Article(id=1324044739682644567, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324044701648695723, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202509065, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756828800000, receivedDateStr=2025-09-03, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793606465502, onlineDateStr=2026-11-02, pubDate=1779638400000, pubDateStr=2026-05-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793606465502, onlineIssueDateStr=2026-11-02, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793606465502, creator=13701087609, updateTime=1793606465502, updator=13701087609, issue=Issue{id=1324044701648695723, tenantId=1146029695717560320, journalId=1227665162245664772, year='2026', volume='53', issue='10', pageStart='1729', pageEnd='1920', issueExtLink='null', onlineDate='null', pubDate='1779638400000', pubDateStr='2026-05-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793606456434, creator='13701087609', updateTime=1793670074552, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1324311535425815306, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324044701648695723, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1324311535425815307, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324044701648695723, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1766, endPage=1772, ext={EN=ArticleExt(id=1324044739921719896, articleId=1324044739682644567, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=The association between accelerated phenotypic age acceleration and osteoarthritis: a prospective cohort study, columnId=1240413921954295836, journalTitle=Modern Preventive Medicine, columnName=Epidemiology and Statistical Methods, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the association between accelerated phenotypic aging(PAA) and risk of osteoarthritis(OA), and to assess the modifying effect of genetic susceptibility, as well as the mediating effect of body mass index(BMI) on the PAA-OA association.
Methods Using baseline survey, diagnostic, and genetic data from the UK Biobank(UKB), Cox proportional hazards regression models was employedto analyze the association between PAA and OA, and pathway analysis was employed to explore the mediating effect of BMI.
Results With an average follow-up of 13.7 years, a total of 42 977 incident OA cases were recorded. PAA acceleration was significantly associated with an increased risk of OA(HR=2.13, 95%CI:2.11-2.15). BMI mediated 77.1%(95%CI:65.5%-92.1%) of the total effect. Further subgroup analyses revealed that the PAA-OA association was significant across all subgroups, including different sex, age, and BMI levels. No gene-PAA interaction was identified for OA risk.
