Article(id=1240375106912964705, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240375105386238038, articleNumber=null, orderNo=null, doi=10.20043/j.cnki.MPM.202308255, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1692028800000, receivedDateStr=2023-08-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1773658070542, onlineDateStr=2026-03-16, pubDate=1711296000000, pubDateStr=2024-03-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1773658070542, onlineIssueDateStr=2026-03-16, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1773658070542, creator=13701087609, updateTime=1773658070542, updator=13701087609, issue=Issue{id=1240375105386238038, tenantId=1146029695717560320, journalId=1227665162245664772, year='2024', volume='51', issue='6', pageStart='961', pageEnd='1152', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1773658070179, creator=13701087609, updateTime=1773658539618, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1240377074414833974, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240375105386238038, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1240377074414833975, tenantId=1146029695717560320, journalId=1227665162245664772, issueId=1240375105386238038, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1017, endPage=1023, ext={EN=ArticleExt(id=1240375107160428648, articleId=1240375106912964705, tenantId=1146029695717560320, journalId=1227665162245664772, language=EN, title=Analyses of the incidence and influencing factors of thyroid diseases in perimenopausal women, columnId=1228016568949474136, journalTitle=Modern Preventive Medicine, columnName=Child and Adolescent Health, Maternal and Child Health, runingTitle=null, highlight=null, articleAbstract=
Objective To assess the prevalence and identify risk factors of thyroid diseases among perimenopausal women, providing a theoretical basis for scientific prevention and control measures.
Methods 533 perimenopausal women in Shenzhen, aged 40-60, were statistically analyzed for demographics, living habits, residential pollution, and biochemical indicators, with multionmial logistic regression used to assess their links to thyroid disease occurrence.
Results The prevalence of thyroid dysfunction in perimenopausal women was 37.0% (197/533). The prevalence of thyroid nodules was 49.7% (265/533) and 14.3% (76/533) in other thyroid ultrasound abnormalities types. The prevalence of thyroid ultrasound abnormalities accordingly tended to increase with age. Multionmial logistic regression analysis showed that systolic blood pressure (OR=1.066, 95% CI:1.024-1.110) and history of thyroid disease (OR=6.853, 95% CI:1.537-30.555) were the risk factors of thyroid dysfunction; 55-60 years old (OR=5.011, 95% CI:1.938-12.956), occupation of clerical staff (OR=3.332, 95% CI:1.196-9.282), diastolic blood pressure (OR=1.050, 95% CI:1.004-1.098), and history of thyroid disease (OR=6.704, 95% CI:1.820-24.698) were the risk factors of thyroid nodules; TGAb antibody positivity (OR=3.763, 95% CI: 1.177-12.031), occupation of technician (OR=4.196, 95% CI:1.259-13.983), systolic blood pressure (OR=1.036, 95% CI:1.005-1.068) and history of thyroid disease (OR=17.917, 95% CI:5.107-62.851) were the risk factors of thyroid dysfunction and ultrasound.
Conclusion Thyroid dysfunction and nodule rates among perimenopausal women in Shenzhen (37.0% and 49.7%) exceed China's averages (19.9% and 23.7%). Heightened screening and early action for thyroid issues in this group are needed.
