Objective Early diagnosis of breast cancer is of paramount importance. We aim to utilize deep learning models to accurately detect the nipple area in Automated Breast Ultrasound (ABUS) data, ensuring reliable technical diagnostic support for breast tumors at an early stage. Methods Based on the YOLO series models, we locate and detect the nipple in ABUS coronal plane images, providing a positional reference for tumor diagnosis. Results The YOLO series models have all performed well. Particularly, the YOLOv5s model achieved a high precision rate of 0.955, a recall rate of 0.925, and a frame rate of 243, meeting the clinical diagnostic requirements. Conclusion The YOLOv5 model has demonstrated excellent performance in the ABUS nipple localization task. This technology provides crucial technical support for the early detection of breast tumors, with significant clinical implications.

Objective To investigate the clinical features, pathogens and drug resistance of elderly patients with traumatic infective endophthalmitis (PTIE). Methods 76 elderly patients (76 eyes) with PTIE treated in our hospital from January 2023 to January 2024 were retrospectively analyzed. Clinical characteristics and pathogenic bacteria of patients were collected and their drug resistance was analyzed. Results The clinical features of elderly PTIE were related to the location of the wound in area I (84.21%), the penetration injury of intraocular foreign body (60.52%) and the presence of metal foreign body (48.68%). The fungal detection rate in patients who were above 75 years old was higher than that in patients${60}\sim {75}$years old$\left({P <{0.05}}\right)$. In 76 elderly patients with PTIE, a total of 56 pathogenic bacteria were isolated, including 45 Gram-positive bacteria, 8 Gram-negative bacteria and 3 kinds of fungi. Among Gram-positive bacteria, the highest resistance of Staphylococcus epidermidis was penicillin (100%) and gentamicin (88.89%), and the highest resistance of Saprophytic staphylococcus was penicillin (88.89%) and erythromycin (88.89%). Among Gram-negative bacteria, the highest resistance was amikacin (100%) and ampicillin (100%) in Pseudomonas aeruginosa, and ampicillin (100%) in Klebsiella pneumoniae. Conclusion The distribution of pathogenic bacteria in elderly PTIE patients was affected by the location of the injured mouth, the type of trauma, the type of foreign body in the eye and age factors, among which Gram-positive bacteria was the main infection type, Staphylococcus epidermidis was the most common. Staphylococcus epidermidis has a high resistance to penicillin, in contrast to ampicillin and imipenem are relatively low resistance.

Objective To compare the results of high-performance liquid chromatography tandem mass spectrometry (LC-MS/MS) and chemiluminescence immunoassay (CLIA) in the determination of serum estradiol (E2) level. Methods From January 2023 to January 2024, 100 patients who were treated in outpatient department and hospitalized in the hospital were selected as the research subjects. Fresh blood samples were collected from all study subjects on the same day, and serum E2 levels were measured by LC-MS/MS and CLIA respectively. Results Serum E2 level measured by CLIA was significantly higher than that of LC-MS/MS ($P <{0.05}$). Pearson correlation test results showed that LC-MS/MS was significantly correlated with CLIA in measuring serum E2 level$\left({r ={0.866}, P <{0.05}}\right)$. There was a linear correlation between serum E2 level measured by LC-MS/MS and CLIA, and the linear regression equation was manifested as$Y ={1.161X}-{6.574}$ $\left({r ={0.973}, n={100}}\right)$. Bland-Altman analysis revealed that the average difference between LC-MS/MS and CLIA in measuring serum E2 level was${0.078}\mathrm{{nmol}}/\mathrm{L}\left({{95}\%\mathrm{{CI}}:{0.069}\sim {0.086}\mathrm{{nmol}}/\mathrm{L}}\right)$, and the consistency limit range was (-0.011,0.143). There were 5%(5/100) points outside the 95% consistency limit range, and within the 95% consistency limit range, and the maximum difference between LC-MS/MS and CLIA was${0.156}\mathrm{{nmol}}/\mathrm{L}$. The average value of serum E2 level measured by LC-MS/MS and CLIA was${0.152}\mathrm{{nmol}}/\mathrm{L}$, suggesting that the consistency of the two methods was poor. Conclusion Serum E2 level determined by CLIA is higher than that determined by LC-MS/MS. There is a certain correlation between the two methods for the determination of serum E2 level, but the consistency is not good. The determination of serum E2 level by CLIA is more suitable for rapid screening. When accurate clinical diagnosis is needed, it is necessary to apply LC-MS/MS to measure serum E2 level.

