Home Journals Articles Updates About
CN
image
收藏切换
Assessment of ochratoxin A exposure in Gejie Dingchuan Pills and evaluation of its maximum limit levels
收藏切换
PDF
Xiao-Yan HUANG1, Jia-Hong SONG1, Yue WU1, Jian-Hong WU2, Xiao-Yi HUA1, *
Laboratory Testing | 2024, 2(10) : 87 - 90
Less
收藏切换
Laboratory Testing | 2024, 2(10): 87-90
• Evaluation and Analysis •
Assessment of ochratoxin A exposure in Gejie Dingchuan Pills and evaluation of its maximum limit levels
Full
Xiao-Yan HUANG1, Jia-Hong SONG1, Yue WU1, Jian-Hong WU2, Xiao-Yi HUA1, *
Affiliations
  • 1 Wuxi Institute of Drug Safety Control Wuxi 214000 China
  • 2 The Affiliated Mental Health Center of Jiangnan University Wuxi 214000 China
Outline
收藏切换

Objective Evaluation of ochratoxin A (OTA) contamination inGejie Dingchuan Pills. Methods Eighty-six samples from sevenpharmaceutical manufacturers were analyzed for OTA content usingultra-high-performance liquid chromatography-tandem mass spectrometry.Results The method displayed excellent linearity within the range ofconcentrations ${0.1}\sim {10}\mathrm{{ng}}/\mathrm{{mL}}$ .The limits of detection and quantification were ${0.2}\mathrm{{\mu g}}/\mathrm{{kg}}$ and $1\mathrm{{\mu g}}/\mathrm{{kg}}$ ,respectively. Seventy-two samples were detected to be contaminated withOTA, resulting in an 84% positive rate. Furthermore, ten samples failedto meet the required standards, reflecting a failure rate of 12%. Theactual sample test results showed that the OTA detection rate of GejieDingchuan pills was high and the pollution was serious, which suggestedthe urgency of detecting and determining the maximum OTA limit ofproprietary Chinese medicine. Conclusion This study assesses the extentof OTA contamination in Gejie Dingchuan pills, offering a scientificbasis for future investigations of OTA maximum limits in Chineseproprietary medicines.

ochratoxin A (OTA)  /  Gejie Dingchuan Pills  /  maximum limit  /  Chinese proprietary medicine
Xiao-Yan HUANG, Jia-Hong SONG, Yue WU, Jian-Hong WU, Xiao-Yi HUA. Assessment of ochratoxin A exposure in Gejie Dingchuan Pills and evaluation of its maximum limit levels[J]. Laboratory Testing, 2024 , 2 (10) : 87 -90 .
Funding
Less
  • Jiangsu Provincial Market Supervision Administration Science and Technology Plan Project "Research on Quality Control of Animal Drugs and Mineral Drugs"(KJ2023044)
Appendix
Less
Year 2024 volume 2 Issue 10
PDF
23
11
Cite this Article
BibTeX
Article Info
  • Online Date：2025-07-29
Article Data
Affiliations
History
Funding
Jiangsu Provincial Market Supervision Administration Science and Technology Plan Project "Research on Quality Control of Animal Drugs and Mineral Drugs"(KJ2023044)
Affiliations
    1 Wuxi Institute of Drug Safety Control Wuxi 214000 China
    2 The Affiliated Mental Health Center of Jiangnan University Wuxi 214000 China

Corresponding:

*HUA Xiao-Yi, Ph.D, Deputy Chief Pharmacist, Wuxi Institute of Drug Safety Control, Wuxi 214000, China. E-mail:
References
Share
https://castjournals.cast.org.cn/joweb/sysjc/EN/
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House