Article(id=1323941260926526254, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1323941237702668764, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202506094, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749398400000, receivedDateStr=2025-06-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1793581794244, onlineDateStr=2026-11-02, pubDate=1765296000000, pubDateStr=2025-12-10, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793581794244, onlineIssueDateStr=2026-11-02, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793581794244, creator=13701087609, updateTime=1793581794244, updator=13701087609, issue=Issue{id=1323941237702668764, tenantId=1146029695717560320, journalId=1227665162245664772, year='2025', volume='52', issue='23', pageStart='4225', pageEnd='4416', issueExtLink='null', onlineDate='null', pubDate='1765296000000', pubDateStr='2025-12-10', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793581788707, creator='13701087609', updateTime=1793581887795, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1323941653374959780, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1323941237702668764, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1323941653374959781, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1323941237702668764, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=4303, endPage=4309, ext={EN=ArticleExt(id=1323941261304013615, articleId=1323941260926526254, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Association between serum 25-Hydroxyvitamin D levels and the risk of respiratory tract infections in obese populations: an NHANES-based analysis, columnId=1228016572783063333, journalTitle=Modern Preventive Medicine, columnName=Nutrition and Food Hygiene, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the association between serum 25-hydroxyvitamin D [25(OH)D] concentration and the risk of respiratory tract infections(RTIs) in obese populations, analyze the influence of obesity stratification on the relationship between the two, and provide a scientific basis for the infection prevention and control strategies of RTIs in obese populations.
Methods Based on the data of the National Health and Nutrition Examination Survey（NHANES） of the United States from 2009 to 2018,participants over 20 years old were included as the research subjects. The relationship between serum 25(OH)D and the risk of RTIs in obese people was analyzed using multivariable logistic regression, subgroup analysis, restricted cubic spline analysis,and logistic inflection point model.
Results A total of 21 532 research subjects were finally included (12 989 cases in the non-obese group, 4 629 cases in the grade I obese group, 2 196 cases in the grade II obese group, and 1 718 cases in the grade III obese group), and there were significant differences in baseline characteristics among the groups (P<0.001). The overall prevalence rate of RTIs was 17.5%. Compared with the non-obese group, the serum 25(OH)D levels of obese people at all levels were significantly decreased, and the proportion of serum 25(OH)D deficiency increased with the aggravation of obesity (up to 16.9% in the grade III obese group). Serum 25(OH)D level was a protective factor for reducing the risk of RTIs. However, its protective effect showed a gradient decreasing trend with the increase of obesity degree. Among participants with adequate serum 25(OH)D, the protective effect persisted: grade I obesity group (OR=0.75, 95% CI: 0.62-0.88), grade II obesity group (OR=0.78, 95% CI: 0.70-0.86),and grade III obesity group (OR=0.82, 95% CI: 0.74-0.90). There was a clear threshold effect in the non-obese group (inflection point=29.96 nmol/L), the threshold in the grade I obese group shifted down to 25.97 nmol/L, while the grade II and grade III obese groups showed a linear relationship.
Conclusion Obese individuals have a deficiency in serum 25(OH)D, which is closely associated with an increased risk of respiratory tract infections. Moreover, the higher the degree of obesity, the more limited the protective effect of serum 25(OH)D. Therefore, stratified joint intervention strategies need to be developed for obese individuals.
