Article(id=1228016567917670557, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1228016566646801206, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202504268, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1744560000000, receivedDateStr=2025-04-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1770711565235, onlineDateStr=2026-02-10, pubDate=1758729600000, pubDateStr=2025-09-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1770711565235, onlineIssueDateStr=2026-02-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1770711565235, creator=13701087609, updateTime=1770711565235, updator=13701087609, issue=Issue{id=1228016566646801206, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='18', pageStart='3265', pageEnd='3456', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1770711564932, creator=13701087609, updateTime=1770711815039, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1228017615784833769, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1228016566646801206, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1228017615784833770, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1228016566646801206, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=3318, endPage=3323, ext={EN=ArticleExt(id=1228016570966929612, articleId=1228016567917670557, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Exposure levels and health risks of nine pollutants in drinking water of Liaoning, columnId=1228016570660745413, journalTitle=Modern Preventive Medicine, columnName=Environmental and Occupational Health, runingTitle=null, highlight=null, articleAbstract=
Objective

To analyze the exposure levels and health risks of nine pollutants in urban and rural drinking water of Liaoning Province, and to provide a reference for ensuring drinking water safety.

Methods

Water samples from 28 large-scale water supply units were monitored in 2024. The indicators included bisphenol A (BPA), nitrosodimethylamine (NDMA), di(2-ethylhexyl) adipate (DEHA), diethyl phthalate (DEP), dibutyl phthalate (DBP), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), vanadium (V), and chlorinated paraffins (CPs). The results were evaluated according to the standards for drinking water quality (GB 5749-2022), except for CPs. The comparison of concentration differences between the two groups was performed using the Mann-Whitney U test, while the Kruskal-Wallis rank-sum test was employed for comparisons among multiple groups. The χ2 test was used for the comparison of rates. Using the health risk assessment methods of the U.S. Environmental Protection Agency and the technical guide for environmental health risk assessment of chemical exposure (WS/T 777-2021), the health risks to people through oral of drinking water were assessed.

Results

A total of 112 water samples were collected and tested. The detection rates of the indicators, in descending order, were PFOA (36.61%)> NDMA (25.89%)> PFOS (16.07%)> DBP (15.18%)> BPA (4.46%)>CPs (2.67%). DEHA, DEP, and V were not detected. Except for CPs, the compliance rate for DBP was 99.96%, while all other indicators reached 100%. BPA and NDMA concentrations in wet season were higher than that in dry season, and the detection rate of NDMA was also higher in the wet season compared to the dry season; the NDMA concentration in the finished water was higher than that in the tap water, and all these differences were statistically significant (P<0.05). In surface water sources for drinking water, the concentrations of NDMA and DBP were higher than those in groundwater (P<0.05); the detection rates of DBP and PFOA in surface water were higher than those in groundwater (P<0.05). The hazard quotient (HQ) for PFOA is greater than 1, indicating a high non-carcinogenic risk; the carcinogenic risk values (CR) of NDMA, PFOA of male and female, and PFOS are all between 1.0×10-6 to 1.0×10-4, indicating a certain risk.

Conclusion

In Liaoning Province, there is exposure to BPA, NDMA, DBP, PFOA, PFOS and CPs in drinking water samples. NDMA, PFOA and PFOS carry a certain level of potential carcinogenic risks, but all are within the acceptable range. PFOA presents a certain non-carcinogenic risk and requires attention.

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目的

分析辽宁省城乡饮用水中9种污染物暴露水平及健康风险,为保障饮用水安全提供参考。

方法

2024年对28家大规模供水单位进行监测,分析双酚A(BPA)、亚硝基二甲胺(NDMA)、二(2-乙基己基)己二酸酯(DEHA)、邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)、全氟辛酸(PFOA)、全氟辛烷磺酸(PFOS)、钒(V)和氯化石蜡(CPs)污染状况和健康风险。除CPs外,检验结果按照《生活饮用水卫生标准》(GB 5749-2022)进行评价。两组间浓度差异比较采用Mann-Whitney U检验,多组间比较采用Kruskal-Wallis秩和检验;率的比较采用χ2检验。结合美国国家环境保护署健康风险评价方法和我国《化学物质环境健康风险评估技术指南》(WS/T 777—2021),对饮用水经口摄入的健康风险进行评估。

结果

共采集检测水样112份,检出率由高到低为PFOA(36.61%)>NDMA(25.89%)>PFOS(16.07%)>DBP(15.18%)>BPA(4.46%)>CPs(2.67%), DEHA、DEP和V未检出。除CPs外,DBP达标率为99.96%,其它指标均为100%。丰水期BPA和NDMA浓度高于枯水期,且丰水期NDMA检出率高于枯水期;出厂水NDMA浓度高于末梢水,以上差异均有统计学意义(P<0.05)。地表水水源饮用水中NDMA和DBP浓度高于地下水(P<0.05);地表水DBP和PFOA检出率高于地下水(P<0.05)。PFOA的危害商(HQ)>1,非致癌风险较高;致癌风险中,NDMA、男性和女性PFOA、PFOS的致癌风险值(CR)均在1.0×10-6~1.0×10-4,具有一定风险,但在可接受范围内。

结论

辽宁省饮用水中BPA、NDMA、DBP、PFOA、PFOS和CPs均有不同程度的检出。NDMA、PFOA和PFOS的致癌风险在可接受范围内。PFOA具有一定非致癌风险,需加以关注。

