Article(id=1240413930229650246, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240413921266429979, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202504145, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1744387200000, receivedDateStr=2025-04-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773667326742, onlineDateStr=2026-03-16, pubDate=1754755200000, pubDateStr=2025-08-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773667326742, onlineIssueDateStr=2026-03-16, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773667326742, creator=13701087609, updateTime=1773667326742, updator=13701087609, issue=Issue{id=1240413921266429979, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='15', pageStart='2689', pageEnd='2880', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1773667324606, creator=13701087609, updateTime=1773667356299, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1240414054267802325, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240413921266429979, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1240414054267802326, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240413921266429979, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2695, endPage=2699, ext={EN=ArticleExt(id=1240413930581971814, articleId=1240413930229650246, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Association of serum albumin with the risk of developing respiratory failure in male pneumoconiosis patients with pulmonary infection: a retrospective cohort study, columnId=1240413921954295836, journalTitle=Modern Preventive Medicine, columnName=Epidemiology and Statistical Methods, runingTitle=null, highlight=null, articleAbstract=
Objective To study the association between serum albumin level and the risk of respiratory failure after pulmonary infection in patients with pneumoconiosis.
Methods This study utilized data of hospitalized pneumoconiosis patients from 2012 to 2021 and employed the Cox model to analyze the association between baseline serum albumin levels and the risk of respiratory failure following pulmonary infection in male pneumoconiosis patients.
Results The average age of 1 301 male inpatients with pneumoconiosis was 50.94 ±11.12 years, with a median age of 48 years old. Respiratory failure occurred in 194 patients after infection, and the incidence density was 44.14 per 1 000 person-years. Grouped by whether respiratory failure occurred, there were significant differences between the two groups in terms of age, smoking status, drinking status, length of dust exposure, ALB, BMI and stage of pneumoconiosis (P<0.05). Multivariate Cox regression analysis indicated that compared with pneumoconiosis patients with serum ALB≤35.1 g/L, those with ALB≥40.9 g/L had a reduced risk of developing respiratory failure after infection (HR=0.48, 95%CI: 0.02-0.94, P=0.002). Subgroup analysis revealed that compared with the lowest quartile group (Q1) of serum ALB, in the low BMI group (BMI<18.5 kg/m2), patients in the Q4 group of serum ALB had a significantly lower risk of developing respiratory failure after infection (HR=0.36, 95% CI: 0.20-0.64, P=0.001); in normal BMI group (18.5 kg/m2≤BMI<24 kg/m2), the Q4 group of serum ALB significantly reduced the risk of developing respiratory failure after infection (HR=0.22, 95% CI: 0.09-0.53, P=0.001); and in pneumoconiosis stage 3 group, the Q4 group of serum ALB significantly reduced the risk of developing respiratory failure after infection (HR=0.42, 95% CI: 0.25-0.71, P=0.001). The restricted cubic spline plot showed that when ALB>38.1 g/L, the risk of developing respiratory failure after pulmonary infection in male pneumoconiosis patients decreased progressively with increasing baseline serum albumin levels.
Conclusion High serum albumin is a protective factor for respiratory failure in male pneumoconiosis patients after pulmonary infection. Serum ALB concentration higher than 38.1 g/L can reduce the risk of respiratory failure after infection.
, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xue-jie DENG, Chi-fei ZHOU, Wen-ao YU, Wen DU, Yu-qin YAO, Qiu-rong HE), CN=ArticleExt(id=1240413933182440397, articleId=1240413930229650246, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=肺部感染的男性尘肺患者血清白蛋白与呼吸衰竭的发生风险的关联——一项回顾性队列研究, columnId=1228016567632462653, journalTitle=现代预防医学, columnName=流行病与统计方法, runingTitle=null, highlight=null, articleAbstract=
目的 研究血清白蛋白(serum albumin, ALB)水平与尘肺患者肺部感染后呼吸衰竭发生风险的关联。
方法 本研究基于2012—2021年住院尘肺患者数据,采用Cox模型分析基线ALB水平与男性尘肺患者肺部感染后发生呼吸衰竭风险的关联。
结果 1 301名男性尘肺住院患者平均年龄为(50.94±11.12)岁,中位数年龄48岁,194名患者感染后发生呼吸衰竭,发病密度44.14/千人年。按是否发生呼吸衰竭分组,两组在年龄、吸烟状况、饮酒状况、接尘工龄、ALB、BMI及尘肺期别上差异显著(P<0.05)。多因素Cox回归分析表明,与ALB≤35.1 g/L的尘肺患者相比,ALB≥40.9 g/L的尘肺患者感染后呼吸衰竭的发病风险降低(HR=0.48,95%CI:0.02~0.94,P=0.002)。亚组分析发现,与ALB Q1组相比,在BMI偏低组(BMI<18.5 kg/m2)中,Q4组患者感染后发生呼吸衰竭风险降低(HR=0.36,95% CI:0.20~0.64);在BMI正常组(18.5 kg/m2≤BMI<24.0 kg/m2)中,Q4组患者感染后发生呼吸衰竭风险降低(HR=0.22,95% CI:0.09~0.53);在尘肺叁期组中,Q4组患者感染后发生呼吸衰竭风险降低(HR=0.42,95% CI:0.25~0.71)。限制性立方样条图显示,当ALB>38.1 g/L时,随着基线ALB浓度的增加,男性尘肺患者肺部感染后呼吸衰竭的发生风险逐渐降低。
结论 高ALB是男性尘肺患者肺部感染后发生呼吸衰竭的保护因素,ALB浓度高于38.1 g/L,可降低感染后呼吸衰竭的发生风险。
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点,除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=Lw5VS3qrTved2wqVbKJD5w==, magXml=2XDE8gYCYS3ftgEckK3/AQ==, pdfUrl=null, pdf=ykogHdgwkLRaX9s0J9CgRg==, pdfFileSize=669873, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=Ch7FUuhlFR4fCzszijHonw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=n/s/2KIWlU97jnN0URNoOQ==, mapNumber=null, authorCompany=null, fund=null, authors=
邓学杰(1999—),男,硕士在读,研究方向:劳动卫生与环境卫生学
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The dose-response relationship between baseline serum albumin concentration and the risk of respiratory failure following infection, figureFileSmall=tJR/kQHCCkj6dkYgLHr3Ew==, figureFileBig=aH7g3rNFh3sWZBSV26qItw==, tableContent=null), ArticleFig(id=1240424353041535519, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240413930229650246, language=CN, label=图1, caption=
基线ALB浓度与感染后呼吸衰竭发生风险的剂量反应关系注:实线表示HR;阴影部分表示95%CI。
, figureFileSmall=tJR/kQHCCkj6dkYgLHr3Ew==, figureFileBig=aH7g3rNFh3sWZBSV26qItw==, tableContent=null), ArticleFig(id=1240424353179947563, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240413930229650246, language=EN, label=Table 1, caption=
Baseline of pneumoconiosis patients [(n=1 301),n(%),(
)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 特征 | 未发生 呼吸衰竭 | 发生 呼吸衰竭 | t/χ2值 | P值 |
|---|
| (n=1 107) | (n=194) |
