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Lipid-lowering Activity and Mechanisms of Artemisia argyi Leaf Flavonoids Extract
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Rong LI1, *, Liang ZHANG1, Deyan ZHU1, Xianghui KONG2, Yechuan HUANG1, Wenjie DUAN3
Science and Technology of Food Industry | 2026, 47(12) : 455 - 461
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Science and Technology of Food Industry | 2026, 47(12): 455-461
• Nutrition and Healthcare •
Lipid-lowering Activity and Mechanisms of Artemisia argyi Leaf Flavonoids Extract
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Rong LI1, *, Liang ZHANG1, Deyan ZHU1, Xianghui KONG2, Yechuan HUANG1, Wenjie DUAN3
Affiliations
  • 1Functional Exploration and Comprehensive Utilization Team for Specialty Foods, Jingchu University of Technology, Jingmen 448000, China
  • 2Jingmen Central Hospital of Jingchu University of Technology, Jingmen 448001, China
  • 3Hubei Xianzhiling Foods Corporation, Jingmen 431935, China
Published: 2026-06-15 doi: 10.13386/j.issn1002-0306.2025060257
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In this study, the flavonoids of Artemisia argyi leaf were extracted and identified. Subsequently, the lipid-lowering effects of Artemisia argyi leaf flavonoids extract (AALE) and its underlying mechanisms were investigated using a combination of the Caenorhabditis elegans (C. elegans) model and in vitro lipase inhibition assays. The results showed that AALE exhibited significant inhibitory activity against pancreatic lipase, with a half-maximal inhibitory concentration (IC50) of 8.085±0.28 mg/mL, and this inhibition was non-competitive. Furthermore, AALE significantly reduced triglyceride (TG) levels in a high-fat nematode model (P<0.05). The TG content in the high-fat control group was 2.35 mmol/g, whereas in the treatment groups supplemented with 240 and 360 µg/mL of AALE, the TG levels decreased 37.45% and 34.04% (P<0.05), respectively. Further studies revealed that AALE significantly downregulated the expression of key genes involved in fat synthesis pathways in nematodes, including fat-6, fat-7, pod-2, and fasn-1, while upregulating the expression of acs-2, a gene associated with lipolysis. Moreover, the effect of AALE in reducing TG levels was dependent on the critical fatty acid synthesis genes fat-6 and fat-7. In conclusion, AALE can inhibit pancreatic lipase activity and reduce the TG content in nematodes, demonstrating a good lipid-lowering effect. This study provides a theoretical basis for the high-value utilization of Artemisia argyi.

Artemisia argyi leaf  /  flavonoid  /  pancreatic lipase  /  Caenorhabditis elegans  /  lipid-lowering
李蓉, 张亮, 朱德艳, 孔祥辉, 黄业传, 段文杰. 蕲艾叶黄酮提取物降脂活性及作用机制. 食品工业科技, 2026 , 47 (12) : 455 -461 . DOI: 10.13386/j.issn1002-0306.2025060257
Rong LI, Liang ZHANG, Deyan ZHU, Xianghui KONG, Yechuan HUANG, Wenjie DUAN. Lipid-lowering Activity and Mechanisms of Artemisia argyi Leaf Flavonoids Extract[J]. Science and Technology of Food Industry, 2026 , 47 (12) : 455 -461 . DOI: 10.13386/j.issn1002-0306.2025060257
Appendix
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Year 2026 volume 47 Issue 12
142
56
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Article Info
doi: 10.13386/j.issn1002-0306.2025060257
  • Receive Date：2025-06-20
  • Online Date：2026-10-22
  • Published：2026-06-15
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History
  • Received：2025-06-20
Affiliations
    1Functional Exploration and Comprehensive Utilization Team for Specialty Foods, Jingchu University of Technology, Jingmen 448000, China
    2Jingmen Central Hospital of Jingchu University of Technology, Jingmen 448001, China
    3Hubei Xianzhiling Foods Corporation, Jingmen 431935, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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