Full
Outline
To assess the toxicological safety of Cornu cervi pantotrichum-Ganoderma lucidum liquor.
According to GB 15193—2014 National food safety standard-Acute oral toxicity test, the safety of Cornu cervi pantotrichum-Ganoderma lucidum liquor was evaluated through acute oral toxicity test on mice, 3 genetic toxicity tests and 28-day oral toxicity test.
The maximum tolerated dose (MTD) of Cornu cervi pantotrichum-Ganoderma lucidum liquor for both male and female mice was greater than 42 mL/kg, indicating it was a practically non-toxic sample. No mutagenic effects were found in the genetic toxicity test. In the 28-day oral toxicity test, Cornu cervi pantotrichum-Ganoderma lucidum liquor at all doses had no significant impact on the body weight, food utilization rate, urine indicators and organ-to-body weight ratio of rats. The hemoglobin and hematocrit values of female rats in the low-dose group were significantly reduced compared to base liquor control group, but no abnormal changes related to the sample were found in the histopathological examination. The no-observed-adverse-effect level of Cornu cervi pantotrichum-Ganoderma lucidum liquor for both male and female rats in the 28-day oral toxicity test was 42 mL/kg.
Cornu cervi pantotrichum-Ganoderma lucidum liquor does not show general toxicity or genetic toxicity at the doses studied in this research, indicating a high level of edible safety. This study provides a scientific basis for the development and utilization of Cornu cervi pantotrichum-Ganoderma lucidum liquor.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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