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Synergistic Hypoglycemic Effect and Mechanism of Wheat Peptides and Mulberry Leaf Extract
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Sinian LIU1, Yishan SONG1, Zhongyan BAO2, Nanhai XIAO3, Fengqin FENG3, Xi ZHANG1, 4, *
Science and Technology of Food Industry | 2026, 47(13) : 398 - 407
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Science and Technology of Food Industry | 2026, 47(13): 398-407
• Nutrition and Healthcare •
Synergistic Hypoglycemic Effect and Mechanism of Wheat Peptides and Mulberry Leaf Extract
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Sinian LIU1, Yishan SONG1, Zhongyan BAO2, Nanhai XIAO3, Fengqin FENG3, Xi ZHANG1, 4, *
Affiliations
  • 1School of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China
  • 2Hangzhou Kangyuan Food Science & Technology Co., Ltd., Hangzhou 310003, China
  • 3College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
  • 4Key Laboratory of Yunnan Provincial Department of Education on Substance Benchmark Research of Ethnic Medicines, Kunming 650500, China
Published: 2026-07-01 doi: 10.13386/j.issn1002-0306.2025060182
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The study investigated the hypoglycemic activity and mechanism of a combination comprising wheat peptides and mulberry leaf extract. In alloxan-glucose co-induced hyperglycemic zebrafish models, the 1:2 (w/w) combination exhibited hypoglycemic effects. In high-fat diet-induced obese hyperglycemic mice, the combination significantly inhibited body weight gain and blood glucose level, improved glucose metabolism and insulin sensitivity, and alleviated inflammatory responses. Mechanism studies revealed that the combination remodeled gut microbiota composition in obese hyperglycemic mice, decreasing the relative abundance of pathogenic Ileibacterium while increasing probiotics such as Faecalibaculum and Dubosiella. Non-targeted serum metabolomics identified 8 different metabolites, including LysoPC(14:0/0:0), Prostaglandin F2α, and 5-Hydroxyindoleacetate, etc. Correlation analysis demonstrated significant relationships between the relative abundance of gut microbiota (Ileibacterium, Faecalibaculum, Dubosiella, Clostridium_sensu_stricto_1, Coriobacteriaceae_UCG-002) and alterations in these metabolites. Collectively, the wheat peptides and mulberry leaf extract combination potentially exerts hypoglycemic effects through multi-target regulation of glucose-lipid metabolism and inflammation via gut microbiota and serum metabolites, providing new insights for functional food development.

wheat peptides  /  mulberry leaf extract  /  blood glucose  /  gut microbiota  /  metabolomics
刘思念, 宋宜珊, 鲍忠燕, 肖南海, 冯凤琴, 张希. 小麦肽复配桑叶提取物协同降血糖作用及机制. 食品工业科技, 2026 , 47 (13) : 398 -407 . DOI: 10.13386/j.issn1002-0306.2025060182
Sinian LIU, Yishan SONG, Zhongyan BAO, Nanhai XIAO, Fengqin FENG, Xi ZHANG. Synergistic Hypoglycemic Effect and Mechanism of Wheat Peptides and Mulberry Leaf Extract[J]. Science and Technology of Food Industry, 2026 , 47 (13) : 398 -407 . DOI: 10.13386/j.issn1002-0306.2025060182
Appendix
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Year 2026 volume 47 Issue 13
119
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doi: 10.13386/j.issn1002-0306.2025060182
  • Receive Date：2025-06-16
  • Online Date：2026-10-24
  • Published：2026-07-01
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  • Received：2025-06-16
Affiliations
    1School of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China
    2Hangzhou Kangyuan Food Science & Technology Co., Ltd., Hangzhou 310003, China
    3College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
    4Key Laboratory of Yunnan Provincial Department of Education on Substance Benchmark Research of Ethnic Medicines, Kunming 650500, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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