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Research Progress on the Generation, Metabolism and Control Methods of Semicarbazide in Aquatic Products
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Honglin ZHANG1, Wanting CHEN1, Xiaoyan WANG1, Yongchang SU2, *, Xiaoting CHEN2, Yihui CHEN1, Zhiyu LIU2, 3, *, Yuejian HE4
Science and Technology of Food Industry | 2026, 47(16) : 525 - 537
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Science and Technology of Food Industry | 2026, 47(16): 525-537
• Reviews •
Research Progress on the Generation, Metabolism and Control Methods of Semicarbazide in Aquatic Products
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Honglin ZHANG1, Wanting CHEN1, Xiaoyan WANG1, Yongchang SU2, *, Xiaoting CHEN2, Yihui CHEN1, Zhiyu LIU2, 3, *, Yuejian HE4
Affiliations
  • 1College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
  • 2Fujian Key Laboratory of Marine Biological Aquaculture and High-value Utilization, Fujian Fisheries Research Institute, Xiamen 361013, China
  • 3College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China
  • 4Gelan Ruike (Xiamen) Food Technology Co., Ltd., Xiamen 361013, China
Published: 2026-08-15 doi: 10.13386/j.issn1002-0306.2025070246
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Semicarbazide (SEM) is widely monitored as a metabolite of the nitrofuran antibiotic nitrofurazone (NFZ). In recent years, frequent occurrences of excessive SEM residues in aquatic products have seriously hindered the export trade and sustainable development of the Chinese aquaculture industry. Studies have shown that SEM derives from both exogenous and endogenous sources. Exogenous sources include illegal drug use, contamination from water, feed, and algae, and chemical reactions during processing. Endogenous formation, conversely, occurs through pathways such as amino acid metabolism, the urea cycle, and chitin metabolism. This review systematically examines the sources, formation mechanisms, and metabolic behavior of SEM in aquatic products with a focus on advanced detection methods, including metabolomics, transcriptomics, and high performance liquid chromatography. Furthermore, targeted control strategies are proposed, encompassing aquaculture environmental management, optimization of processing procedures, and regulation of key metabolites. This review aims to provide a scientific foundation for the effective prevention and control of SEM contamination in aquatic products in China.

aquatic products  /  nitrofurazone  /  semicarbazide  /  generation mechanism  /  detection technology
张泓麟, 陈婉婷, 王晓燕, 苏永昌, 陈晓婷, 陈艺晖, 刘智禹, 何跃建. 水产品中氨基脲的产生、代谢及控制方法研究进展. 食品工业科技, 2026 , 47 (16) : 525 -537 . DOI: 10.13386/j.issn1002-0306.2025070246
Honglin ZHANG, Wanting CHEN, Xiaoyan WANG, Yongchang SU, Xiaoting CHEN, Yihui CHEN, Zhiyu LIU, Yuejian HE. Research Progress on the Generation, Metabolism and Control Methods of Semicarbazide in Aquatic Products[J]. Science and Technology of Food Industry, 2026 , 47 (16) : 525 -537 . DOI: 10.13386/j.issn1002-0306.2025070246
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Year 2026 volume 47 Issue 16
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doi: 10.13386/j.issn1002-0306.2025070246
  • Receive Date：2025-07-21
  • Online Date：2026-10-24
  • Published：2026-08-15
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History
  • Received：2025-07-21
Affiliations
    1College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    2Fujian Key Laboratory of Marine Biological Aquaculture and High-value Utilization, Fujian Fisheries Research Institute, Xiamen 361013, China
    3College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou 362000, China
    4Gelan Ruike (Xiamen) Food Technology Co., Ltd., Xiamen 361013, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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