Home Journals Articles Updates About
CN
image
收藏切换
Effect of Yeast Extract on Relieving β-Lactoglobulin-induced Allergy and Regulating the Gut Microbiota in Mice
收藏切换
PDF
Haili YU1, 2, Mingshan ZHENG1, 2, Xiaoying HUANG1, 2, Xuemei YUAN1, 2, Hu WANG1, 2, Xiaowen LIU3, Zhixian CHEN*, 1, 2
Science and Technology of Food Industry | 2026, 47(9) : 412 - 420
Less
收藏切换
Science and Technology of Food Industry | 2026, 47(9): 412-420
• Nutrition and Healthcare •
Effect of Yeast Extract on Relieving β-Lactoglobulin-induced Allergy and Regulating the Gut Microbiota in Mice
Full
Haili YU1, 2, Mingshan ZHENG1, 2, Xiaoying HUANG1, 2, Xuemei YUAN1, 2, Hu WANG1, 2, Xiaowen LIU3, Zhixian CHEN*, 1, 2
Affiliations
  • 1.National Key Laboratory of Agricultural Microbialogy, Yichang 443000, China
  • 2.The Hubei Provincial Key Laboratory of Yeast Function, Yichang 443000, China
  • 3.China Three Gorges University Medical College, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Yichang 443002, China
Published: 2026-05-01 doi: 10.13386/j.issn1002-0306.2025050179
Outline
收藏切换
Objective:

To investigate the ameliorative effect of yeast extract on β-lactoglobulin allergy in mice and its regulatory effect on the gut microbiota, and to explore its mechanism of action.

Methods:

A mouse model of β-lactoglobulin allergy was established to explore the effects of yeast extract intervention on allergic symptoms, serum histamine, immunoglobulin E (IgE), and mast cell protease-1, as well as the morphology of spleen and colon tissues, intestinal microbiota, and short-chain fatty acids.

Results:

Yeast extract could alleviate allergic symptoms in β-lactoglobulin-allergic mice, reduce serum IgE levels, mast cell protease activity, and histamine content, improve intestinal inflammatory infiltration, increase the expression of CXCR3+Th1 and FOXP3+Treg cells in the spleen, up-regulate the expression of Th1-type factors (IFN-γ) and Treg-type factors (TGF-β) in serum, increase the content of acetic acid, butyric acid, and short-chain fatty acids, and increase the relative abundance of Faecalibacterium, Lactobacillus, and Bifidobacterium.

Conclusion:

Yeast extract can alleviate food allergy induced by β-lactoglobulin, and its mechanism may be related to the regulation of intestinal microbiota, enhancement of intestinal barrier function, regulation of Th1/Treg cell immune balance, and inhibition of IgE secretion.

yeast extract  /  β-lactoglobulin  /  allergy  /  gut microbiota  /  intestinal barrier
Haili YU, Mingshan ZHENG, Xiaoying HUANG, Xuemei YUAN, Hu WANG, Xiaowen LIU, Zhixian CHEN. Effect of Yeast Extract on Relieving β-Lactoglobulin-induced Allergy and Regulating the Gut Microbiota in Mice[J]. Science and Technology of Food Industry, 2026 , 47 (9) : 412 -420 . DOI: 10.13386/j.issn1002-0306.2025050179
Appendix
Less
Year 2026 volume 47 Issue 9
PDF
50
24
Cite this Article
BibTeX
Article Info
doi: 10.13386/j.issn1002-0306.2025050179
  • Receive Date：2025-05-21
  • Online Date：2026-05-13
  • Published：2026-05-01
Article Data
Affiliations
History
  • Received：2025-05-21
Affiliations
    1.National Key Laboratory of Agricultural Microbialogy, Yichang 443000, China
    2.The Hubei Provincial Key Laboratory of Yeast Function, Yichang 443000, China
    3.China Three Gorges University Medical College, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Yichang 443002, China
References
Share
https://castjournals.cast.org.cn/joweb/spgykj/EN/10.13386/j.issn1002-0306.2025050179
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House