|---|
| 年龄(岁) | 50.10 (10.76) | 55.69 (11.96) | -6.08 | <0.001 |
| 随访时间(d) | 1 266.07 (942.14) | 1 043.89 (769.88) | 3.58 | 0.002 |
| 年龄(岁) | | | 35.01 | <0.001 |
| < 60 | 881 (79.6) | 116 (59.8) | | |
| ≥ 60 | 226 (20.4) | 78 (40.2) | | |
| 吸烟状况 | | | 8.07 | 0.018 |
| 无吸烟史 | 187 (16.9) | 35 (18.0) | | |
| 既往吸烟者 | 620 (56.0) | 125 (64.4) | | |
| 当前吸烟者 | 300 (27.1) | 34 (17.5) | | |
| 饮酒状况 | | | 6.09 | 0.048 |
| 无饮酒史 | 614 (55.5) | 98 (50.5) | | |
| 当前饮酒者 | 172 (15.5) | 44 (22.7) | | |
| 既往饮酒者 | 321 (29.0) | 52 (26.8) | | |
| 接尘工龄(年) | 11.08±8.68 | 12.72±9.38 | -2.27 | 0.017 |
| 尘肺期别 | | | 34.08 | < 0.001 |
| 壹期 | 231 (20.9) | 19 (9.8) | | |
| 贰期 | 434 (39.2) | 55 (28.4) | | |
| 叁期 | 442 (39.9) | 120 (61.9) | | |
| BMI(kg/m2) | | | 44.56 | <0.001 |
| <18.5 | 697 (63.0) | 112 (57.7) | | |
| 18.5~<24.0 | 74 (6.7) | 41 (21.1) | | |
| ≥24.0 | 336 (30.4) | 41 (21.1) | | |
| ALB(g/L) | | | 25.2 | <0.001 |
| <35.1 | 258 (23.3) | 74 (38.1) | | |
| 35.1~<38.1 | 283 (25.6) | 44 (22.7) | | |
| 38.1~<40.9 | 267 (24.1) | 48 (24.7) | | |
| ≥40.9 | 299 (27.0) | 28 (14.4) | | |
), ArticleFig(id=1240424353335136824, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240413930229650246, language=CN, label=表1, caption=
尘肺患者的基线特征分布[(n=1 301),n(%),(
)]
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| 特征 | 未发生 呼吸衰竭 | 发生 呼吸衰竭 | t/χ2值 | P值 |
|---|
| (n=1 107) | (n=194) |
|---|
| 年龄(岁) | 50.10 (10.76) | 55.69 (11.96) | -6.08 | <0.001 |
| 随访时间(d) | 1 266.07 (942.14) | 1 043.89 (769.88) | 3.58 | 0.002 |
| 年龄(岁) | | | 35.01 | <0.001 |
| < 60 | 881 (79.6) | 116 (59.8) | | |
| ≥ 60 | 226 (20.4) | 78 (40.2) | | |
| 吸烟状况 | | | 8.07 | 0.018 |
| 无吸烟史 | 187 (16.9) | 35 (18.0) | | |
| 既往吸烟者 | 620 (56.0) | 125 (64.4) | | |
| 当前吸烟者 | 300 (27.1) | 34 (17.5) | | |
| 饮酒状况 | | | 6.09 | 0.048 |
| 无饮酒史 | 614 (55.5) | 98 (50.5) | | |
| 当前饮酒者 | 172 (15.5) | 44 (22.7) | | |
| 既往饮酒者 | 321 (29.0) | 52 (26.8) | | |
| 接尘工龄(年) | 11.08±8.68 | 12.72±9.38 | -2.27 | 0.017 |
| 尘肺期别 | | | 34.08 | < 0.001 |
| 壹期 | 231 (20.9) | 19 (9.8) | | |
| 贰期 | 434 (39.2) | 55 (28.4) | | |
| 叁期 | 442 (39.9) | 120 (61.9) | | |
| BMI(kg/m2) | | | 44.56 | <0.001 |
| <18.5 | 697 (63.0) | 112 (57.7) | | |
| 18.5~<24.0 | 74 (6.7) | 41 (21.1) | | |
| ≥24.0 | 336 (30.4) | 41 (21.1) | | |
| ALB(g/L) | | | 25.2 | <0.001 |
| <35.1 | 258 (23.3) | 74 (38.1) | | |
| 35.1~<38.1 | 283 (25.6) | 44 (22.7) | | |
| 38.1~<40.9 | 267 (24.1) | 48 (24.7) | | |
| ≥40.9 | 299 (27.0) | 28 (14.4) | | |
