Objective To explore the clinical significance of thecombined detection of fasting blood glucose and glycosylated hemoglobinin the diagnosis and treatment of diabetes. Methods From January 2023 toJanuary 2024,50 healthy people in our hospital were selected as thecontrol group, and 50 diabetes patients in our hospital at the same timewere selected as the observation group. Compare the fasting bloodglucose (FPG), glycated hemoglobin (HbA1c) levels, HbA1c, FPG, and oralglucose tolerance test (OGTT) blood glucose test results, combined andsingle test results after 2 hours of OGTT glucose administration, aswell as the correlation between HbA1c and FPG in the observation group.Results The blood glucose levels, HbA1c, and FPG of the observationgroup after 2 hours of OGTT administration were higher than those of thecontrol group $\left({P<{0.05}}\right)$ . The observation group showed a positivecorrelation between HbA1c and FPG $(r={0.608}$ , $P <{0.05}$ ).The specificity, sensitivity, and accuracy of HbA1c and FPG combineddetection are superior to single detection $\left({P <{0.05}}\right)$ . Conclusion The combined detection of HbA1c and FPG has high diagnostic accuracy fordiabetes, reduces the rate of misdiagnosis and missed diagnosis, canspeed up the diagnosis of diabetes, is conducive to early treatment, andis worth promoting.