Conclusion PAA is an independent risk factor for OA, and BMI is an important mediating variable in the PAA-OA association. This study provides novel insights and public health implications for delaying aging and preventing OA.
, authors=Xiu-ze TIAN, Mao-yao XIA, Xiao-feng MA, Yan-qiu ZOU, Ting LIU, Hong-xia XIA, Meng-jie HU, Yan SU, Meng-yu FAN, Xia JIANG, Xiao-bing PU, Xiao-ling WEN, authorsList=Xiu-ze TIAN, Mao-yao XIA, Xiao-feng MA, Yan-qiu ZOU, Ting LIU, Hong-xia XIA, Meng-jie HU, Yan SU, Meng-yu FAN, Xia JIANG, Xiao-bing PU, Xiao-ling WEN, authorCompany=null, correspAuthors=Xiao-ling WEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1324044746804572774, articleId=1324044739682644567, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=表型年龄衰老加速与骨关节炎关联的前瞻性队列研究, columnId=1228016567632462653, journalTitle=现代预防医学, columnName=流行病与统计方法, runingTitle=null, highlight=null, articleAbstract=
目的 探索表型年龄衰老加速（PAA）与骨关节炎（OA）发病风险的关联，评估遗传易感性对PAA与OA关联的效应修饰作用及体质指数（BMI）的中介作用。
方法 利用英国生物样本库（UK Biobank）中基线调查、疾病诊断及遗传数据，采用Cox比例风险回归模型分析PAA、遗传风险评分与OA的关联，通过中介路径分析探索BMI的中介效应。
结果 平均随访13.7年，共记录新发OA 42 977例。PAA加速与OA发病风险显著相关（HR=1.13，95%CI：1.11~1.15）；BMI部分介导关联，中介比例达77.1%（95%CI：65.5%~92.1%）。进一步亚组分析发现，不同性别、年龄及BMI中，PAA与OA的关联均显著。联合分析、分层分析及交互效应分析未发现遗传易感性对PAA与OA关联的修饰。
结论 PAA是OA的独立危险因素，BMI是重要的中介变量。本研究对延缓衰老，防治OA具有一定公共卫生学启示。
, authors=田修泽, 夏茂瑶, 马小凤, 邹雁秋, 刘婷, 夏红霞, 胡梦婕, 苏颜, 樊萌语, 姜侠, 蒲小兵, 温晓玲, authorsList=田修泽, 夏茂瑶, 马小凤, 邹雁秋, 刘婷, 夏红霞, 胡梦婕, 苏颜, 樊萌语, 姜侠, 蒲小兵, 温晓玲, authorCompany=null, correspAuthors=温晓玲, authorNote=
田修泽（2002—），男，硕士在读，研究方向：慢性病流行病学
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=ME2QxrJZtAyOavozS3B0yg==, magXml=soREIq0ACTPimQRRWwl6Aw==, pdfUrl=null, pdf=cwdSzhq92c2coyX0hp5L6Q==, pdfFileSize=775714, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=gEG3CjgRGkstKnq94kuxNg==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=gt+zQ4+QInf95vNqsaP5QA==, mapNumber=null, fund=null)}, authors=[Author(id=1324044747333055083, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324044747488244333, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, authorId=1324044747333055083, language=EN, stringName=Xiu-ze TIAN, firstName=Xiu-ze, middleName=null, lastName=TIAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324044747614073454, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, authorId=1324044747333055083, language=CN, stringName=田修泽, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院，四川 成都 610041, bio={"content":"