, authors=Quan CHEN
1, Nan ZHOU
2, Shan-shan XU
1, Xiao-ting LEI
1, Jing XU
1, Li RUI
1, Zheng-xiang DAI
1, authorsList=Quan CHEN, Nan ZHOU, Shan-shan XU, Xiao-ting LEI, Jing XU, Li RUI, Zheng-xiang DAI, authorCompany=null, correspAuthors=Zheng-xiang DAI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1323941265137607482, articleId=1323941260926526254, tenantId=1146029695717560320, journalId=1227665162245664772, language=CN, title=基于NHANES的血清25-羟基维生素D水平与肥胖人群呼吸道感染风险的关联分析, columnId=1228016573034721597, journalTitle=现代预防医学, columnName=营养与食品卫生, runingTitle=null, highlight=null, articleAbstract=
目的 探讨血清25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]水平与肥胖人群呼吸道感染（respiratory tract infections, RTIs）风险的关联，分析肥胖分层对两者关系的影响，为肥胖人群RTIs的感染防控策略提供科学依据。
方法 基于2009—2018年美国国家健康与营养调查（National Health and Nutrition Examination Survey,NHANES）数据，纳入20岁以上的参与者作为研究对象，利用多因素 logistic 回归、亚组分析、限制性立方样条分析、logistic拐点模型分析血清25(OH)D与肥胖人群RTIs风险的关系。
结果 最终纳入21 532名研究对象，非肥胖组12 989例、I级肥胖组4 629例、II级肥胖组2 196例、III级肥胖组1 718例，各组基线特征存在显著差异（P<0.001），RTIs总患病率为17.5%。与非肥胖组相比，各级肥胖人群的血清25(OH)D水平显著降低，且血清25(OH)D缺乏比例随肥胖程度加重而升高（III级肥胖组达16.9%）。血清25(OH)D水平是RTIs风险降低的保护因素，但随着肥胖程度增加其保护作用呈梯度递减趋势，I级、II级、III级肥胖组血清25(OH)D充足组的保护效应OR=0.75（95% CI: 0.62～0.88）、0.78（95% CI: 0.70～0.86）、0.82（95% CI:0.74～0.90）。非肥胖组存在明确阈值效应（拐点=29.96 nmol/L），I级肥胖组阈值下移至25.97 nmol/L，而II级和III级肥胖组则呈现线性关系。
结论 肥胖人群血清25(OH)D缺乏与RTIs风险增加密切相关，且肥胖程度越高，血清25(OH)D的保护作用越受限，需针对肥胖人群分层制定联合干预策略。
, authors=陈权
1, 周楠
2, 许珊珊
1, 雷晓婷
1, 徐静
1, 芮丽
1, 戴正香
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陈权（1996—），男，硕士，中医师，研究方向：感染性疾病防治研究
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点，除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=IMgxgPbWHIMDyV7WNQ4a6g==, magXml=WbC9/E/CLbqHRAPKMr4Nig==, pdfUrl=null, pdf=fQ4lbCoDlic4hVeMvE8jgA==, pdfFileSize=985450, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=YRWcuUmqChb5XTRJHy60/g==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=d80phXJjR2I5BVuLLpf4cA==, mapNumber=null, fund=null)}, authors=[Author(id=1323941265951302465, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1323941266043577155, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, authorId=1323941265951302465, language=EN, stringName=Quan CHEN, firstName=Quan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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Diabetes,Metabolic Syndrome and Obesity: Targets and Therapy,
2020,
13:4131-4139., articleTitle=Inadequacy of vitamin D nutritional status in individuals with metabolically unhealthy obesity phenotype: the relevance of insulin