Article(id=1324070911091016494, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324070892967428793, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202506272, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1750089600000, receivedDateStr=2025-06-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793612705251, onlineDateStr=2026-11-02, pubDate=1766592000000, pubDateStr=2025-12-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793612705251, onlineIssueDateStr=2026-11-02, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793612705251, creator=13701087609, updateTime=1793612705251, updator=13701087609, issue=Issue{id=1324070892967428793, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='24', pageStart='4417', pageEnd='4608', issueExtLink='null', onlineDate='null', pubDate='1766592000000', pubDateStr='2025-12-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793612700931, creator='13701087609', updateTime=1793612772549, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1324071193430602023, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324070892967428793, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1324071193430602024, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1324070892967428793, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=4431, endPage=4435, ext={EN=ArticleExt(id=1324070912848429872, articleId=1324070911091016494, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=The association of frailty with heart failure risk and the mediating effect of metabolomics, columnId=1228016567443718970, journalTitle=Modern Preventive Medicine, columnName=Epidemiology and Statistical Methods Advances, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the association between frailty and heart failure onset, and to identify the metabolomic features mediating the relationship between frailty and heart failure.
Methods Based on the UK Biobank (UKB), 255 160 participants who underwent baseline testing for 168 metabolites were included. The Fried frailty phenotype assessment data were obtained and divided into three groups: non-frailty (0), pre-frailty (1-2), and frailty (≥3). The Cox proportional hazards model was used to analyze the relationship between frailty and the risk of heart failure. Additionally, a mediation analysis was conducted on metabolites to assess the mediating role of metabolic markers in the relationship between frailty and heart failure.
Results Compared with non-frail participants, participants in the pre-frailty and frailty states had an increased risk of heart failure, with hazard ratios ( HR) of 1.441 (95% CI: 1.374–1.55) and 2.544 (95% CI: 2.323–2.785), respectively. Mediation analysis revealed that small high-density lipoprotein-related metabolites and low-density lipoprotein components played an important mediating role in the relationship between frailty and heart failure, with corresponding mediation proportions of 3.8%–5.5%.
Conclusion Frailty is associated with an increased risk of heart failure, and plasma metabolites characterised by small high-density lipoproteins and low-density lipoproteins may be key biomarkers mediating the association between frailty and heart failure.
, authors=Yong-hua YE, Huan XU, Pan CHENG, Xue-wei TANG, Huang-yi YANG, Wei LIAO, Ju-ying ZHANG, Xing ZHAO, authorsList=Yong-hua YE, Huan XU, Pan CHENG, Xue-wei TANG, Huang-yi YANG, Wei LIAO, Ju-ying ZHANG, Xing ZHAO, authorCompany=null, correspAuthors=Ju-ying ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1324070914744255297, articleId=1324070911091016494, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=衰弱对心力衰竭风险的影响和代谢组学的中介效应分析, columnId=1228016567632462653, journalTitle=现代预防医学, columnName=流行病与统计方法, runingTitle=null, highlight=null, articleAbstract=
目的 探究衰弱与心衰发病的关联，同时确定介导衰弱和心衰之间关系的代谢组学特征。
方法 基于英国生物银行(UK Biobank, UKB)，纳入255 160名基线检测了168种代谢物的参与者。获取Fried衰弱表型评估数据，分为非衰弱(0)、衰弱前期(1～2)和衰弱(≥3)三组，Cox比例风险模型分析衰弱与心衰风险之间的关系。同时，对代谢物进行中介分析，评估代谢标志物在衰弱与心衰关系间的中介作用。
结果 与非衰弱参与者相比，衰弱前期和衰弱状态参与者的心力衰竭风险增加，风险比(Hazard Ratio, HR)分别为1.441(95% CI:1.374～1.55)和2.544(95% CI:2.323～2.785)。中介分析显示，小的高密度脂蛋白相关代谢物和低密度脂蛋白组分在衰弱与心衰关系中起到重要的介导作用，相应的中介比例为3.8%～5.5%。
结论 衰弱状态与心衰风险增加有关，以小的高密度脂蛋白和低密度脂蛋白为特征的血浆代谢物可能是介导衰弱与心衰关联的关键标志物。
, authors=叶泳华, 许欢, 程盼, 唐雪薇, 杨黄毅, 廖伟, 张菊英, 赵星, authorsList=叶泳华, 许欢, 程盼, 唐雪薇, 杨黄毅, 廖伟, 张菊英, 赵星, authorCompany=null, correspAuthors=张菊英, authorNote=
叶泳华（2000—），男，硕士在读，研究方向：流行病与卫生统计学
, correspAuthorsNote=
, copyrightStatement=
本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=9DUtFVfq7VH3h+OffR0unA==, magXml=RwLwl5DA7x6f1GIfE5z8Wg==, pdfUrl=null, pdf=H8ro9q0x5BlVB7r7TA33Lw==, pdfFileSize=813863, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=oPqkTi0YgVZtlA3qwYLnnA==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=56HadOzfhKA+fHfQhVUcIw==, mapNumber=null, fund=null)}, authors=[Author(id=1324070915163685702, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324070915260154696, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070915163685702, language=EN, stringName=Yong-hua YE, firstName=Yong-hua, middleName=null, lastName=YE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324070915339846473, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070915163685702, language=CN, stringName=叶泳华, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio={"content":"
叶泳华（2000—），男，硕士在读，研究方向：流行病与卫生统计学
"}, bioImg=null, bioContent=
叶泳华（2000—），男，硕士在读，研究方向：流行病与卫生统计学