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74(4): 969-993., articleTitle=Correcting for bias due to mismeasured exposure in mediation analysis with a survival outcome, refAbstract=null)], funds=[Fund(id=1324044761941816000, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, awardId=2025ZNSFSC1775, language=CN, fundingSource=四川省自然科学基金(2025ZNSFSC1775), fundOrder=null, country=null), Fund(id=1324044762059256513, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, awardId=null, language=CN, fundingSource=教育部留学回国博士后科研启动基金, fundOrder=null, country=null), Fund(id=1324044762201862850, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, awardId=YJ202455, language=CN, fundingSource=四川大学高层次人才科研启动基金(YJ202455), fundOrder=null, country=null), Fund(id=1324044762369635012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, awardId=2024NSFTD0030, language=CN, fundingSource=四川省科学技术厅创新研究团队科学基金(2024NSFTD0030), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1324044747165282919, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, xref=null, ext=[AuthorCompanyExt(id=1324044747182060136, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, companyId=1324044747165282919, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324044747194643049, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, companyId=1324044747165282919, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院，四川 成都 610041)])], figs=[ArticleFig(id=1324044757885924016, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=EN, label=Fig.1, caption=
Stratified analysis of Genetic Risk Score, PAA, and the risk of incident OA, figureFileSmall=JL9/F04KYjynxJPFP8r0RQ==, figureFileBig=gEG3CjgRGkstKnq94kuxNg==, tableContent=null), ArticleFig(id=1324044758066279089, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=CN, label=图1, caption=
遗传风险得分和PAA与OA发生风险的分层分析注：模型校正了基线年龄、性别、汤森剥夺指数、教育程度、吸烟状况、饮酒状况、健康睡眠评分、健康膳食评分、身体活动水平、心血管疾病、类风湿性关节炎、骨质疏松症、遗传主成分、基因分型批次。
, figureFileSmall=JL9/F04KYjynxJPFP8r0RQ==, figureFileBig=gEG3CjgRGkstKnq94kuxNg==, tableContent=null), ArticleFig(id=1324044759970493106, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=EN, label=Fig.2, caption=
Joint analyses of Genetic Risk Score, PAA, and the risk of incident OA, figureFileSmall=Hm/w2ukFyB0MKpMziF1ewg==, figureFileBig=bStaepfJ9gdyYB54eGdFBw==, tableContent=null), ArticleFig(id=1324044760176014004, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=CN, label=图2, caption=
遗传风险得分和PAA与OA发生风险的联合分析注：模型校正了基线年龄、性别、汤森剥夺指数、教育程度、吸烟状况、饮酒状况、健康睡眠评分、健康膳食评分、身体活动水平、心血管疾病、类风湿性关节炎、骨质疏松症、遗传主成分、基因分型批次。
, figureFileSmall=Hm/w2ukFyB0MKpMziF1ewg==, figureFileBig=bStaepfJ9gdyYB54eGdFBw==, tableContent=null), ArticleFig(id=1324044760297648821, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=EN, label=Fig.3, caption=
The mediating effect of BMI in the association between PAA and the risk of OA, figureFileSmall=vO1kcSqpJV8NDs9GbUC3nw==, figureFileBig=SQMrYAwVxmOesSypScMvvw==, tableContent=null), ArticleFig(id=1324044760461226679, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=CN, label=图3, caption=
