOS One, 2022, 17(1): e0259944.
[16]
中国医师协会肾脏内科医师分会肾性贫血指南工作组.中国肾性贫血诊治临床实践指南[J].中华医学杂志，2021，101（20）：1463-1502.
Working Group on Guidelines for Renal Anemia, Chinese Nephrologist Association. Clinical practice guideline for the diagnosis and treatment of renal anemia in China[J]. National Medical Journal of China, 2021, 101(20): 1463-1502.(In Chinese)
[17]
Abioye Ai, Sudfeld CR, Noor RA, et al. Anemia and Iron supplementation in relation to viral load and mortality among 70,442 People living with human immunodeficiency virus in Tanzania[J].Journal of Nutrition, 2024, 154(6): 1927-1935.
2025年第52卷第19期
PDF下载
86
37
引用本文
BibTeX
文章信息
doi: 10.20043/j.cnki.MPM.202503554
  • 接收时间：2025-03-30
  • 首发时间：2026-03-17
  • 出版时间：2025-10-10
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2025-03-30
基金
广州市科技计划项目(202206010009)
作者信息
    1.广东药科大学公共卫生学院，广东 广州 510310
    2.广州医科大学附属市八医院感染ICU
    3.暨南大学基础医学与公共卫生学院公共卫生与预防医学系，广东 广州 510632

通讯作者:

李丽霞，E-mail:；
郜艳晖，E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202503554
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持