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王舒,E-mail :
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李继芳(1979—),女,本科,主任医师,研究方向:环境卫生与健康研究

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Research progress on pollution status and ecological risks of phthalates in the environment[J]. Liaoning Urban and Rural Environmental Science & Technology, 2020, 40(2): 34-40,60.(In Chinese), articleTitle=Research progress on pollution status and ecological risks of phthalates in the environment, refAbstract=null), Reference(id=1228016584216735828, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, doi=null, pmid=null, pmcid=null, year=2004, volume=36, issue=2, pageStart=114, pageEnd=122, url=null, language=null, rfNumber=[24], rfOrder=39, authorNames=Konno Y, Suzuki H, Kudo H, journalName=Polymer Joumal, refType=null, unstructuredReference=Konno Y, Suzuki H, Kudo H, et al. Smhesis and popeties of Fluorine containing poly(ecther)s with pendant hydoxyl groups by thepalyaddition of bis(oxetane)s and bisphenol AF[J]. Polymer Joumal, 2004, 36(2): 114-122., articleTitle=Smhesis and popeties of Fluorine containing poly(ecther)s with pendant hydoxyl groups by thepalyaddition of bis(oxetane)s and bisphenol AF, refAbstract=null), Reference(id=1228016584342564953, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, doi=null, pmid=null, pmcid=null, year=2025, volume=44, issue=10, pageStart=1, pageEnd=11, url=null, language=null, rfNumber=[25], rfOrder=40, authorNames=王若男, 史箴, 胥倩, journalName=环境化学, refType=null, unstructuredReference=王若男,史箴,胥倩,等.四川省地市级饮用水源地全氟化合物污染状况调查研究[J].环境化学2025, 44(10): 1-11., articleTitle=四川省地市级饮用水源地全氟化合物污染状况调查研究, refAbstract=null), Reference(id=1228016584447422556, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, doi=null, pmid=null, pmcid=null, year=2025, volume=44, issue=10, pageStart=1, pageEnd=11, url=null, language=null, rfNumber=[25], rfOrder=41, authorNames=Wang RN, Shi Z, Xu Q, journalName=Environmental Chemistry, refType=null, unstructuredReference=Wang RN, Shi Z, Xu Q, et al. Occurrence of perfluoroalkyl substances in drinking water sources at prefecture and municipal levels in Sichuan Province[J]. Environmental Chemistry, 2025, 44(10): 1-11.(In Chinese), articleTitle=Occurrence of perfluoroalkyl substances in drinking water sources at prefecture and municipal levels in Sichuan Province, refAbstract=null)], funds=[Fund(id=1228016579183571730, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, awardId=2024JH2/102500087, language=CN, fundingSource=辽宁省重点研发项目(2024JH2/102500087), fundOrder=null, country=null), Fund(id=1228016579296817950, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, awardId=2018225113, language=CN, fundingSource=辽宁省重点实验室(2018225113), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1228016572854366508, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, xref=null, ext=[AuthorCompanyExt(id=1228016572862755118, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, companyId=1228016572854366508, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Institute for Environmental Health, Liaoning Provincial Center for Disease Control and Prevention, Shenyang, Liaoning 110172, China), AuthorCompanyExt(id=1228016572875338031, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, companyId=1228016572854366508, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=辽宁省疾病预防控制中心,环境卫生所,辽宁 沈阳 110172)])], figs=[ArticleFig(id=1228016577199665792, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=EN, label=Table 1, caption=

Slope factors, reference doses of chemicals

, figureFileSmall=null, figureFileBig=null, tableContent=
指标非致癌参考剂量
(RfD,mg/(kg·d))
致癌斜率因子
(SF,kg·d /mg)
BPA5×10-2-
NDMA-51.0
DEHA6×10-1-
DEP8×10-1-
DBP1×10-1-
PFOA3×10-829.3
PFOS1×10-739.5
), ArticleFig(id=1228016577321300620, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=CN, label=表1, caption=

污染物参考剂量和斜率因子

, figureFileSmall=null, figureFileBig=null, tableContent=
指标非致癌参考剂量
(RfD,mg/(kg·d))
致癌斜率因子
(SF,kg·d /mg)
BPA5×10-2-
NDMA-51.0
DEHA6×10-1-
DEP8×10-1-
DBP1×10-1-
PFOA3×10-829.3
PFOS1×10-739.5
), ArticleFig(id=1228016577438741141, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=EN, label=Table 2, caption=

Health risk assessment parameters

, figureFileSmall=null, figureFileBig=null, tableContent=
人群日摄入量
(IR,L/d)
暴露频率
(EF,d/a)
暴露周期(ED,a)体重
(BW,kg)
平均接触时间(AT,d)
非致癌效应致癌效应非致癌效应致癌效应
男性2.47536574.127066.127 053.825 550
女性2.12436578.867057.828 783.925 550
), ArticleFig(id=1228016577560375967, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=CN, label=表2, caption=

健康风险评估参数

, figureFileSmall=null, figureFileBig=null, tableContent=
人群日摄入量
(IR,L/d)
暴露频率
(EF,d/a)
暴露周期(ED,a)体重
(BW,kg)
平均接触时间(AT,d)
非致癌效应致癌效应非致癌效应致癌效应
男性2.47536574.127066.127 053.825 550
女性2.12436578.867057.828 783.925 550
), ArticleFig(id=1228016577698788012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=EN, label=Table 3, caption=