体质指数在PAA与OA发病风险关联中的中介作用注：OA表示骨关节炎；HR表示风险比；CI表示置信区间；PAA表示Phenotypic Age acceleration，表型年龄加速；BMI表示Body mass index，体质指数。
, figureFileSmall=vO1kcSqpJV8NDs9GbUC3nw==, figureFileBig=SQMrYAwVxmOesSypScMvvw==, tableContent=null), ArticleFig(id=1324044760612221624, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=EN, label=Table 1, caption=
The baseline characteristics of study participants ［
,n(%)］
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 总人群
n=278 664 | PAA未加速
n=149 177 | PAA加速
n=129 487 | F/χ2 | P值a |
|---|
| 年龄(岁) | 56.08±8.08 | 56.05±7.93 | 56.12±8.25 | 5.26 | 0.022 |
| PA（岁） | 49.58±9.06 | 46.65±8.17 | 52.96±8.84 | 38 223.64 | <0.001 |
| 性别 | | | | 7 018.12 | <0.001 |
| 女性 | 148 196(53.18) | 90 340(60.56) | 57 856(44.68) | | |
| 男性 | 130 468(46.82) | 58 837(39.44) | 71 631(55.32) | | |
| TDI | -1.58±2.92 | -1.78±2.79 | -1.33±3.04 | 1 648.72 | <0.001 |
| 教育程度 | | | | 1 014.03 | <0.001 |
| 高 | 29 080(10.44) | 16 426(11.01) | 12 654(9.77) | | |
| 中 | 46 046(16.52) | 25 145(16.86) | 20 901(16.14) | | |
| 低 | 91 104(32.69) | 44 894(30.09) | 46 210(35.69) | | |
| 缺失 | 112 434(40.35) | 62 712(42.04) | 49 722(38.40) | | |
| 吸烟状况 | | | | 5 730.05 | <0.001 |
| 仍吸烟 | 27 751(9.96) | 9 015(6.04) | 18 736(14.47) | | |
| 以前吸 | 94 011(33.74) | 50 742(34.01) | 43 269(33.42) | | |
| 从不吸 | 155 984(55.98) | 88 974(59.64) | 67 010(51.75) | | |
| 缺失 | 918(0.33) | 446(0.30) | 472(0.36) | | |
| 饮酒状况 | | | | 152.49 | <0.001 |
| 从不喝 | 17 726(6.36) | 8 746(5.86) | 8 980(6.94) | | |
| 偶尔/经常喝 | 260 747(93.57) | 140 358(94.09) | 120 389(92.97) | | |
| 缺失 | 191(0.07) | 73(0.05) | 118(0.09) | | |
| 体力活动a | | | | 312.78 | <0.001 |
| 低强度体力活动 | 38 607(13.85) | 19 419(13.02) | 19 188(14.82) | | |
| 高强度体力活动 | 180 877(64.91) | 98 944(66.33) | 81 933(63.28) | | |
| 缺失 | 59 180(21.24) | 30 814(20.66) | 28 366(21.91) | | |
| 健康睡眠评分 | 2.99±1.07 | 3.05±1.05 | 2.92±1.09 | 927.7 | <0.001 |
| 健康膳食评分 | 2.35±1.15 | 2.48±1.12 | 2.21±1.16 | 4 073.26 | <0.001 |
| BMI分组（kg/m2） | | | | 6 705.96 | <0.001 |
| <25 | 97 014(34.81) | 59 825(40.10) | 37 189(28.72) | | |
| 25~29.9 | 120 798(43.35) | 64 679(43.36) | 56 119(43.34) | | |
| ≥30 | 60 852(21.84) | 24 673(16.54) | 36 179(27.94) | | |
| 基线是否患心血管疾病 | | | | 1 204.60 | <0.001 |
| 否 | 265 414(95.25) | 144 029(96.55) | 121 385(93.74) | | |
| 是 | 13 250(4.75) | 5 148(3.45) | 8 102(6.26) | | |
| 基线是否患骨质疏松 | | | | 84.57 | <0.001 |
| 否 | 273 954(98.31) | 146 343(98.10) | 127 611(98.55) | | |
| 是 | 4 710(1.69) | 2 834(1.90) | 1 876(1.45) | | |
| 基线是否患类风湿性关节炎 | | | | 332.75 | <0.001 |