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目的 揭示围绝经期女性甲状腺疾病的患病情况及影响因素,为发现甲状腺疾病风险因素和防控措施提供理论依据。
方法 选取深圳市年龄在40~60岁的533名围绝经期女性为研究对象,对其人口学特征、生活习惯、居住地污染情况和临床生化指标进行统计分析,采用无序多分类logistic回归分析上述指标与甲状腺疾病发生的关联。
结果 围绝经期女性甲状腺功能异常的检出率为37.0 %(197/533),甲状腺结节的检出率为49.7 %(265/533),其他甲状腺超声异常的检出率为14.3 %(76/533)。甲状腺超声异常检出率随年龄增长而呈现上升趋势。无序多分类logistic回归分析结果显示,收缩压升高(OR=1.066,95% CI:1.024~1.110)和既往有甲状腺疾病史(OR=6.853,95% CI:1.537~30.555)是甲功异常的危险因素;年龄在55~60岁(OR=5.011,95% CI:1.938~12.956)、职业为文职人员(OR=3.332,95% CI:1.196~9.282)、舒张压升高(OR=1.050,95% CI:1.004~1.098)以及既往有甲状腺疾病史(OR=6.704,95% CI:1.820~24.698)是结节的危险因素;TGAb抗体阳性(OR=3.763,95% CI:1.177~12.031)、职业为技术人员(OR=4.196,95% CI:1.259~13.983)、收缩压升高(OR=1.036,95% CI:1.005~1.068)和既往有甲状腺疾病史(OR=17.917,95% CI:5.107~62.851)是甲状腺功能和超声均异常的危险因素。
结论 深圳地区围绝经期女性甲状腺功能异常和甲状腺结节的检出率分别为37.0%和49.7%,高于我国31省市女性甲功异常(患病率为19.9%)和甲状腺结节(患病率为23.7%)的平均水平,应加强对围绝经期女性甲状腺疾病的筛查并制定早期干预措施。
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本刊刊出的所有文章不代表中华预防医学会和本刊编委会的观点,除非特别声明。, copyrightOwner=中华预防医学会和四川大学华西公共卫生学院, extLink=null, articleAbsUrl=null, sourceXml=NTB6REuHatzjKtzHUYXyrQ==, magXml=orfLuUbAsSrebJYfSPB6iA==, pdfUrl=null, pdf=ex7PSEeK7oFb0f5y5POeJA==, pdfFileSize=740938, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=9Sk2p6dGABjUMx29wEvpvw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=keK7RNTKebn/3sGhij+qyA==, mapNumber=null, authorCompany=null, fund=null, authors=
陆锦萍(2000—),女,硕士在读,研究方向:公共卫生
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1.中山大学公共卫生学院,广东 广州 510080
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1.中山大学公共卫生学院,广东 广州 510080
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34(1): 70-73., articleTitle=Iodine nutrition status thyroid nodule detection and influencing factors in 450 health check-up residents in Chengdu, refAbstract=null), Reference(id=1240746313906704851, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, doi=null, pmid=null, pmcid=null, year=2020, volume=28, issue=9, pageStart=692, pageEnd=695, url=null, language=null, rfNumber=[19], rfOrder=28, authorNames=曹毅, 李斌, 陈柯余, journalName=中国慢性病预防与控制, refType=null, unstructuredReference=曹毅,李斌,陈柯余,等.女性甲状腺结节与生活及月经生殖因素的相关性分析[J].
中国慢性病预防与控制,
2020,
28(9):692-695., articleTitle=女性甲状腺结节与生活及月经生殖因素的相关性分析, refAbstract=null), Reference(id=1240746313978008023, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, doi=null, pmid=null, pmcid=null, year=2020, volume=28, issue=9, pageStart=692, pageEnd=695, url=null, language=null, rfNumber=[19], rfOrder=29, authorNames=Cao Y, Li B, Chen KY, journalName=Chinese Journal of Prevention and Control of Chronic Diseases, refType=null, unstructuredReference=
Cao Y,
Li B,
Chen KY, et al. Analysis of the correlation between thyroid nodules andlife and menstrual reproductive factors in women[J].