Basic information of water supply units of Liaoning Province(n

, figureFileSmall=null, figureFileBig=null, tableContent=
组别城市农村合计
水源类型地表水13417
地下水11011
水处理方式常规处理14418
仅消毒-44
未处理-66
消毒方式次氯酸钠448
液氯9-9
复合二氧化氯123
高纯二氧化氯-22
), ArticleFig(id=1228016577853977268, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=CN, label=表3, caption=

辽宁省调查供水单位基本情况(个)

, figureFileSmall=null, figureFileBig=null, tableContent=
组别城市农村合计
水源类型地表水13417
地下水11011
水处理方式常规处理14418
仅消毒-44
未处理-66
消毒方式次氯酸钠448
液氯9-9
复合二氧化氯123
高纯二氧化氯-22
), ArticleFig(id=1228016577975612090, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=EN, label=Table 4, caption=

Detection results of pollutants in drinking water of Liaoning Province

, figureFileSmall=null, figureFileBig=null, tableContent=
指标样本数浓度范围
(mg/L)
中位数
(mg/L)
检出率
(%)
BPA112ND~7.0×10-62.5×10-64.46
NDMA112ND~5.3×10-52.5×10-625.89
DEHA112NDND0.00
DEP112NDND0.00
DBP112ND~3.9×10-22.0×10-415.18
PFOA112ND~1.4×10-51.5×10-636.61
PFOS112ND~1.5×10-51.5×10-616.07
V112NDND0.00
CPs112ND~8.4×10-31.0×10-32.67
), ArticleFig(id=1228016578076275395, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=CN, label=表4, caption=

辽宁省饮用水中污染物检测结果

, figureFileSmall=null, figureFileBig=null, tableContent=
指标样本数浓度范围
(mg/L)
中位数
(mg/L)
检出率
(%)
BPA112ND~7.0×10-62.5×10-64.46
NDMA112ND~5.3×10-52.5×10-625.89
DEHA112NDND0.00
DEP112NDND0.00
DBP112ND~3.9×10-22.0×10-415.18
PFOA112ND~1.4×10-51.5×10-636.61
PFOS112ND~1.5×10-51.5×10-616.07
V112NDND0.00
CPs112ND~8.4×10-31.0×10-32.67
), ArticleFig(id=1228016578277602002, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=EN, label=Table 5, caption=

Temporal and spatial exposure levels of pollutants in drinking water of Liaoning Province

, figureFileSmall=null, figureFileBig=null, tableContent=
组别样本数BPANDMADBP
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
水期
枯水期56ND0.0002.5×10-6
(ND~4.3×10-5
16.0702.0×10-4
(ND~3.9×10-2
10.710
丰水期562.5×10-6
(ND~7.0×10-6
8.9302.5×10-6
(ND~5.3×10-5
35.7102.0×10-4
(ND~2.8×10-2
19.640
统计量1 428.0003.3501 244.5004.6501 443.5001.110
P0.0230.0670.0100.0310.2480.292
区域
城区562.5×10-6
(ND~6.0×10-6
3.5702.5×10-6
(ND~4.0×10-5
30.3602.0×10-4
(ND~3.9×10-2
17.860
农村562.5×10-6
(ND~7.0×10-6
5.3602.5×10-6
(ND~5.3×10-5
21.4302.0×10-4
(ND~ 1.7×10-2
12.500
统计量1 538.5000.0001 7152.9801 659.0000.000
P0.6371.0000.2700.0840.3991.000
水样类型
出厂水562.5×10-6
(ND~7.0×10-6
5.3502.5×10-6
(ND~5.3×10-5
33.9302.0×10-4
(ND~3.9×10-2
16.070
末梢水562.5×10-6
(ND~7.0×10-6
3.5702.5×10-6
(ND~4.3×10-5
17.8602.0×10-4
(ND~1.4×10-3
14.290
统计量1 594.5000.0001 8400.7401 613.0000.280
P0.6721.0000.0400.3880.6780.598
组别样本数PFOAPFOSCPs
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
水期
枯水期561.5×10-6
(ND~1.4×10-5
37.5001.5×10-6
(ND~1.5×10-5
14.2901.0×10-3
(ND~8.4×10-3
1.780
丰水期561.5×10-6
(ND~1.0×10-5
35.7101.5×10-6
(ND~1.0×10-5
17.8601.0×10-3
(ND~4.6×10-3
0.890
统计量1 610.5000.0001 546.0000.0701 596.0000.000
P0.7771.0000.8450.7970.5671.000
区域
城区561.5×10-6
(ND~1.4×10-5
41.0701.5×10-6
(ND~1.3×10-5
17.8601.0×10-3
(ND~3.0×10-3
0.890
农村561.5×10-6
(ND~1.3×10-5
32.1401.5×10-6
(ND~1.5×10-5
14.2901.0×10-3
(ND~8.4×10-3
1.780
统计量1 747.0002.4601 626.5000.0701 539.0000.000
P0.2290.1170.5980.7970.5531.000
水样类型
出厂水561.5×10-6
(ND~1.4×10-5
44.6401.5×10-6
(ND~1.2×10-5
17.8601.0×10-3
(ND~3.0×10-3
0.890
末梢水561.5×10-6
(ND~1.3×10-5
28.5701.5×10-6
(ND~1.5×10-5
14.2901.0×10-3
(ND~8.4×10-3
1.780
统计量1 758.5000.6201 604.0000.0701 539.0000.000
P0.2000.4330.7470.7970.5531.000
), ArticleFig(id=1228016578449568476, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=CN, label=表5, caption=