resistance, refAbstract=null)], funds=[Fund(id=1323941275107468155, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, awardId=JSYB2024KF19, language=CN, fundingSource=江苏省中医疫病研究中心开放课题(JSYB2024KF19), fundOrder=null, country=null), Fund(id=1323941275187159932, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, awardId=Ym2023104, language=CN, fundingSource=江苏省预防医学科研课题(Ym2023104), fundOrder=null, country=null), Fund(id=1323941275254268797, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, awardId=JSYGY-2-2020-95, language=CN, fundingSource=江苏省医院协会医院管理创新研究课题(JSYGY-2-2020-95), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1323941265565426491, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, xref=1., ext=[AuthorCompanyExt(id=1323941265573815100, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, companyId=1323941265565426491, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Hospital Infection Management Office, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029,China), AuthorCompanyExt(id=1323941265586398013, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, companyId=1323941265565426491, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.南京中医药大学附属医院感染管理办公室，江苏 南京 210029)]), AuthorCompany(id=1323941265884193598, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, xref=2., ext=[AuthorCompanyExt(id=1323941265892582207, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, companyId=1323941265884193598, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.南京中医药大学第二附属医院中医康复中心)])], figs=[ArticleFig(id=1323941271739442029, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=EN, label=Figure 1, caption=
Flowchart of the screening process for research participants, figureFileSmall=HU1cPGxDyQQtD+98K3KpKQ==, figureFileBig=YRWcuUmqChb5XTRJHy60/g==, tableContent=null), ArticleFig(id=1323941273417163630, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=CN, label=图1, caption=
研究参与人员筛选流程图, figureFileSmall=HU1cPGxDyQQtD+98K3KpKQ==, figureFileBig=YRWcuUmqChb5XTRJHy60/g==, tableContent=null), ArticleFig(id=1323941273685599087, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=EN, label=Figure 2, caption=
Curve fitting graph of serum 25(OH)D and the risk of respiratory tract infection in obese population, figureFileSmall=B39YWeoXj1Uhh1QkEruq9w==, figureFileBig=SVH/xah83neX4kOC7yBLQg==, tableContent=null), ArticleFig(id=1323941273765290864, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=CN, label=图2, caption=
血清25(OH)D水平与肥胖人群RTIs风险的曲线拟合图注：A、B、C、D依次为非肥胖组、I级肥胖组、II级肥胖组、III级肥胖组血清25（OH）D水平与RTIs风险的曲线拟合图。
, figureFileSmall=B39YWeoXj1Uhh1QkEruq9w==, figureFileBig=SVH/xah83neX4kOC7yBLQg==, tableContent=null), ArticleFig(id=1323941273853371249, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=EN, label=Table 1, caption=
General information of populations with different characteristics ［n（%）, （
）］
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 总参与者 (n=21 532) | 非肥胖组 (n=12 989) | I级肥胖组 (n=4 629) | II级肥胖组 (n=2 196) | III级肥胖组 (n=1 718) | P值 |
|---|
| 性别 | | | | | | <0.001 |
| 男性 | 10 614 (49.3) | 6 799 (52.3) | 2 334 (50.4) | 905 (41.2) | 576 (33.5) | |
| 女性 | 10 918 (50.7) | 6 190 (47.7) | 2 295 (49.6) | 1 291 (58.8) | 1 142 (66.5) | |
