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Progress of Sulforaphane Activating Nrf2 Signaling Pathway in Nervous System Diseases
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Haidong TIAN1, 2, Jiadi LIU1, 3, 4, Duling XU1, 4, 5, Haiwei REN6, Meng DONG7, *, Hongyan LI1, 3, 4, 5, *
Science and Technology of Food Industry | 2026, 47(15) : 472 - 480
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Science and Technology of Food Industry | 2026, 47(15): 472-480
• Reviews •
Progress of Sulforaphane Activating Nrf2 Signaling Pathway in Nervous System Diseases
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Haidong TIAN1, 2, Jiadi LIU1, 3, 4, Duling XU1, 4, 5, Haiwei REN6, Meng DONG7, *, Hongyan LI1, 3, 4, 5, *
Affiliations
  • 1Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
  • 2College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
  • 3School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100039, China
  • 4Gansu Province Laboratory of Isotopes, Lanzhou 730300, China
  • 5Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516029, China
  • 6School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China
  • 7Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China
Published: 2026-08-01 doi: 10.13386/j.issn1002-0306.2025060371
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Sulforaphane (SFN) is a naturally occurring compound that has been demonstrated to possess a range of biological activities, including antioxidant, anti-inflammatory, detoxifying, anti-glycation, and immunomodulatory effects. Nuclear factor erythroid-2-related factor 2 (Nrf2) has been identified as a key target for the action of sulforaphane (SFN). This review summarises recent advances in research concerning the functional mechanisms and roles of SFN-activated Nrf2 signalling pathways in various neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, epilepsy, stroke, and traumatic brain injury. The process of interaction between NRF2-Keap1 (Kelch-like ECH-associated protein 1) has been extensively documented. The initial step in this process involves the binding of Nrf2 to Keap1, which subsequently leads to the ubiquitination and subsequent degradation of Nrf2. Upon stimulation by activators such as SFN or reactive oxygen species (ROS), Nrf2 dissociates from Keap1, translocates to the nucleus, and binds to Maf proteins. This process initiates the transcription of downstream genes regulated by the antioxidant response element (ARE), including heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase catalytic subunit (GCLC). Consequently, this enhances the cellular antioxidant capacity. This article aims to systematically review dietary sources of sulforaphane (SFN) and its potential role, through the activation of the Nrf2 signaling pathway, in intervening in and delaying the progression of various neurological diseases, thereby providing a scientific basis for developing SFN-based dietary strategies for neurological health.

neurodegenerative diseases  /  sulforaphane  /  Nrf2  /  Alzheimer's disease
田海东, 柳佳娣, 徐度玲, 任海伟, 董猛, 李鸿岩. 萝卜硫素激活Nrf2信号通路在神经系统疾病中的研究进展. 食品工业科技, 2026 , 47 (15) : 472 -480 . DOI: 10.13386/j.issn1002-0306.2025060371
Haidong TIAN, Jiadi LIU, Duling XU, Haiwei REN, Meng DONG, Hongyan LI. Progress of Sulforaphane Activating Nrf2 Signaling Pathway in Nervous System Diseases[J]. Science and Technology of Food Industry, 2026 , 47 (15) : 472 -480 . DOI: 10.13386/j.issn1002-0306.2025060371
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Year 2026 volume 47 Issue 15
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doi: 10.13386/j.issn1002-0306.2025060371
  • Receive Date：2025-06-29
  • Online Date：2026-10-24
  • Published：2026-08-01
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History
  • Received：2025-06-29
Affiliations
    1Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
    2College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
    3School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100039, China
    4Gansu Province Laboratory of Isotopes, Lanzhou 730300, China
    5Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516029, China
    6School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China
    7Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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