| 否 | 277 764(99.68) | 148 895(99.81) | 128 869(99.52) | | |
| 是 | 900(0.32) | 282(0.19) | 618(0.48) | | |
| 随访发生骨关节炎 | 42 977(15.42) | 21 851(14.65) | 21 126(16.32) | 147.63 | <0.001 |
| 随访人年（年） | 13.72±3.10 | 13.82±3.00 | 13.60±3.20 | 332.75 | <0.001 |
), ArticleFig(id=1324044760901628601, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=CN, label=表1, caption=
研究对象基线特征［
, n(%)］
, figureFileSmall=null, figureFileBig=null, tableContent=
| 组别 | 总人群
n=278 664 | PAA未加速
n=149 177 | PAA加速
n=129 487 | F/χ2 | P值a |
|---|
| 年龄(岁) | 56.08±8.08 | 56.05±7.93 | 56.12±8.25 | 5.26 | 0.022 |
| PA（岁） | 49.58±9.06 | 46.65±8.17 | 52.96±8.84 | 38 223.64 | <0.001 |
| 性别 | | | | 7 018.12 | <0.001 |
| 女性 | 148 196(53.18) | 90 340(60.56) | 57 856(44.68) | | |
| 男性 | 130 468(46.82) | 58 837(39.44) | 71 631(55.32) | | |
| TDI | -1.58±2.92 | -1.78±2.79 | -1.33±3.04 | 1 648.72 | <0.001 |
| 教育程度 | | | | 1 014.03 | <0.001 |
| 高 | 29 080(10.44) | 16 426(11.01) | 12 654(9.77) | | |
| 中 | 46 046(16.52) | 25 145(16.86) | 20 901(16.14) | | |
| 低 | 91 104(32.69) | 44 894(30.09) | 46 210(35.69) | | |
| 缺失 | 112 434(40.35) | 62 712(42.04) | 49 722(38.40) | | |
| 吸烟状况 | | | | 5 730.05 | <0.001 |
| 仍吸烟 | 27 751(9.96) | 9 015(6.04) | 18 736(14.47) | | |
| 以前吸 | 94 011(33.74) | 50 742(34.01) | 43 269(33.42) | | |
| 从不吸 | 155 984(55.98) | 88 974(59.64) | 67 010(51.75) | | |
| 缺失 | 918(0.33) | 446(0.30) | 472(0.36) | | |
| 饮酒状况 | | | | 152.49 | <0.001 |
| 从不喝 | 17 726(6.36) | 8 746(5.86) | 8 980(6.94) | | |
| 偶尔/经常喝 | 260 747(93.57) | 140 358(94.09) | 120 389(92.97) | | |
| 缺失 | 191(0.07) | 73(0.05) | 118(0.09) | | |
| 体力活动a | | | | 312.78 | <0.001 |
| 低强度体力活动 | 38 607(13.85) | 19 419(13.02) | 19 188(14.82) | | |
| 高强度体力活动 | 180 877(64.91) | 98 944(66.33) | 81 933(63.28) | | |
| 缺失 | 59 180(21.24) | 30 814(20.66) | 28 366(21.91) | | |
| 健康睡眠评分 | 2.99±1.07 | 3.05±1.05 | 2.92±1.09 | 927.7 | <0.001 |
| 健康膳食评分 | 2.35±1.15 | 2.48±1.12 | 2.21±1.16 | 4 073.26 | <0.001 |
| BMI分组（kg/m2） | | | | 6 705.96 | <0.001 |
| <25 | 97 014(34.81) | 59 825(40.10) | 37 189(28.72) | | |
| 25~29.9 | 120 798(43.35) | 64 679(43.36) | 56 119(43.34) | | |
| ≥30 | 60 852(21.84) | 24 673(16.54) | 36 179(27.94) | | |
| 基线是否患心血管疾病 | | | | 1 204.60 | <0.001 |
| 否 | 265 414(95.25) | 144 029(96.55) | 121 385(93.74) | | |
| 是 | 13 250(4.75) | 5 148(3.45) | 8 102(6.26) | | |
| 基线是否患骨质疏松 | | | | 84.57 | <0.001 |
| 否 | 273 954(98.31) | 146 343(98.10) | 127 611(98.55) | | |
| 是 | 4 710(1.69) | 2 834(1.90) | 1 876(1.45) | | |
| 基线是否患类风湿性关节炎 | | | | 332.75 | <0.001 |
| 否 | 277 764(99.68) | 148 895(99.81) | 128 869(99.52) | | |
| 是 | 900(0.32) | 282(0.19) | 618(0.48) | | |
| 随访发生骨关节炎 | 42 977(15.42) | 21 851(14.65) | 21 126(16.32) | 147.63 | <0.001 |
