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Validation of the microbial limit methodology of erythromycin ointment
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Jian JIN, Yu CHEN, Yong-Xue CUI, Gui-Hua JIN*
Laboratory Testing | 2024, 2(6) : 141 - 144
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Laboratory Testing | 2024, 2(6): 141-144
Evaluation and Analysis
Validation of the microbial limit methodology of erythromycin ointment
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Jian JIN, Yu CHEN, Yong-Xue CUI, Gui-Hua JIN*
Affiliations
  • Food and Drug Control Institute, Yanbian Korean Autonomous Prefecture Yanji 133000 China
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Objective To verify the experimental method of erythromycin ointment. Methods Three batch numbers of erythromycin ointment (S1~S3) were selected and divided into three washing methods: test group and positive and negative control group (test article control group and bacterial solution control group). The microbial limit detection method of erythromycin ointment was analyzed by test. Results The recovery ratio of oxygen bacteria, yeast, mold and added bacteria required for different batches of erythromycin ointment in the test is between 0.5 and 2, and the inhibition of microbial strains of erythromycin ointment test can be adopted by membrane filtration method. Therefore, all the methods can effectively eliminate the antibacterial components of erythromycin ointment, and the experimental results can truly reflect the microbial contamination of erythromycin dye ointment. Conclusion The application of centrifugal method in antibacterial removal will not affect the microbial limit test of erythromycin ointment.

erythromycin ointment  /  microbial limits  /  bacteriostasic activity  /  recovery rate
Jian JIN, Yu CHEN, Yong-Xue CUI, Gui-Hua JIN. Validation of the microbial limit methodology of erythromycin ointment[J]. Laboratory Testing, 2024 , 2 (6) : 141 -144 .
Year 2024 volume 2 Issue 6
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  • Online Date:2025-07-29
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Affiliations
    Food and Drug Control Institute, Yanbian Korean Autonomous Prefecture Yanji 133000 China

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*JIN Gui-Hua, Deputy Chief Pharmacist, Director, Food and Drug Control Institute, Yanbian Korean Autonomous Prefecture, Yanji 133000, China. E-mail:
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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