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Advances in Pathological Classification, Pathogenesis, and Dietary Intervention Strategies for Inflammatory Bowel Disease
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Tao LI1, 2, Min JIANG1, 3, Minglu SUN1, 3, Wenhua JI1, 2, Hongjing DONG1, 2, Xiao WANG1, 2, *
Science and Technology of Food Industry | 2026, 47(12) : 485 - 496
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Science and Technology of Food Industry | 2026, 47(12): 485-496
• Reviews •
Advances in Pathological Classification, Pathogenesis, and Dietary Intervention Strategies for Inflammatory Bowel Disease
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Tao LI1, 2, Min JIANG1, 3, Minglu SUN1, 3, Wenhua JI1, 2, Hongjing DONG1, 2, Xiao WANG1, 2, *
Affiliations
  • 1Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
  • 2Key Laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
  • 3School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
Published: 2026-06-15 doi: 10.13386/j.issn1002-0306.2025060077
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Inflammatory bowel diseases (IBD) are complex disorders characterized by chronic intestinal inflammation, exhibiting a steadily rising global incidence. The pathogenesis of IBD involves multifactorial interactions among genetic susceptibility, gut microbiota dysbiosis, immune dysregulation, and environmental factors (notably dietary patterns). While current pharmacological therapies have advanced, significant challenges persist in achieving sustained clinical remission and preventing relapse. The dietary intervention strategies hold considerable therapeutic potential for IBD management due to their favorable safety profile and unique capacity to modulate the gut microbiome. Recent studies demonstrated that dietary interventions could alleviate IBD through multiple mechanisms, including restructuring the gut microbiota, promoting the production of short-chain fatty acids, enhancing epithelial barrier function, and balancing the immune responses of Th17/Treg. These strategies exhibit multi-target efficacy and offer a promising direction for innovating preventive and therapeutic approaches against IBD. Therefore, this review systematically summarizes the principal pathological subtypes and pathogenic mechanisms of IBD, with a specific focus on the regulatory effects and underlying mechanisms of dietary interventions, including functional oligosaccharides, polysaccharides, probiotics, and fecal microbiota transplantation. The findings will offer the novel theoretical insights and therapeutic approaches for IBD prevention and clinical management.

inflammatory bowel disease  /  pathogenesis  /  gut microbiota  /  functional sugars  /  probiotics  /  fecal microbiota transplantation
李涛, 姜敏, 孙铭璐, 纪文华, 董红敬, 王晓. 炎症性肠病的病理分型、发病机制与膳食干预策略研究进展. 食品工业科技, 2026 , 47 (12) : 485 -496 . DOI: 10.13386/j.issn1002-0306.2025060077
Tao LI, Min JIANG, Minglu SUN, Wenhua JI, Hongjing DONG, Xiao WANG. Advances in Pathological Classification, Pathogenesis, and Dietary Intervention Strategies for Inflammatory Bowel Disease[J]. Science and Technology of Food Industry, 2026 , 47 (12) : 485 -496 . DOI: 10.13386/j.issn1002-0306.2025060077
Appendix
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Year 2026 volume 47 Issue 12
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Article Info
doi: 10.13386/j.issn1002-0306.2025060077
  • Receive Date：2025-06-09
  • Online Date：2026-10-22
  • Published：2026-06-15
Article Data
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History
  • Received：2025-06-09
Affiliations
    1Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
    2Key Laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province, School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
    3School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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