辽宁省饮用水中污染物时间和空间暴露水平

, figureFileSmall=null, figureFileBig=null, tableContent=
组别样本数BPANDMADBP
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
水期
枯水期56ND0.0002.5×10-6
(ND~4.3×10-5
16.0702.0×10-4
(ND~3.9×10-2
10.710
丰水期562.5×10-6
(ND~7.0×10-6
8.9302.5×10-6
(ND~5.3×10-5
35.7102.0×10-4
(ND~2.8×10-2
19.640
统计量1 428.0003.3501 244.5004.6501 443.5001.110
P0.0230.0670.0100.0310.2480.292
区域
城区562.5×10-6
(ND~6.0×10-6
3.5702.5×10-6
(ND~4.0×10-5
30.3602.0×10-4
(ND~3.9×10-2
17.860
农村562.5×10-6
(ND~7.0×10-6
5.3602.5×10-6
(ND~5.3×10-5
21.4302.0×10-4
(ND~ 1.7×10-2
12.500
统计量1 538.5000.0001 7152.9801 659.0000.000
P0.6371.0000.2700.0840.3991.000
水样类型
出厂水562.5×10-6
(ND~7.0×10-6
5.3502.5×10-6
(ND~5.3×10-5
33.9302.0×10-4
(ND~3.9×10-2
16.070
末梢水562.5×10-6
(ND~7.0×10-6
3.5702.5×10-6
(ND~4.3×10-5
17.8602.0×10-4
(ND~1.4×10-3
14.290
统计量1 594.5000.0001 8400.7401 613.0000.280
P0.6721.0000.0400.3880.6780.598
组别样本数PFOAPFOSCPs
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
水期
枯水期561.5×10-6
(ND~1.4×10-5
37.5001.5×10-6
(ND~1.5×10-5
14.2901.0×10-3
(ND~8.4×10-3
1.780
丰水期561.5×10-6
(ND~1.0×10-5
35.7101.5×10-6
(ND~1.0×10-5
17.8601.0×10-3
(ND~4.6×10-3
0.890
统计量1 610.5000.0001 546.0000.0701 596.0000.000
P0.7771.0000.8450.7970.5671.000
区域
城区561.5×10-6
(ND~1.4×10-5
41.0701.5×10-6
(ND~1.3×10-5
17.8601.0×10-3
(ND~3.0×10-3
0.890
农村561.5×10-6
(ND~1.3×10-5
32.1401.5×10-6
(ND~1.5×10-5
14.2901.0×10-3
(ND~8.4×10-3
1.780
统计量1 747.0002.4601 626.5000.0701 539.0000.000
P0.2290.1170.5980.7970.5531.000
水样类型
出厂水561.5×10-6
(ND~1.4×10-5
44.6401.5×10-6
(ND~1.2×10-5
17.8601.0×10-3
(ND~3.0×10-3
0.890
末梢水561.5×10-6
(ND~1.3×10-5
28.5701.5×10-6
(ND~1.5×10-5
14.2901.0×10-3
(ND~8.4×10-3
1.780
统计量1 758.5000.6201 604.0000.0701 539.0000.000
P0.2000.4330.7470.7970.5531.000
), ArticleFig(id=1228016578650895081, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=EN, label=Table 6, caption=

Exposure levels of pollutants in drinking water from different water sources and treatment measures

, figureFileSmall=null, figureFileBig=null, tableContent=
组别样本数BPANDMADBP
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
水源类型
地表水682.5×10-6
(ND~7.0×10-6
4.4102.5×10-6
(ND~5.3×10-5
32.3502.0×10-4
(ND~3.9×10-2
22.060
地下水442.5×10-6
(ND~7.0×10-6
4.5402.5×10-6
(ND~2.2×10-5
15.9102.0×10-4
(ND~9.6×10-4
4.550
统计量1 494.0000.0001 758.0002.9601 765.0005.080
P0.9801.0000.0430.0860.0100.024
水处理方式
常规处理722.5×10-6
(ND~7.0×10-6
4.1702.5×10-6
(ND~5.3×10-5
30.5602.0×10-4
(ND~3.9×10-2
16.670
仅消毒162.5×10-6
(ND~7.0×10-6
12.5002.5×10-6
(ND~2.2×10-5
31.2502.0×10-4
(ND~9.6×10-4
6.250
未处理24ND0.0002.5×10-6
(ND~1.8×10-5
8.3302.0×10-4
(ND~1.7×10-2
16.670
统计量3.5253.5604.9114.9101.1981.160
P0.1720.1690.0860.0860.5490.561
组别样本数PFOAPFOSCPs
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
水源类型
地表水681.5×10-6
(ND~1.4×10-5
47.0601.5×10-6
(ND~1.3×10-5
17.6501.0×10-3
(ND~8.4×10-3
2.670
地下水441.5×10-6
(ND~6.2×10-6
20.4501.5×10-6
(ND~1.5×10-5
13.640ND0.000
统计量1 925.0007.0401 554.0000.0901 562.0000.660
P0.0030.0080.5920.7630.1630.416
水处理方式
常规处理721.5×10-6
(ND~1.4×10-5
43.0601.5×10-6
(ND~1.3×10-5
16.6701.0×10-3
(ND~8.4×10-3
2.670
仅消毒161.5×10-6
(ND~6.2×10-6
25.0001.5×10-6
(ND~1.5×10-5
18.750ND0.000
未处理241.5×10-6
(ND~1.3×10-5
25.0001.5×10-6
(ND~4.6×10-6
12.500ND0.000
统计量2.7913.6100.5420.3301.6971.710
P0.2480.1640.7630.8470.4280.425
), ArticleFig(id=1228016578780918515, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=CN, label=表6, caption=