), ArticleFig(id=1240424353481937472, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240413930229650246, language=EN, label=Table 2, caption=
Univariate and multivariate Cox regression analysis of risk factors for respiratory failure in patients with pneumoconiosis after infection
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 单因素Cox回归分析 | 多因素Cox回归分析 |
|---|
| HR(95%CI) | P值 | HR(95%CI) | P值 |
|---|
| 年龄(岁) | | | | |
| < 60 | 1(Ref) | | 1(Ref) | |
| ≥ 60 | 2.48(2.20~2.77) | <0.001 | 2.48(2.14~2.82) | <0.001 |
| 吸烟状况 | | | | |
| 无吸烟史 | 1(Ref) | | 1(Ref) | |
| 既往吸烟者 | 1.02(0.65~1.4) | 0.916 | 0.98(0.6~1.37) | 0.938 |
| 当前吸烟者 | 0.62(0.15~1.09) | 0.048 | 0.6(0.12~1.08) | 0.037 |
| 饮酒状况 | | | | |
| 无饮酒史 | 1(Ref) | | 1(Ref) | |
| 既往饮酒者 | 1.50(1.14~1.85) | 0.026 | 1.31(0.95~1.68) | 0.146 |
| 当前饮酒者 | 1.03(0.69~1.36) | 0.875 | 1.40(1.06~1.75) | 0.057 |
| 接尘工龄(年) | 1.02(1.01~1.04) | 0.001 | 1.00(0.98~1.01) | 0.789 |
| BMI(kg/m2) | | | | |
| <18.5 | 1(Ref) | | 1(Ref) | |
| 18.5~<24 | 0.31(-0.04~0.67) | <0.001 | 0.39(0.02~0.77) | <0.001 |
| ≥24 | 0.21(-0.22~0.65) | <0.001 | 0.30(-0.16~0.76) | <0.001 |
| 尘肺期别 | | | | |
| 壹期 | 1(Ref) | | 1(Ref) | |
| 贰期 | 1.57(1.05~2.09) | 0.089 | 1.72(1.19~2.24) | 0.043 |
| 叁期 | 3.02(2.54~3.51) | <0.001 | 2.86(2.37~3.35) | <0.001 |
| ALB(g/L) | | | | |
| <35.1 | 1(Ref) | | 1(Ref) | |
| 35.1~<38.1 | 0.47(0.1~0.84) | <0.001 | 0.62(0.23~1.00) | 0.014 |
| 38.1~<40.9 | 0.50(0.13~0.86) | <0.001 | 0.69(0.31~1.07) | 0.059 |
| ≥40.9 | 0.31(-0.12~0.75) | <0.001 | 0.48(0.02~0.94) | 0.002 |
), ArticleFig(id=1240424353595183691, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240413930229650246, language=CN, label=表2, caption=
尘肺病患者感染后发生呼吸衰竭风险影响因素的单因素、多因素Cox回归分析
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 单因素Cox回归分析 | 多因素Cox回归分析 |
|---|
| HR(95%CI) | P值 | HR(95%CI) | P值 |
|---|
| 年龄(岁) | | | | |
| < 60 | 1(Ref) | | 1(Ref) | |
| ≥ 60 | 2.48(2.20~2.77) | <0.001 | 2.48(2.14~2.82) | <0.001 |
| 吸烟状况 | | | | |
| 无吸烟史 | 1(Ref) | | 1(Ref) | |
| 既往吸烟者 | 1.02(0.65~1.4) | 0.916 | 0.98(0.6~1.37) | 0.938 |
| 当前吸烟者 | 0.62(0.15~1.09) | 0.048 | 0.6(0.12~1.08) | 0.037 |
| 饮酒状况 | | | | |
| 无饮酒史 | 1(Ref) | | 1(Ref) | |
| 既往饮酒者 | 1.50(1.14~1.85) | 0.026 | 1.31(0.95~1.68) | 0.146 |
| 当前饮酒者 | 1.03(0.69~1.36) | 0.875 | 1.40(1.06~1.75) | 0.057 |
| 接尘工龄(年) | 1.02(1.01~1.04) | 0.001 | 1.00(0.98~1.01) | 0.789 |
| BMI(kg/m2) | | | | |
| <18.5 | 1(Ref) | | 1(Ref) | |
| 18.5~<24 | 0.31(-0.04~0.67) | <0.001 | 0.39(0.02~0.77) | <0.001 |
| ≥24 | 0.21(-0.22~0.65) | <0.001 | 0.30(-0.16~0.76) | <0.001 |