| 年龄（岁） | 49.8±17.5 | 49.4±18.2 | 51.7±16.6 | 50.2±16.1 | 47.9±15.3 | <0.001 |
| 种族 | | | | | | <0.001 |
| 墨西哥美国人 | 9 008 (41.8) | 5 582 (43.0) | 1 869 (40.4) | 883 (40.2) | 674 (39.2) | |
| 非西班牙裔白人 | 4 467 (20.7) | 2 270 (17.5) | 1 054 (22.8) | 582 (26.5) | 561 (32.7) | |
| 非西班牙裔黑人 | 3 156 (14.7) | 1 683 (13.0) | 835 (18.0) | 376 (17.1) | 262 (15.3) | |
| 其他种族 | 4 901 (22.8) | 3 454 (26.6) | 871 (18.8) | 355 (16.2) | 221 (12.9) | |
| 学历 | | | | | | <0.001 |
| 高中以下 | 1 940 ( 9.0) | 1 132 (8.7) | 489 (10.6) | 194 (8.8) | 125 (7.3) | |
| 高中 | 7 665 (35.6) | 4 444 (34.2) | 1 728 (37.3) | 849 (38.7) | 644 (37.5) | |
| 大学及以上 | 11 927 (55.4) | 7 413 (57.1) | 2 412 (52.1) | 1 153 (52.5) | 949 (55.2) | |
| 贫困收入比 | | | | | | <0.001 |
| <1.3 | 6 944 (32.2) | 4 060 (31.3) | 1 468 (31.7) | 760 (34.6) | 656 (38.2) | |
| 1.3～3.5 | 8 070 (37.5) | 4 731 (36.4) | 1 796 (38.8) | 864 (39.3) | 679 (39.5) | |
| >3.5 | 6 518 (30.3) | 4 198 (32.3) | 1 365 (29.5) | 572 (26.0) | 383 (22.3) | |
| 饮酒 | | | | | | <0.001 |
| 否 | 5 165 (24.0) | 2 963 (22.8) | 1 136 (24.5) | 583 (26.5) | 483 (28.1) | |
| 是 | 16 367 (76.0) | 10 026 (77.2) | 3 493 (75.5) | 1 613 (73.5) | 1 235 (71.9) | |
| 吸烟 | | | | | | <0.001 |
| 从未吸烟 | 12 024 (55.8) | 7 219 (55.6) | 2 576 (55.6) | 1 252 (57.0) | 977 (56.9) | |
| 曾有吸烟史 | 5 238 (24.3) | 3 000 (23.1) | 1 231 (26.6) | 570 (26.0) | 437 (25.4) | |
| 现在吸烟 | 4 270 (19.8) | 2 770 (21.3) | 822 (17.8) | 374 (17.0) | 304 (17.7) | |
| 医疗保险 | | | | | | 0.009 |
| 否 | 4 460 (20.7) | 2 789 (21.5) | 903 (19.5) | 427 (19.4) | 341 (19.8) | |
| 是 | 17 072 (79.3) | 10 200 (78.5) | 3 726 (80.5) | 1 769 (80.6) | 1 377 (80.2) | |
| 呼吸道感染 | | | | | | <0.001 |
| 否 | 17 756 (82.5) | 10 826 (83.3) | 3 790 (81.9) | 1 769 (80.6) | 1 371 (79.8) | |
| 是 | 3 776 (17.5) | 2 163 (16.7) | 839 (18.1) | 427 (19.4) | 347 (20.2) | |
| 糖尿病 | | | | | | <0.001 |
| 否 | 18 625 (86.5) | 11 804 (90.9) | 3 803 (82.2) | 1 735 (79.0) | 1 283 (74.7) | |
| 是 | 2 907 (13.5) | 1 185 (9.1) | 826 (17.8) | 461 (21.0) | 435 (25.3) | |
| 哮喘 | | | | | | <0.001 |
| 否 | 18 321 (85.1) | 11 320 (87.2) | 3 930 (84.9) | 1 796 (81.8) | 1 275 (74.2) | |
| 是 | 3 211 (14.9) | 1 669 (12.8) | 699 (15.1) | 400 (18.2) | 443 (25.8) | |
| 抑郁 | | | | | | <0.001 |
| 否 | 19 276 (89.5) | 11 881 (91.5) | 4 077 (88.1) | 1 907 (86.8) | 1 411 (82.1) | |
| 是 | 2 256 (10.5) | 1 108 (8.5) | 552 (11.9) | 289 (13.2) | 307 (17.9) | |
| 睡眠障碍 | | | | | | <0.001 |
| 否 | 15 712 (73.0) | 9 955 (76.6) | 3 305 (71.4) | 1 418 (64.6) | 1 034 (60.2) | |
| 是 | 5 820 (27.0) | 3 034 (23.4) | 1 324 (28.6) | 778 (35.4) | 684 (39.8) | |
| BMI（kg/m2） | 29.4±7.1 | 25.0±3.1 | 32.2±1.4 | 37.1±1.4 | 45.7±5.8 | <0.001 |
| 血清糖化血红蛋白（%） | 5.8±1.1 | 5.6±0.9 | 6.0±1.2 | 6.1±1.3 | 6.2±1.3 | <0.001 |
| 血清白蛋白（g/L） | 42.3±3.4 | 43.0±3.3 | 41.9±3.2 | 41.1±3.1 | 39.8±3.2 | <0.001 |
| 25(OH)D浓度（nmol/L） | 65.8±28.7 | 68.7±29.0 | 64.2±27.6 | 60.0±28.1 | 55.8±26.4 | <0.001 |