不同水源和水处理措施饮用水中污染物暴露水平

, figureFileSmall=null, figureFileBig=null, tableContent=
组别样本数BPANDMADBP
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
水源类型
地表水682.5×10-6
(ND~7.0×10-6
4.4102.5×10-6
(ND~5.3×10-5
32.3502.0×10-4
(ND~3.9×10-2
22.060
地下水442.5×10-6
(ND~7.0×10-6
4.5402.5×10-6
(ND~2.2×10-5
15.9102.0×10-4
(ND~9.6×10-4
4.550
统计量1 494.0000.0001 758.0002.9601 765.0005.080
P0.9801.0000.0430.0860.0100.024
水处理方式
常规处理722.5×10-6
(ND~7.0×10-6
4.1702.5×10-6
(ND~5.3×10-5
30.5602.0×10-4
(ND~3.9×10-2
16.670
仅消毒162.5×10-6
(ND~7.0×10-6
12.5002.5×10-6
(ND~2.2×10-5
31.2502.0×10-4
(ND~9.6×10-4
6.250
未处理24ND0.0002.5×10-6
(ND~1.8×10-5
8.3302.0×10-4
(ND~1.7×10-2
16.670
统计量3.5253.5604.9114.9101.1981.160
P0.1720.1690.0860.0860.5490.561
组别样本数PFOAPFOSCPs
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
中位数(范围)
(mg/L)
检出率
(%)
水源类型
地表水681.5×10-6
(ND~1.4×10-5
47.0601.5×10-6
(ND~1.3×10-5
17.6501.0×10-3
(ND~8.4×10-3
2.670
地下水441.5×10-6
(ND~6.2×10-6
20.4501.5×10-6
(ND~1.5×10-5
13.640ND0.000
统计量1 925.0007.0401 554.0000.0901 562.0000.660
P0.0030.0080.5920.7630.1630.416
水处理方式
常规处理721.5×10-6
(ND~1.4×10-5
43.0601.5×10-6
(ND~1.3×10-5
16.6701.0×10-3
(ND~8.4×10-3
2.670
仅消毒161.5×10-6
(ND~6.2×10-6
25.0001.5×10-6
(ND~1.5×10-5
18.750ND0.000
未处理241.5×10-6
(ND~1.3×10-5
25.0001.5×10-6
(ND~4.6×10-6
12.500ND0.000
统计量2.7913.6100.5420.3301.6971.710
P0.2480.1640.7630.8470.4280.425
), ArticleFig(id=1228016578927719165, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=EN, label=Table 7, caption=

Health risk assessment of oral intake of drinking water for adults in Liaoning Province

, figureFileSmall=null, figureFileBig=null, tableContent=
指标HQ值CR值
男性女性男性女性
BPA1.80×10-61.80×10-6--
NDMA--4.77×10-64.69×10-6
DBP7.49×10-57.35×10-5--
PFOA1.871.841.65×10-61.62×10-6
PFOS5.62×10-15.51×10-12.22×10-62.18×10-6
), ArticleFig(id=1228016579040965380, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1228016567917670557, language=CN, label=表7, caption=

辽宁省成人饮用水经口摄入健康风险评估

, figureFileSmall=null, figureFileBig=null, tableContent=
指标HQ值CR值
男性女性男性女性
BPA1.80×10-61.80×10-6--
NDMA--4.77×10-64.69×10-6
DBP7.49×10-57.35×10-5--
PFOA1.871.841.65×10-61.62×10-6
PFOS5.62×10-15.51×10-12.22×10-62.18×10-6
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辽宁省饮用水9种污染物暴露水平及健康风险分析
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李继芳 , 丛琳 , 高津悦 , 王俊龙 , 于连政 , 王舒
现代预防医学 | 环境与职业卫生 2025,52(18): 3318-3323
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现代预防医学 | 环境与职业卫生 2025, 52(18): 3318-3323
辽宁省饮用水9种污染物暴露水平及健康风险分析
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李继芳, 丛琳, 高津悦, 王俊龙, 于连政, 王舒
作者信息
  • 辽宁省疾病预防控制中心,环境卫生所,辽宁 沈阳 110172
  • 李继芳(1979—),女,本科,主任医师,研究方向:环境卫生与健康研究

通讯作者:

王舒,E-mail :
Exposure levels and health risks of nine pollutants in drinking water of Liaoning
Ji-fang LI, Lin CONG, Jin-yue GAO, Jun-long WANG, Lian-zheng YU, Shu WANG
Affiliations
  • Institute for Environmental Health, Liaoning Provincial Center for Disease Control and Prevention, Shenyang, Liaoning 110172, China
出版时间: 2025-09-25 doi: 10.20043/j.cnki.MPM.202504268
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目的

