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Screening of Breast Milk-derived Bifidobacteria with Anti-inflammatory Activity and Preparation of Freeze-dried Microcapsules Thereof
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Haoran SONG1, 2, Julong LIU3, Yumeng LIU1, 4, Meihong MA1, 2, Jing LI1, 4, Wentao XING1, 2, Junrui WU1, 3, 4, Yudong SHI5, *, Rina WU1, 3, 4, *
Science and Technology of Food Industry | 2026, 47(4) : 226 - 237
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Science and Technology of Food Industry | 2026, 47(4): 226-237
• Bioengineering •
Screening of Breast Milk-derived Bifidobacteria with Anti-inflammatory Activity and Preparation of Freeze-dried Microcapsules Thereof
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Haoran SONG1, 2, Julong LIU3, Yumeng LIU1, 4, Meihong MA1, 2, Jing LI1, 4, Wentao XING1, 2, Junrui WU1, 3, 4, Yudong SHI5, *, Rina WU1, 3, 4, *
Affiliations
  • 1College of Food Science and Technology, Shenyang Agricultural Univercity, Shenyang 110866, China
  • 2Liaoning Food Fermentation Technology Engineering Research Centre Liaoning Province, Shenyang 110866, China
  • 3Mengniu Gaoke Dairy Products (Beijing) Co., Ltd., Beijing 102200, China
  • 4Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang 110866, China
  • 5Inner Mongolia Mengniu Dairy Group, Co., Ltd., Hohhot 011500, China
Published: 2026-02-15 doi: 10.13386/j.issn1002-0306.2025020008
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In this paper, 21 strains of Bifidobacteria were isolated and identified from healthy breast milk samples, and the strain with the best activity was selected by spleen lymphocyte proliferation assay, drug sensitivity, haemolysis, bacteriostatic activity, and adhesion capacity evaluation. After identification by 16S rRNA, the lyophilisation technique was optimised and lyophilised microcapsules were prepared. The results showed that the bacterium was Bifidobacterium animalis subsp. lactis, named BA-9. B. lactis BA-9 was safe, with a hydrophobicity of 36.24%, a self-agglutination rate of 77.4%, and could significantly reduce NO activity in RAW264.7 cells, with in vitro Anti-inflammatory potential. Sodium alginate and carrageenan were prepared as a 1:1 composite wall with the addition of a composite lyoprotectant (11.25% skimmed milk powder, 4.93% xylooligosaccharides and 2.74% glycerol). The activity of B. lactis BA-9 microcapsules with the addition of lyophilisation protectant after lyophilisation decreased by only 1.3 lg CFU/g after simulated gastrointestinal fluid digestion. The survival rate of B. lactis BA-9 microcapsules could reach up to 90.03% for 28 days of storage at 4 ℃, which effectively enhanced the stability of storage. This study provides a research basis for the screening of Bifidobacterium bifidum with immuno-anti-inflammatory regulatory activities and the development and application of its lyophilised carrier.

breast milk  /  Bifidobacterium bifidum  /  strain screening  /  anti-inflammatory activity  /  lyophilised microcapsules
宋浩然, 刘巨龙, 刘语萌, 马美红, 李静, 邢文涛, 武俊瑞, 史玉东, 乌日娜. 具有抗炎活性母乳源双歧杆菌的筛选及其冻干微胶囊的制备. 食品工业科技, 2026 , 47 (4) : 226 -237 . DOI: 10.13386/j.issn1002-0306.2025020008
Haoran SONG, Julong LIU, Yumeng LIU, Meihong MA, Jing LI, Wentao XING, Junrui WU, Yudong SHI, Rina WU. Screening of Breast Milk-derived Bifidobacteria with Anti-inflammatory Activity and Preparation of Freeze-dried Microcapsules Thereof[J]. Science and Technology of Food Industry, 2026 , 47 (4) : 226 -237 . DOI: 10.13386/j.issn1002-0306.2025020008
Appendix
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Year 2026 volume 47 Issue 4
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Article Info
doi: 10.13386/j.issn1002-0306.2025020008
  • Receive Date：2025-02-08
  • Online Date：2026-10-24
  • Published：2026-02-15
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  • Received：2025-02-08
Affiliations
    1College of Food Science and Technology, Shenyang Agricultural Univercity, Shenyang 110866, China
    2Liaoning Food Fermentation Technology Engineering Research Centre Liaoning Province, Shenyang 110866, China
    3Mengniu Gaoke Dairy Products (Beijing) Co., Ltd., Beijing 102200, China
    4Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang 110866, China
    5Inner Mongolia Mengniu Dairy Group, Co., Ltd., Hohhot 011500, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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