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Human-Residential Bifidobacteria are important beneficial bacteria in the intestinal tract. The dominant species change with age and can be classified into infant-type Bifidobacteria and Adult-type Bifidobacteria. Recent studies have shown that infant-type Bifidobacteria have unique intestinal adhesion and colonization capabilities, can specifically metabolize human milk oligosaccharides (HMOs) and synthesize bioactive substances such as short-chain fatty acids (SCFAs), tryptophan derivatives, and secondary bile acids. It demonstrates unique probiotic effects in regulating host metabolism and safety. However, current research mainly focus on the functional domain, while there are still many bottlenecks in industrial technology research,which seriously limit its application scope and efficacy. In the future, in addition to continuing to study the functions and mechanisms of infant-type Bifidobacteria, research on processing technology should also be actively developed to break through the technical bottlenecks of commercial application of infant-type Bifidobacteria, enabling it to exert a greater role in maintaining human health and preventing diseases.

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人源性双歧杆菌是肠道重要的有益菌，其优势菌种会随着年龄变化而发生变化，可分为婴儿型双歧杆菌和成人型双歧杆菌。近年有研究表明，婴儿型双歧杆菌具有独特的肠道黏附及定植能力，可特异性代谢人乳低聚糖(human milk oligosaccharides, HMOs)以及合成短链脂肪酸(short-chain fatty acids, SCFAs)、色氨酸衍生物和次级胆汁酸等生物活性物质，在调节宿主代谢和安全性方面展现出特有的益生作用。目前研究多聚焦于功能领域，在工业化技术研究上仍存在许多瓶颈，严重限制其应用范围与效果。今后，除继续对婴儿型双歧杆菌功能与机制研究外，也应积极强化加工工艺技术研究，以突破婴儿型双歧杆菌商业化应用的技术瓶颈，才能使其在维护人体健康和预防疾病上发挥出更大作用。

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任磊（1988—），男，博士在读，高级工程师，研究方向：益生菌功能、工艺开发

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任磊（1988—），男，博士在读，高级工程师，研究方向：益生菌功能、工艺开发

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