"Method" is one of the five elements of total quality management. In the inspection and testing laboratory, "method" refers to the method used in the whole process of testing. Laboratory information management system can combine scientific laboratory management theory and computer technology organically, and provide advanced technical support for the overall improvement of laboratory management level. This paper combined the "method" of the five elements of quality management with the laboratory information management system, conducted in-depth discussions from three aspects: Standard management, electronic original record management and quality system document management, and verified that the laboratory information management system could assist managers to discover and control the key factors affecting the inspection quality, so as to achieve quality improvement and self-perfection of the quality system. Improve the competitiveness of the laboratory.