| 随访人年（年） | 13.72±3.10 | 13.82±3.00 | 13.60±3.20 | 332.75 | <0.001 |
), ArticleFig(id=1324044761069400763, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=EN, label=Table 2, caption=
The association of PA and PAA with the risk of OA
, figureFileSmall=null, figureFileBig=null, tableContent=
| 生物衰老指标 | 发生数/总人数 | 模型1 | 模型2 |
|---|
| HR (95%CI) | P值 | HR (95%CI) | P值 |
|---|
| PA（连续变量） | 42 977/278 664 | 1.02(1.02~1.03) | <0.001 | 1.02(1.02~1.03) | <0.001 |
| PAA（连续变量） | 42 977/278 664 | 1.02(1.01~1.02) | <0.001 | 1.02(1.01~1.02) | <0.001 |
| PAA四分位数 | | | | | |
| Q1 | 10 133/69 755 | 1.00 | Ref. | 1.00 | Ref. |
| Q2 | 10 312/69 851 | 1.06(1.04~1.09) | <0.001 | 1.06(1.03~1.08) | <0.001 |
| Q3 | 10 620/69 777 | 1.12(1.09~1.15) | <0.001 | 1.10(1.07~1.13) | <0.001 |
| Q4 | 11 912/69 281 | 1.28(1.25~1.32) | <0.001 | 1.22(1.18~1.25) | <0.001 |
| PAA二分类变量 | | | | | |
| 未加速 | 21 851/149 177 | 1.00 | Ref. | 1.00 | Ref. |
| 加速 | 21 126/129 487 | 1.17(1.15~1.19) | <0.001 | 1.13(1.11~1.15) | <0.001 |
), ArticleFig(id=1324044761212007100, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=CN, label=表2, caption=
PA和PAA与OA发生风险的关联
, figureFileSmall=null, figureFileBig=null, tableContent=
| 生物衰老指标 | 发生数/总人数 | 模型1 | 模型2 |
|---|
| HR (95%CI) | P值 | HR (95%CI) | P值 |
|---|
| PA（连续变量） | 42 977/278 664 | 1.02(1.02~1.03) | <0.001 | 1.02(1.02~1.03) | <0.001 |
| PAA（连续变量） | 42 977/278 664 | 1.02(1.01~1.02) | <0.001 | 1.02(1.01~1.02) | <0.001 |
| PAA四分位数 | | | | | |
| Q1 | 10 133/69 755 | 1.00 | Ref. | 1.00 | Ref. |
| Q2 | 10 312/69 851 | 1.06(1.04~1.09) | <0.001 | 1.06(1.03~1.08) | <0.001 |
| Q3 | 10 620/69 777 | 1.12(1.09~1.15) | <0.001 | 1.10(1.07~1.13) | <0.001 |
| Q4 | 11 912/69 281 | 1.28(1.25~1.32) | <0.001 | 1.22(1.18~1.25) | <0.001 |
| PAA二分类变量 | | | | | |
| 未加速 | 21 851/149 177 | 1.00 | Ref. | 1.00 | Ref. |
| 加速 | 21 126/129 487 | 1.17(1.15~1.19) | <0.001 | 1.13(1.11~1.15) | <0.001 |
), ArticleFig(id=1324044761358807741, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=EN, label=Table 3, caption=
Subgroup analysis of the association between PAA and the risk of OA
, figureFileSmall=null, figureFileBig=null, tableContent=
| 亚组 | 发生数/总人数 | HR (95%CI) | P值 | 交互P值 |
|---|
| 性别 | | | | |
| 男性 | 18 559/130 468 | 1.11(1.08~1.15) | 0.001 | 0.001 |
| 女性 | 24 418/148 196 | 1.13(1.10~1.16) | 0.001 | |
| 年龄（岁） | | | | |
| <60 | 18 661/164 780 | 1.12(1.09~1.16) | 0.001 | 0.088 |
| ≥60 | 24 316/113 884 | 1.13(1.10~1.16) | 0.001 | |
| BMI(kg/m2) | | | | |
| <25 | 10 780/97 014 | 1.04(1.00~1.08) | 0.062 | 0.992 |
| 25~29.9 | 18 748/120 798 | 1.04(1.01~1.07) | 0.006 | |
| ≥30 | 13 449/60 852 | 1.04(1.01~1.08) | 0.015 | |
| 教育程度 | | | | |
| 低 | 3 503/29 080 | 1.11(1.04~1.19) | 0.002 | 0.443 |