| 尘肺期别 | | | | |
| 壹期 | 1(Ref) | | 1(Ref) | |
| 贰期 | 1.57(1.05~2.09) | 0.089 | 1.72(1.19~2.24) | 0.043 |
| 叁期 | 3.02(2.54~3.51) | <0.001 | 2.86(2.37~3.35) | <0.001 |
| ALB(g/L) | | | | |
| <35.1 | 1(Ref) | | 1(Ref) | |
| 35.1~<38.1 | 0.47(0.1~0.84) | <0.001 | 0.62(0.23~1.00) | 0.014 |
| 38.1~<40.9 | 0.50(0.13~0.86) | <0.001 | 0.69(0.31~1.07) | 0.059 |
| ≥40.9 | 0.31(-0.12~0.75) | <0.001 | 0.48(0.02~0.94) | 0.002 |
), ArticleFig(id=1240424353741984341, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240413930229650246, language=EN, label=Table 3, caption=
Association between ALB and the risk of respiratory failure after infection among pneumoconiosis patients, stratified by BMI and pneumoconiosis stage
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | Q1 | Q2[HR(95%CI)] | P1值 | Q3[HR(95%CI)] | P2值 | Q4[HR(95%CI)] | P3值 |
|---|
| BMI(kg/m2) | | | | | | | |
| <18.5 | 1(Ref) | 0.49(0.30~0.80) | 0.004 | 0.62(0.39~1.00) | 0.049 | 0.36(0.20~0.64) | 0.001 |
| 18.5~<24 | 1(Ref) | 0.38(0.16~0.87) | 0.021 | 0.27(0.12~0.63) | 0.002 | 0.22(0.09~0.53) | 0.001 |
| ≥24 | 1(Ref) | 1.09(0.47~2.51) | 0.358 | 0.92(0.41~2.04) | 0.388 | 0.95(0.35~2.58) | 0.053 |
| 尘肺期别 | | | | | | | |
| 壹期 | 1(Ref) | 0.45(0.22~0.92) | 0.029 | 0.54(0.28~1.07) | 0.076 | 0.27(0.12~0.61) | 0.002 |
| 贰期 | 1(Ref) | 0.6(0.20~1.79) | 0.358 | 0.59(0.18~1.94) | 0.388 | 0.12(0.01~1.03) | 0.053 |
| 叁期 | 1(Ref) | 0.54(0.33~0.88) | 0.012 | 0.49(0.31~0.78) | 0.003 | 0.42(0.25~0.71) | 0.001 |
), ArticleFig(id=1240424353897173596, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240413930229650246, language=CN, label=表3, caption=
以BMI、尘肺期别分层后ALB与尘肺患者感染后发生呼吸衰竭发生风险的相关性分析
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | Q1 | Q2[HR(95%CI)] | P1值 | Q3[HR(95%CI)] | P2值 | Q4[HR(95%CI)] | P3值 |
|---|
| BMI(kg/m2) | | | | | | | |
| <18.5 | 1(Ref) | 0.49(0.30~0.80) | 0.004 | 0.62(0.39~1.00) | 0.049 | 0.36(0.20~0.64) | 0.001 |
| 18.5~<24 | 1(Ref) | 0.38(0.16~0.87) | 0.021 | 0.27(0.12~0.63) | 0.002 | 0.22(0.09~0.53) | 0.001 |
| ≥24 | 1(Ref) | 1.09(0.47~2.51) | 0.358 | 0.92(0.41~2.04) | 0.388 | 0.95(0.35~2.58) | 0.053 |
| 尘肺期别 | | | | | | | |
| 壹期 | 1(Ref) | 0.45(0.22~0.92) | 0.029 | 0.54(0.28~1.07) | 0.076 | 0.27(0.12~0.61) | 0.002 |
| 贰期 | 1(Ref) | 0.6(0.20~1.79) | 0.358 | 0.59(0.18~1.94) | 0.388 | 0.12(0.01~1.03) | 0.053 |
| 叁期 | 1(Ref) | 0.54(0.33~0.88) | 0.012 | 0.49(0.31~0.78) | 0.003 | 0.42(0.25~0.71) | 0.001 |
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