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Comparative Analysis of Structural Characterization, Antioxidant, and Hypolipidemic Activities of Chondroitin Sulfate from Different Sources
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Yuan YUAN1, Bingbing SONG1, Jing CHEN1, Ziyu LI1, Yaoying HUANG1, Saiyi ZHONG1, 2, 3, *
Science and Technology of Food Industry | 2026, 47(3) : 42 - 51
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Science and Technology of Food Industry | 2026, 47(3): 42-51
• Research and Investigation •
Comparative Analysis of Structural Characterization, Antioxidant, and Hypolipidemic Activities of Chondroitin Sulfate from Different Sources
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Yuan YUAN1, Bingbing SONG1, Jing CHEN1, Ziyu LI1, Yaoying HUANG1, Saiyi ZHONG1, 2, 3, *
Affiliations
  • 1Guangdong Key Laboratory of Aquatic Product Processing and Safety, School of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China
  • 2Guangdong Marine Bioproducts Engineering Laboratory, Zhanjiang 524088, China
  • 3Shenzhen Research Institute, Guangdong Ocean University, Shenzhen 518100, China
Published: 2026-02-01 doi: 10.13386/j.issn1002-0306.2024110311
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Chondroitin sulfate (CS), a glycosaminoglycan covalently linked to proteins in proteoglycans, exhibits significant pharmacological activities. However, systematic comparisons of structural and functional differences among CS from diverse sources remain limited. This study comparatively analyzed CS extracted from tilapia heads in our laboratory and commercially available animal sources (bovine cartilage, chicken cartilage, and shark cartilage) using UV, IR, and NMR spectroscopy, and evaluated their antioxidant and hypolipidemic activities through DPPH, ABTS+ radical scavenging assays and bile-acid binding tests. Results revealed that tilapia head-derived CS and shark CS shared similar sulfation patterns, predominantly classified as CS-C type (6-O-sulfation), whereas bovine and chicken-derived CS belonged to CS-A (4-O-sulfation). Notably, tilapia CS exhibited the highest ABTS+ scavenging capacity (90.72%±0.19%) at 4 mg/mL, while shark CS showed superior cholesterol micelle binding (39.38%±0.86%) at 6 mg/mL. This study revealed that the CS-C type configuration (dominant in tilapia head- and shark-derived CS) exhibited significantly superior antioxidant and lipid-regulating activities compared to the CS-A type (bovine and chicken sources) due to the positional advantage of 6-O-sulfation. This work systematically compared structural and functional divergences between terrestrial and marine-sourced CS, elucidating the critical impact of sulfation sites (C4 vs C6) on bioactivity while highlighting the application potential of marine-derived CS, thereby providing strategic insights for source-specific CS exploitation.

chondroitin sulfate (CS)  /  structural characterization  /  antioxidant activity  /  hypolipidemic activities  /  tilapia
袁媛, 宋兵兵, 陈菁, 黎梓玉, 黄耀莹, 钟赛意. 不同来源硫酸软骨素的结构特征及抗氧化活性与降脂活性比较. 食品工业科技, 2026 , 47 (3) : 42 -51 . DOI: 10.13386/j.issn1002-0306.2024110311
Yuan YUAN, Bingbing SONG, Jing CHEN, Ziyu LI, Yaoying HUANG, Saiyi ZHONG. Comparative Analysis of Structural Characterization, Antioxidant, and Hypolipidemic Activities of Chondroitin Sulfate from Different Sources[J]. Science and Technology of Food Industry, 2026 , 47 (3) : 42 -51 . DOI: 10.13386/j.issn1002-0306.2024110311
Appendix
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Year 2026 volume 47 Issue 3
105
46
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Article Info
doi: 10.13386/j.issn1002-0306.2024110311
  • Receive Date：2024-11-25
  • Online Date：2026-10-25
  • Published：2026-02-01
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  • Received：2024-11-25
Affiliations
    1Guangdong Key Laboratory of Aquatic Product Processing and Safety, School of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China
    2Guangdong Marine Bioproducts Engineering Laboratory, Zhanjiang 524088, China
    3Shenzhen Research Institute, Guangdong Ocean University, Shenzhen 518100, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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