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1324070915423732555, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324070917114037069, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070915423732555, language=EN, stringName=Huan XU, firstName=Huan, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324070917223088974, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070915423732555, language=CN, stringName=许欢, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1324070917315363664, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324070917462164306, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070917315363664, language=EN, stringName=Pan CHENG, firstName=Pan, middleName=null, lastName=CHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324070917558633299, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070917315363664, language=CN, stringName=程盼, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1324070917646713685, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324070917780931415, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070917646713685, language=EN, stringName=Xue-wei TANG, firstName=Xue-wei, middleName=null, lastName=TANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324070917877400408, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070917646713685, language=CN, stringName=唐雪薇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1324070917982258010, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324070918078727004, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070917982258010, language=EN, stringName=Huang-yi YANG, firstName=Huang-yi, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324070918158418781, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070917982258010, language=CN, stringName=杨黄毅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1324070918246499167, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324070918342968161, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070918246499167, language=EN, stringName=Wei LIAO, firstName=Wei, middleName=null, lastName=LIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324070918422659938, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070918246499167, language=CN, stringName=廖伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1324070918535906148, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=juying109@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1324070918632375142, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070918535906148, language=EN, stringName=Ju-ying ZHANG, firstName=Ju-ying, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324070918745621351, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070918535906148, language=CN, stringName=张菊英, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])]), Author(id=1324070918846284649, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1324070918938559339, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070918846284649, language=EN, stringName=Xing ZHAO, firstName=Xing, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1324070919009862508, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, authorId=1324070918846284649, language=CN, stringName=赵星, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])])], keywords=[Keyword(id=1324070919152468845, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=EN, orderNo=1, keyword=Frailty), Keyword(id=1324070919227966318, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=EN, orderNo=2, keyword=Heart failure), Keyword(id=1324070919295075183, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=EN, orderNo=3, keyword=Metabolomics), Keyword(id=1324070919378961264, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=EN, orderNo=4, keyword=Mediation analysis), Keyword(id=1324070919458653041, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=CN, orderNo=1, keyword=衰弱), Keyword(id=1324070919542539122, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=CN, orderNo=2, keyword=心力衰竭), Keyword(id=1324070919630619507, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=CN, orderNo=3, keyword=代谢组学), Keyword(id=1324070919697728372, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=CN, orderNo=4, keyword=中介分析)], refs=[Reference(id=1324070922499523455, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2024, volume=149, issue=8, pageStart=e347, pageEnd=e913, url=null, language=null, rfNumber=［1］, rfOrder=0, authorNames=Martin SS, Aday AW, Almarzooq ZI, journalName=Circulation, refType=null, unstructuredReference=
Martin SS,
Aday AW,
Almarzooq ZI,
et al. 2024 heart disease and stroke statistics: a report of US and global data from the American heart association [J].
Circulation,
2024,
149 (8): e347-e913., articleTitle=2024 heart disease and stroke statistics: a report of US and global data from the American heart association, refAbstract=null), Reference(id=1324070922604381056, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2023, volume=118, issue=17, pageStart=3272, pageEnd=3287, url=null, language=null, rfNumber=［2］, rfOrder=1, authorNames=Savarese G, Becher PM, Lund LH, journalName=Cardiovascular Research, refType=null, unstructuredReference=
Savarese G,
Becher PM,
Lund LH,
et al. Global burden of heart failure: a comprehensive and updated review of epidemiology [J].
Cardiovascular Research,
2023,
118 (17): 3272-3287., articleTitle=Global burden of heart failure: a comprehensive and updated review of epidemiology, refAbstract=null), Reference(id=1324070922671489921, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2022, volume=28, issue=5, pageStart=e1, pageEnd=e167, url=null, language=null, rfNumber=［3］, rfOrder=2, authorNames=Heidenreich PA, Bozkurt B, Aguilar D, journalName=Journal of Cardiac Failure, refType=null, unstructuredReference=
Heidenreich PA,
Bozkurt B,
Aguilar D,
et al. 2022 ACC/AHA/HFSA guideline for the management of heart failure [J].
