Objective To explore and analyze the value of seruminflammatory indexes, D-dimer (D-D) and bone biochemical indexes inwound healing of patients with fractures. Methods The clinical data of92 patients with fracturesin the hospitalwere retrospectively analyzedfrom March 2021 to February 2023. The above patients were divided intodelayed group $(n ={47}$ , delayedfracture healing) and normal group $(n={47}$ , normal fracture healing). The levels of high-sensitivityC-reactive protein (hs-CRP), procalcitonin (PCT), D-D and bonebiochemical indexes (bone gla protein (BGP), type I procollagen aminoterminal peptide (PINP), type I collagen cross-linked carboxy terminalpeptide (CTX), bone alkaline phosphatase (BALP) were compared betweengroups. Pearson analysis was used to analyze the correlation between theabove indexes and delayed fracture healing. Receiver operatingcharacteristic curve (ROC) was adopted to evaluate the predictive valueof the above indexeson predicting delayed fracture healing. Results Thelevels of hs-CRP, PCT, D-D and CTX in delayed group were higher thanthose in normal group $\left({P<{0.05}}\right)$ while the levels of BGP, PINP and BALP werelower than those in normal group $\left({P<{0.05}}\right)$ . Serum hs-CRP, PCT, D-D and CTX in patientswith fractures were positively correlated with delayed fracture healing $\left({P <{0.05}}\right)$ , andBGP, PINP and BALP were negatively correlated with delayed fracturehealing $\left({P<{0.05}}\right)$ . Under the ROC curve, the areas under thecurves (AUCs) of hs-CRP, PCT, D-D, CTX, BGP, PINP, and BALP inpredicting delayed fracture healing were 0.693, 0.810, 0.722, 0.763,0.746, 0.868 and 0.839, the sensitivities were 59.57%, ${59.57}\%,{72.34}\%,{59.57}\%,{85.11}\%,{93.62}\%$ and 76.60%, and the specificities were 78.72%,97.87%,65.96%,89.36%,59.57%, 72.34% and 80.85% respectively. Conclusion hs-CRP, PCT, D-D andbone biochemical indexes are closely related to delayed fracture healingin patients with fractures, which should be paid attention to inclinical practice.