| 25(OH)D浓度分组 | | | | | | <0.001 |
| 严重缺乏 | 1 721 (8.0) | 840 (6.5) | 351 (7.6) | 239 (10.9) | 291 (16.9) | |
| 中度缺乏 | 4 938 (22.9) | 2 659 (20.5) | 1 142 (24.7) | 642 (29.2) | 495 (28.8) | |
| 不足 | 7 799 (36.2) | 4 720 (36.3) | 1 762 (38.1) | 769 (35.0) | 548 (31.9) | |
| 充足 | 7 074 (32.9) | 4 770 (36.7) | 1 374 (29.7) | 546 (24.9) | 384 (22.4) | |
), ArticleFig(id=1323941273970811764, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=CN, label=表1, caption=
不同特征人群一般资料 ［n（%）,（
）］
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 总参与者 (n=21 532) | 非肥胖组 (n=12 989) | I级肥胖组 (n=4 629) | II级肥胖组 (n=2 196) | III级肥胖组 (n=1 718) | P值 |
|---|
| 性别 | | | | | | <0.001 |
| 男性 | 10 614 (49.3) | 6 799 (52.3) | 2 334 (50.4) | 905 (41.2) | 576 (33.5) | |
| 女性 | 10 918 (50.7) | 6 190 (47.7) | 2 295 (49.6) | 1 291 (58.8) | 1 142 (66.5) | |
| 年龄（岁） | 49.8±17.5 | 49.4±18.2 | 51.7±16.6 | 50.2±16.1 | 47.9±15.3 | <0.001 |
| 种族 | | | | | | <0.001 |
| 墨西哥美国人 | 9 008 (41.8) | 5 582 (43.0) | 1 869 (40.4) | 883 (40.2) | 674 (39.2) | |
| 非西班牙裔白人 | 4 467 (20.7) | 2 270 (17.5) | 1 054 (22.8) | 582 (26.5) | 561 (32.7) | |
| 非西班牙裔黑人 | 3 156 (14.7) | 1 683 (13.0) | 835 (18.0) | 376 (17.1) | 262 (15.3) | |
| 其他种族 | 4 901 (22.8) | 3 454 (26.6) | 871 (18.8) | 355 (16.2) | 221 (12.9) | |
| 学历 | | | | | | <0.001 |
| 高中以下 | 1 940 ( 9.0) | 1 132 (8.7) | 489 (10.6) | 194 (8.8) | 125 (7.3) | |
| 高中 | 7 665 (35.6) | 4 444 (34.2) | 1 728 (37.3) | 849 (38.7) | 644 (37.5) | |
| 大学及以上 | 11 927 (55.4) | 7 413 (57.1) | 2 412 (52.1) | 1 153 (52.5) | 949 (55.2) | |
| 贫困收入比 | | | | | | <0.001 |
| <1.3 | 6 944 (32.2) | 4 060 (31.3) | 1 468 (31.7) | 760 (34.6) | 656 (38.2) | |
| 1.3～3.5 | 8 070 (37.5) | 4 731 (36.4) | 1 796 (38.8) | 864 (39.3) | 679 (39.5) | |
| >3.5 | 6 518 (30.3) | 4 198 (32.3) | 1 365 (29.5) | 572 (26.0) | 383 (22.3) | |
| 饮酒 | | | | | | <0.001 |
| 否 | 5 165 (24.0) | 2 963 (22.8) | 1 136 (24.5) | 583 (26.5) | 483 (28.1) | |
| 是 | 16 367 (76.0) | 10 026 (77.2) | 3 493 (75.5) | 1 613 (73.5) | 1 235 (71.9) | |
| 吸烟 | | | | | | <0.001 |
| 从未吸烟 | 12 024 (55.8) | 7 219 (55.6) | 2 576 (55.6) | 1 252 (57.0) | 977 (56.9) | |
| 曾有吸烟史 | 5 238 (24.3) | 3 000 (23.1) | 1 231 (26.6) | 570 (26.0) | 437 (25.4) | |
| 现在吸烟 | 4 270 (19.8) | 2 770 (21.3) | 822 (17.8) | 374 (17.0) | 304 (17.7) | |
| 医疗保险 | | | | | | 0.009 |
| 否 | 4 460 (20.7) | 2 789 (21.5) | 903 (19.5) | 427 (19.4) | 341 (19.8) | |
| 是 | 17 072 (79.3) | 10 200 (78.5) | 3 726 (80.5) | 1 769 (80.6) | 1 377 (80.2) | |
| 呼吸道感染 | | | | | | <0.001 |
| 否 | 17 756 (82.5) | 10 826 (83.3) | 3 790 (81.9) | 1 769 (80.6) | 1 371 (79.8) | |
| 是 | 3 776 (17.5) | 2 163 (16.7) | 839 (18.1) | 427 (19.4) | 347 (20.2) | |
| 糖尿病 | | | | | | <0.001 |
| 否 | 18 625 (86.5) | 11 804 (90.9) | 3 803 (82.2) | 1 735 (79.0) | 1 283 (74.7) | |
| 是 | 2 907 (13.5) | 1 185 (9.1) | 826 (17.8) | 461 (21.0) | 435 (25.3) | |