分析辽宁省城乡饮用水中9种污染物暴露水平及健康风险,为保障饮用水安全提供参考。

方法

2024年对28家大规模供水单位进行监测,分析双酚A(BPA)、亚硝基二甲胺(NDMA)、二(2-乙基己基)己二酸酯(DEHA)、邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)、全氟辛酸(PFOA)、全氟辛烷磺酸(PFOS)、钒(V)和氯化石蜡(CPs)污染状况和健康风险。除CPs外,检验结果按照《生活饮用水卫生标准》(GB 5749-2022)进行评价。两组间浓度差异比较采用Mann-Whitney U检验,多组间比较采用Kruskal-Wallis秩和检验;率的比较采用χ2检验。结合美国国家环境保护署健康风险评价方法和我国《化学物质环境健康风险评估技术指南》(WS/T 777—2021),对饮用水经口摄入的健康风险进行评估。

结果

共采集检测水样112份,检出率由高到低为PFOA(36.61%)>NDMA(25.89%)>PFOS(16.07%)>DBP(15.18%)>BPA(4.46%)>CPs(2.67%), DEHA、DEP和V未检出。除CPs外,DBP达标率为99.96%,其它指标均为100%。丰水期BPA和NDMA浓度高于枯水期,且丰水期NDMA检出率高于枯水期;出厂水NDMA浓度高于末梢水,以上差异均有统计学意义(P<0.05)。地表水水源饮用水中NDMA和DBP浓度高于地下水(P<0.05);地表水DBP和PFOA检出率高于地下水(P<0.05)。PFOA的危害商(HQ)>1,非致癌风险较高;致癌风险中,NDMA、男性和女性PFOA、PFOS的致癌风险值(CR)均在1.0×10-6~1.0×10-4,具有一定风险,但在可接受范围内。

结论

辽宁省饮用水中BPA、NDMA、DBP、PFOA、PFOS和CPs均有不同程度的检出。NDMA、PFOA和PFOS的致癌风险在可接受范围内。PFOA具有一定非致癌风险,需加以关注。

饮用水  /  污染物  /  暴露  /  健康风险评估
Objective

To analyze the exposure levels and health risks of nine pollutants in urban and rural drinking water of Liaoning Province, and to provide a reference for ensuring drinking water safety.

Methods

Water samples from 28 large-scale water supply units were monitored in 2024. The indicators included bisphenol A (BPA), nitrosodimethylamine (NDMA), di(2-ethylhexyl) adipate (DEHA), diethyl phthalate (DEP), dibutyl phthalate (DBP), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), vanadium (V), and chlorinated paraffins (CPs). The results were evaluated according to the standards for drinking water quality (GB 5749-2022), except for CPs. The comparison of concentration differences between the two groups was performed using the Mann-Whitney U test, while the Kruskal-Wallis rank-sum test was employed for comparisons among multiple groups. The χ2 test was used for the comparison of rates. Using the health risk assessment methods of the U.S. Environmental Protection Agency and the technical guide for environmental health risk assessment of chemical exposure (WS/T 777-2021), the health risks to people through oral of drinking water were assessed.

Results

A total of 112 water samples were collected and tested. The detection rates of the indicators, in descending order, were PFOA (36.61%)> NDMA (25.89%)> PFOS (16.07%)> DBP (15.18%)> BPA (4.46%)>CPs (2.67%). DEHA, DEP, and V were not detected. Except for CPs, the compliance rate for DBP was 99.96%, while all other indicators reached 100%. BPA and NDMA concentrations in wet season were higher than that in dry season, and the detection rate of NDMA was also higher in the wet season compared to the dry season; the NDMA concentration in the finished water was higher than that in the tap water, and all these differences were statistically significant (P<0.05). In surface water sources for drinking water, the concentrations of NDMA and DBP were higher than those in groundwater (P<0.05); the detection rates of DBP and PFOA in surface water were higher than those in groundwater (P<0.05). The hazard quotient (HQ) for PFOA is greater than 1, indicating a high non-carcinogenic risk; the carcinogenic risk values (CR) of NDMA, PFOA of male and female, and PFOS are all between 1.0×10-6 to 1.0×10-4, indicating a certain risk.

Conclusion

In Liaoning Province, there is exposure to BPA, NDMA, DBP, PFOA, PFOS and CPs in drinking water samples. NDMA, PFOA and PFOS carry a certain level of potential carcinogenic risks, but all are within the acceptable range. PFOA presents a certain non-carcinogenic risk and requires attention.