Journal of Cardiac Failure,
2022,
28 (5): e1-e167., articleTitle=2022 ACC/AHA/HFSA guideline for the management of heart failure, refAbstract=null), Reference(id=1324070922746987394, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2021, volume=1, issue=1, pageStart=36, pageEnd=46, url=null, language=null, rfNumber=［4］, rfOrder=3, authorNames=Fried LP, Cohen AA, Xue QL, journalName=Nat Aging, refType=null, unstructuredReference=
Fried LP,
Cohen AA,
Xue QL,
et al. The physical frailty syndrome as a transition from homeostatic symphony to cacophony [J].
Nat Aging,
2021,
1 (1): 36-46., articleTitle=The physical frailty syndrome as a transition from homeostatic symphony to cacophony, refAbstract=null), Reference(id=1324070922826679171, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2019, volume=394, issue=10206, pageStart=1376, pageEnd=1386, url=null, language=null, rfNumber=［5］, rfOrder=4, authorNames=Dent E, Martin FC, Bergman H, journalName=Lancet, refType=null, unstructuredReference=
Dent E,
Martin FC,
Bergman H,
et al. Management of frailty: opportunities, challenges, and future directions [J].
Lancet,
2019,
394 (10206): 1376-1386., articleTitle=Management of frailty: opportunities, challenges, and future directions, refAbstract=null), Reference(id=1324070922910565252, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2025, volume=25, issue=1, pageStart=118, pageEnd=null, url=null, language=null, rfNumber=［6］, rfOrder=5, authorNames=Xu Z, Wang Y, Li X, journalName=BMC Cardiovascular Disorders, refType=null, unstructuredReference=
Xu Z,
Wang Y,
Li X,
et al. Interacting and joint effects of frailty and inflammation on cardiovascular disease risk and the mediating role of inflammation in middle-aged and elderly populations [J].
BMC Cardiovascular Disorders,
2025,
25 (1): 118., articleTitle=Interacting and joint effects of frailty and inflammation on cardiovascular disease risk and the mediating role of inflammation in middle-aged and elderly populations, refAbstract=null), Reference(id=1324070922998645637, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2023, volume=14, issue=5, pageStart=1959, pageEnd=1972, url=null, language=null, rfNumber=［7］, rfOrder=6, authorNames=Talha KM, Pandey A, Fudim M, journalName=Journal of Cachexia, Sarcopenia and Muscle, refType=null, unstructuredReference=
Talha KM,
Pandey A,
Fudim M,
et al. Frailty and heart failure: State-of-the-art review [J].
Journal of Cachexia, Sarcopenia and Muscle,
2023,
14 (5): 1959-1972., articleTitle=Frailty and heart failure: State-of-the-art review, refAbstract=null), Reference(id=1324070923166417798, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2023, volume=389, issue=12, pageStart=1145, pageEnd=1146, url=null, language=null, rfNumber=［8］, rfOrder=7, authorNames=Pinto YM, journalName=New England Journal of Medicine, refType=null, unstructuredReference=
Pinto YM. Heart failure with preserved ejection fraction-a metabolic disease? [J].
New England Journal of Medicine,
2023,
389 (12): 1145-1146., articleTitle=Heart failure with preserved ejection fraction-a metabolic disease?, refAbstract=null), Reference(id=1324070923258692487, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2019, volume=62, issue=9, pageStart=1153, pageEnd=1167, url=null, language=null, rfNumber=［9］, rfOrder=8, authorNames=Zhang XX, Liu HY, Gao J, journalName=Science China. Life Sciences, refType=null, unstructuredReference=
Zhang XX,
Liu HY,
Gao J,
et al. Metabolic disorder in the progression of heart failure [J].
Science China. Life Sciences,
2019,
62 (9): 1153-1167., articleTitle=Metabolic disorder in the progression of heart failure, refAbstract=null), Reference(id=1324070923376133000, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2018, volume=6, issue=9, pageStart=743, pageEnd=752, url=null, language=null, rfNumber=［10］, rfOrder=9, authorNames=Clegg A, Hassan-Smith Z, journalName=Lancet Diabetes Endocrinol, refType=null, unstructuredReference=
Clegg A,
Hassan-Smith Z. Frailty and the endocrine system [J].
Lancet Diabetes Endocrinol,
2018,
6 (9): 743-752., articleTitle=Frailty and the endocrine system, refAbstract=null), Reference(id=1324070923460019081, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2024, volume=36, issue=5, pageStart=893, pageEnd=911, url=null, language=null, rfNumber=［11］, rfOrder=10, authorNames=Mishra M, Wu J, Kane AE, journalName=Cell Metabolism, refType=null, unstructuredReference=
Mishra M,
Wu J,
Kane AE,
et al. The intersection of frailty and metabolism [J].
