Objective To evaluate the application value ofhigh-performance liquid chromatography fluorescence detection method fordetermining nitrite in drinking water. Method Collect mineral water, tapwater, and source water as water samples, and use high-performanceliquid chromatography fluorescence detection method to determine.Analyze the detection advantages of this method and the stability ofnitrite derivative 2,3 naphthalene triazole in the water standard. Result The nitrite concentration detected in pure water was ${0.6\mu }\mathrm{g}/\mathrm{L}$ , with goodpeak shape and no impurity interference; The detection limit ofhigh-performance liquid chromatography fluorescence detection method is ${0.3\mu }\mathrm{g}/\mathrm{L}$ , andthe quantitative limit is $1\mathrm{{\mug}}/\mathrm{L}$ ; After derivatization with nitrite, thestability of the derivative is high, and the measurement error is smallwithin 7 days; The recovery rate of nitrite spiking is between90.29%-102.60%, and the precision is between 0.71%-3.66%. Conclusion Thedetermination of nitrite in drinking water by high-performance liquidchromatography fluorescence detection method has the characteristics ofaccuracy and convenience, providing important technical support fordrinking water safety monitoring.