| 哮喘 | | | | | | <0.001 |
| 否 | 18 321 (85.1) | 11 320 (87.2) | 3 930 (84.9) | 1 796 (81.8) | 1 275 (74.2) | |
| 是 | 3 211 (14.9) | 1 669 (12.8) | 699 (15.1) | 400 (18.2) | 443 (25.8) | |
| 抑郁 | | | | | | <0.001 |
| 否 | 19 276 (89.5) | 11 881 (91.5) | 4 077 (88.1) | 1 907 (86.8) | 1 411 (82.1) | |
| 是 | 2 256 (10.5) | 1 108 (8.5) | 552 (11.9) | 289 (13.2) | 307 (17.9) | |
| 睡眠障碍 | | | | | | <0.001 |
| 否 | 15 712 (73.0) | 9 955 (76.6) | 3 305 (71.4) | 1 418 (64.6) | 1 034 (60.2) | |
| 是 | 5 820 (27.0) | 3 034 (23.4) | 1 324 (28.6) | 778 (35.4) | 684 (39.8) | |
| BMI（kg/m2） | 29.4±7.1 | 25.0±3.1 | 32.2±1.4 | 37.1±1.4 | 45.7±5.8 | <0.001 |
| 血清糖化血红蛋白（%） | 5.8±1.1 | 5.6±0.9 | 6.0±1.2 | 6.1±1.3 | 6.2±1.3 | <0.001 |
| 血清白蛋白（g/L） | 42.3±3.4 | 43.0±3.3 | 41.9±3.2 | 41.1±3.1 | 39.8±3.2 | <0.001 |
| 25(OH)D浓度（nmol/L） | 65.8±28.7 | 68.7±29.0 | 64.2±27.6 | 60.0±28.1 | 55.8±26.4 | <0.001 |
| 25(OH)D浓度分组 | | | | | | <0.001 |
| 严重缺乏 | 1 721 (8.0) | 840 (6.5) | 351 (7.6) | 239 (10.9) | 291 (16.9) | |
| 中度缺乏 | 4 938 (22.9) | 2 659 (20.5) | 1 142 (24.7) | 642 (29.2) | 495 (28.8) | |
| 不足 | 7 799 (36.2) | 4 720 (36.3) | 1 762 (38.1) | 769 (35.0) | 548 (31.9) | |
| 充足 | 7 074 (32.9) | 4 770 (36.7) | 1 374 (29.7) | 546 (24.9) | 384 (22.4) | |
), ArticleFig(id=1323941274235052917, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=EN, label=Table 2, caption=
Multivariable logistic regression of serum 25(OH)D level and the risk of respiratory tract infection
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 模型1
OR（95% CI） | P值 | 模型2
OR（95% CI） | P值 | 模型3
OR（95% CI） | P值 |
|---|
| 25（OHD）浓度（连续变量） | 0.95 (0.93～0.97) | <0.001 | 0.96 (0.94～0.98) | 0.002 | 0.97 (0.95～0.99) | 0.004 |
| 25（OHD）浓度（分类变量） | | | | | | |
| 严重缺乏 | Ref | | Ref | | Ref | |
| 中度缺乏 | 0.82 (0.72～0.94) | 0.004 | 0.84 (0.73～0.96) | 0.010 | 0.87 (0.76～0.99) | <0.001 |
| 不足 | 0.75 (0.65～0.86) | <0.001 | 0.76 (0.66～0.87) | <0.001 | 0.80 (0.69～0.92) | <0.001 |
| 充足 | 0.67 (0.58～0.76) | <0.001 | 0.69 (0.60～0.78) | <0.001 | 0.72(0.62～0.82) | <0.001 |
), ArticleFig(id=1323941274339910518, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=CN, label=表2, caption=
血清25（OHD）水平与RTIs风险的多因素logistic回归
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 模型1
OR（95% CI） | P值 | 模型2
OR（95% CI） | P值 | 模型3
OR（95% CI） | P值 |
|---|
| 25（OHD）浓度（连续变量） | 0.95 (0.93～0.97) | <0.001 | 0.96 (0.94～0.98) | 0.002 | 0.97 (0.95～0.99) | 0.004 |
| 25（OHD）浓度（分类变量） | | | | | | |
| 严重缺乏 | Ref | | Ref | | Ref | |
| 中度缺乏 | 0.82 (0.72～0.94) | 0.004 | 0.84 (0.73～0.96) | 0.010 | 0.87 (0.76～0.99) | <0.001 |
| 不足 | 0.75 (0.65～0.86) | <0.001 | 0.76 (0.66～0.87) | <0.001 | 0.80 (0.69～0.92) | <0.001 |
| 充足 | 0.67 (0.58～0.76) | <0.001 | 0.69 (0.60～0.78) | <0.001 | 0.72(0.62～0.82) | <0.001 |
), ArticleFig(id=1323941274650289015, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=EN, label=Table 3, caption=
