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SnoaL family proteins belong to a class of the nuclear transport factor 2 (NTF2)-like superfamily, which are characterized by a distinctive α+β barrel fold structure. To date, proteins of this family have been demonstrated to catalyze a variety of reactions, such as aldol reaction, hydroxylation, decarboxylation, epoxide hydrolysis, and cycloaddition reaction, playing crucial roles in the biosynthesis of complex bioactive natural products. These proteins are widely distributed in various organisms including bacteria and fungi. However, research on proteins of this family is relatively limited at present. We reviewed the research progress on proteins of SnoaL family. The review not only provides beneficial guidance for the subsequent functional identification and mechanism research of related proteins but also helps to discover novel biocatalytic tools, laying a foundation for the research of bioactive molecule biosynthesis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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