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Research progress in the mechanism of freeze-drying in protecting the high vitality of probiotics
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Jialin WU1, 2, Ying LI1, Zhenjie LIU1, Moutong CHEN1, *, Qingping WU1, *
Acta Microbiologica Sinica | 2024, 64(5) : 1402 - 1416
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Acta Microbiologica Sinica | 2024, 64(5): 1402-1416
• Reviews •
Research progress in the mechanism of freeze-drying in protecting the high vitality of probiotics
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Jialin WU1, 2, Ying LI1, Zhenjie LIU1, Moutong CHEN1, *, Qingping WU1, *
Affiliations
  • 1 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China
  • 2 College of Food Science, South China Agricultural University, Guangzhou 510642, Guangdong, China
Published: 2024-05-04 doi: 10.13343/j.cnki.wsxb.20230730
Outline
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Adequate intake of probiotics helps in maintaining the homeostasis of the gut microbiota, which is of great significance for human intestinal health. However, probiotics are vulnerable to stress and necessitate stringent storage conditions in industrial settings, which pose challenges to the vitality maintenance of probiotics in transportation and shelf-life. Therefore, it is essential to develop the preparation process capable of protecting the high vitality of probiotics. Drying beneficial for sustaining probiotic vitality is often used to maintain the strain stability. Among the drying methods, freeze-drying is widely used. However, during the freeze-drying process, probiotics encounter environmental stress conditions, which lead to cellular damage and even death. Therefore, the freeze-drying protectants that can significantly improve probiotic survival rate have become a research hotspot in the industrial application of probiotics. This article systematically summarizes both the commonly used and the newly discovered protectants for freeze-drying of probiotics and elucidates their mechanisms of action. It provides an overview of the factors affecting cell viability post freeze-drying while outlining the prospective research directions of freeze-drying protectants. This review is expected to furnish theoretical substantiation for the development of freeze-dried probiotics with high vitality.

probiotics  /  freeze-drying  /  freeze-drying protectants  /  physiological state  /  regulation of fatty acids
Jialin WU, Ying LI, Zhenjie LIU, Moutong CHEN, Qingping WU. Research progress in the mechanism of freeze-drying in protecting the high vitality of probiotics[J]. Acta Microbiologica Sinica, 2024 , 64 (5) : 1402 -1416 . DOI: 10.13343/j.cnki.wsxb.20230730
Funding
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  • National Key Research and Development Program of China(2022YFD2100703)
  • National Natural Science Foundation of China(32222068)
  • National Natural Science Foundation of China(32072326)
  • Basic and Applied Basic Research Foundation of Guangdong Province(2022B1515020068)
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Year 2024 volume 64 Issue 5
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118
51
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Article Info
doi: 10.13343/j.cnki.wsxb.20230730
  • Receive Date：2023-11-29
  • Online Date：2026-03-19
  • Published：2024-05-04
Article Data
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History
  • Received：2023-11-29
  • Accepted：2024-01-31
Funding
National Key Research and Development Program of China(2022YFD2100703)
National Natural Science Foundation of China(32222068)
National Natural Science Foundation of China(32072326)
Basic and Applied Basic Research Foundation of Guangdong Province(2022B1515020068)
Affiliations
    1 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China
    2 College of Food Science, South China Agricultural University, Guangzhou 510642, Guangdong, China

Corresponding:

*CHEN Moutong, E-mail:;
WU Qingping, E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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