Chinese Journal of Prevention and Control of Chronic Diseases,
2020,
28(9): 692-695., articleTitle=Analysis of the correlation between thyroid nodules andlife and menstrual reproductive factors in women, refAbstract=null)], funds=[Fund(id=1240746310811308356, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, awardId=22176132, language=CN, fundingSource=国家自然科学基金面上项目(22176132), fundOrder=null, country=null), Fund(id=1240746310891000137, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, awardId=JCYJ20210324135000001, language=CN, fundingSource=深圳市科创委面上项目(JCYJ20210324135000001), fundOrder=null, country=null), Fund(id=1240746311025217871, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, awardId=20221119115615564, language=CN, fundingSource=广东省医学科研基金(20221119115615564), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1240746306252100600, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, xref=1., ext=[AuthorCompanyExt(id=1240746306273072123, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, companyId=1240746306252100600, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China), AuthorCompanyExt(id=1240746306302432252, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, companyId=1240746306252100600, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.中山大学公共卫生学院,广东 广州 510080)]), AuthorCompany(id=1240746306407288837, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, xref=2., ext=[AuthorCompanyExt(id=1240746306415677447, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, companyId=1240746306407288837, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.深圳市疾病预防控制中心持久性有机污染物研究室)])], figs=[ArticleFig(id=1240746309628514563, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=EN, label=Fig.1, caption=
Forest plot of univariate analysis of influencing factors for thyroid diseases, figureFileSmall=02YTMAOSIqnyFP6eUzToUg==, figureFileBig=ONIgRMlw1O6eF4Fl+6uJug==, tableContent=null), ArticleFig(id=1240746309724983563, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=CN, label=图1, caption=
甲状腺疾病影响因素单因素分析的森林图注:1-A:围绝经期女性仅甲状腺功能异常的单因素logistic回归分析森林图;1-B:围绝经期女性仅甲状腺超声异常的单因素logistic回归分析森林图;1-C:围绝经期女性甲状腺功能和超声均异常的单因素logistic回归分析森林图。
, figureFileSmall=02YTMAOSIqnyFP6eUzToUg==, figureFileBig=ONIgRMlw1O6eF4Fl+6uJug==, tableContent=null), ArticleFig(id=1240746309825646865, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=EN, label=Table 1, caption=
Detection rates of thyroid dysfunction and ultrasound abnormalities among different age groups [n (%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 指标 | 年龄(岁) | 趋势χ2 | P值 |
|---|
| 40~44 | 45~49 | 50~54 | 55~60 |
|---|
| 甲状腺功能 | | | | | | |
| 正常 | 117(63.6) | 86(67.7) | 64(60.4) | 69(59.5) | 0.04 | 0.849 |
