Home Journals Articles Updates About
CN
image
收藏切换
Advances in Nutritional Intervention of Neurodegenerative Diseases: Food-Derived Peptides and Neuronal Mitophagy
收藏切换
Jiawen SUN1, Peijun ZHAO1, Qian LI1, Tiange LI1, Guangshan ZHAO1, Xianqing HUANG1, Lianjun SONG1, Mingwu QIAO1, Bei ZHANG1, Galaverna GIANNI2, Ning LI1, *
Science and Technology of Food Industry | 2026, 47(11) : 470 - 478
Less
收藏切换
Science and Technology of Food Industry | 2026, 47(11): 470-478
• Reviews •
Advances in Nutritional Intervention of Neurodegenerative Diseases: Food-Derived Peptides and Neuronal Mitophagy
Full
Jiawen SUN1, Peijun ZHAO1, Qian LI1, Tiange LI1, Guangshan ZHAO1, Xianqing HUANG1, Lianjun SONG1, Mingwu QIAO1, Bei ZHANG1, Galaverna GIANNI2, Ning LI1, *
Affiliations
  • 1College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
  • 2Food and Drug Department, University of Parma, Parma 43124, Italy
Published: 2026-06-01 doi: 10.13386/j.issn1002-0306.2025050162
Outline
收藏切换

Neurodegenerative diseases (NDs) are chronic disorders marked by progressive neuronal loss, with pathogenesis involving abnormal protein aggregation, oxidative stress, mitochondrial dysfunction, and other contributing factors. As a core mechanism regulating mitochondrial quality control and cellular homeostasis, mitophagy has gained increasing attention as a therapeutic target in NDs. Food-derived bioactive peptides have attracted interest due to their high safety and low toxicity, demonstrating considerable potential for the nutritional intervention of NDs. This review systematically outlines the molecular mechanisms of mitophagy and its dysregulation in neurodegenerative conditions, with a focus on how specific dietary peptides—including corn, rice, walnut, and marine collagen peptides—modulate mitophagy and restore mitochondrial function via pathways such as PINK1/Parkin, AMPK/mTOR, and Bnip3/Nix. We also summarize evidence regarding their efficacy in reducing neuronal apoptosis and improving cognitive performance in animal models. This work provides a theoretical foundation for the use of food-derived peptides in neuroprotective nutritional strategies and offers insights for developing functional foods and early dietary interventions against NDs.

food-derived peptides  /  mitophagy  /  neurodegenerative diseases  /  nutritional intervention
孙佳雯, 赵培均, 李倩, 李天歌, 赵广山, 黄现青, 宋莲军, 乔明武, 张蓓, Galaverna GIANNI, 李宁. 食源性肽通过调节神经元线粒体自噬营养干预神经退行性疾病的研究进展. 食品工业科技, 2026 , 47 (11) : 470 -478 . DOI: 10.13386/j.issn1002-0306.2025050162
Jiawen SUN, Peijun ZHAO, Qian LI, Tiange LI, Guangshan ZHAO, Xianqing HUANG, Lianjun SONG, Mingwu QIAO, Bei ZHANG, Galaverna GIANNI, Ning LI. Advances in Nutritional Intervention of Neurodegenerative Diseases: Food-Derived Peptides and Neuronal Mitophagy[J]. Science and Technology of Food Industry, 2026 , 47 (11) : 470 -478 . DOI: 10.13386/j.issn1002-0306.2025050162
Appendix
Less
Year 2026 volume 47 Issue 11
126
53
Cite this Article
BibTeX
Article Info
doi: 10.13386/j.issn1002-0306.2025050162
  • Receive Date：2025-05-19
  • Online Date：2026-10-22
  • Published：2026-06-01
Article Data
Affiliations
History
  • Received：2025-05-19
Affiliations
    1College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
    2Food and Drug Department, University of Parma, Parma 43124, Italy
References
Share
https://castjournals.cast.org.cn/joweb/spgykj/EN/10.13386/j.issn1002-0306.2025050162
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House