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Advances in Nutritional Intervention of Neurodegenerative Diseases: Food-Derived Peptides and Neuronal Mitophagy
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Jiawen SUN1, Peijun ZHAO1, Qian LI1, Tiange LI1, Guangshan ZHAO1, Xianqing HUANG1, Lianjun SONG1, Mingwu QIAO1, Bei ZHANG1, Galaverna GIANNI2, Ning LI1, *
Science and Technology of Food Industry | 2026, 47(11) : 470 - 478
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Science and Technology of Food Industry | 2026, 47(11): 470-478
• Reviews •
Advances in Nutritional Intervention of Neurodegenerative Diseases: Food-Derived Peptides and Neuronal Mitophagy
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Jiawen SUN1, Peijun ZHAO1, Qian LI1, Tiange LI1, Guangshan ZHAO1, Xianqing HUANG1, Lianjun SONG1, Mingwu QIAO1, Bei ZHANG1, Galaverna GIANNI2, Ning LI1, *
Affiliations
  • 1College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
  • 2Food and Drug Department, University of Parma, Parma 43124, Italy
Published: 2026-06-01 doi: 10.13386/j.issn1002-0306.2025050162
Outline
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Neurodegenerative diseases (NDs) are chronic disorders marked by progressive neuronal loss, with pathogenesis involving abnormal protein aggregation, oxidative stress, mitochondrial dysfunction, and other contributing factors. As a core mechanism regulating mitochondrial quality control and cellular homeostasis, mitophagy has gained increasing attention as a therapeutic target in NDs. Food-derived bioactive peptides have attracted interest due to their high safety and low toxicity, demonstrating considerable potential for the nutritional intervention of NDs. This review systematically outlines the molecular mechanisms of mitophagy and its dysregulation in neurodegenerative conditions, with a focus on how specific dietary peptides—including corn, rice, walnut, and marine collagen peptides—modulate mitophagy and restore mitochondrial function via pathways such as PINK1/Parkin, AMPK/mTOR, and Bnip3/Nix. We also summarize evidence regarding their efficacy in reducing neuronal apoptosis and improving cognitive performance in animal models. This work provides a theoretical foundation for the use of food-derived peptides in neuroprotective nutritional strategies and offers insights for developing functional foods and early dietary interventions against NDs.

food-derived peptides  /  mitophagy  /  neurodegenerative diseases  /  nutritional intervention
孙佳雯, 赵培均, 李倩, 李天歌, 赵广山, 黄现青, 宋莲军, 乔明武, 张蓓, Galaverna GIANNI, 李宁. 食源性肽通过调节神经元线粒体自噬营养干预神经退行性疾病的研究进展. 食品工业科技, 2026 , 47 (11) : 470 -478 . DOI: 10.13386/j.issn1002-0306.2025050162
Jiawen SUN, Peijun ZHAO, Qian LI, Tiange LI, Guangshan ZHAO, Xianqing HUANG, Lianjun SONG, Mingwu QIAO, Bei ZHANG, Galaverna GIANNI, Ning LI. Advances in Nutritional Intervention of Neurodegenerative Diseases: Food-Derived Peptides and Neuronal Mitophagy[J]. Science and Technology of Food Industry, 2026 , 47 (11) : 470 -478 . DOI: 10.13386/j.issn1002-0306.2025050162
Appendix
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Year 2026 volume 47 Issue 11
128
53
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Article Info
doi: 10.13386/j.issn1002-0306.2025050162
  • Receive Date：2025-05-19
  • Online Date：2026-10-22
  • Published：2026-06-01
Article Data
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History
  • Received：2025-05-19
Affiliations
    1College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China
    2Food and Drug Department, University of Parma, Parma 43124, Italy
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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