Drinking water  /  Pollutants  /  Exposure  /  Health risk assessment
李继芳, 丛琳, 高津悦, 王俊龙, 于连政, 王舒. 辽宁省饮用水9种污染物暴露水平及健康风险分析. 现代预防医学, 2025 , 52 (18) : 3318 -3323 . DOI: 10.20043/j.cnki.MPM.202504268
Ji-fang LI, Lin CONG, Jin-yue GAO, Jun-long WANG, Lian-zheng YU, Shu WANG. Exposure levels and health risks of nine pollutants in drinking water of Liaoning[J]. Modern Preventive Medicine, 2025 , 52 (18) : 3318 -3323 . DOI: 10.20043/j.cnki.MPM.202504268
饮用水是维持身体机能,关系居民身体健康的重要物质。我国新《生活饮用水卫生标准》(GB 5749-2022)中,已将双酚A(BPA)、亚硝基二甲胺(NDMA)、二(2-乙基己基)己二酸酯(DEHA)、邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)、全氟辛酸(PFOA)、全氟辛烷磺酸(PFOS)、钒(V)纳入参考指标,以上有机物在多个地区有检出情况[1-4],但进行健康风险评估的较少。目前,氯化石蜡(CPs)尚未列入饮用水卫生标准,但短链氯化石蜡已被列入我国2023年版重点管控新污染清单,其为一种持久性有机物,在环境中广泛存在[5]。目前,按照饮用水卫生标准,可以评价指标是否超出限值,但长期低剂量摄入可能对人体造成健康风险[6],采用污染物风险评价模型和达标情况相结合的方式,评价对人体健康的风险更为科学[7-8]。本研究对全省城乡饮用水BPA等9种污染物浓度及检出率进行分析,并进行健康风险评估,为进一步提升水质,保障饮用水安全提供参考。
2024年,在辽宁省范围内,结合水源类型和水处理工艺的代表性,每个市选择1家日供水规模最大的市政供水单位和1家日供水规模在1千吨及以上的农村集中式供水工程。每个供水单位设置1个出厂水和1个末梢水监测点,于枯水期(3—4月)和丰水期(7—8月)各监测1次。全省共选取28家大规模供水单位,采集检测水样112份。
本次检测指标包括双酚A(BPA)、亚硝基二甲胺(NDMA)、二(2-乙基己基)己二酸酯(DEHA)、邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)、全氟辛酸(PFOA)、全氟辛烷磺酸(PFOS)、钒(V)和氯化石蜡(CPs),共9项指标。CPs采用固相微萃取气相色谱串联质谱法检测,其它指标按照《生活饮用水标准检验方法》(GB/T 5750-2023)[9]进行检测。检验结果按照《生活饮用水卫生标准》(GB 5749-2022)[10]进行评价,目前CPs没有列入我国饮用水卫生标准,本次研究暂不做达标率评价。
结合美国国家环境保护署(United States Environmental Protection Agency, US EPA)健康风险评价方法和《化学物质环境健康风险评估技术指南》(WS/T 777—2021)[11],对饮用水经口摄入途径的人群健康风险进行评估。危害识别和剂量-反应关系评估通过查阅国际癌症研究机构(International Agency for Research on Cancer, IARC)网站[12]和美国国家环保署综合风险信息查询系统(Integrated Risk Information System, IRIS)[13]确定。目前,V和CPs暂无相关数据,本次研究暂不做健康风险评价。见表1
通过饮水经口摄入的暴露量按公式(1)计算:
 
式中:ADDoral为经口摄入日均暴露量,mg/(kg·d);C为饮水中物质浓度,mg / L;IR为日摄入量,L/d;EF为暴露频率,d/a;ED为暴露周期,a;BW 为暴露人群体重,kg;AT为平均接触时间,d。
非致癌风险HQ和致癌风险CR分别通过公式(2)和(3)计算:
 