| 中 | 7 245/46 046 | 1.15(1.10~1.21) | 0.001 | |
| 高 | 17 830/91 104 | 1.12(1.09~1.16) | 0.001 | |
| 吸烟状况 | | | | |
| 仍吸烟 | 4 189/27 751 | 1.14(1.06~1.22) | 0.001 | 0.067 |
| 以前吸 | 16 573/94 011 | 1.10(1.07~1.14) | 0.001 | |
| 从不吸 | 22 036/155 984 | 1.14(1.11~1.17) | 0.001 | |
| 饮酒状况 | | | | |
| 从不喝 | 3 277/17 726 | 1.11(1.03~1.19) | 0.004 | 0.381 |
| 偶尔/经常喝 | 39 673/260 747 | 1.12(1.10~1.15) | 0.001 | |
| 体力活动 | | | | |
| 低强度体力活动 | 5 470/38 607 | 1.20(1.14~1.27) | 0.001 | 0.002 |
| 高强度体力活动 | 26 619/180 877 | 1.09(1.06~1.12) | 0.001 | |
| 基线是否患心血管疾病 | | | | |
| 是 | 3 033/13 250 | 1.09(1.01~1.17) | 0.001 | 0.089 |
| 否 | 39 944/265 414 | 1.13(1.10~1.15) | 0.001 | |
| 基线是否患骨质疏松 | | | | |
| 是 | 1 205/4 710 | 1.10(0.98~1.24) | 0.011 | 0.815 |
| 否 | 41 772/273 954 | 1.12(1.10~1.15) | 0.001 | |
| 基线是否患类风湿关节炎 | | | | |
| 是 | 349/900 | 1.16(0.92~1.47) | 0.22 | 0.774 |
| 否 | 42 628/277 764 | 1.12(1.10~1.14) | 0.001 | |
), ArticleFig(id=1324044761635631807, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324044739682644567, language=CN, label=表3, caption=
PAA与OA发生风险关联的亚组分析
, figureFileSmall=null, figureFileBig=null, tableContent=
| 亚组 | 发生数/总人数 | HR (95%CI) | P值 | 交互P值 |
|---|
| 性别 | | | | |
| 男性 | 18 559/130 468 | 1.11(1.08~1.15) | 0.001 | 0.001 |
| 女性 | 24 418/148 196 | 1.13(1.10~1.16) | 0.001 | |
| 年龄（岁） | | | | |
| <60 | 18 661/164 780 | 1.12(1.09~1.16) | 0.001 | 0.088 |
| ≥60 | 24 316/113 884 | 1.13(1.10~1.16) | 0.001 | |
| BMI(kg/m2) | | | | |
| <25 | 10 780/97 014 | 1.04(1.00~1.08) | 0.062 | 0.992 |
| 25~29.9 | 18 748/120 798 | 1.04(1.01~1.07) | 0.006 | |
| ≥30 | 13 449/60 852 | 1.04(1.01~1.08) | 0.015 | |
| 教育程度 | | | | |
| 低 | 3 503/29 080 | 1.11(1.04~1.19) | 0.002 | 0.443 |
| 中 | 7 245/46 046 | 1.15(1.10~1.21) | 0.001 | |
| 高 | 17 830/91 104 | 1.12(1.09~1.16) | 0.001 | |
| 吸烟状况 | | | | |
| 仍吸烟 | 4 189/27 751 | 1.14(1.06~1.22) | 0.001 | 0.067 |
| 以前吸 | 16 573/94 011 | 1.10(1.07~1.14) | 0.001 | |
| 从不吸 | 22 036/155 984 | 1.14(1.11~1.17) | 0.001 | |
| 饮酒状况 | | | | |
| 从不喝 | 3 277/17 726 | 1.11(1.03~1.19) | 0.004 | 0.381 |
| 偶尔/经常喝 | 39 673/260 747 | 1.12(1.10~1.15) | 0.001 | |
| 体力活动 | | | | |
| 低强度体力活动 | 5 470/38 607 | 1.20(1.14~1.27) | 0.001 | 0.002 |
| 高强度体力活动 | 26 619/180 877 | 1.09(1.06~1.12) | 0.001 | |
| 基线是否患心血管疾病 | | | | |
| 是 | 3 033/13 250 | 1.09(1.01~1.17) | 0.001 | 0.089 |
| 否 | 39 944/265 414 | 1.13(1.10~1.15) | 0.001 | |
| 基线是否患骨质疏松 | | | | |
| 是 | 1 205/4 710 | 1.10(0.98~1.24) | 0.011 | 0.815 |
| 否 | 41 772/273 954 | 1.12(1.10~1.15) | 0.001 | |
| 基线是否患类风湿关节炎 | | | | |
| 是 | 349/900 | 1.16(0.92~1.47) | 0.22 | 0.774 |
| 否 | 42 628/277 764 | 1.12(1.10~1.14) | 0.001 | |
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