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Hepatitis B virus genotype distribution and drug resistance mutation site analysis
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Wei-Jie WANG1, 2, Xiao-Ben ZHANG2, Bao-Di LIU2, Da-Lei LU1, *
Laboratory Testing | 2024, 2(7) : 153 - 156
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Laboratory Testing | 2024, 2(7): 153-156
• Evaluation and Analysis •
Hepatitis B virus genotype distribution and drug resistance mutation site analysis
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Wei-Jie WANG1, 2, Xiao-Ben ZHANG2, Bao-Di LIU2, Da-Lei LU1, *
Affiliations
  • 1 Kaifeng Institute of Medical Sciences Kaifeng 475000 China
  • 2 Department of Clinical Laboratory Kaifeng Hospital of Traditional Chinese Medicine Kaifeng 475000 China
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Objective To investigate the distribution of hepatitis Bvirus (HBV) genotypes and drug resistance mutation sites in Kaifengarea. Methods A total of 200 hepatitis B surface antigen (HBsAg)positive patients were selected from Kaifeng area from January 2018 toDecember 2020. The genotype of the patients was detected by genesequencing technology, and the test results were statistically analyzed.Nucleoside analogues (NAs) resistance gene loci in serum HBV-DNA of 200untreated patients were analyzed. Results Among 200 HBsAg positivepatients in Kaifeng area, 179 cases were genotype C, accounting for ${97.8}\%,4$ cases were genotype B,accounting for ${2.2}\%$ , and no B+Cor other types were detected. Among the 200 patients, 26 were detectedNAs gene drug resistance mutation sites, and the detection rate of drugresistance mutation sites in patients with gene $\mathrm{C}$ was higher than that inpatients with gene B. Conclusion Hepatitis B surface antigen positivepatients in Kaifeng area of HBV genotype mainly $\mathrm{C}$ type, B type is less, no othergenotype was detected. The detection rate of NAs resistance sites ingenotype C was higher than that in genotype B. A total of 9 differentcombinations of NAs drug-resistant mutation sites were detected, mainlyunit point mutation.

hepatitis B surface antigen positive  /  genotype  /  drug resistance mutation sites
Wei-Jie WANG, Xiao-Ben ZHANG, Bao-Di LIU, Da-Lei LU. Hepatitis B virus genotype distribution and drug resistance mutation site analysis[J]. Laboratory Testing, 2024 , 2 (7) : 153 -156 .
Funding
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  • Kaifeng Science and Technology Research Project(1803024)
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Year 2024 volume 2 Issue 7
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  • Online Date：2025-07-29
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Funding
Kaifeng Science and Technology Research Project(1803024)
Affiliations
    1 Kaifeng Institute of Medical Sciences Kaifeng 475000 China
    2 Department of Clinical Laboratory Kaifeng Hospital of Traditional Chinese Medicine Kaifeng 475000 China

Corresponding:

*LU Da-Lei, Master, Associate Research Fellow, Kaifeng Institute of Medical Sciences, Kaifeng 475000, China. E-mail:
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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