| 异常 | 67(36.4) | 41(32.3) | 42(39.6) | 47(40.5) |
| 甲状腺超声 | | | | | | |
| 正常 | 81(44.0) | 53(41.7) | 33(31.1) | 25(21.6) | 7.80 | 0.005 |
| 异常 | 103(56.0) | 74(58.3) | 73(68.9) | 91(78.4) |
), ArticleFig(id=1240746309930504472, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=CN, label=表1, caption=
不同年龄段甲状腺功能异常及超声异常的检出率[n(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 指标 | 年龄(岁) | 趋势χ2 | P值 |
|---|
| 40~44 | 45~49 | 50~54 | 55~60 |
|---|
| 甲状腺功能 | | | | | | |
| 正常 | 117(63.6) | 86(67.7) | 64(60.4) | 69(59.5) | 0.04 | 0.849 |
| 异常 | 67(36.4) | 41(32.3) | 42(39.6) | 47(40.5) |
| 甲状腺超声 | | | | | | |
| 正常 | 81(44.0) | 53(41.7) | 33(31.1) | 25(21.6) | 7.80 | 0.005 |
| 异常 | 103(56.0) | 74(58.3) | 73(68.9) | 91(78.4) |
), ArticleFig(id=1240746310039556381, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=EN, label=Table 2, caption=
Comparison of basic characteristics among perimenopausal women with different thyroid statuses [n (%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 指标 | 分组 | 甲功+超声均正常 (n =140) | 仅甲功异常 (n =52) | 仅有甲状腺结节 (n =147) | 甲功+超声均异常 (n =194) | 合计 (n =533) | χ2 | P |
|---|
| 年龄(岁) | 40~44 | 62(44.3) | 19(36.5) | 39(26.5) | 64(33.0) | 184(34.5) | 26.50 | 0.002 |
| 45~49 | 42(30.0) | 11(21.2) | 36(24.5) | 38(19.6) | 127(23.8) | | |
| 50~54 | 21(15.0) | 12(23.1) | 33(22.4) | 40(20.6) | 106(19.9) | | |
| 55~60 | 15(10.7) | 10(19.2) | 39(26.5) | 52(26.8) | 116(21.8) | | |
| BMI | 偏瘦 | 5(3.6) | 1(2.0) | 4(2.8) | 6(3.1) | 16(3.1) | 16.44 | 0.058 |
| 正常 | 101(73.2) | 32(64.0) | 97(67.4) | 105(55.0) | 335(64.1) | | |
| 超重 | 30(21.7) | 15(30.0) | 38(26.4) | 67(35.1) | 150(28.7) | | |
| 肥胖 | 2(1.4) | 2(4.0) | 5(3.5) | 13(6.8) | 22(4.2) | | |
| 文化程度 | 小学、初中及以下 | 34(24.5) | 10(19.2) | 34(23.4) | 43(22.8) | 121(23.0) | 6.71 | 0.667 |
| 高中及中专 | 36(25.9) | 9(17.3) | 28(19.3) | 35(18.5) | 108(20.6) | | |
| 大专及本科 | 62(44.6) | 28(53.8) | 77(53.1) | 102(54.0) | 269(51.2) | | |
| 研究生及以上 | 7(5.0) | 5(9.6) | 6(4.1) | 9(4.8) | 27(5.1) | | |
| 职业 | 文职人员 | 32(22.9) | 14(27.5) | 43(29.5) | 45(23.6) | 134(25.4) | 26.88 | 0.030 |
| 技术人员 | 13(9.3) | 10(19.6) | 20(13.7) | 43(22.5) | 86(16.3) | | |
| 服务人员 | 26(18.6) | 5(9.8) | 15(10.3) | 19(9.9) | 65(12.3) | | |
| 家务 | 31(22.1) | 6(11.8) | 24(16.4) | 27(14.1) | 88(16.7) | | |
| 其他(农林牧渔水利业生产人员、军人或其他劳动者) | 19(13.6) | 8(15.7) | 16(11.0) | 34(17.8) | 77(14.6) | | |
| 未就业或离退休人员 | 19(13.6) | 8(15.7) | 28(19.2) | 23(12.0) | 78(14.8) | | |
| 吸烟 | 是 | 1(0.7) | 2(3.8) | 1(0.7) | 5(2.6) | 9(1.7) | 4.01 | 0.261 |
| 否 | 13(99.3) | 50(96.2) | 14(99.3) | 187(97.4) | 518(98.3) | | |
| 饮酒 | 是 | 26(18.7) | 3(5.8) | 23(16.1) | 23(12.1) | 75(14.3) | 7.03 | 0.071 |
| 否 | 113(81.3) | 49(94.2) | 120(83.9) | 167(87.9) | 449(85.7) | | |
