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Research Advances on Resveratrol Targeted Modulation of Aβ Protein in Improving Cognitive Dysfunction
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Xinmiao PAN1, Qian LI1, Peijun ZHAO1, Tiange LI1, Guangshan ZHAO1, Xianqing HUANG1, Lianjun SONG1, Mingwu QIAO1, Bei ZHANG1, Galaverna GIANNI2, Ning LI1, *
Science and Technology of Food Industry | 2026, 47(7) : 481 - 489
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Science and Technology of Food Industry | 2026, 47(7): 481-489
• Reviews •
Research Advances on Resveratrol Targeted Modulation of Aβ Protein in Improving Cognitive Dysfunction
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Xinmiao PAN1, Qian LI1, Peijun ZHAO1, Tiange LI1, Guangshan ZHAO1, Xianqing HUANG1, Lianjun SONG1, Mingwu QIAO1, Bei ZHANG1, Galaverna GIANNI2, Ning LI1, *
Affiliations
  • 1College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
  • 2Food and Drug Department, University of Parma, Parma 43124, Italy
Published: 2026-04-01 doi: 10.13386/j.issn1002-0306.2025040116
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Alzheimer's disease (AD) is a neurodegenerative disorder characterized by excessive beta-amyloid (Aβ) deposition and hyperphosphorylated Tau protein accumulation in the brain, leading to neuronal damage and cognitive impairment. Recent studies suggest that resveratrol (Res), a natural polyphenol, may mitigate AD-related cognitive dysfunction by targeting Aβ-induced neurotoxicity through multiple mechanisms. This article systematically reviews the relevant research on the improvement of cognitive dysfunction in AD by Res, with a focus on elucidating its mechanisms of action, including promoting Aβ clearance, inhibiting neuroinflammatory responses, and protecting neuronal function, as well as the associated signaling pathways and molecular mechanisms. These findings provide a theoretical foundation for the application and development of Res in food sciencce and medicine.

resveratrol  /  beta-amyloid protein  /  Alzheimer's disease  /  cognitive function  /  neuronal damage  /  mechanism of action
潘馨苗, 李倩, 赵培均, 李天歌, 赵广山, 黄现青, 宋莲军, 乔明武, 张蓓, Galaverna GIANNI, 李宁. 白藜芦醇靶向调控Aβ蛋白改善认知功能障碍的研究进展. 食品工业科技, 2026 , 47 (7) : 481 -489 . DOI: 10.13386/j.issn1002-0306.2025040116
Xinmiao PAN, Qian LI, Peijun ZHAO, Tiange LI, Guangshan ZHAO, Xianqing HUANG, Lianjun SONG, Mingwu QIAO, Bei ZHANG, Galaverna GIANNI, Ning LI. Research Advances on Resveratrol Targeted Modulation of Aβ Protein in Improving Cognitive Dysfunction[J]. Science and Technology of Food Industry, 2026 , 47 (7) : 481 -489 . DOI: 10.13386/j.issn1002-0306.2025040116
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Year 2026 volume 47 Issue 7
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Article Info
doi: 10.13386/j.issn1002-0306.2025040116
  • Receive Date：2025-04-09
  • Online Date：2026-10-24
  • Published：2026-04-01
Article Data
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History
  • Received：2025-04-09
Affiliations
    1College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
    2Food and Drug Department, University of Parma, Parma 43124, Italy
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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