Subgroup analysis of serum 25(OH)D levels and the risk of respiratory tract infections in obese populations
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 非肥胖组
OR（95% CI） | P值 | I级肥胖组
OR（95% CI） | P值 | II级肥胖组
OR（95% CI） | P值 | III级肥胖组
OR（95% CI） | P值 | 交互作用
P值 |
|---|
| 25（OHD）浓度（连续变量） | 0.95 (0.93～0.97) | <0.001 | 0.97 (0.96～0.98) | <0.001 | 0.98 (0.97～0.99) | <0.001 | 0.98 (0.97～0.99) | 0.005 | 0.024 |
| 25（OHD）浓度（分类变量） | | | | | | | | | |
| 严重缺乏 | Ref | | Ref | | Ref | | Ref | | 0.031 |
| 中度缺乏 | 0.78 (0.64～0.95) | 0.001 | 0.83 (0.68～0.98) | 0.008 | 0.85 (0.78～0.92) | 0.011 | 0.89 (0.80～0.98) | 0.005 | |
| 不足 | 0.74 (0.61～0.87) | <0.001 | 0.79 (0.65～0.95) | 0.002 | 0.82(0.75～0.89) | <0.001 | 0.86 (0.78～0.94) | 0.001 | |
| 充足 | 0.68 (0.55～0.81) | <0.001 | 0.75 (0.62～0.88) | <0.001 | 0.78(0.70～0.86) | <0.001 | 0.82 (0.74～0.90) | <0.001 | |
), ArticleFig(id=1323941274721592184, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=CN, label=表3, caption=
血清25(OH)D水平与肥胖人群RTIs风险的亚组分析
, figureFileSmall=null, figureFileBig=null, tableContent=
| 变量 | 非肥胖组
OR（95% CI） | P值 | I级肥胖组
OR（95% CI） | P值 | II级肥胖组
OR（95% CI） | P值 | III级肥胖组
OR（95% CI） | P值 | 交互作用
P值 |
|---|
| 25（OHD）浓度（连续变量） | 0.95 (0.93～0.97) | <0.001 | 0.97 (0.96～0.98) | <0.001 | 0.98 (0.97～0.99) | <0.001 | 0.98 (0.97～0.99) | 0.005 | 0.024 |
| 25（OHD）浓度（分类变量） | | | | | | | | | |
| 严重缺乏 | Ref | | Ref | | Ref | | Ref | | 0.031 |
| 中度缺乏 | 0.78 (0.64～0.95) | 0.001 | 0.83 (0.68～0.98) | 0.008 | 0.85 (0.78～0.92) | 0.011 | 0.89 (0.80～0.98) | 0.005 | |
| 不足 | 0.74 (0.61～0.87) | <0.001 | 0.79 (0.65～0.95) | 0.002 | 0.82(0.75～0.89) | <0.001 | 0.86 (0.78～0.94) | 0.001 | |
| 充足 | 0.68 (0.55～0.81) | <0.001 | 0.75 (0.62～0.88) | <0.001 | 0.78(0.70～0.86) | <0.001 | 0.82 (0.74～0.90) | <0.001 | |
), ArticleFig(id=1323941274797089657, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=EN, label=Table 4, caption=
Threshold effect analysis of serum 25(OH)D and respiratory tract infection risk in different obese subgroups
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| 分析指标 | 非肥胖组OR（95% CI） | P值 | I级肥胖组OR（95% CI） | P值 |
|---|
| 拐点（nmol/L） | 29.96（27.20～32.74） | 0.014 | 25.97（21.23～30.72） | 0.035 |
| 拐点前斜率（OR） | 0.97（0.96～0.98） | 0.001 | 0.98（0.89～1.09） | 0.751 |
| 拐点后斜率（OR） | 1.00（0.99～1.00） | 0.983 | 0.99（0.99～1.00） | 0.593 |
), ArticleFig(id=1323941274885170042, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1323941260926526254, language=CN, label=表4, caption=
不同肥胖亚组血清25(OH)D水平与RTIs风险的阈值效应分析
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| 分析指标 | 非肥胖组OR（95% CI） | P值 | I级肥胖组OR（95% CI） | P值 |
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| 拐点（nmol/L） | 29.96（27.20～32.74） | 0.014 | 25.97（21.23～30.72） | 0.035 |
| 拐点前斜率（OR） | 0.97（0.96～0.98） | 0.001 | 0.98（0.89～1.09） | 0.751 |
| 拐点后斜率（OR） | 1.00（0.99～1.00） | 0.983 | 0.99（0.99～1.00） | 0.593 |
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