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Hypoglycemic Effects and Mechanism of Metabolites of Irpex lacteus on Type 2 Diabetic Mice
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Jing YAN1, Jin QI2, Mingguo JIANG2, Jincheng WU1, Zhenxin ZHU2, Xianke LI2, Rui ZHOU2, Jiahui WANG1, Lifang YANG1, 3, *
Science and Technology of Food Industry | 2026, 47(2) : 398 - 407
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Science and Technology of Food Industry | 2026, 47(2): 398-407
• Nutrition and Healthcare •
Hypoglycemic Effects and Mechanism of Metabolites of Irpex lacteus on Type 2 Diabetic Mice
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Jing YAN1, Jin QI2, Mingguo JIANG2, Jincheng WU1, Zhenxin ZHU2, Xianke LI2, Rui ZHOU2, Jiahui WANG1, Lifang YANG1, 3, *
Affiliations
  • 1School of Chemistry and Chemical Engineering, Guangxi Minzu University, Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products/Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Nanning 530006, China
  • 2School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Nanning 530006, China
  • 3State Key Laboratory of Traditional Chinese Medicines, China Guangxi Institute for Food and Drug Control, Nanning 530021, China
Published: 2026-01-15 doi: 10.13386/j.issn1002-0306.2024120127
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This study aimed to investigate the hypoglycemic effects and underlying mechanisms of metabolites of Irpex lacteus (MIL) on type 2 diabetic mice. T2DM mice model was induced by intraperitoneal injection of streptozotocin (STZ), and the mice were divided into normal group, model group, metformin group, and MIL high, medium, and low dose groups. After 5 weeks of administration, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), liver glycogen, serum creatinine (SCR), blood urea nitrogen (BUN), insulin (INS), and glucose transporter 4 (GLUT4) levels were measured, and pathological observations of the kidneys were conducted. Network pharmacology was used to predict pathways and targets. RT-qPCR and Western blot were employed to detect the mRNA and protein expression levels of related genes of T2DM mice. The results indicated that MIL could significantly reduce the levels of FBG, BUN, SCR, INS, and OGTT-AUC in T2DM mice (P<0.01), and significantly increase the levels of GLUT4 and liver glycogen (P<0.01). Renal pathological observations showed that MIL could improve the inflammatory state of cells in renal tissue and effectively alleviate nephritis symptoms caused by hyperglycemia. Additionally, MIL significantly upregulated the mRNA expression levels of protein kinase B (AKT), GLUT4, and phosphatidylinositol 3-kinase (PI3K), while downregulating INS expression (P<0.05), significantly increased the protein expression levels of p-PI3K and p-AKT (P<0.05). These findings suggest that MIL may regulate blood glucose disorders by activating the PI3K/AKT signaling pathway.

glucose metabolism disorder  /  metabolites of Irpex lacteus  /  PI3K/AKT signaling pathway  /  network pharmacology
严静, 齐晋, 姜明国, 吴金城, 朱震鑫, 李先可, 周芮, 王嘉辉, 杨立芳. 白耙齿菌提取物对2型糖尿病小鼠的降糖作用及机制. 食品工业科技, 2026 , 47 (2) : 398 -407 . DOI: 10.13386/j.issn1002-0306.2024120127
Jing YAN, Jin QI, Mingguo JIANG, Jincheng WU, Zhenxin ZHU, Xianke LI, Rui ZHOU, Jiahui WANG, Lifang YANG. Hypoglycemic Effects and Mechanism of Metabolites of Irpex lacteus on Type 2 Diabetic Mice[J]. Science and Technology of Food Industry, 2026 , 47 (2) : 398 -407 . DOI: 10.13386/j.issn1002-0306.2024120127
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Year 2026 volume 47 Issue 2
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doi: 10.13386/j.issn1002-0306.2024120127
  • Receive Date：2024-12-12
  • Online Date：2026-10-24
  • Published：2026-01-15
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  • Received：2024-12-12
Affiliations
    1School of Chemistry and Chemical Engineering, Guangxi Minzu University, Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products/Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Nanning 530006, China
    2School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Nanning 530006, China
    3State Key Laboratory of Traditional Chinese Medicines, China Guangxi Institute for Food and Drug Control, Nanning 530021, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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