 
式中:HQ为危害商,无量纲;ADDoral为经口摄入日均暴露量,mg/(kg·d);RfD为非致癌物参考剂量,mg/(kg·d);CR为致癌风险,无量纲;SF为致癌斜率因子, kg·d/mg。
暴露评估参数中经口摄入日摄入率、暴露周期、体重数据来自《中国人群暴露参数手册》(成人卷)中推荐值[14]。评估结合美国环保总署评价方法和《化学物质环境健康风险评估技术指南》进行判定。评估参数见表2
采用R 4.3.3软件进行数据分析。低于方法最低检出限的结果,以最低检出浓度的1/2表示。各指标检测结果不符合正态分布,使用中位数(范围)进行统计描述。两组间浓度比较采用Mann-Whitney U检验,多组间比较采用 Kruskal-Wallis 秩和检验;率的比较采用χ2检验,检验水准α=0.05。
本研究共调查供水单位28个。水源类型中市政供水92.86%(13/14)为地表水,农村供水单位71.43%(10/14)为地下水。进行常规处理(含混凝、沉淀、过滤、消毒)的有64.29%(18/28),消毒方式主要为次氯酸钠和液氯。见表3
本次调查共采集检测水样112份。检出率由高到低顺序为PFOA(36.61%)>NDMA(25.89%)>PFOS(16.07%)>DBP(15.18%)>BPA(4.46%)>CPs(2.67%)。DEHA、DEP和V未检出。除CPs外,DBP达标率为99.96%,其它指标均为100%。见表4
按照水期、城乡区域、水样类型分层分析结果显示,丰水期BPA和NDMA浓度高于枯水期,出厂水NDMA浓度高于末梢水,以上差异均有统计学意义(P<0.05)。除CPs外,其它指标丰水期检出率均高于枯水期;NDMA检出率差异有统计学意义(P<0.05)。见表5
在不同水源类型分析结果中,地表水水源饮用水中NDMA和DBP浓度均高于地下水,差异有统计学意义(P<0.05)。地表水水源饮用水中DBP和PFOA检出率高于地下水,且差异有统计学意义(P<0.05)。不同水处理方式结果中,各指标浓度和检出率分布差异均无统计学意义(P>0.05)。见表6
检出指标致癌风险中,NDMA、PFOA和PFOS的CR值均低于1.0×10-6或在1.0×10-6~1.0×10-4,表明风险较低或具有一定致癌风险,在可接受范围内。非致癌风险中, BPA、DBP和PFOS 的危害商HQ<1,风险较低,PFOA的HQ>1,有一定风险,宜引起关注。按性别分层分析,男性HQ和CR值均大于女性。见表7
本次调查共检测了辽宁省饮用水中9种污染物,其中包括PFOA和PFOS两种全氟化合物,结果显示均有检出,表明该地区饮用水存在全氟化合物的污染;且浓度均低于我国重点流域地区水平[15],污染特征呈现出区域性差异。值得注意的是,PFOA的污染程度显著高于PFOS,这一趋势与苏州市[16]和武汉市[17]的调查结果一致。这种差异与国家管控政策相关,持久性有机物PFOA类和PFOS类已被国家列入2023年版重点管控新污染物清单,文件提出禁止生产PFOS类,而PFOA类管控较之宽松,污染相对较重。虽然当前PFOA和PFOS检出浓度低于我国《生活饮用水卫生标准》限值,但由于全氟化合物的持久性和生物累积性[18],仍需警惕长期低剂量暴露风险,尤其是PFOA,建议加强对相关行业监管,并建立长期监测机制。
本研究在饮用水样品中检出NDMA,污染程度低于我国2010—2020年城市和东北地区出厂水水平[19]。同时,其污染特征呈现出城区污染高于农村的差异。这种差异主要源于城乡供水单位消毒状况的不同。 NDMA主要来源于饮用水的消毒处理[20],也有研究显示液氯消毒的NDMA浓度较高[19-20]。本次调查的城区供水单位均有消毒措施,且以液氯为主;而农村地区部分未进行消毒,并以次氯酸钠为主,这些原因均能导致城乡污染程度的不同。另外,本研究还发现出厂水浓度高于末梢水,与罗曼研究结果相契合[21]。NDMA的生成与原水中消毒剂和反应条件有关[21]。大型水厂通常供水管网较长,在输送过程中,消毒剂含量会出现削减,生成 NDMA 的强度会随之减弱,进而末梢水中浓度相应降低。另外,在辽宁省饮用水中DBP、BPA以及CPs也均有检出,表明饮用水存在不同程度的污染状况。DBP和BPA广泛应用于塑料制品的生产[22-23],加之塑料制品使用普遍,在自然环境中,这些污染物会随着雨水冲刷或地表径流的作用,从污染源进入水体[24],会对水体产生一定影响。特别值得关注的是,部分水样中的DBP含量已经超过国家卫生标准限值,这一现象亟需引起相关部门的重视,并采取切实有效的措施加以管控。对于CPs,尽管目前尚未被纳入我国饮用水卫生标准,但已列入2023年版重点管控新污染物清单,且在本省区域内的饮用水样本中也有检出。鉴于其潜在的健康危害,应当严格控制CPs的生产排放,加强管理,从而有效减少污染,保障公众健康。
在对水期分层分析时发现,丰水期NDMA和BPA的污染水平高于枯水期。其成因可能与两方面相关。首先,北方地区丰水期降雨量显著高于枯水期。大量降雨增加了地表径流,促进雨水渗透,污染物更易被携带进入水体,从而导致污染加剧。其次,由于丰水期水源受污染风险增加,为确保饮用水安全,供水单位往往采取加大消毒剂用量的措施,在这个过程中消毒副产物的生成会加强,包括NDMA,从而进一步造成丰水期与枯水期污染的差异。综上所述,这种差异是自然因素导致污染物迁移以及消毒强度改变共同作用的结果。
此次研究还进一步从水源选择和水处理工艺两方面对影响因素进行探索,结果表明,以地表水为水源的饮用水中NDMA、DBP和PFOA污染水平高于以地下水为水源的饮用水,说明地表水水源具有更高的污染风险。地表水由于其开放性,更易受到污染源的影响,进而导致污染物浓度升高[25]。与之比较,地下水相对封闭,地表径流携带的污染物在渗透过程中也会有部分被土壤截留,从而在一定程度上降低进入地下水的污染物浓度。由此可见,保护水源、减少周边污染源排放,是保障饮用水安全有效且可行的措施。
通过健康风险评估显示,致癌风险中,NDMA、PFOA和PFOS具有一定风险,均在可接受范围内。非致癌风险中,BPA、DBP和PFOS风险较低;PFOA的HQ值大于1,具有一定风险,应引起关注。2020年,我国生态环境部、工业和信息化部、卫生健康委联合印发《优先控制化学品名录(第二批)》,PFOA被列入其中,并提出了相应的环境风险管控措施,降低对人群健康的风险。在对不同性别的健康风险分析中发现,由于体重、日摄入量、期望寿命等方面的生理差异,男性非致癌和致癌风险均高于女性,应为重点关注人群。本研究通过健康风险评估,揭示了一定的风险,但也存在局限性,一是仅评价了通过饮用水摄入途径的风险,没有纳入经皮肤、食物等其它途径摄入,在一定程度上低估了健康风险;二是评价没有体现生活方式及习惯等个体差异,结果会有一定偏差;三是仅在枯水期和丰水期两个阶段采集样品,没有持续且长期进行监测,并形成时间序列,对全年风险评估不够精准,有高估或低估风险的可能性。
  • 辽宁省重点研发项目(2024JH2/102500087)
  • 辽宁省重点实验室(2018225113)
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2025年第52卷第18期
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doi: 10.20043/j.cnki.MPM.202504268
  • 接收时间:2025-04-14
  • 首发时间:2026-02-10
  • 出版时间:2025-09-25
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  • 收稿日期:2025-04-14
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辽宁省重点研发项目(2024JH2/102500087)
辽宁省重点实验室(2018225113)
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    辽宁省疾病预防控制中心,环境卫生所,辽宁 沈阳 110172

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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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