| 家里食盐加碘情况 | 加碘 | 103(75.2) | 42(80.8) | 97(67.8) | 125(66.5) | 367(70.6) | 18.03 | 0.026 |
| 不加碘 | 18(13.1) | 7(13.5) | 37(25.9) | 47(25.0) | 109(21.0) | | |
| 其他盐(如硒盐等) | 5(3.6) | 1(1.9) | 1(0.7) | 9(4.8) | 16(3.1) | | |
| 加碘不加碘换着吃 | 11(8.0) | 2(3.8) | 8(5.6) | 7(3.7) | 28(5.4) | | |
| 既往是否有甲状腺疾病史 | 是 | 6(4.4) | 7(13.5) | 25(17.2) | 73(38.0) | 111(21.1) | 63.40 | <0.001 |
| 否 | 131(95.6) | 45(86.5) | 120(82.8) | 119(62.0) | 415(78.9) | | |
| 血缘亲属中是否有人曾被诊断为其他癌症 | 是 | 102(75.0) | 43(82.7) | 118(82.5) | 145(75.5) | 408(78.0) | 3.86 | 0.148 |
| 否 | 34(25.0) | 9(17.3) | 25(17.5) | 47(24.5) | 115(22.0) | | |
| 居住地附近是否有空气污染 | 是 | 31(22.3) | 12(23.1) | 23(16.0) | 26(13.5) | 92(17.5) | 5.67 | 0.122 |
| 否 | 108(77.7) | 40(76.9) | 121(84.0) | 166(86.5) | 435(82.5) | | |
), ArticleFig(id=1240746310165385509, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=CN, label=表2, caption=
不同甲状腺功能状态的围绝经期女性基本情况比较[n(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 指标 | 分组 | 甲功+超声均正常 (n =140) | 仅甲功异常 (n =52) | 仅有甲状腺结节 (n =147) | 甲功+超声均异常 (n =194) | 合计 (n =533) | χ2 | P |
|---|
| 年龄(岁) | 40~44 | 62(44.3) | 19(36.5) | 39(26.5) | 64(33.0) | 184(34.5) | 26.50 | 0.002 |
| 45~49 | 42(30.0) | 11(21.2) | 36(24.5) | 38(19.6) | 127(23.8) | | |
| 50~54 | 21(15.0) | 12(23.1) | 33(22.4) | 40(20.6) | 106(19.9) | | |
| 55~60 | 15(10.7) | 10(19.2) | 39(26.5) | 52(26.8) | 116(21.8) | | |
| BMI | 偏瘦 | 5(3.6) | 1(2.0) | 4(2.8) | 6(3.1) | 16(3.1) | 16.44 | 0.058 |
| 正常 | 101(73.2) | 32(64.0) | 97(67.4) | 105(55.0) | 335(64.1) | | |
| 超重 | 30(21.7) | 15(30.0) | 38(26.4) | 67(35.1) | 150(28.7) | | |
| 肥胖 | 2(1.4) | 2(4.0) | 5(3.5) | 13(6.8) | 22(4.2) | | |
| 文化程度 | 小学、初中及以下 | 34(24.5) | 10(19.2) | 34(23.4) | 43(22.8) | 121(23.0) | 6.71 | 0.667 |
| 高中及中专 | 36(25.9) | 9(17.3) | 28(19.3) | 35(18.5) | 108(20.6) | | |
| 大专及本科 | 62(44.6) | 28(53.8) | 77(53.1) | 102(54.0) | 269(51.2) | | |
| 研究生及以上 | 7(5.0) | 5(9.6) | 6(4.1) | 9(4.8) | 27(5.1) | | |
| 职业 | 文职人员 | 32(22.9) | 14(27.5) | 43(29.5) | 45(23.6) | 134(25.4) | 26.88 | 0.030 |
| 技术人员 | 13(9.3) | 10(19.6) | 20(13.7) | 43(22.5) | 86(16.3) | | |
| 服务人员 | 26(18.6) | 5(9.8) | 15(10.3) | 19(9.9) | 65(12.3) | | |
| 家务 | 31(22.1) | 6(11.8) | 24(16.4) | 27(14.1) | 88(16.7) | | |
| 其他(农林牧渔水利业生产人员、军人或其他劳动者) | 19(13.6) | 8(15.7) | 16(11.0) | 34(17.8) | 77(14.6) | | |
| 未就业或离退休人员 | 19(13.6) | 8(15.7) | 28(19.2) | 23(12.0) | 78(14.8) | | |
| 吸烟 | 是 | 1(0.7) | 2(3.8) | 1(0.7) | 5(2.6) | 9(1.7) | 4.01 | 0.261 |
| 否 | 13(99.3) | 50(96.2) | 14(99.3) | 187(97.4) | 518(98.3) | | |
| 饮酒 | 是 | 26(18.7) | 3(5.8) | 23(16.1) | 23(12.1) | 75(14.3) | 7.03 | 0.071 |
| 否 | 113(81.3) | 49(94.2) | 120(83.9) | 167(87.9) | 449(85.7) | | |
| 家里食盐加碘情况 | 加碘 | 103(75.2) | 42(80.8) | 97(67.8) | 125(66.5) | 367(70.6) | 18.03 | 0.026 |