Cell Metabolism,
2024,
36 (5): 893-911., articleTitle=The intersection of frailty and metabolism, refAbstract=null), Reference(id=1324070923543905162, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2023, volume=10, issue=1, pageStart=64, pageEnd=null, url=null, language=null, rfNumber=［12］, rfOrder=11, authorNames=Ritchie SC, Surendran P, Karthikeyan S, journalName=Sci Data, refType=null, unstructuredReference=
Ritchie SC,
Surendran P,
Karthikeyan S,
et al. Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants [J].
Sci Data,
2023,
10 (1): 64., articleTitle=Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants, refAbstract=null), Reference(id=1324070923652957067, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2001, volume=56, issue=3, pageStart=M146, pageEnd=M156, url=null, language=null, rfNumber=［13］, rfOrder=12, authorNames=Fried LP, Tangen CM, Walston J, journalName=The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences, refType=null, unstructuredReference=
Fried LP,
Tangen CM,
Walston J,
et al. Frailty in older adults: evidence for a phenotype [J].
The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences,
2001,
56 (3): M146-M156., articleTitle=Frailty in older adults: evidence for a phenotype, refAbstract=null), Reference(id=1324070923778786188, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2018, volume=3, issue=7, pageStart=e323, pageEnd=e332, url=null, language=null, rfNumber=［14］, rfOrder=13, authorNames=Hanlon P, Nicholl BI, Jani BD, journalName=Lancet Public Health, refType=null, unstructuredReference=
Hanlon P,
Nicholl BI,
Jani BD,
et al. Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants [J].
Lancet Public Health,
2018,
3 (7): e323-e332., articleTitle=Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants, refAbstract=null), Reference(id=1324070923854283661, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2022, volume=2, issue=1, pageStart=67, pageEnd=null, url=null, language=null, rfNumber=［15］, rfOrder=14, authorNames=Han X, Metabolomicsr LL, journalName=Bioinform Adv, refType=null, unstructuredReference=
Han X,
Metabolomicsr LL. A streamlined workflow to analyze metabolomic data in R [J].
Bioinform Adv,
2022,
2 (1): 67., articleTitle=A streamlined workflow to analyze metabolomic data in R, refAbstract=null), Reference(id=1324070923933975438, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2016, volume=31, issue=10, pageStart=1065, pageEnd=1066, url=null, language=null, rfNumber=［16］, rfOrder=15, authorNames=Naimi AI, journalName=European Journal of Epidemiology, refType=null, unstructuredReference=
Naimi AI. Tyler J VanderWeele. explanation in causal inference: methods for mediation and interaction [J].
European Journal of Epidemiology,
2016,
31 (10): 1065-1066., articleTitle=Tyler J VanderWeele. explanation in causal inference: methods for mediation and interaction, refAbstract=null), Reference(id=1324070924038833039, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2019, volume=7, issue=12, pageStart=1001, pageEnd=1011, url=null, language=null, rfNumber=［17］, rfOrder=16, authorNames=Pandey A, Kitzman D, Reeves G, journalName=JACC. Heart Failure, refType=null, unstructuredReference=
Pandey A,
Kitzman D,
Reeves G. Frailty is intertwined with heart failure: mechanisms, prevalence, prognosis, assessment, and management [J].
JACC. Heart Failure,
2019,
7 (12): 1001-1011., articleTitle=Frailty is intertwined with heart failure: mechanisms, prevalence, prognosis, assessment, and management, refAbstract=null), Reference(id=1324070924114330512, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2022, volume=80, issue=12, pageStart=1144, pageEnd=1146, url=null, language=null, rfNumber=［18］, rfOrder=17, authorNames=Heckman GA, Rockwood K, journalName=Journal of the American College of Cardiology, refType=null, unstructuredReference=
Heckman GA,
Rockwood K. Frailty, risk, and heart failure care: commission or omission? [J].
Journal of the American College of Cardiology,
2022,
80 (12): 1144-1146., articleTitle=Frailty, risk, and heart failure care: commission or omission?, refAbstract=null), Reference(id=1324070924198216593, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2024, volume=4, issue=7, pageStart=547, pageEnd=556, url=null, language=null, rfNumber=［19］, rfOrder=18, authorNames=Shi QF, Huang J, Wan JX, journalName=JACC Asia, refType=null, unstructuredReference=
Shi QF,
Huang J,
Wan JX,
et al. Physical frailty, genetic predisposition, and incident heart failure [J].
