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Bifidobacterium longum subsp. infantis Y46 Extended the Lifespan of Caenorhabditis elegans by Enhancing Stress Resistance
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Liupeng WANG1, 2, Yishan JIANG1, 2, Shuangshuang HE1, 2, Xin LI2, 3, Yan WANG1, 2, Yu JI1, 2, Lili ZHANG1, 2, *, Jianchun HAN2, 3, *
Science and Technology of Food Industry | 2026, 47(6) : 437 - 445
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Science and Technology of Food Industry | 2026, 47(6): 437-445
• Nutrition and Healthcare •
Bifidobacterium longum subsp. infantis Y46 Extended the Lifespan of Caenorhabditis elegans by Enhancing Stress Resistance
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Liupeng WANG1, 2, Yishan JIANG1, 2, Shuangshuang HE1, 2, Xin LI2, 3, Yan WANG1, 2, Yu JI1, 2, Lili ZHANG1, 2, *, Jianchun HAN2, 3, *
Affiliations
  • 1Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China
  • 2College of Food Science, Northeast Agricultural University, Harbin 150030, China
  • 3Heilongjiang Green Food Science Research Institute, Harbin 150023, China
Published: 2026-03-15 doi: 10.13386/j.issn1002-0306.2025030291
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Probiotics are thought to slow aging and extend lifespan, yet their exact molecular mechanisms remain unclear. This study investigated the anti-aging effects of Bifidobacterium longum subsp. infantis Y46 (BI_Y46) using the model organism Caenorhabditis elegans. We assessed the effect of BI_Y46 on lifespan, developmental cycle, reproductive capacity, body length, locomotion, stress resistance, lipofuscin accumulation, ROS level and gene expression of C. elegans. Findings indicated that BI_Y46 significantly extended C. elegans lifespan by 12.40% (P<0.05). Moreover, BI_Y46 significantly improved C. elegans motility while reducing lipofuscin accumulation and reactive oxygen species levels, without affecting growth, development, or reproductive capacity. Additionally, BI_Y46 enhances the nematode's resistance to oxidative and heat stress. RNA-seq analysis revealed that BI_Y46 bolstered C. elegans' antioxidant capacity by regulating cuticle integrity and drug metabolism. RT-qPCR confirmed that BI_Y46 promoted expression of the antioxidant gene gst-2. This study demonstrates that BI_Y46 extends the lifespan of nematodes by improving stress resistance, providing a theoretical basis for understanding the health benefits of probiotics and establishing a foundation for probiotic-targeted anti-aging strategies.

Bifidobacterium  /  Caenorhabditis elegans  /  anti-aging  /  stress resistance
王刘鹏, 姜懿珊, 何双双, 李欣, 王妍, 吉宇, 张莉丽, 韩建春. 长双歧杆菌婴儿亚种Y46通过提升应激抗性延长线虫寿命. 食品工业科技, 2026 , 47 (6) : 437 -445 . DOI: 10.13386/j.issn1002-0306.2025030291
Liupeng WANG, Yishan JIANG, Shuangshuang HE, Xin LI, Yan WANG, Yu JI, Lili ZHANG, Jianchun HAN. Bifidobacterium longum subsp. infantis Y46 Extended the Lifespan of Caenorhabditis elegans by Enhancing Stress Resistance[J]. Science and Technology of Food Industry, 2026 , 47 (6) : 437 -445 . DOI: 10.13386/j.issn1002-0306.2025030291
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Year 2026 volume 47 Issue 6
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Article Info
doi: 10.13386/j.issn1002-0306.2025030291
  • Receive Date：2025-03-21
  • Online Date：2026-10-24
  • Published：2026-03-15
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  • Received：2025-03-21
Affiliations
    1Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, China
    2College of Food Science, Northeast Agricultural University, Harbin 150030, China
    3Heilongjiang Green Food Science Research Institute, Harbin 150023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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