| 不加碘 | 18(13.1) | 7(13.5) | 37(25.9) | 47(25.0) | 109(21.0) | | |
| 其他盐(如硒盐等) | 5(3.6) | 1(1.9) | 1(0.7) | 9(4.8) | 16(3.1) | | |
| 加碘不加碘换着吃 | 11(8.0) | 2(3.8) | 8(5.6) | 7(3.7) | 28(5.4) | | |
| 既往是否有甲状腺疾病史 | 是 | 6(4.4) | 7(13.5) | 25(17.2) | 73(38.0) | 111(21.1) | 63.40 | <0.001 |
| 否 | 131(95.6) | 45(86.5) | 120(82.8) | 119(62.0) | 415(78.9) | | |
| 血缘亲属中是否有人曾被诊断为其他癌症 | 是 | 102(75.0) | 43(82.7) | 118(82.5) | 145(75.5) | 408(78.0) | 3.86 | 0.148 |
| 否 | 34(25.0) | 9(17.3) | 25(17.5) | 47(24.5) | 115(22.0) | | |
| 居住地附近是否有空气污染 | 是 | 31(22.3) | 12(23.1) | 23(16.0) | 26(13.5) | 92(17.5) | 5.67 | 0.122 |
| 否 | 108(77.7) | 40(76.9) | 121(84.0) | 166(86.5) | 435(82.5) | | |
), ArticleFig(id=1240746310249271595, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=EN, label=Table 3, caption=
Comparison on blood pressure and clinical biochemical indices among perimenopausal women with different thyroid statuses[n(%) or (
)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 指标 | 甲功+超声均正常 (n=140) | 仅甲功异常 (n=52) | 仅有甲状腺结节 (n=147) | 甲功+超声均异常 (n=194) | χ2 /H值 | P |
|---|
| TPOAb状况 | | | | | | |
| 阳性 | 6(4.3) | 4(7.7) | 13(8.8) | 40(20.6) | 23.92 | <0.001 |
| 阴性 | 132(95.7) | 48(92.3) | 134(91.2) | 154(79.4) | 20.65 | <0.001 |
| TGAb状况 | | | | | | |
| 阳性 | 8(5.7) | 1(1.9) | 18(12.2) | 36(18.6) | 23.92 | <0.001 |
| 阴性 | 132(94.3) | 51(98.1) | 129(87.8) | 158(81.4) | 20.65 | <0.001 |
| 收缩压(mmHg) | 114.40±15.64 | 121.69±16.72 | 118.62±18.42 | 121.35±16.76 | 15.85 | 0.001 |
| 舒张压(mmHg) | 71.11±9.78 | 72.29±10.14 | 74.76±9.90 | 74.01±11.14 | 9.42 | 0.024 |
| HDL-C(mmol/L) | 1.45±0.41 | 1.46±0.39 | 1.41±0.44 | 1.50±0.41 | 5.67 | 0.129 |
| LDL-C(mmol/L) | 3.14±0.82 | 3.16±0.82 | 3.22±0.75 | 3.16±0.79 | 1.50 | 0.682 |
| TG(mmol/L) | 1.18±0.75 | 1.34±1.06 | 1.30±1.07 | 1.31±0.94 | 5.34 | 0.136 |
| TC(mmol/L) | 4.99±1.00 | 5.03±0.92 | 5.09±0.92 | 5.13±0.91 | 3.14 | 0.370 |
| FPG(mmol/L) | 4.95±0.81 | 4.97±0.74 | 5.15±1.45 | 4.99±0.82 | 11.39 | 0.707 |
| Cre(mmol/L) | 60.56±12.99 | 60.10±10.51 | 59.21±10.49 | 60.76±11.57 | 1.95 | 0.583 |
| SUA(mmol/L) | 283.66±70.40 | 294.14±61.82 | 278.87±62.98 | 305.18±71.65 | 16.60 | 0.001 |
), ArticleFig(id=1240746310375100721, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=CN, label=表3, caption=
不同甲状腺状态的围绝经期女性血压与临床生化指标比较[n(%)或(
) ]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 指标 | 甲功+超声均正常 (n=140) | 仅甲功异常 (n=52) | 仅有甲状腺结节 (n=147) | 甲功+超声均异常 (n=194) | χ2 /H值 | P |
|---|
| TPOAb状况 | | | | | | |
| 阳性 | 6(4.3) | 4(7.7) | 13(8.8) | 40(20.6) | 23.92 | <0.001 |
| 阴性 | 132(95.7) | 48(92.3) | 134(91.2) | 154(79.4) | 20.65 | <0.001 |
| TGAb状况 | | | | | | |
| 阳性 | 8(5.7) | 1(1.9) | 18(12.2) | 36(18.6) | 23.92 | <0.001 |
| 阴性 | 132(94.3) | 51(98.1) | 129(87.8) | 158(81.4) | 20.65 | <0.001 |