JACC Asia,
2024,
4 (7): 547-556., articleTitle=Physical frailty, genetic predisposition, and incident heart failure, refAbstract=null), Reference(id=1324070924273714066, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2021, volume=11, issue=1, pageStart=3141, pageEnd=null, url=null, language=null, rfNumber=［20］, rfOrder=19, authorNames=Teis A, Cediel G, Amigó N, journalName=Scientific Reports, refType=null, unstructuredReference=
Teis A,
Cediel G,
Amigó N,
et al. Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure [J].
Scientific Reports,
2021,
11 (1): 3141., articleTitle=Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure, refAbstract=null), Reference(id=1324070924378571667, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2019, volume=124, issue=10, pageStart=1505, pageEnd=1518, url=null, language=null, rfNumber=［21］, rfOrder=20, authorNames=Ouimet M, Barrett TJ, Fisher EA, journalName=Circulation Research, refType=null, unstructuredReference=
Ouimet M,
Barrett TJ,
Fisher EA. HDL and reverse cholesterol transport: basic mechanisms and their roles in vascular health and disease [J].
Circulation Research,
2019,
124 (10): 1505-1518., articleTitle=HDL and reverse cholesterol transport: basic mechanisms and their roles in vascular health and disease, refAbstract=null), Reference(id=1324070924475040660, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2014, volume=371, issue=25, pageStart=2383, pageEnd=2393, url=null, language=null, rfNumber=［22］, rfOrder=21, authorNames=Rohatgi A, Khera A, Berry JD, journalName=New England Journal of Medicine, refType=null, unstructuredReference=
Rohatgi A,
Khera A,
Berry JD,
et al. HDL cholesterol efflux capacity and incident cardiovascular events [J].
New England Journal of Medicine,
2014,
371 (25): 2383-2393., articleTitle=HDL cholesterol efflux capacity and incident cardiovascular events, refAbstract=null), Reference(id=1324070926135985045, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2021, volume=56, issue=4, pageStart=426, pageEnd=439, url=null, language=null, rfNumber=［23］, rfOrder=22, authorNames=Groenen AG, Halmos B, Tall AR, journalName=Critical Reviews in Biochemistry and Molecular Biology, refType=null, unstructuredReference=
Groenen AG,
Halmos B,
Tall AR,
et al. Cholesterol efflux pathways, inflammation, and atherosclerosis [J].
Critical Reviews in Biochemistry and Molecular Biology,
2021,
56 (4): 426-439., articleTitle=Cholesterol efflux pathways, inflammation, and atherosclerosis, refAbstract=null), Reference(id=1324070926215676822, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2022, volume=9, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=［24］, rfOrder=23, authorNames=Diab A, Valenzuela Ripoll C, Guo Z, journalName=Front Cardiovasc Med, refType=null, unstructuredReference=
Diab A,
Valenzuela Ripoll C,
Guo Z,
et al. HDL composition, heart failure, and its comorbidities [J].
Front Cardiovasc Med,
2022,
9: 846990., articleTitle=HDL composition, heart failure, and its comorbidities, refAbstract=null), Reference(id=1324070926295368599, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2017, volume=38, issue=32, pageStart=2459, pageEnd=2472, url=null, language=null, rfNumber=［25］, rfOrder=24, authorNames=Ference BA, Ginsberg HN, Graham I, journalName=European Heart Journal, refType=null, unstructuredReference=
Ference BA,
Ginsberg HN,
Graham I,
et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel [J].
European Heart Journal,
2017,
38 (32): 2459-2472., articleTitle=Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel, refAbstract=null), Reference(id=1324070926375060376, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, doi=null, pmid=null, pmcid=null, year=2021, volume=33, issue=Supplement 1, pageStart=25, pageEnd=32, url=null, language=null, rfNumber=［26］, rfOrder=25, authorNames=Guijarro C, Cosín-Sales J, journalName=Clínica e Investigación en Arteriosclerosis, refType=null, unstructuredReference=
Guijarro C,
Cosín-Sales J. Colesterol LDL y aterosclerosis: evidencias [J].