Objective To study the combined value of Sysmex XN-20 (A1) automated hematology analyzer and blood smear. Methods 280 blood samples from June 2023 to June 2024 were selected as research objects, including 105 abnormal blood samples. Automated hematology analyzer test and blood smear test were performed, the test results were observed and analyzed, and the coincidence rate of automated hematology analyzer, blood smear test alone and combined test was calculated. Results Sysmex XN-20 (A1) automated blood cell analyzer + blood smear detected 105 abnormal blood samples, with a positive test rate of 37.50%(105/280); Sysmex XN-20 (A1) automated The blood cell analyzer detected 100 abnormal blood samples, and the test compliance rate was 35.71%(100/280); the compliance rate of Sysmex XN-20 (A1) automated hematology analyzer + blood smear test was significantly higher, but the two There is no significant difference$\left({P ={0.661},{\chi }^{2}= {0.192}}\right)$. Among the 105 abnormal blood samples, neutrophils had the highest proportion of abnormalities in 27 cases; red blood cells had the second highest proportion of abnormalities in 19 cases; lymphocytes had the third highest proportion of abnormalities in 17 cases. Conclusion The combined application of Sysmex XN-20 (A1) automated hematology analyzer and blood smear can significantly promote the improvement of the coincidence rate of blood specimen test.

Objective To evaluate the advantage clinical value of cold digestion method and national standard method in the determination of serum iodine. Methods The DAT-500 iodine detector of Changsha Seclude and the cold digested serum iodine detection reagent (patent: CN113340888A reagent kit and detection method for serum quantitative detection) were used to compare with the national standard Determination of Iodine in Serum by Catalytic Spectrophotometry. Results From 0 to${300\mu }\mathrm{g}/\mathrm{L}$iodine content range, the absolute value of correlation coefficient of standard curve of 5 batches exceeded 0.9995, the detection limit was${2.1\mu }\mathrm{g}/\mathrm{L}$; the recovery rate of 9 serum samples with different concentrations was${94.6}\%\sim {108.8}\%;6$batches of 3 serum samples with different concentrations were tested, the RSD was${3.41}\%\sim {4.01}\%$, and the recovery rate was${94.6}\%\sim {108.8}\%$; there was no statistical significance between 20 serum samples and national standard method$\left({t =- {1.660}, P ={0.113}> {0.05}}\right)$. Conclusion Cold digestion method has the advantages of high accuracy and accuracy, simple operation, short time consuming, low demand for temperature control, easy storage and transportation at room temperature.

ABSTRACT: With the advancement of technology and the improvement of people's living standards, the application of active medical devices in the medical field is becoming increasingly widespread. Among them, ultrasound therapy products have received widespread attention due to their non-invasive and significant therapeutic effects. However, due to the complexity of ultrasound therapy products, research on their detection techniques and standards is particularly important. This article provides an overview of the basic principles and testing methods of ultrasound therapy products, conducts in-depth research on the detection technology and standards of ultrasonic therapy products in active medical devices, analyzes relevant testing standards at home and abroad, compares their advantages and disadvantages, and explores the challenges and development trends of testing technology, in order to provide a reference for the detection and quality control of ultrasonic therapy products and promote the standardization and normalization of the medical device industry.

With the increasing prosperity of the toy market, children are exposed to a wide variety of toys, but the hidden harmful chemical substances can not be ignored. The purpose of this paper is to focus on the analysis of common toxic and harmful substances in the toy manufacturing process, through technological innovation and application, the improvement of standards and regulations and other measures to ensure that the toy market products are safe and harmless, protect children from harmful substances, provide scientific basis and practical guidance for government regulators, manufacturers and consumers, and promote the healthy development of the toy industry. Protect children's right to healthy growth.

Laboratory safety accidents have occurred from time to time, and their harm and impact are far-reaching. In view of the characteristics of agricultural laboratory, such as high density and strong mobility of personnel, diversified and complex instruments and equipment, large types and quantities of chemicals, many kinds of wastes and complex components, etc., combined with the problems in safety management, countermeasures are proposed in terms of funding investment, management system, daily management level, safety inspection, safety education, providing a solid foundation for building a safer and more harmonious laboratory environment and reliable guarantee for the school to achieve the construction of a "Double First Class" university.

The normal module operating temperature (NMOT) of photovoltaic modules plays an important role in analyzing the actual power generation performance of the modules, but it is difficult to accurately measure. In the experimental teaching of heat transfer course, the introduction of photovoltaic module temperature rise cases has expanded the scope of teaching cases, cultivated students' ability to solve engineering problems of photovoltaic module temperature rise modeling using heat transfer mechanisms, and broadened their knowledge of factors affecting photovoltaic power generation. Finally, the theoretical calculation method for the temperature rise characteristic model of photovoltaic modules was analyzed, and experiments were designed to verify the accuracy of the model. The validated model was used to calculate the NMOT of photovoltaic modules

Objective To study the killing effect of glycine combined with iodophor disinfectant on drug-resistant Staphylococcus aureus. Methods Neutralizing agent identification and suspension quantitative killing experiment were used to observe the effect of glycine compound combined with iodophor disinfectant in killing drug-resistant Staphylococcus aureus. Results Iodophor can kill Staphylococcus aureus, with a dilution sterilization efficiency of 63.7%. At the same time, the addition of 4% glycine and a synergistic iodophor disinfectant found a sterilization rate of 79.6%. When killing Staphylococcus aureus in suspension, there was a significant promotion of sterilization effect, which was significantly different from the group with only iodophor$\left({P <{0.01}}\right)$. Conclusion Glycine compounds can significantly enhance the killing effect of iodine on Staphylococcus aureus and increase the sensitivity of bacteria to disinfectants.