| 收缩压(mmHg) | 114.40±15.64 | 121.69±16.72 | 118.62±18.42 | 121.35±16.76 | 15.85 | 0.001 |
| 舒张压(mmHg) | 71.11±9.78 | 72.29±10.14 | 74.76±9.90 | 74.01±11.14 | 9.42 | 0.024 |
| HDL-C(mmol/L) | 1.45±0.41 | 1.46±0.39 | 1.41±0.44 | 1.50±0.41 | 5.67 | 0.129 |
| LDL-C(mmol/L) | 3.14±0.82 | 3.16±0.82 | 3.22±0.75 | 3.16±0.79 | 1.50 | 0.682 |
| TG(mmol/L) | 1.18±0.75 | 1.34±1.06 | 1.30±1.07 | 1.31±0.94 | 5.34 | 0.136 |
| TC(mmol/L) | 4.99±1.00 | 5.03±0.92 | 5.09±0.92 | 5.13±0.91 | 3.14 | 0.370 |
| FPG(mmol/L) | 4.95±0.81 | 4.97±0.74 | 5.15±1.45 | 4.99±0.82 | 11.39 | 0.707 |
| Cre(mmol/L) | 60.56±12.99 | 60.10±10.51 | 59.21±10.49 | 60.76±11.57 | 1.95 | 0.583 |
| SUA(mmol/L) | 283.66±70.40 | 294.14±61.82 | 278.87±62.98 | 305.18±71.65 | 16.60 | 0.001 |
), ArticleFig(id=1240746310471569715, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=EN, label=Table 4, caption=
Multivariate logistic regression analysis of influencing factors for thyroid diseases among perimenopausal women
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| 甲状腺疾病分类 | 变量 | β | SE | Wald | OR (95% CI) | P值 |
|---|
| 仅甲状腺功能异常 | 收缩压 | 0.06 | 0.02 | 9.83 | 1.066(1.024~1.110) | 0.002 |
| 既往甲状腺疾病史 | 1.93 | 0.76 | 6.37 | 6.853(1.537~30.555) | 0.012 |
| 仅甲状腺结节 | 舒张压 | 0.05 | 0.02 | 4.50 | 1.050(1.004~1.098) | 0.034 |
| 55~60岁 | 1.61 | 0.49 | 11.06 | 5.011(1.938~12.956) | 0.001 |
| 文职人员 | 1.20 | 0.52 | 5.30 | 3.332(1.196~9.282) | 0.021 |
| 既往甲状腺疾病史 | 1.90 | 0.67 | 8.18 | 6.704(1.820~24.698) | 0.004 |
| 甲功和超声均异常 | 收缩压 | 0.04 | 0.02 | 5.17 | 1.036(1.005~1.068) | 0.023 |
| 技术人员 | 1.43 | 0.61 | 5.45 | 4.196(1.259~13.983) | 0.020 |
| TGAb阳性 | 1.33 | 0.59 | 4.99 | 3.763(1.177~12.031) | 0.025 |
| 既往甲状腺疾病史 | 2.89 | 0.64 | 20.31 | 17.917(5.107~62.851) | <0.001 |
), ArticleFig(id=1240746310563844408, tenantId=1146029695717560320, journalId=1227665162245664772, articleId=1240375106912964705, language=CN, label=表4, caption=
围绝经期女性甲状腺疾病影响因素的多因素logistic回归分析
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| 甲状腺疾病分类 | 变量 | β | SE | Wald | OR (95% CI) | P值 |
|---|
| 仅甲状腺功能异常 | 收缩压 | 0.06 | 0.02 | 9.83 | 1.066(1.024~1.110) | 0.002 |
| 既往甲状腺疾病史 | 1.93 | 0.76 | 6.37 | 6.853(1.537~30.555) | 0.012 |
| 仅甲状腺结节 | 舒张压 | 0.05 | 0.02 | 4.50 | 1.050(1.004~1.098) | 0.034 |
| 55~60岁 | 1.61 | 0.49 | 11.06 | 5.011(1.938~12.956) | 0.001 |
| 文职人员 | 1.20 | 0.52 | 5.30 | 3.332(1.196~9.282) | 0.021 |
| 既往甲状腺疾病史 | 1.90 | 0.67 | 8.18 | 6.704(1.820~24.698) | 0.004 |
| 甲功和超声均异常 | 收缩压 | 0.04 | 0.02 | 5.17 | 1.036(1.005~1.068) | 0.023 |
| 技术人员 | 1.43 | 0.61 | 5.45 | 4.196(1.259~13.983) | 0.020 |
| TGAb阳性 | 1.33 | 0.59 | 4.99 | 3.763(1.177~12.031) | 0.025 |
| 既往甲状腺疾病史 | 2.89 | 0.64 | 20.31 | 17.917(5.107~62.851) | <0.001 |
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