Home Journals Articles Updates About
CN
image
收藏切换
Comparison of in Vitro Digestibility Characteristics and Regulatory Effects on Infant Intestinal Flora between Different Milk Powders and Soybean Powder
收藏切换
Linzi LI1, Min ZHOU2, Han RONG3, Fayin YE1, 4, Guohua ZHAO1, 4, 5, Lin LEI1, 4, *
Science and Technology of Food Industry | 2026, 47(12) : 446 - 454
Less
收藏切换
Science and Technology of Food Industry | 2026, 47(12): 446-454
• Nutrition and Healthcare •
Comparison of in Vitro Digestibility Characteristics and Regulatory Effects on Infant Intestinal Flora between Different Milk Powders and Soybean Powder
Full
Linzi LI1, Min ZHOU2, Han RONG3, Fayin YE1, 4, Guohua ZHAO1, 4, 5, Lin LEI1, 4, *
Affiliations
  • 1College of Food Science, Southwest University, Chongqing 400715, China
  • 2Department of Military Nutrition and Food Hygiene, Military Preventive Medicine, Army Medical University, Chongqing 400038, China
  • 3School of Materials and Environment, Beijing Institute of Technology Zhuhai College, Zhuhai 519088, China
  • 4Chongqing Key Laboratory of Speciality Food Co-built by Sichuan and Chongqing, Chongqing 400715, China
  • 5College of Life Science, Sichuan Normal University, Chengdu 610101, China
Published: 2026-06-15 doi: 10.13386/j.issn1002-0306.2025060123
Outline
收藏切换

To investigate the digestive characteristics of milk and soybean powders from different sources in the infant gastrointestinal tract and their effects on gut microbiota, this study compared cow milk powder (CM), goat milk powder (GM), sheep milk powder (SM), and soybean powder (SB). An in vitro continuous infant gastrointestinal digestion model combined with fecal fermentation was established to evaluate protein hydrolysis, short-chain fatty acid (SCFA) production, and gut microbial composition. Results showed GM and CM exhibited significantly higher in vitro protein hydrolysis rates than SM and SB (P<0.05). During in vitro fecal fermentation, the three animal milk powders increased butyric acid and valeric acid concentrations by 4~7 times and 1~2 times, respectively. Microbiota analysis revealed that CM and SM generated gut microbial profiles more similar to those of breastfed infants, significantly increasing the abundance of Anaerococcus (P<0.05), which was associated with butyrate production. In contrast, SB showed lower protein digestibility, significantly elevated acetic acid levels and disrupted microbial homeostasis. It was characterized by a marked reduction in the abundance of beneficial genera such as Bifidobacterium and Clostridium_sensu_stricto_1. Correlation analysis further confirmed a strong negative correlation between acetic acid concentration and Bifidobacterium abundance (P<0.01). In summary, goat-milk powder and sheep-milk powder were more suitable raw materials for infant formula, offering scientific evidence to inform the rational selection of base powders in infant formula development.

milk powder  /  soybean powder  /  in vitro simulated gastrointestinal digestion  /  protein digestion  /  short-chain fatty acids  /  gut microbiota
李淋滋, 周敏, 荣菡, 叶发银, 赵国华, 雷琳. 不同乳粉和大豆粉体外消化特性及对婴儿肠道菌群的调节作用比较. 食品工业科技, 2026 , 47 (12) : 446 -454 . DOI: 10.13386/j.issn1002-0306.2025060123
Linzi LI, Min ZHOU, Han RONG, Fayin YE, Guohua ZHAO, Lin LEI. Comparison of in Vitro Digestibility Characteristics and Regulatory Effects on Infant Intestinal Flora between Different Milk Powders and Soybean Powder[J]. Science and Technology of Food Industry, 2026 , 47 (12) : 446 -454 . DOI: 10.13386/j.issn1002-0306.2025060123
Appendix
Less
Year 2026 volume 47 Issue 12
117
49
Cite this Article
BibTeX
Article Info
doi: 10.13386/j.issn1002-0306.2025060123
  • Receive Date：2025-06-11
  • Online Date：2026-10-22
  • Published：2026-06-15
Article Data
Affiliations
History
  • Received：2025-06-11
Affiliations
    1College of Food Science, Southwest University, Chongqing 400715, China
    2Department of Military Nutrition and Food Hygiene, Military Preventive Medicine, Army Medical University, Chongqing 400038, China
    3School of Materials and Environment, Beijing Institute of Technology Zhuhai College, Zhuhai 519088, China
    4Chongqing Key Laboratory of Speciality Food Co-built by Sichuan and Chongqing, Chongqing 400715, China
    5College of Life Science, Sichuan Normal University, Chengdu 610101, China
References
Share
https://castjournals.cast.org.cn/joweb/spgykj/EN/10.13386/j.issn1002-0306.2025060123
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House