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To investigate the absorption pathways and efficacy of Gold Butterfly Collagen Peptides in mice, Gold Butterfly Collagen Peptides were extracted and purified using an in vitro digestion method, and their amino acid composition was analyzed. Subsequently, isotope-labeled peptide segments [13C5-15N1-Pro] were prepared via solid-phase synthesis to replace all homologous amino acids in the target peptide segments, and peptides were administered to C57BL/6 mice via gavage. Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was employed to dynamically monitor the metabolic distribution of labeled proline in various tissues and organs over 24 hours. The characteristic predominant amino acids of Gold Butterfly Collagen Peptides were glycine (20.80%), proline (10.72%), and alanine (10.60%). The small intestine was the primary organ absorbing Gold Butterfly Collagen Peptides, with uptake exceeding 50% across all time points. Skin absorption increased to 11.71% at 12 hours, suggesting potential involvement of Gold Butterfly Collagen Peptides in skin tissue repair. Uptake into the stomach, cecum, and colon exhibited dynamic fluctuations, while uptake by the heart and lungs was relatively low. This study demonstrates that Gold Butterfly Collagen Peptide digestion and absorption processes exhibit prominent temporal and organ-specific characteristics, providing theoretical foundation for their nutritional applications.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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