Clínica e Investigación en Arteriosclerosis,
2021,
33, Supplement 1: 25-32., articleTitle=Colesterol LDL y aterosclerosis: evidencias, refAbstract=null)], funds=[Fund(id=1324070922285613949, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, awardId=82073667, language=CN, fundingSource=国家自然科学基金(82073667), fundOrder=null, country=null), Fund(id=1324070922365305726, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, awardId=2025ZNSFSC1784, language=CN, fundingSource=四川省自然科学基金项目(2025ZNSFSC1784), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1324070915046245186, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, xref=null, ext=[AuthorCompanyExt(id=1324070915058828099, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Departmentof Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China), AuthorCompanyExt(id=1324070915071411012, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, companyId=1324070915046245186, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=四川大学华西公共卫生学院/华西第四医院流行病与卫生统计学系，四川 成都 610041)])], figs=[ArticleFig(id=1324070919861306229, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=EN, label=Fig.1, caption=
Associations between frailty, metabolomic markers, and the risk of HF, figureFileSmall=5xONtnf16COiYHphQ9bm8A==, figureFileBig=oPqkTi0YgVZtlA3qwYLnnA==, tableContent=null), ArticleFig(id=1324070919936803702, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=CN, label=图1, caption=
衰弱、代谢组学标志物与心力衰竭风险之间的关联, figureFileSmall=5xONtnf16COiYHphQ9bm8A==, figureFileBig=oPqkTi0YgVZtlA3qwYLnnA==, tableContent=null), ArticleFig(id=1324070921778103159, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=EN, label=Fig.2, caption=
Mediating effects of metabolites on the relationship between frailty and HF risk, figureFileSmall=qCUQBOetTjEo+VEDnGhUaA==, figureFileBig=bgXsa65UA620X0nazfQKzw==, tableContent=null), ArticleFig(id=1324070921849406328, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=CN, label=图2, caption=
代谢物在衰弱与心衰风险关系间的中介作用, figureFileSmall=qCUQBOetTjEo+VEDnGhUaA==, figureFileBig=bgXsa65UA620X0nazfQKzw==, tableContent=null), ArticleFig(id=1324070921929098105, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=EN, label=Table 1, caption=
Baseline characteristics of study participants
, figureFileSmall=null, figureFileBig=null, tableContent=
| 基本特征 | 总人数（n=255 160） | 心衰 |
|---|
| 不发病(n=247 228) | 发病(n=7 932) |
|---|
年龄（岁, ） | 56.5±8.1 | 56.3±8.1 | 62.2±6.1 |
| 性别[n（%）] | | | |
| 女 | 137 784（54.0） | 134 887（54.6） | 2 897（36.5） |
| 男 | 117 376（46.0） | 112 341（45.4） | 5 035（63.5） |
| 种族[n（%）] | | | |
| 白人 | 242 394（95.0） | 234 812（95.0） | 7 582（95.6） |
| 其他 | 11 928（4.7） | 11 609（4.7） | 319（4.0） |
| 未知 | 838（0.3） | 807（0.3） | 31（0.4） |
| 教育[n（%）] | | | |
| 高中及以上 | 195 742（76.7） | 190 958（77.3） | 4 784（60.3） |
| 其他 | 56 934（22.3） | 53 895（21.8） | 3 039（38.3） |
| 未知 | 2 484（1.0） | 2 375（0.9） | 109（1.4） |
体重指数（Kg/m2, ） | 27.4±4.7 | 27.3±4.7 | 29.8±5.8 |
Townsend贫困指数（分, ） | -1.4±3.0 | -1.4±3.0 | -0.8±3.3 |
| 饮酒[n（%）] | | | |
| 从不 | 10 715（4.2） | 10 284（4.2） | 431（5.4） |
| 以前饮酒 | 8 821（3.5） | 8 313（3.4） | 508（6.4） |
| 现在饮酒 | 235 375（92.2） | 228 398（92.4） | 6 977（88.0） |
| 未知 | 249（0.1） | 233（0.1） | 16（0.2） |
| 吸烟[n（%）] | | | |
| 从不 | 139 603（54.7） | 136 487（55.2） | 3 116（39.3） |
| 以前吸烟 | 88 319（34.6） | 84 795（34.3） | 3 524（44.4） |
| 现在吸烟 | 26 354（10.3） | 25 108（10.2） | 1 246（15.7） |
| 未知 | 884（0.3） | 838（0.3） | 46（0.6） |
饮食评分（分, ） | 2.4±1.2 | 2.4±1.2 | 2.3±1.1 |
| 高血压[n（%）] | | | |
| 否 | 187 749（73.6） | 184 049（74.4） | 3 700（46.6） |
| 是 | 67 411（26.4） | 63 179（25.6） | 4 232（53.4） |
| 糖尿病[n（%）] | | | |
| 否 | 248 724（97.5） | 241 614（97.7） | 7 110（89.6） |
| 是 | 6 436（2.5） | 5 614（2.3） | 822（10.4） |
| 衰弱[n（%）] | | | |
| 非衰弱 | 158 219（62.0） | 154 552（62.5） | 3 667（46.2） |
| 衰弱前期 | 90 591（35.5） | 86 969（35.2） | 3 622（45.7） |
| 衰弱 | 6 350（2.5） | 5 707（2.3） | 643（8.1） |
衰弱得分（分, ） | 0.5±0.8 | 0.5±0.7 | 0.9±1.0 |
), ArticleFig(id=1324070922021372794, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=CN, label=表1, caption=
参与者的基本特征描述
, figureFileSmall=null, figureFileBig=null, tableContent=
| 基本特征 | 总人数（n=255 160） | 心衰 |
|---|
| 不发病(n=247 228) | 发病(n=7 932) |
|---|
| 年龄（岁,） | 56.5±8.1 | 56.3±8.1 | 62.2±6.1 |
| 性别[n（%）] | | | |
| 女 | 137 784（54.0） | 134 887（54.6） | 2 897（36.5） |
| 男 | 117 376（46.0） | 112 341（45.4） | 5 035（63.5） |
| 种族[n（%）] | | | |
| 白人 | 242 394（95.0） | 234 812（95.0） | 7 582（95.6） |
| 其他 | 11 928（4.7） | 11 609（4.7） | 319（4.0） |
| 未知 | 838（0.3） | 807（0.3） | 31（0.4） |
