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This study aimed to optimize the preparation of Lycium barbarum glycopeptide complex chewable tablets and investigate their potential anti-fatigue properties. Using single-factor experiments and response surface methodology, optimal manufacturing parameters were identified based on tablets' appearance, flavor, taste and texture as a function of L. barbarum glycopeptide. The male KM mice were randomly divided into a blank group, model group, ginsenoside group (10 mg·kg-1), excipient group (400 mg·kg-1), low-dose Lycium barbarum glycopeptide compound chewable tablet group, and high-dose Lycium barbarum glycopeptide compound chewable tablet group (400, 1200 mg·kg-1). A fatigue model was established by restraint combined with forced swimming for 35 consecutive days, during which the samples were administered intragastrically. After 35 days of continuous administration, a forced swimming test was conducted, and the serum levels of urea nitrogen (BUN), 5-hydroxytryptamine (5-HT), lactate dehydrogenase (LDH), and creatine kinase (CK) as well as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) content in gastrocnemius muscle and brain tissues were determined. Results showed that, the optimal tablet formulation was constituted of 29% L. barbarum glycopeptide, 17% raspberry fruit powder (sweetener), 1% sea buckthorn fruit powder (acidulant), and 1.5% magnesium stearate (lubricant). Under these conditions, the comprehensive score of the chewable tablets was 85.87±0.76 points, the average tablet weight was 0.345±0.006 g, and the weight variation limit was within5%; The average hardness was 79.364±2.83 N, all above 75 N, with moderate hardness; The friability of the chewable tablets was less than 1%. Mouse experimental results indicated that, compared with the model group, high formulation dose significantly reduced the immobility time during forced swimming (P<0.01), decreased serum BUN, LDH and CK and tissue MDA levels (P<0.01), increased serum 5-HT level, and boosted SOD and GSH-Px activities in both muscle and brain tissues (P<0.01). L. barbarum glycopeptide complex chewable tablets alleviated physical fatigue induced by strenuous exercise through reduction of oxidative stress in muscle and brain tissues, modulation of neurotransmitters, and improvement of energy metabolism.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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