| 教育[n（%）] | | | |
| 高中及以上 | 195 742（76.7） | 190 958（77.3） | 4 784（60.3） |
| 其他 | 56 934（22.3） | 53 895（21.8） | 3 039（38.3） |
| 未知 | 2 484（1.0） | 2 375（0.9） | 109（1.4） |
| 体重指数（Kg/m2,） | 27.4±4.7 | 27.3±4.7 | 29.8±5.8 |
| Townsend贫困指数（分,） | -1.4±3.0 | -1.4±3.0 | -0.8±3.3 |
| 饮酒[n（%）] | | | |
| 从不 | 10 715（4.2） | 10 284（4.2） | 431（5.4） |
| 以前饮酒 | 8 821（3.5） | 8 313（3.4） | 508（6.4） |
| 现在饮酒 | 235 375（92.2） | 228 398（92.4） | 6 977（88.0） |
| 未知 | 249（0.1） | 233（0.1） | 16（0.2） |
| 吸烟[n（%）] | | | |
| 从不 | 139 603（54.7） | 136 487（55.2） | 3 116（39.3） |
| 以前吸烟 | 88 319（34.6） | 84 795（34.3） | 3 524（44.4） |
| 现在吸烟 | 26 354（10.3） | 25 108（10.2） | 1 246（15.7） |
| 未知 | 884（0.3） | 838（0.3） | 46（0.6） |
| 饮食评分（分,） | 2.4±1.2 | 2.4±1.2 | 2.3±1.1 |
| 高血压[n（%）] | | | |
| 否 | 187 749（73.6） | 184 049（74.4） | 3 700（46.6） |
| 是 | 67 411（26.4） | 63 179（25.6） | 4 232（53.4） |
| 糖尿病[n（%）] | | | |
| 否 | 248 724（97.5） | 241 614（97.7） | 7 110（89.6） |
| 是 | 6 436（2.5） | 5 614（2.3） | 822（10.4） |
| 衰弱[n（%）] | | | |
| 非衰弱 | 158 219（62.0） | 154 552（62.5） | 3 667（46.2） |
| 衰弱前期 | 90 591（35.5） | 86 969（35.2） | 3 622（45.7） |
| 衰弱 | 6 350（2.5） | 5 707（2.3） | 643（8.1） |
| 衰弱得分（分,） | 0.5±0.8 | 0.5±0.7 | 0.9±1.0 |
), ArticleFig(id=1324070922109453179, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=EN, label=Table 2, caption=
Associations of frailty with HF risk in the UK Biobank study
, figureFileSmall=null, figureFileBig=null, tableContent=
| 衰弱状态 | 模型1 | 模型2 |
|---|
| HR (95% CI) | P值 | HR (95% CI) | P值 |
|---|
| 非衰弱 | 1.000（参照组） | | 1.000（参照组） | |
| 衰弱前期 | 1.889（1.804～1.978） | <0.001 | 1.441（1.374～1.511） | <0.001 |
| 衰弱 | 5.439（5.000～5.915） | <0.001 | 2.544（2.323～2.785） | <0.001 |
| 衰弱得分 | 1.693（1.657～1.731） | <0.001 | 1.353（1.321～1.387） | <0.001 |
), ArticleFig(id=1324070922189144956, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1324070911091016494, language=CN, label=表2, caption=
英国生物银行研究中衰弱与心力衰竭风险的关联
, figureFileSmall=null, figureFileBig=null, tableContent=
| 衰弱状态 | 模型1 | 模型2 |
|---|
| HR (95% CI) | P值 | HR (95% CI) | P值 |
|---|
| 非衰弱 | 1.000（参照组） | | 1.000（参照组） | |
| 衰弱前期 | 1.889（1.804～1.978） | <0.001 | 1.441（1.374～1.511） | <0.001 |
| 衰弱 | 5.439（5.000～5.915） | <0.001 | 2.544（2.323～2.785） | <0.001 |
| 衰弱得分 | 1.693（1.657～1.731） | <0.001 | 1.353（1.321～1.387） | <0.001 |
)], attaches=null, journal=Journal(id=1227664546253402114, delFlag=0, nameCn=现代预防医学, nameEn=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, issn=1003-8507, eissn=null, cn=51-1365/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=IeiuPXEZi6AA+k0VfvoiOQ==, journalPrice=null, startedYear=null, abbrevIsoEn=Modern Preventive Medicine, journalRemark=null, publicationField=null, createdTime=1770627636734, updatedTime=1788949112281, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=X, firstLetterEn=X, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=IeiuPXEZi6AA+k0VfvoiOQ==, picEn=/9iTl8/ndms4tBz1fL28Pg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304510385713861624, language=CN, name=现代预防医学, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949112585, updatedTime=1788949112585, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1304510385772581881, language=EN, name=Modern Preventive Medicine, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788949112599, updatedTime=1788949112599, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=http://xdyfyxzz.paperopen.com/#/regist, submissionEditorUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionReviewUrl=http://xdyfyxzz.paperopen.com/#/Login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1227665162245664772, websiteList=[Website(id=1227687234141352800, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/CN, language=CN, createTime=1770633045945, createBy=18614031015, updateTime=1770633090526, updateBy=18614031015, name=现代预防医学-中文, tplId=1146099689490845704, title=现代预防医学, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687735088051072, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=articleTextType, value=kx, createTime=1770633165380, updateTime=1770633165380, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735071273853, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=banner, value=null, createTime=1770633165376, updateTime=1770633165376, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735113216899, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=grayFlag, value=0, createTime=1770633165386, updateTime=1770633165386, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735062885244, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633165374, updateTime=1770633165374, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735125799813, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=minRunFlag, value=0, createTime=1770633165389, updateTime=1770633165389, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735083856767, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/file/pic, createTime=1770633165379, updateTime=1770633165379, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735121605508, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=silenceFlag, value=0, createTime=1770633165388, updateTime=1770633165388, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735079662462, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1770633165378, updateTime=1770633165378, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735096439681, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeColor, value=null, createTime=1770633165382, updateTime=1770633165382, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687735104828290, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234141352800, code=themeStyle, value=null, createTime=1770633165384, updateTime=1770633165384, creator=18614031015, updator=18614031015)]), Website(id=1227687234338485094, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1227665162245664772, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/xdyfyx/EN, language=EN, createTime=1770633045992, createBy=18614031015, updateTime=1770633115374, updateBy=18614031015, name=现代预防医学-英文, tplId=1146101810881728533, title=Modern Preventive Medicine, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1227687709129507332, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=articleTextType, value=kx, createTime=1770633159191, updateTime=1770633159191, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709108535809, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=banner, value=null, createTime=1770633159186, updateTime=1770633159186, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709167256071, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=grayFlag, value=0, createTime=1770633159200, updateTime=1770633159200, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709095952896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=logo, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic?fileId=/XB5plC0xuykmQnycvtyrw==, createTime=1770633159183, updateTime=1770633159183, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709179838985, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=minRunFlag, value=0, createTime=1770633159203, updateTime=1770633159203, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709121118723, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/file/pic, createTime=1770633159189, updateTime=1770633159189, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709171450376, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=silenceFlag, value=0, createTime=1770633159201, updateTime=1770633159201, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709112730114, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1770633159187, updateTime=1770633159187, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709133701637, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeColor, value=null, createTime=1770633159192, updateTime=1770633159192, creator=18614031015, updator=18614031015), WebsiteProps(id=1227687709154673158, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1227687234338485094, code=themeStyle, value=null, createTime=1770633159197, updateTime=1770633159197, creator=18614031015, updator=18614031015)])], journalTitle=现代预防医学, weixinUrl=null, journalUrl=http://xdyfyxzz.paperopen.com/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Modern Preventive Medicine, journalPhotoCn=IeiuPXEZi6AA+k0VfvoiOQ==, journalPhotoEn=/9iTl8/ndms4tBz1fL28Pg==, journalFirstLetter=X, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/10.20043/j.cnki.MPM.202506272, detailUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/10.20043/j.cnki.MPM.202506272, pdfUrlCn=https://castjournals.cast.org.cn/joweb/xdyfyx/CN/PDF/10.20043/j.cnki.MPM.202506272, pdfUrlEn=https://castjournals.cast.org.cn/joweb/xdyfyx/EN/PDF/10.20043/j.cnki.MPM.202506272, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1766592000000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
15
8
关闭全屏
北京市海淀区学院南路86号
010-62662699（运营及技术支持）
qkjq@cast.org.cn
